Adipokine gene expression in a novel hypothalamic neuronal cell line: Resistin-dependent regulation of fasting-induced adipose factor and SOCS-3

Neuroendocrinology

Volumn 85, Issue 4, 2007, Pages 232-241

  Brown, Russell ^a   Imran, Syed A ^a   Belsham, Denise D ^b   Ur, Ehud ^a   Wilkinson, Michael ^a,c  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c IWK HEALTH CENTRE   (Canada)

Author keywords

3T3 L1 adipocytes; Angiopoietin like 4 protein (angptl4); Brain; N 1 neurons; RNA interference

Indexed keywords

ADIPOCYTOKINE; FASTING INDUCED ADIPOSE FACTOR; LEPTIN; MESSENGER RNA; RESISTIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; HYPOTHALAMUS; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 34547204416     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000104248     Document Type: Article

References (62)

1. Kershaw EE, Flier JS: Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004;89:2548-2556.
2. Himms-Hagen J: Physiological roles of the leptin endocrine system: differences between mice and humans. Crit Rev Clin Lab Sci 1999;36:575-655.
3. Trayhurn P, Wood IS: Adipokines: Inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004;92:347-355.
4. Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, Gonzalez FJ, Desvergne B, Wahli W: Characterization of the fasting-induced adipose factor fiaf, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem 2000;275:28488-28493.
5. Funahashi H, Yada T, Suzuki R, Shioda S: Distribution, function, and properties of leptin receptors in the brain. Int Rev Cytol 2003;224:1-27.
6. Wilkinson M, Morash B, Ur E: The brain is a source of leptin. Front Horm Res 2000;26:106-125.
7. Ur E, Wilkinson DA, Morash BA, Wilkinson M: Leptin immunoreactivity is localized to neurons in rat brain. Neuroendocrinology 2002;75:264-272.
8. Beretta E, Dube MG, Kalra PS, Kalra SP: Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes. Pediatr Res 2002;52:189-198.
9. Knerr I, Schuster S, Nomikos P, Buchfelder M, Dotsch J, Schoof E, Fahlbusch R, Rascher W: Gene expression of adrenomedullin, leptin, their receptors and neuropeptide Y in hormone-secreting and non-functioning pituitary adenomas, meningiomas and malignant intracranial tumours in humans. Neuropathol Appl Neurobiol 2001;27:215-222.
10. Ehrhardt RA, Bell AW, Boisclair YR: Spatial and developmental regulation of leptin in fetal sheep. Am J Physiol 2002;282:R1628-R1635.
11. Smolinska N, Przala J, Kaminski T, Siawrys G, Gajewska A, Kochman K, Okrasa S: Leptin gene expression in the hypothalamus and pituitary of pregnant pigs. Neuro Endocrinol Lett 2004;25:191-195.
12. Kaminski T, Smolinska N, Gajewska A, Siawrys G, Okrasa S, Kochman K, Przala J: Leptin and long form of leptin receptor genes expression in the hypothalamus and pituitary during the luteal phase and early pregnancy in pigs. J Physiol Pharmacol 2006;57:95-108.
13. Li HY, Wang LL, Yeh RS: Leptin immunoreactivity in the central nervous system in normal and diabetic rats. Neuroreport 1999;10:437-442.
14. Johnson RM, Johnson TM, Londraville RL: Evidence for leptin expression in fishes. J Exp Zool 2000;286:718-724.
15. Boswell T, Dunn IC, Wilson PW, Joseph N, Burt DW, Sharp PJ: Identification of a nonmammalian leptin-like gene: characterization and expression in the tiger salamander (Ambystoma tigrinum). Gen Comp Endocrinol 2006;146: 157-166.
16. Brown R, Morash B, Ur E, Wilkinson M: Rnai-mediated silencing of leptin gene expression increases cell death in c6 glioblastoma cells. Brain Res Mol Brain Res 2005;139:357-360.
17. Eikelis N, Esler M: The neurobiology of human obesity. Exp Physiol 2005;90:673-682.
18. Russo VC, Metaxas S, Kobayashi K, Harris M, Werther GA: Antiapoptotic effects of leptin in human neuroblastoma cells. Endocrinology 2004;145:4103-4112.
