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Volumn 124, Issue 5, 2014, Pages 2087-2098

Development of a conditionally immortalized human pancreatic β cell line

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; INSULIN;

EID: 84899740700     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI72674     Document Type: Article
Times cited : (141)

References (43)
  • 1
    • 84877151865 scopus 로고    scopus 로고
    • Anonymous sources: Where do adult cells come from?
    • German MS. Anonymous sources: where do adult cells come from? J Clin Invest. 2013;123(5):1936-1938.
    • (2013) J Clin Invest , vol.123 , Issue.5 , pp. 1936-1938
    • German, M.S.1
  • 2
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004; 429(6987):41-46.
    • (2004) Nature , vol.429 , Issue.6987 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 3
    • 33748935803 scopus 로고    scopus 로고
    • Intrinsic regulators of pancreatic cell proliferation
    • Heit JJ, Karnik SK, Kim SK. Intrinsic regulators of pancreatic cell proliferation. Annu Rev Cell Dev Biol. 2006;22:311-338.
    • (2006) Annu Rev Cell Dev Biol. , vol.22 , pp. 311-338
    • Heit, J.J.1    Karnik, S.K.2    Kim, S.K.3
  • 4
    • 84877707122 scopus 로고    scopus 로고
    • Betatrophin: A hormone that controls pancreatic cell proliferation
    • Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic cell proliferation. Cell. 2013;153(4):747-758.
    • (2013) Cell , vol.153 , Issue.4 , pp. 747-758
    • Yi, P.1    Park, J.S.2    Melton, D.A.3
  • 5
    • 36649000083 scopus 로고    scopus 로고
    • Proliferation of sorted human and rat cells
    • Parnaud G, et al. Proliferation of sorted human and rat cells. Diabetologia. 2008;51(1):91-100.
    • (2008) Diabetologia. , vol.51 , Issue.1 , pp. 91-100
    • Parnaud, G.1
  • 6
    • 77949289481 scopus 로고    scopus 로고
    • The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
    • Cnop M, et al. The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation. Diabetologia. 2010;53(2):321-330.
    • (2010) Diabetologia. , vol.53 , Issue.2 , pp. 321-330
    • Cnop, M.1
  • 7
    • 77957787230 scopus 로고    scopus 로고
    • Significant human cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating
    • Perl S, et al. Significant human cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab. 2010;95(10):E234-E239.
    • (2010) J Clin Endocrinol Metab. , vol.95 , Issue.10
    • Perl, S.1
  • 8
    • 84865520395 scopus 로고    scopus 로고
    • Human beta-cell proliferation and intracellular signaling: Driving in the dark without a road map
    • Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF. Human beta-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes. 2012;61(9):2205-2213.
    • (2012) Diabetes. , vol.61 , Issue.9 , pp. 2205-2213
    • Kulkarni, R.N.1    Mizrachi, E.B.2    Ocana, A.G.3    Stewart, A.F.4
  • 9
    • 84865596106 scopus 로고    scopus 로고
    • Overexpression of hepatocyte nuclear factor-4alpha initiates cell cycle entry, but is not sufficient to promote beta-cell expansion in human islets
    • Rieck S, et al. Overexpression of hepatocyte nuclear factor-4alpha initiates cell cycle entry, but is not sufficient to promote beta-cell expansion in human islets. Mol Endocrinol. 2012;26(9):1590-1602.
    • (2012) Mol Endocrinol. , vol.26 , Issue.9 , pp. 1590-1602
    • Rieck, S.1
  • 10
    • 80052343967 scopus 로고    scopus 로고
    • A genetically engineered human pancreatic beta cell line exhibiting glucose-inducible insulin secretion
    • Ravassard P, et al. A genetically engineered human pancreatic beta cell line exhibiting glucose-inducible insulin secretion. J Clin Invest. 2011;121(9):3589-3597.
