Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition

Neuroscience and Biobehavioral Reviews

Volumn 58, Issue , 2015, Pages 36-45

  Morris, Margaret J ^a   Beilharz, Jessica E ^a   Maniam, Jayanthi ^a   Reichelt, Amy C ^a   Westbrook, R Frederick ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Dopamine; Hippocampus; Memory; Obesity; Overeating; Reward; Stress

Indexed keywords

ACUTE STRESS; BINGE EATING DISORDER; BRAIN FUNCTION; COGNITION; COGNITIVE DEFECT; DEVELOPED COUNTRY; DEVELOPING COUNTRY; DISEASE ASSOCIATION; EARLY LIFE STRESS; ENCEPHALITIS; ENERGY BALANCE; FEEDING BEHAVIOR; FOOD AVAILABILITY; FOOD COMPOSITION; FOOD INTAKE; FOOD PREFERENCE; HEALTH PROMOTION; HIPPOCAMPUS; HUMAN; IMMOBILIZATION STRESS; LEARNING DISORDER; LIFESTYLE MODIFICATION; LIPID DIET; MATERNAL DEPRIVATION; MEMORY DISORDER; NERVE CELL NETWORK; NEUROCHEMISTRY; NEUROTRANSMISSION; NONHUMAN; OBESITY; OXIDATIVE STRESS; PALATABILITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REVIEW; REWARD; RODENT; STRESS; SUGAR INTAKE; ANIMAL; ASSOCIATION; HISTORY; MENTAL STRESS; PHYSIOLOGY; PSYCHOLOGY; RAT;

ANIMALS; COGNITION; CUES; FOOD PREFERENCES; HISTORY, 21ST CENTURY; HUMANS; OBESITY; RATS; REWARD; STRESS, PSYCHOLOGICAL;

EID: 84949537665     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2014.12.002     Document Type: Review

References (170)

1. Abargouei A.S., Kalantari N., Omidvar N., Rashidkhani B., Rad A.H., Ebrahimi A.A., Khosravi-Boroujeni H., Esmaillzadeh A. Refined carbohydrate intake in relation to non-verbal intelligence among Tehrani schoolchildren. Public Health Nutr. 2012, 15:1925-1931.
2. Adam T.C., Epel E.S. Stress, eating and the reward system. Physiol. Behav. 2007, 91:449-458.
3. Aggleton J.P., Brown M.W. Contrasting hippocampal and perirhinal cortex function using immediate early gene imaging. Q. J. Exp. Psychol. B 2005, 58:218-233.
4. Ahmed S.H., Koob G.F. Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function. Psychopharmacology (Berl.) 2005, 180:473-490.
5. Alberti L., Girola A., Gilardini L., Conti A., Cattaldo S., Micheletto G., Invitti C. Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects. Int. J. Obes. (Lond.) 2007, 31:1826-1831.
6. Alencar R.C., Cobas R.A., Gomes M.B. Assessment of cognitive status in patients with type 2 diabetes through the mini-mental status examination: a cross-sectional study. Diabetol. Metab. Syndr. 2010, 2:10.
7. Alsio J., Olszewski P.K., Norback A.H., Gunnarsson Z.E., Levine A.S., Pickering C., Schioth H.B. Dopamine D1 receptor gene expression decreases in the nucleus accumbens upon long-term exposure to palatable food and differs depending on diet-induced obesity phenotype in rats. Neuroscience 2010, 171:779-787.
8. Avena N.M., Bocarsly M.E., Rada P., Kim A., Hoebel B.G. After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance. Physiol. Behav. 2008, 94:309-315.
9. Avena N.M., Long K.A., Hoebel B.G. Sugar-dependent rats show enhanced responding for sugar after abstinence: evidence of a sugar deprivation effect. Physiol. Behav. 2005, 84:359-362.
10. Avena N.M., Rada P., Hoebel B.G. Sugar bingeing in rats. Curr. Protoc. Neurosci. 2006, 36:23. C:29.23C.21-29.23C.26.
11. Badland H., Schofield G. Understanding the relationship between town size and physical activity levels: a population study. Health Place 2006, 12:538-546.
12. Barker D.J. In utero programming of chronic disease. Clin. Sci. (Lond.) 1998, 95:115-128.
13. Barrington W.E., Beresford S.A., McGregor B.A., White E. Perceived stress and eating behaviors by sex, obesity status, and stress vulnerability: findings from the vitamins and lifestyle (VITAL) study. J. Acad. Nutr. Diet 2014, 14:1791-1799.
14. Beilharz J.E., Maniam J., Morris M.J. Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats. Brain Behav. Immun. 2014, 37:134-141.