19. Morash BA, Wilkinson D, Ur E, Wilkinson M: Resistin expression and regulation in mouse pituitary. FEBS Lett 2002;526:26-30.
20. Morash BA, Ur E, Wiesner G, Roy J, Wilkinson M: Pituitary resistin gene expression: effects of age, gender and obesity. Neuroendocrinology 2004;79:149-156.
21. Wiesner G, Morash BA, Ur E, Wilkinson M: Food restriction regulates adipose-specific cytokines in pituitary gland but not in hypothalamus. J Endocrinol 2004;180:R1-R6.
22. Wilkinson M, Wilkinson D, Wiesner G, Morash B, Ur E: Hypothalamic resistin immunoreactivity is reduced by obesity in the mouse: co-localization with α-melanostimulating hormone. Neuroendocrinology 2005;81:19-30.
23. Tovar S, Nogueiras R, Tung LY, Castaneda TR, Vazquez MJ, Morris A, Williams LM, Dickson SL, Dieguez C: Central administration of resistin promotes short-term satiety in rats. Eur J Endocrinol 2005;153:R1-R5.
24. Ort T, Arjona AA, MacDougall JR, Nelson PJ, Rothenberg ME, Wu F, Eisen A, Halvorsen YD: Recombinant human fizz3/resistin stimulates lipolysis in cultured human adipocytes, mouse adipose explants, and normal mice. Endocrinology 2005;146:2200-2209.
25. Le Jan S, Amy C, Cazes A, Monnot C, Lamande N, Favier J, Philippe J, Sibony M, Gasc JM, Corvol P, Germain S: Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma. Am J Pathol 2003;162:1521-1528.
26. Maddineni S, Metzger S, Ocon O, Hendricks G 3rd, Ramachandran R: Adiponectin gene is expressed in multiple tissues in the chicken: food deprivation influences adiponectin messenger ribonucleic acid expression. Endocrinology 2005;146:4250-4256.
27. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003;423:762-769.
28. Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS: Adiponectin acts in the brain to decrease body weight. Nat Med 2004;10:524-529.
29. Masaki T, Chiba S, Yasuda T, Tsubone T, Kakuma T, Shimomura I, Funahashi T, Matsuzawa Y, Yoshimatsu H: Peripheral, but not central, administration of adiponectin reduces visceral adiposity and upregulates the expression of uncoupling protein in agouti yellow (ay/a) obese mice. Diabetes 2003;52:2266-2273.
30. Brunetti L, Orlando G, Recinella L, Michelotto B, Ferrante C, Vacca M: Resistin, but not adiponectin, inhibits dopamine and norepinephrine release in the hypothalamus. Eur J Pharmacol 2004;493:41-44.
31. Ahima RS, Qi Y, Singhal NS: Adipokines that link obesity and diabetes to the hypothalamus. Prog Brain Res 2006;153:155-174.
32. Singhal NS, Qi Y, Lazar MA, Ahima RS: Resistin regulates hepatic glucose metabolism via a central mechanism. Society for Neuroscience, 2006.
33. Belsham DD, Cai F, Cui H, Smukler SR, Salapatek AM, Shkreta L: Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders. Endocrinology 2004;145:393-400.
34. Song H, Shojima N, Sakoda H, Ogihara T, Fujishiro M, Katagiri H, Anai M, Onishi Y, Ono H, Inukai K, Fukushima Y, Kikuchi M, Shimano H, Yamada N, Oka Y, Asano T: Resistin is regulated by c/ebps, ppars, and signal-transducing molecules. Biochem Biophys Res Commun 2002;299:291-298.
35. Sato N, Kobayashi K, Inoguchi T, Sonoda N, Imamura M, Sekiguchi N, Nakashima N, Nawata H: Adenovirus-mediated high expression of resistin causes dyslipidemia in mice. Endocrinology 2005;146:273-279.
36. Xu A, Lam MC, Chan KW, Wang Y, Zhang J, Hoo RL, Xu JY, Chen B, Chow WS, Tso AW, Lam KS: Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc Natl Acad Sci USA 2005;102:6086-6091.
37. Brown R, Wiesner G, Ur E, Wilkinson M: Pituitary resistin gene expression is upregulated in vitro and in vivo by dexamethasone but is unaffected by rosiglitazone. Neuroendocrinology 2005;81:41-48.
38. Steppan CM, Wang J, Whiteman EL, Birnbaum MJ, Lazar MA: Activation of socs-3 by resistin. Mol Cell Biol 2005;25:1569-1575.
39. Wiesner G, Brown RE, Robertson GS, Imran SA, Ur E, Wilkinson M: Increased expression of the adipokine genes resistin and fasting-induced adipose factor in hypoxic/ischaemic mouse brain. Neuroreport 2006;17:1195-1198.