    • (2011) J Clin Invest. , vol.121 , Issue.9 , pp. 3589-3597
    • Ravassard, P.1
  • 11
    • 0035199577 scopus 로고    scopus 로고
    • Blood glucose normalization upon transplantation of human embryonic pancreas into cell-deficient SCID mice
    • Castaing M, Peault B, Basmaciogullari A, Casal I, Czernichow P, Scharfmann R. Blood glucose normalization upon transplantation of human embryonic pancreas into cell-deficient SCID mice. Diabetologia. 2001;44(11):2066-2076.
    • (2001) Diabetologia. , vol.44 , Issue.11 , pp. 2066-2076
    • Castaing, M.1    Peault, B.2    Basmaciogullari, A.3    Casal, I.4    Czernichow, P.5    Scharfmann, R.6
  • 12
    • 0028147867 scopus 로고
    • Normal human pancreas cultures display functional ductal characteristics
    • Vila MR, Lloreta J, Real FX. Normal human pancreas cultures display functional ductal characteristics. Lab Invest. 1994;71(3):423-431.
    • (1994) Lab Invest. , vol.71 , Issue.3 , pp. 423-431
    • Vila, M.R.1    Lloreta, J.2    Real, F.X.3
  • 13
    • 8344271936 scopus 로고    scopus 로고
    • Cell lines derived from pancreatic islets
    • Hohmeier HE, Newgard CB. Cell lines derived from pancreatic islets. Mol Cell Endocrinol. 2004; 228(1-2):121-128.
    • (2004) Mol Cell Endocrinol. , vol.228 , Issue.1-2 , pp. 121-128
    • Hohmeier, H.E.1    Newgard, C.B.2
  • 14
    • 84873462829 scopus 로고    scopus 로고
    • Concise review: In search of unlimited sources of functional human pancreatic cells
    • Scharfmann R, Rachdi L, Ravassard P. Concise review: in search of unlimited sources of functional human pancreatic cells. Stem Cells Transl Med. 2013;2(1):61-67.
    • (2013) Stem Cells Transl Med. , vol.2 , Issue.1 , pp. 61-67
    • Scharfmann, R.1    Rachdi, L.2    Ravassard, P.3
  • 15
    • 79959331354 scopus 로고    scopus 로고
    • Development and functional characterization of insulin-releasing human pancreatic cell lines produced by electrofusion
    • McCluskey JT, Hamid M, Guo-Parke H, McClenaghan NH, Gomis R, Flatt PR. Development and functional characterization of insulin-releasing human pancreatic cell lines produced by electrofusion. J Biol Chem. 2011;286(25):21982-21992.
    • (2011) J Biol Chem. , vol.286 , Issue.25 , pp. 21982-21992
    • McCluskey, J.T.1    Hamid, M.2    Guo-Parke, H.3    McClenaghan, N.H.4    Gomis, R.5    Flatt, P.R.6
  • 16
    • 80052407683 scopus 로고    scopus 로고
    • Clusters of conserved cell marker genes for assessment of cell phenotype
    • Martens GA, et al. Clusters of conserved cell marker genes for assessment of cell phenotype. PLoS One. 2011;6(9):e24134.
    • (2011) PLoS One. , vol.6 , Issue.9
    • Martens, G.A.1
  • 17
    • 50949120712 scopus 로고    scopus 로고
    • Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor
    • Movahedi B, Gysemans C, Jacobs-Tulleneers-Thevissen D, Mathieu C, Pipeleers D. Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor. Diabetes. 2008; 57(8):2128-2136.
    • (2008) Diabetes. , vol.57 , Issue.8 , pp. 2128-2136
    • Movahedi, B.1    Gysemans, C.2    Jacobs-Tulleneers-Thevissen, D.3    Mathieu, C.4    Pipeleers, D.5
  • 18
    • 0032527592 scopus 로고    scopus 로고
    • Generation and characterization of embryonic striatal conditionally immortalized ST14A cells
    • Cattaneo E, Conti L. Generation and characterization of embryonic striatal conditionally immortalized ST14A cells. J Neurosci Res. 1998;53(2):223-234.
    • (1998) J Neurosci Res. , vol.53 , Issue.2 , pp. 223-234
    • Cattaneo, E.1    Conti, L.2
  • 19
    • 0028938747 scopus 로고
    • Conditional transformation of a pancreatic cell line derived from transgenic mice expressing a tetracycline-regulated oncogene
    • Efrat S, Fusco-DeMane D, Lemberg H, al Emran O, Wang X. Conditional transformation of a pancreatic cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc Natl Acad Sci U S A. 1995;92(8):3576-3580.