15. Bell M.E., Bhargava A., Soriano L., Laugero K., Akana S.F., Dallman M.F. Sucrose intake and corticosterone interact with cold to modulate ingestive behaviour, energy balance, autonomic outflow and neuroendocrine responses during chronic stress. J. Neuroendocrinol. 2002, 14:330-342.
16. Bell M.E., Bhatnagar S., Akana S.F., Choi S., Dallman M.F. Disruption of arcuate/paraventricular nucleus connections changes body energy balance and response to acute stress. J. Neurosci. 2000, 20:6707-6713.
17. Bello N.T., Hajnal A. Dopamine and binge eating behaviors. Pharmacol. Biochem. Behav. 2010, 97:25-33.
18. Bernardi J.R., Ferreira C.F., Senter G., Krolow R., de Aguiar B.W., Portella A.K., Kauer-Sant'anna M., Kapczinski F., Dalmaz C., Goldani M.Z., Silveira P.P. Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats. PLOS ONE 2013, 8:e62031.
19. Bhatnagar S., Bell M.E., Liang J., Soriano L., Nagy T.R., Dallman M.F. Corticosterone facilitates saccharin intake in adrenalectomized rats: does corticosterone increase stimulus salience?. J. Neuroendocrinol. 2000, 12:453-460.
20. Bjorntorp P. Do stress reactions cause abdominal obesity and comorbidities?. Obes. Rev. 2001, 2:73-86.
21. Bocarsly M.E., Hoebel B.G., Paredes D., von Loga I., Murray S.M., Wang M., Arolfo M.P., Yao L., Diamond I., Avena N.M. GS 455534 selectively suppresses binge eating of palatable food and attenuates dopamine release in the accumbens of sugar-bingeing rats. Behav. Pharmacol. 2014, 25:147-157.
22. Bragulat V., Dzemidzic M., Bruno C., Cox C.A., Talavage T., Considine R.V., Kareken D.A. Food-related odor probes of brain reward circuits during hunger: a pilot FMRI study. Obesity (Silver Spring) 2010, 18:1566-1571.
23. Bruce-Keller A.J., Keller J.N., Morrison C.D. Obesity and vulnerability of the CNS. Biochim. Biophys. Acta 2009, 1792:395-400.
24. Burger K.S., Stice E. Variability in reward responsivity and obesity: evidence from brain imaging studies. Curr. Drug Abuse Rev. 2011, 4:182-189.
25. Carroll M.E., Lac S.T. Dietary additives and the acquisition of cocaine self-administration in rats. Psychopharmacology (Berl.) 1998, 137:81-89.
26. Castellanos E.H., Charboneau E., Dietrich M.S., Park S., Bradley B.P., Mogg K., Cowan R.L. Obese adults have visual attention bias for food cue images: evidence for altered reward system function. Int. J. Obes. (Lond.) 2009, 33:1063-1073.
27. Chaput J.P., Perusse L., Despres J.P., Tremblay A., Bouchard C. Findings from the Quebec family study on the etiology of obesity: genetics and environmental highlights. Curr. Obes. Rep. 2014, 3:54-66.
28. Cohen R.A., Grieve S., Hoth K.F., Paul R.H., Sweet L., Tate D., Gunstad J., Stroud L., McCaffery J., Hitsman B., Niaura R., Clark C.R., McFarlane A., Bryant R., Gordon E., Williams L.M. Early life stress and morphometry of the adult anterior cingulate cortex and caudate nuclei. Biol. Psychiatry 2006, 59:975-982.
29. Cook T., Rutishauser I., Seelig M. Comparable Measurements from the 1983, 1985 and 1995 National Nutrition Surveys 2001, Australian Food and Nutrition Monitoring Unit, Canberra.
30. D'Argenio A., Mazzi C., Pecchioli L., Di Lorenzo G., Siracusano A., Troisi A. Early trauma and adult obesity: is psychological dysfunction the mediating mechanism?. Physiol. Behav. 2009, 98:543-546.
31. Dallman M.F., Akana S.F., Strack A.M., Hanson E.S., Sebastian R.J. The neural network that regulates energy balance is responsive to glucocorticoids and insulin and also regulates HPA axis responsivity at a site proximal to CRF neurons. Ann. N. Y. Acad. Sci. 1995, 771:730-742.
32. Dallman M.F., Pecoraro N.C., La Fleur S.E., Warne J.P., Ginsberg A.B., Akana S.F., Laugero K.C., Houshyar H., Strack A.M., Bhatnagar S., Bell M.E. Glucocorticoids, chronic stress, and obesity. Prog. Brain Res. 2006, 153:75-105.
33. Danese A., Moffitt T.E., Harrington H., Milne B.J., Polanczyk G., Pariante C.M., Poulton R., Caspi A. Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch. Pediatr. Adolesc. Med. 2009, 163:1135-1143.
