The procognitive effects of leptin in the brain and their clinical implications

International Journal of Clinical Practice

Volumn 64, Issue 13, 2010, Pages 1808-1812

  Paz Filho, G ^a   Wong, M L ^a   Licinio, J ^a  

^a Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; LEPTIN;

ALZHEIMER DISEASE; ANXIETY; ARTICLE; BRAIN FUNCTION; CINGULATE GYRUS; COGNITION; COGNITIVE DEFECT; DENDRITE; DEPRESSION; DISEASE MODEL; FRONTAL LOBE; HIPPOCAMPUS; HUMAN; HUNGER; INSULA; LEARNING; MEDLINE; MEMORY; MOOD; NERVE CELL EXCITABILITY; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; OCCIPITAL LOBE; OLIGODENDROGLIA; PARIETAL LOBE; PREFRONTAL CORTEX; PRIORITY JOURNAL; REGULATORY MECHANISM; SATIETY; SYNAPTOGENESIS; TEMPORAL CORTEX; THALAMUS;

ALZHEIMER DISEASE; BRAIN; COGNITION; HUMANS; LEPTIN; OBESITY;

EID: 78649308474     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2010.02536.x     Document Type: Article

References (58)

1. Friedman JM,. Leptin, leptin receptors, and the control of body weight. Nutr Rev 1998; 56: S38 - 46; discussion s54-75.
2. Bluher S, Mantzoros CS,. Leptin in reproduction. Curr Opin Endocrinol Diabetes Obes 2007; 14: 458 - 64.
3. Chan JL, Mantzoros CS,. Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet 2005; 366: 74 - 85.
4. Brennan AM, Mantzoros CS,. Leptin and adiponectin: their role in diabetes. Curr Diab Rep 2007; 7: 1 - 2.
5. Ceddia RB,. Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis. Int J Obes (Lond) 2005; 29: 1175 - 83.
6. Hamrick MW, Ferrari SL,. Leptin and the sympathetic connection of fat to bone. Osteoporos Int 2008; 19: 905 - 12.
7. Karsenty G,. Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab 2006; 4: 341 - 8.
8. Barouch LA, Berkowitz DE, Harrison RW, O'Donnell CP, Hare JM,. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 2003; 108: 754 - 9.
9. Otero M, Lago R, Lago F, et al. Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 2005; 579: 295 - 301.
10. Ahima RS,. Adipose tissue as an endocrine organ. Obesity (Silver Spring) 2006; 14 (Suppl. 5): 242S - 9S.
11. Chan JL, Heist K, DePaoli AM, Veldhuis JD, Mantzoros CS,. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 2003; 111: 1409 - 21.
12. Lam QL, Lu L,. Role of leptin in immunity. Cell Mol Immunol 2007; 4: 1 - 13.
13. Fulton S, Pissios P, Manchon RP, et al. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 2006; 51: 811 - 22.
14. Hommel JD, Trinko R, Sears RM, et al. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 2006; 51: 801 - 10.
15. Lu XY, Kim CS, Frazer A, Zhang W,. Leptin: a potential novel antidepressant. Proc Natl Acad Sci U S A 2006; 103: 1593 - 8.
16. Hayes MR, Skibicka KP, Leichner TM, et al. Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab 2010; 11: 77 - 83.
17. Bouret SG,. Neurodevelopmental actions of leptin. Brain Res 2010; 1350: 2 - 9.
18. Morrison CD,. Leptin signaling in brain: a link between nutrition and cognition? Biochim Biophys Acta 2009; 1792: 401 - 8.
19. Zhang F, Wang S, Signore AP, Chen J,. Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia. Stroke 2007; 38: 2329 - 36.
20. O'Malley D, MacDonald N, Mizielinska S, Connolly CN, Irving AJ, Harvey J,. Leptin promotes rapid dynamic changes in hippocampal dendritic morphology. Mol Cell Neurosci 2007; 35: 559 - 72.
21. Zhao C, Deng W, Gage FH,. Mechanisms and functional implications of adult neurogenesis. Cell 2008; 132: 645 - 60.
22. Garza JC, Guo M, Zhang W, Lu XY,. Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J Biol Chem 2008; 283: 18238 - 47.
23. Udagawa J, Hashimoto R, Suzuki H, et al. The role of leptin in the development of the cerebral cortex in mouse embryos. Endocrinology 2006; 147: 647 - 58.
24. Valerio A, Ghisi V, Dossena M, et al. Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3beta. J Biol Chem 2006; 281: 12950 - 8.
25. Udagawa J, Nimura M, Otani H,. Leptin affects oligodendroglial development in the mouse embryonic cerebral cortex. Neuro Endocrinol Lett 2006; 27: 177 - 82.
26. Harvey J,. Leptin regulation of neuronal excitability and cognitive function. Curr Opin Pharmacol 2007; 7: 643 - 7.
27. Harvey J,. Leptin: a diverse regulator of neuronal function. J Neurochem 2007; 100: 307 - 13.
