p16 Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

Nature Medicine

Volumn 22, Issue 4, 2016, Pages 412-420

  Helman, Aharon ^a   Klochendler, Agnes ^a   Azazmeh, Narmen ^a   Gabai, Yael ^a   Horwitz, Elad ^a   Anzi, Shira ^a   Swisa, Avital ^a   Condiotti, Reba ^a   Granit, Roy Z ^a   Nevo, Yuval ^a   Fixler, Yaakov ^a   Shreibman, Dorin ^a   Zamir, Amit ^a   Tornovsky Babeay, Sharona ^b   Dai, Chunhua ^c   Glaser, Benjamin ^b   Powers, Alvin C ^c,d,e   Shapiro, A M James ^f,g   Magnuson, Mark A ^d   Dor, Yuval ^a   Ben Porath, Ittai ^a   more..

^a HEBREW UNIVERSITY   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Veteran's Affairs Tennessee Valley Healthcare System   (United States)

^f UNIVERSITY OF ALBERTA   (Canada)

^g UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GLUCOSE; HISTONE H3; INSULIN; LYSINE; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P53; PROTEIN S6; TETRACYCLINE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR PDX 1; TARGET OF RAPAMYCIN KINASE;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; ELECTRON MICROSCOPY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONTENT; PROTEIN INDUCTION; SENESCENCE; UPREGULATION; AGING; ANIMAL; BIOSYNTHESIS; CELL AGING; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; SECRETION (PROCESS); TRANSGENIC MOUSE;

AGING; ANIMALS; CELL AGING; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FIBROBLASTS; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, TRANSGENIC; PPAR GAMMA; TOR SERINE-THREONINE KINASES;

EID: 84960156528     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4054     Document Type: Article

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