34. Davids S., Lauffer H., Thoms K., Jagdhuhn M., Hirschfeld H., Domin M., Hamm A., Lotze M. Increased dorsolateral prefrontal cortex activation in obese children during observation of food stimuli. Int. J. Obes. (Lond.) 2010, 34:94-104.
35. Davidson T.L., Chan K., Jarrard L.E., Kanoski S.E., Clegg D.J., Benoit S.C. Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation. Hippocampus 2009, 19:235-252.
36. Davidson T.L., Hargrave S.L., Swithers S.E., Sample C.H., Fu X., Kinzig K.P., Zheng W. Inter-relationships among diet, obesity and hippocampal-dependent cognitive function. Neuroscience 2013, 253:110-122.
37. Davidson T.L., Kanoski S.E., Schier L.A., Clegg D.J., Benoit S.C. A potential role for the hippocampus in energy intake and body weight regulation. Curr. Opin. Pharmacol. 2007, 7:613-616.
38. Davidson T.L., Kanoski S.E., Walls E.K., Jarrard L.E. Memory inhibition and energy regulation. Physiol. Behav. 2005, 86:731-746.
39. Dean R.G., White B.D. Neuropeptide Y expression in rat brain: effects of adrenalectomy. Neurosci. Lett. 1990, 114:339-344.
40. Demos K.E., Heatherton T.F., Kelley W.M. Individual differences in nucleus accumbens activity to food and sexual images predict weight gain and sexual behavior. J. Neurosci. 2012, 32:5549-5552.
41. Di Chiara G. A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use. J. Psychopharmacol. 1998, 12:54-67.
42. Di Chiara G., Tanda G. Blunting of reactivity of dopamine transmission to palatable food: a biochemical marker of anhedonia in the CMS model?. Psychopharmacology (Berl.) 1997, 134:351-353.
43. Edwards L.M., Murray A.J., Holloway C.J., Carter E.E., Kemp G.J., Codreanu I., Brooker H., Tyler D.J., Robbins P.A., Clarke K. Short-term consumption of a high-fat diet impairs whole-body efficiency and cognitive function in sedentary men. FASEB J. 2011, 25:1088-1096.
44. Eskelinen M.H., Ngandu T., Helkala E.L., Tuomilehto J., Nissinen A., Soininen H., Kivipelto M. Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study. Int. J. Geriatr. Psychiatry 2008, 23:741-747.
45. Farr S.A., Yamada K.A., Butterfield D.A., Abdul H.M., Xu L., Miller N.E., Banks W.A., Morley J.E. Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology 2008, 149:2628-2636.
46. Finucane M.M., Stevens G.A., Cowan M.J., Danaei G., Lin J.K., Paciorek C.J., Singh G.M., Gutierrez H.R., Lu Y., Bahalim A.N., Farzadfar F., Riley L.M., Ezzati M., Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating G. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 2011, 377:557-567.
47. Flegal K.M., Graubard B.I., Williamson D.F., Gail M.H. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA 2007, 298:2028-2037.
48. Foster M.T., Solomon M.B., Huhman K.L., Bartness T.J. Social defeat increases food intake, body mass, and adiposity in Syrian hamsters. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R1284-R1293.
49. Francis H.M., Stevenson R.J. Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals. Behav. Neurosci. 2011, 125:943-955.
50. Furlong T.M., Jayaweera H.K., Balleine B.W., Corbit L.H. Binge-like consumption of a palatable food accelerates habitual control of behavior and is dependent on activation of the dorsolateral striatum. J. Neurosci. 2014, 34:5012-5022.
51. Gearhardt A.N., Yokum S., Orr P.T., Stice E., Corbin W.R., Brownell K.D. Neural correlates of food addiction. Arch. Gen. Psychiatry 2011, 68:808-816.
52. Geiger B.M., Haburcak M., Avena N.M., Moyer M.C., Hoebel B.G., Pothos E.N. Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity. Neuroscience 2009, 159:1193-1199.
53. Goto M., Arima H., Watanabe M., Hayashi M., Banno R., Sato I., Nagasaki H., Oiso Y. Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures. Endocrinology 2006, 147:5102-5109.
54. Grant W.B., Campbell A., Itzhaki R.F., Savory J. The significance of environmental factors in the etiology of Alzheimer's disease. J. Alzheimers Dis. 2002, 4:179-189.
55. Greenwood C.E., Winocur G. Learning and memory impairment in rats fed a high saturated fat diet. Behav. Neural Biol. 1990, 53:74-87.
56. Greenwood C.E., Winocur G. Cognitive impairment in rats fed high-fat diets: a specific effect of saturated fatty-acid intake. Behav. Neurosci. 1996, 110:451-459.
57. Greenwood C.E., Winocur G. High-fat diets, insulin resistance and declining cognitive function. Neurobiol. Aging 2005, 26(Suppl. 1):42-45.