28. Matochik JA, London ED, Yildiz BO, et al. Effect of leptin replacement on brain structure in genetically leptin-deficient adults. J Clin Endocrinol Metab 2005; 90: 2851 - 4.
29. Baicy K, London ED, Monterosso J, et al. Leptin replacement alters brain response to food cues in genetically leptin-deficient adults. Proc Natl Acad Sci U S A 2007; 104: 18276 - 9.
30. Paz-Filho GJ, Babikian T, Asarnow R, et al. Leptin replacement improves cognitive development. PLoS ONE 2008; 3: e3098.
31. Liu J, Garza JC, Bronner J, Kim CS, Zhang W, Lu XY,. Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine. Psychopharmacology (Berl) 2010; 207: 535 - 45.
32. Hebebrand J, Muller TD, Holtkamp K, Herpertz-Dahlmann B,. The role of leptin in anorexia nervosa: clinical implications. Mol Psychiatry 2007; 12: 23 - 35.
33. Farr SA, Banks WA, Morley JE,. Effects of leptin on memory processing. Peptides 2006; 27: 1420 - 5.
34. Li XL, Aou S, Oomura Y, Hori N, Fukunaga K, Hori T,. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 2002; 113: 607 - 15.
35. Oomura Y, Hori N, Shiraishi T, et al. Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides 2006; 27: 2738 - 49.
36. Power DA, Noel J, Collins R, O'Neill D,. Circulating leptin levels and weight loss in Alzheimer's disease patients. Dement Geriatr Cogn Disord 2001; 12: 167 - 70.
37. Holden KF, Lindquist K, Tylavsky FA, Rosano C, Harris TB, Yaffe K,. Serum leptin level and cognition in the elderly: findings from the Health ABC Study. Neurobiol Aging 2009; 30: 1483 - 9.
38. Lieb W, Beiser AS, Vasan RS, et al. Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA 2009; 302: 2565 - 72.
39. Ahima RS, Bjorbaek C, Osei S, Flier JS,. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 1999; 140: 2755 - 62.
40. Schwartz MW, Porte D Jr,. Diabetes, obesity, and the brain. Science 2005; 307: 375 - 9.
41. Kroner Z,. The relationship between Alzheimer's disease and diabetes: Type 3 diabetes? Altern Med Rev 2009; 14: 373 - 9.
42. Ott A, Stolk RP, Van Harskamp F, Pols HA, Hofman A, Breteler MM,. Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 1999; 53: 1937 - 42.
43. Takeda S, Sato N, Uchio-Yamada K, et al. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci USA 2010; 107: 7036 - 41.
44. Erol A,. An integrated and unifying hypothesis for the metabolic basis of sporadic Alzheimer's disease. J Alzheimers Dis 2008; 13: 241 - 53.
45. Elias MF, Elias PK, Sullivan LM, Wolf PA, D'Agostino RB,. Obesity, diabetes and cognitive deficit: The Framingham Heart Study. Neurobiol Aging 2005; 26 (Suppl. 1): 11 - 6.
46. Raji CA, Ho AJ, Parikshak NN, et al. Brain structure and obesity. Hum Brain Mapp 2010; 31: 353 - 64.
47. Ho AJ, Stein JL, Hua X, et al. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A 2010; 107: 8404 - 9.
48. Pannacciulli N, Del Parigi A, Chen K, Le DS, Reiman EM, Tataranni PA,. Brain abnormalities in human obesity: a voxel-based morphometric study. Neuroimage 2006; 31: 1419 - 25.
49. Gazdzinski S, Kornak J, Weiner MW, Meyerhoff DJ,. Body mass index and magnetic resonance markers of brain integrity in adults. Ann Neurol 2008; 63: 652 - 7.
50. Myers MG, Cowley MA, Munzberg H,. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 2008; 70: 537 - 56.
51. Fewlass DC, Noboa K, Pi-Sunyer FX, Johnston JM, Yan SD, Tezapsidis N,. Obesity-related leptin regulates Alzheimer's Abeta. FASEB J 2004; 18: 1870 - 8.
52. Greco SJ, Sarkar S, Johnston JM, et al. Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochem Biophys Res Commun 2008; 376: 536 - 41.
53. Tezapsidis N, Johnston JM, Smith MA, et al. Leptin: a novel therapeutic strategy for Alzheimer's disease. J Alzheimers Dis 2009; 16: 731 - 40.
54. Ramamurthy S, Ronnett GV,. Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol 2006; 574: 85 - 93.
55. Dagon Y, Avraham Y, Magen I, Gertler A, Ben-Hur T, Berry EM,. Nutritional status, cognition, and survival: a new role for leptin and AMP kinase. J Biol Chem 2005; 280: 42142 - 8.
56. Paz-Filho GJ, Delibasi T, Erol HK, Wong ML, Licinio J,. Cellular immunity before and after leptin replacement therapy. J Pediatr Endocrinol Metab 2009; 22: 1069 - 74.
57. Lago F, Dieguez C, Gomez-Reino J, Gualillo O,. Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol 2007; 3: 716 - 24.
58. Vona-Davis L, Rose DP,. Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer 2007; 14: 189 - 206.