40. Bond BC, Virley DJ, Cairns NJ, Hunter AJ, Moore GB, Moss SJ, Mudge AW, Walsh FS, Jazin E, Preece P: The quantification of gene expression in an animal model of brain ischaemia using Taqman real-time RT-PCR. Brain Res Mol Brain Res 2002;106:101-116.
41. Stewart MJ, Smoak K, Blum MA, Sherry B: Basal and reovirus-induced β-interferon (IFN-β) and IFN-β-stimulated gene expression are cell type specific in the cardiac protective response. J Virol 2005;79:2979-2987.
42. Cui H, Cai F, Belsham DD: Anorexigenic hormones leptin, insulin, and α-melanocyte-stimulating hormone directly induce neurotensin (nt) gene expression in novel nt-expressing cell models. J Neurosci 2005;25:9497-9506.
43. Sahu A: Minireview: A hypothalamic role in energy balance with special emphasis on leptin. Endocrinology 2004;145:2613-2620.
44. Jackson AL, Linsley PS: Noise amidst the silence: off-target effects of sirnas? Trends Genet 2004;20:521-524.
45. Munzberg H, Flier JS, Bjorbaek C: Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004;145:4880-4889.
46. Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, Flier JS: Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of socs-3. Nat Med 2004;10:734-738.
47. Kersten S: Regulation of lipid metabolism via angiopoietin-like proteins. Biochem Soc Trans 2005;33:1059-1062.
48. Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI: The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 2004;101:15718-15723.
49. Wiesner G, Brown R, Robertson G, Ur E, Wilkinson M: Increased expression of the adipokines resistin and fiaf in hypoxic/ischemic mouse brain. Neuroreport 2006;17:1195-1198.
50. Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM: Peroxisome proliferator-activated receptor-γ target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol 2000;20:5343-5349.
51. Rangwala SM, Rich AS, Rhoades B, Shapiro JS, Obici S, Rossetti L, Lazar MA: Abnormal glucose homeostasis due to chronic hyper-resistinemia. Diabetes 2004;53:1937-1941.
52. Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, Wang J, Rajala MW, Pocai A, Scherer PE, Steppan CM, Ahima RS, Obici S, Rossetti L, Lazar MA: Regulation of fasted blood glucose by resistin. Science 2004;303:1195-1198.
53. Palanivel R, Maida A, Liu Y, Sweeney G: Regulation of insulin signalling, glucose uptake and metabolism in rat skeletal muscle cells upon prolonged exposure to resistin. Diabetologia 2006;49:183-190.
54. Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, Seip R, Orlova C, Mantzoros CS: Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab 2003;88:4848-4856.
55. Lee JH, Bullen JW Jr, Stoyneva VL, Mantzoros CS: Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia. Am J Physiol 2005;288:E625-E632.
56. Kim S, Moustaid-Moussa N: Secretory, endocrine and autocrine/paracrine function of the adipocyte. J Nutr 2000;130:3110S-3115S.
57. Mohamed-Ali V, Pinkney JH, Coppack SW: Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord 1998;22: 1145-1158.
58. Fu Y, Luo N, Klein RL, Garvey WT: Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. J Lipid Res 2005;46:1369-1379.
59. Gong H, Ni Y, Guo X, Fei L, Pan X, Guo M, Chen R: Resistin promotes 3t3-l1 preadipocyte differentiation. Eur J Endocrinol 2004;150:885-892.
60. Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L: Disulfide-dependent multimeric assembly of resistin family hormones. Science 2004;304:1154-1158.
61. Spranger J, Verma S, Gohring I, Bobbert T, Seifert J, Sindler AL, Pfeiffer A, Hileman SM, Tschop M, Banks WA: Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes 2006;55:141-147.
62. Wilkinson M, Brown R, Imran SA, Ur E: Adipokine gene expression in brain and pituitary gland. Neuroendocrinology 2007, submitted.