58. Groesz L.M., McCoy S., Carl J., Saslow L., Stewart J., Adler N., Laraia B., Epel E. What is eating you? Stress and the drive to eat. Appetite 2012, 58:717-721.
59. Grosshans M., Vollmert C., Vollstadt-Klein S., Tost H., Leber S., Bach P., Buhler M., von der Goltz C., Mutschler J., Loeber S., Hermann D., Wiedemann K., Meyer-Lindenberg A., Kiefer F. Association of leptin with food cue-induced activation in human reward pathways. Arch. Gen. Psychiatry 2012, 69:529-537.
60. Gunstad J., Paul R.H., Spitznagel M.B., Cohen R.A., Williams L.M., Kohn M., Gordon E. Exposure to early life trauma is associated with adult obesity. Psychiatry Res. 2006, 142:31-37.
61. Hanson E.S., Dallman M.F. Neuropeptide Y (NPY) may integrate responses of hypothalamic feeding systems and the hypothalamo-pituitary-adrenal axis. J. Neuroendocrinol. 1995, 7:273-279.
62. Harris R.B., Zhou J., Youngblood B.D., Rybkin I.I., Smagin G.N., Ryan D.H. Effect of repeated stress on body weight and body composition of rats fed low- and high-fat diets. Am. J. Physiol. 1998, 275:R1928-R1938.
63. Haslam D.W., James W.P. Obesity. Lancet 2005, 366:1197-1209.
64. Heim C., Nemeroff C.B. The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders. Biol. Psychiatry 1999, 46:1509-1522.
65. Henderson Y.O., Smith G.P., Parent M.B. Hippocampal neurons inhibit meal onset. Hippocampus 2013, 23:100-107.
66. Hepworth R., Mogg K., Brignell C., Bradley B.P. Negative mood increases selective attention to food cues and subjective appetite. Appetite 2010, 54:134-142.
67. Hess M.E., Hess S., Meyer K.D., Verhagen L.A., Koch L., Bronneke H.S., Dietrich M.O., Jordan S.D., Saletore Y., Elemento O., Belgardt B.F., Franz T., Horvath T.L., Ruther U., Jaffrey S.R., Kloppenburg P., Bruning J.C. The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat. Neurosci. 2013, 16:1042-1048.
68. Heyward F.D., Walton R.G., Carle M.S., Coleman M.A., Garvey W.T., Sweatt J.D. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neurobiol. Learn. Mem. 2012, 98:25-32.
69. Holloway C.J., Cochlin L.E., Emmanuel Y., Murray A., Codreanu I., Edwards L.M., Szmigielski C., Tyler D.J., Knight N.S., Saxby B.K., Lambert B., Thompson C., Neubauer S., Clarke K. A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. Am. J. Clin. Nutr. 2011, 93:748-755.
70. Ikemoto S., Panksepp J. The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking. Brain Res. Brain Res. Rev. 1999, 31:6-41.
71. Jaaskelainen A., Nevanpera N., Remes J., Rahkonen F., Jarvelin M.R., Laitinen J. Stress-related eating, obesity and associated behavioural traits in adolescents: a prospective population-based cohort study. BMC Public Health 2014, 14:321.
72. James W.P., Astrup A., Finer N., Hilsted J., Kopelman P., Rossner S., Saris W.H., Van Gaal L.F. Effect of sibutramine on weight maintenance after weight loss: a randomised trial. STORM study group. Sibutramine trial of obesity reduction and maintenance. Lancet 2000, 356:2119-2125.
73. Jastreboff A.M., Sinha R., Lacadie C., Small D.M., Sherwin R.S., Potenza M.N. Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels. Diabetes Care 2013, 36:394-402.
74. Johnson P.M., Kenny P.J. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat. Neurosci. 2010, 13:635-641.
75. Karra E., O'Daly O.G., Choudhury A.I., Yousseif A., Millership S., Neary M.T., Scott W.R., Chandarana K., Manning S., Hess M.E., Iwakura H., Akamizu T., Millet Q., Gelegen C., Drew M.E., Rahman S., Emmanuel J.J., Williams S.C., Ruther U.U., Bruning J.C., Withers D.J., Zelaya F.O., Batterham R.L. A link between FTO, ghrelin, and impaired brain food-cue responsivity. J. Clin. Invest. 2013, 123:3539-3551.
76. Kenny P.J. Reward mechanisms in obesity: new insights and future directions. Neuron 2011, 69:664-679.
77. Kenny P.J., Voren G., Johnson P.M. Dopamine D2 receptors and striatopallidal transmission in addiction and obesity. Curr. Opin. Neurobiol. 2013, 23:535-538.
78. Koob G.F., Le Moal M. Plasticity of reward neurocircuitry and the 'dark side' of drug addiction. Nat. Neurosci. 2005, 8:1442-1444.
79. Krysiak R., Obuchowicz E., Herman Z.S. Interactions between the neuropeptide Y system and the hypothalamic-pituitary-adrenal axis. Eur. J. Endocrinol. 1999, 140:130-136.
80. la Fleur S.E., Houshyar H., Roy M., Dallman M.F. Choice of lard, but not total lard calories, damps adrenocorticotropin responses to restraint. Endocrinology 2005, 146:2193-2199.
81. la Fleur S.E., Vanderschuren L.J., Luijendijk M.C., Kloeze B.M., Tiesjema B., Adan R.A. A reciprocal interaction between food-motivated behavior and diet-induced obesity. Int. J. Obes. (Lond.) 2007, 31:1286-1294.
82. LeBlanc K.H., Maidment N.T., Ostlund S.B. Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats. PLOS ONE 2013, 8:e61355.
83. Lehmann J., Feldon J. Long-term biobehavioral effects of maternal separation in the rat: consistent or confusing?. Rev. Neurosci. 2000, 11:383-408.
84. Lippmann M., Bress A., Nemeroff C.B., Plotsky P.M., Monteggia L.M. Long-term behavioural and molecular alterations associated with maternal separation in rats. Eur. J. Neurosci. 2007, 25:3091-3098.
85. Loeber S., Grosshans M., Korucuoglu O., Vollmert C., Vollstadt-Klein S., Schneider S., Wiers R.W., Mann K., Kiefer F. Impairment of inhibitory control in response to food-associated cues and attentional bias of obese participants and normal-weight controls. Int. J. Obes. (Lond.) 2012, 36:1334-1339.
86. Lu Y., Lu J., Wang S., Li C., Liu L., Zheng R., Tian H., Wang X., Yang L., Zhang Y., Pan C. Cognitive function with glucose tolerance status and obesity in Chinese middle-aged and aged adults. Aging Ment. Health 2012, 16:911-914.
87. Lumeng J.C., Wendorf K., Pesch M.H., Appugliese D.P., Kaciroti N., Corwyn R.F., Bradley R.H. Overweight adolescents and life events in childhood. Pediatrics 2013, 132:e1506-e1512.
88. Lutter M., Nestler E.J. Homeostatic and hedonic signals interact in the regulation of food intake. J. Nutr. 2009, 139:629-632.
89. Macht M., Mueller J. Immediate effects of chocolate on experimentally induced mood states. Appetite 2007, 49:667-674.
90. Macri S., Chiarotti F., Wurbel H. Maternal separation and maternal care act independently on the development of HPA responses in male rats. Behav. Brain Res. 2008, 191:227-234.
91. Maniam J., Antoniadis C., Morris M.J. Early-life stress, HPA axis adaptation, and mechanisms contributing to later health outcomes. Front. Endocrinol. (Lausanne) 2014, 5:73.
92. Maniam J., Morris M.J. Long-term postpartum anxiety and depression-like behavior in mother rats subjected to maternal separation are ameliorated by palatable high fat diet. Behav. Brain Res. 2010, 208:72-79.
93. Maniam J., Morris M.J. Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment. Psychoneuroendocrinology 2010, 35:717-728.
94. Maniam J., Morris M.J. The link between stress and feeding behaviour. Neuropharmacology 2012, 63:97-110.
95. Marti O., Marti J., Armario A. Effects of chronic stress on food intake in rats: influence of stressor intensity and duration of daily exposure. Physiol. Behav. 1994, 55:747-753.
96. Martire S.I., Maniam J., South T., Holmes N., Westbrook R.F., Morris M.J. Extended exposure to a palatable cafeteria diet alters gene expression in brain regions implicated in reward, and withdrawal from this diet alters gene expression in brain regions associated with stress. Behav. Brain Res. 2014, 265:132-141.
97. McIntosh J., Anisman H., Merali Z. Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects. Brain Res. Dev. Brain Res. 1999, 113:97-106.
98. McNay E.C., Ong C.T., McCrimmon R.J., Cresswell J., Bogan J.S., Sherwin R.S. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiol. Learn. Mem. 2010, 93:546-553.
99. Mei Z., Grummer-Strawn L.M., Pietrobelli A., Goulding A., Goran M.I., Dietz W.H. Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents. Am. J. Clin. Nutr. 2002, 75:978-985.
100. Meule A., Lutz A., Vogele C., Kubler A. Food cravings discriminate differentially between successful and unsuccessful dieters and non-dieters. Validation of the Food Cravings Questionnaires in German. Appetite 2012, 58:88-97.
101. Meule A., Lutz A.P., Vogele C., Kubler A. Impulsive reactions to food-cues predict subsequent food craving. Eat. Behav. 2014, 15:99-105.
102. Meye F.J., Adan R.A. Feelings about food: the ventral tegmental area in food reward and emotional eating. Trends Pharmacol. Sci. 2014, 35:31-40.
103. Micha R., Rogers P.J., Nelson M. Glycaemic index and glycaemic load of breakfast predict cognitive function and mood in school children: a randomised controlled trial. Br. J. Nutr. 2011, 106:1552-1561.
104. Moore C.J., Cunningham S.A. Social position, psychological stress, and obesity: a systematic review. J. Acad. Nutr. Diet. 2012, 112:518-526.
105. Morgan S.A., McCabe E.L., Gathercole L.L., Hassan-Smith Z.K., Larner D.P., Bujalska I.J., Stewart P.M., Tomlinson J.W., Lavery G.G. 11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess. Proc. Natl. Acad. Sci. 2014, 111:E2482-E2491.
106. Morton N.M., Paterson J.M., Masuzaki H., Holmes M.C., Staels B., Fievet C., Walker B.R., Flier J.S., Mullins J.J., Seckl J.R. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 2004, 53:931-938.
107. Murray A.J., Knight N.S., Cochlin L.E., McAleese S., Deacon R.M., Rawlins J.N., Clarke K. Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding. FASEB J. 2009, 23:4353-4360.
108. Nabb S., Benton D. The influence on cognition of the interaction between the macro-nutrient content of breakfast and glucose tolerance. Physiol. Behav. 2006, 87:16-23.
109. Nelson A., Killcross S. Amphetamine exposure enhances habit formation. J. Neurosci. 2006, 26:3805-3812.
110. Nieuwenhuizen A.G., Rutters F. The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance. Physiol. Behav. 2008, 94:169-177.
111. Noll J.G., Zeller M.H., Trickett P.K., Putnam F.W. Obesity risk for female victims of childhood sexual abuse: a prospective study. Pediatrics 2007, 120:e61-e67.
112. Ogden C.L., Yanovski S.Z., Carroll M.D., Flegal K.M. The epidemiology of obesity. Gastroenterology 2007, 132:2087-2102.
113. Papanikolaou Y., Palmer H., Binns M.A., Jenkins D.J., Greenwood C.E. Better cognitive performance following a low-glycaemic-index compared with a high-glycaemic-index carbohydrate meal in adults with type 2 diabetes. Diabetologia 2006, 49:855-862.
114. Paternain L., de la Garza A.L., Batlle M.A., Milagro F.I., Martinez J.A., Campion J. Prenatal stress increases the obesogenic effects of a high-fat-sucrose diet in adult rats in a sex-specific manner. Stress 2013, 16:220-232.
115. Paulsen S.K., Pedersen S.B., Fisker S., Richelsen B. 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization. Obesity (Silver Spring) 2007, 15:1954-1960.
116. Pecoraro N., Reyes F., Gomez F., Bhargava A., Dallman M.F. Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress. Endocrinology 2004, 145:3754-3762.
117. Pelchat M.L., Johnson A., Chan R., Valdez J., Ragland J.D. Images of desire: food-craving activation during fMRI. Neuroimage 2004, 23:1486-1493.
118. Petrovich G.D., Hobin M.P., Reppucci C.J. Selective Fos induction in hypothalamic orexin/hypocretin, but not melanin-concentrating hormone neurons, by a learned food-cue that stimulates feeding in sated rats. Neuroscience 2012, 224:70-80.
119. Petrovich G.D., Holland P.C., Gallagher M. Amygdalar and prefrontal pathways to the lateral hypothalamus are activated by a learned cue that stimulates eating. J. Neurosci. 2005, 25:8295-8302.
120. Petrovich G.D., Ross C.A., Gallagher M., Holland P.C. Learned contextual cue potentiates eating in rats. Physiol. Behav. 2007, 90:362-367.
121. Pickering C., Alsio J., Hulting A.L., Schioth H.B. Withdrawal from free-choice high-fat high-sugar diet induces craving only in obesity-prone animals. Psychopharmacology (Berl.) 2009, 204:431-443.
122. Pistell P.J., Morrison C.D., Gupta S., Knight A.G., Keller J.N., Ingram D.K., Bruce-Keller A.J. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J. Neuroimmunol. 2010, 219:25-32.
123. Poore K.R., Boullin J.P., Cleal J.K., Newman J.P., Noakes D.E., Hanson M.A., Green L.R. Sex- and age-specific effects of nutrition in early gestation and early postnatal life on hypothalamo-pituitary-adrenal axis and sympathoadrenal function in adult sheep. J. Physiol. 2010, 588:2219-2237.
124. Putnam J.J., Allshouse J.E. Food Consumption, Prices, and Expenditures, 1970-97 1999, E.R.S. Food and Consumers Economics Division, U.S. Department of Agriculture, Washington, DC.
125. Rada P., Avena N.M., Hoebel B.G. Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience 2005, 134:737-744.
126. Ramasubramanian L., Lane S., Rahman A. The association between maternal serious psychological distress and child obesity at 3 years: a cross-sectional analysis of the UK Millennium Cohort Data. Child Care Health Dev. 2013, 39:134-140.
127. Rangan A.M., Randall D., Hector D.J., Gill T.P., Webb K.L. Consumption of 'extra' foods by Australian children: types, quantities and contribution to energy and nutrient intakes. Eur. J. Clin. Nutr. 2008, 62:356-364.
128. Rangan A.M., Schindeler S., Hector D.J., Gill T.P., Webb K.L. Consumption of 'extra' foods by Australian adults: types, quantities and contribution to energy and nutrient intakes. Eur. J. Clin. Nutr. 2009, 63:865-871.
129. Rask E., Olsson T., Soderberg S., Andrew R., Livingstone D.E., Johnson O., Walker B.R. Tissue-specific dysregulation of cortisol metabolism in human obesity. J. Clin. Endocrinol. Metab. 2001, 86:1418-1421.
130. Reichelt A.C., Morris M.J., Westbrook R.F. Cafeteria diet impairs expression of sensory-specific satiety and stimulus-outcome learning. Front. Psychol. 2014, 5:852.
131. Reppucci C.J., Petrovich G.D. Learned food-cue stimulates persistent feeding in sated rats. Appetite 2012, 59:437-447.
132. Roberts R.O., Roberts L.A., Geda Y.E., Cha R.H., Pankratz V.S., O'Connor H.M., Knopman D.S., Petersen R.C. Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia. J. Alzheimers Dis. 2012, 32:329-339.
133. Robinson T.E., Berridge K.C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Brain Res. Rev. 1993, 18:247-291.
134. Rothemund Y., Preuschhof C., Bohner G., Bauknecht H.C., Klingebiel R., Flor H., Klapp B.F. Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals. Neuroimage 2007, 37:410-421.
135. Ryu V., Lee J.H., Yoo S.B., Gu X.F., Moon Y.W., Jahng J.W. Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation. Int. J. Obes. (Lond.) 2008, 32:1355-1362.
136. Saper C.B., Chou T.C., Elmquist J.K. The need to feed: homeostatic and hedonic control of eating. Neuron 2002, 36:199-211.
137. Sato I., Arima H., Ozaki N., Watanabe M., Goto M., Hayashi M., Banno R., Nagasaki H., Oiso Y. Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems. J. Neurosci. 2005, 25:8657-8664.
138. Savontaus E., Conwell I.M., Wardlaw S.L. Effects of adrenalectomy on AGRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats. Brain Res. 2002, 958:130-138.
139. Schmidt M.V., Liebl C., Sterlemann V., Ganea K., Hartmann J., Harbich D., Alam S., Muller M.B. Neuropeptide Y mediates the initial hypothalamic-pituitary-adrenal response to maternal separation in the neonatal mouse. J. Endocrinol. 2008, 197:421-427.
140. Schulz S., Laessle R.G. Stress-induced laboratory eating behavior in obese women with binge eating disorder. Appetite 2012, 58:457-461.
141. Schur E.A., Kleinhans N.M., Goldberg J., Buchwald D., Schwartz M.W., Maravilla K. Activation in brain energy regulation and reward centers by food cues varies with choice of visual stimulus. Int. J. Obes. (Lond.) 2009, 33:653-661.
142. Simmons W.K., Martin A., Barsalou L.W. Pictures of appetizing foods activate gustatory cortices for taste and reward. Cereb. Cortex 2005, 15:1602-1608.
143. Sinha R., Jastreboff A.M. Stress as a common risk factor for obesity and addiction. Biol. Psychiatry 2013, 73:827-835.
144. Solfrizzi V., Frisardi V., Capurso C., D'Introno A., Colacicco A.M., Vendemiale G., Capurso A., Panza F. Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms. Ageing Res. Rev. 2010, 9:184-199.
145. South T., Westbrook F., Morris M.J. Neurological and stress related effects of shifting obese rats from a palatable diet to chow and lean rats from chow to a palatable diet. Physiol. Behav. 2012, 105:1052-1057.
146. Stice E., Yokum S., Blum K., Bohon C. Weight gain is associated with reduced striatal response to palatable food. J. Neurosci. 2010, 30:13105-13109.
147. Strack A.M., Sebastian R.J., Schwartz M.W., Dallman M.F. Glucocorticoids and insulin: reciprocal signals for energy balance. Am. J. Physiol. 1995, 268:R142-R149.
148. Swinburn B., Sacks G., Ravussin E. Increased food energy supply is more than sufficient to explain the US epidemic of obesity. Am. J. Clin. Nutr. 2009, 90:1453-1456.
149. Swinburn B.A., Caterson I., Seidell J.C., James W.P. Diet, nutrition and the prevention of excess weight gain and obesity. Public Health Nutr. 2004, 7:123-146.
150. Tang D.W., Fellows L.K., Small D.M., Dagher A. Food and drug cues activate similar brain regions: a meta-analysis of functional MRI studies. Physiol. Behav. 2012, 106:317-324.
151. Thaler J.P., Yi C.X., Schur E.A., Guyenet S.J., Hwang B.H., Dietrich M.O., Zhao X., Sarruf D.A., Izgur V., Maravilla K.R., Nguyen H.T., Fischer J.D., Matsen M.E., Wisse B.E., Morton G.J., Horvath T.L., Baskin D.G., Tschop M.H., Schwartz M.W. Obesity is associated with hypothalamic injury in rodents and humans. J. Clin. Invest. 2012, 122:153-162.
152. Thanos P.K., Michaelides M., Piyis Y.K., Wang G.J., Volkow N.D. Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography. Synapse 2008, 62:50-61.
153. Tomiyama A.J., Dallman M.F., Epel E.S. Comfort food is comforting to those most stressed: evidence of the chronic stress response network in high stress women. Psychoneuroendocrinology 2011, 36:1513-1519.
154. Tomlinson J.W., Finney J., Gay C., Hughes B.A., Hughes S.V., Stewart P.M. Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity. Diabetes 2008, 57:2652-2660.
155. Tomlinson J.W., Walker E.A., Bujalska I.J., Draper N., Lavery G.G., Cooper M.S., Hewison M., Stewart P.M. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr. Rev. 2004, 25:831-866.
156. Valladolid-Acebes I., Stucchi P., Cano V., Fernandez-Alfonso M.S., Merino B., Gil-Ortega M., Fole A., Morales L., Ruiz-Gayo M., Del Olmo N. High-fat diets impair spatial learning in the radial-arm maze in mice. Neurobiol. Learn. Mem. 2011, 95:80-85.
157. Velders F.P., De Wit J.E., Jansen P.W., Jaddoe V.W., Hofman A., Verhulst F.C., Tiemeier H. FTO at rs9939609, food responsiveness, emotional control and symptoms of ADHD in preschool children. PLoS ONE 2012, 7:e49131.
158. Veyrat-Durebex C., Deblon N., Caillon A., Andrew R., Altirriba J., Odermatt A., Rohner-Jeanrenaud F. Central glucocorticoid administration promotes weight gain and increased 11beta-hydroxysteroid dehydrogenase type 1 expression in white adipose tissue. PLoS ONE 2012, 7:e34002.
159. Volkow N.D., Wang G.J., Fowler J.S., Tomasi D., Baler R. Food and drug reward: overlapping circuits in human obesity and addiction. Curr. Top. Behav. Neurosci. 2012, 11:1-24.
160. Walker A.K., Ibia I.E., Zigman J.M. Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling. Physiol. Behav. 2012, 108:34-43.
161. Wanat M.J., Hopf F.W., Stuber G.D., Phillips P.E., Bonci A. Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih. J. Physiol. 2008, 586:2157-2170.
162. Weingarten H.P. Conditioned cues elicit feeding in sated rats: a role for learning in meal initiation. Science 1983, 220:431-433.
163. Wellman P.J., Nation J.R., Davis K.W. Impairment of acquisition of cocaine self-administration in rats maintained on a high-fat diet. Pharmacol. Biochem. Behav. 2007, 88:89-93.
164. White B.D., Dean R.G., Martin R.J. Adrenalectomy decreases neuropeptide Y mRNA levels in the arcuate nucleus. Brain Res. Bull. 1990, 25:711-715.
165. World Health Organization. (2000). Obesity: preventing and managing the global epidemic (No. 894). World Health Organization.
166. Winocur G., Greenwood C.E. The effects of high fat diets and environmental influences on cognitive performance in rats. Behav. Brain Res. 1999, 101:153-161.
167. Winocur G., Greenwood C.E. Studies of the effects of high fat diets on cognitive function in a rat model. Neurobiol Aging 2005, 26(Suppl. 1):46-49.
168. Wolraich M.L., Lindgren S.D., Stumbo P.J., Stegink L.D., Appelbaum M.I., Kiritsy M.C. Effects of diets high in sucrose or aspartame on the behavior and cognitive performance of children. N. Engl. J. Med. 1994, 330:301-307.
169. Wu A., Ying Z., Gomez-Pinilla F. The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur. J. Neurosci. 2004, 19:1699-1707.
170. Ye X., Gao X., Scott T., Tucker K.L. Habitual sugar intake and cognitive function among middle-aged and older Puerto Ricans without diabetes. Br. J. Nutr. 2011, 106:1423-1432.