    • (1995) Proc Natl Acad Sci U S A. , vol.92 , Issue.8 , pp. 3576-3580
    • Efrat, S.1    Fusco-Demane, D.2    Lemberg, H.3    Al Emran, O.4    Wang, X.5
  • 20
    • 0028856772 scopus 로고
    • Excision of specific DNA-sequences from integrated retroviral vectors via site-specific recombination
    • Bergemann J, Kuhlcke K, Fehse B, Ratz I, Ostertag W, Lother H. Excision of specific DNA-sequences from integrated retroviral vectors via site-specific recombination. Nucleic Acids Res. 1995;23(21):4451-4456.
    • (1995) Nucleic Acids Res. , vol.23 , Issue.21 , pp. 4451-4456
    • Bergemann, J.1    Kuhlcke, K.2    Fehse, B.3    Ratz, I.4    Ostertag, W.5    Lother, H.6
  • 21
    • 0030025850 scopus 로고    scopus 로고
    • Transfer of single gene-containing long terminal repeats into the genome of mammalian cells by a retroviral vector carrying the cre gene and the loxP site
    • Choulika A, Guyot V, Nicolas JF. Transfer of single gene-containing long terminal repeats into the genome of mammalian cells by a retroviral vector carrying the cre gene and the loxP site. J Virol. 1996; 70(3):1792-1798.
    • (1996) J Virol. , vol.70 , Issue.3 , pp. 1792-1798
    • Choulika, A.1    Guyot, V.2    Nicolas, J.F.3
  • 22
    • 0029810898 scopus 로고    scopus 로고
    • Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination
    • Westerman KA, Leboulch P. Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination. Proc Natl Acad Sci U S A. 1996;93(17):8971-8976.
    • (1996) Proc Natl Acad Sci U S A. , vol.93 , Issue.17 , pp. 8971-8976
    • Westerman, K.A.1    Leboulch, P.2
  • 23
    • 0034296940 scopus 로고    scopus 로고
    • Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes
    • Salmon P, Oberholzer J, Occhiodoro T, Morel P, Lou J, Trono D. Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes. Mol Ther. 2000;2(4):404-414.
    • (2000) Mol Ther. , vol.2 , Issue.4 , pp. 404-414
    • Salmon, P.1    Oberholzer, J.2    Occhiodoro, T.3    Morel, P.4    Lou, J.5    Trono, D.6
  • 24
    • 27144551716 scopus 로고    scopus 로고
    • A human cell line for transplantation therapy to control type 1 diabetes
    • Narushima M, et al. A human cell line for transplantation therapy to control type 1 diabetes. Nat Biotechnol. 2005;23(10):1274-1282.
    • (2005) Nat Biotechnol. , vol.23 , Issue.10 , pp. 1274-1282
    • Narushima, M.1
  • 25
    • 19944432939 scopus 로고    scopus 로고
    • Long-term controlled immortalization of a primate hepatic progenitor cell line after Simian virus 40 T-Antigen gene transfer
    • Delgado JP, et al. Long-term controlled immortalization of a primate hepatic progenitor cell line after Simian virus 40 T-Antigen gene transfer. Oncogene. 2005;24(4):541-551.
    • (2005) Oncogene. , vol.24 , Issue.4 , pp. 541-551
    • Delgado, J.P.1
  • 26
    • 43549100675 scopus 로고    scopus 로고
    • Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis
    • Haataja L, Gurlo T, Huang CJ, Butler PC. Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr Rev. 2008;29(3):303-316.
    • (2008) Endocr Rev. , vol.29 , Issue.3 , pp. 303-316
    • Haataja, L.1    Gurlo, T.2    Huang, C.J.3    Butler, P.C.4
  • 27
    • 64149126546 scopus 로고    scopus 로고
    • Regulation of insulin secretion: A matter of phase control and amplitude modulation
    • Henquin JC. Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia. 2009;52(5):739-751.
    • (2009) Diabetologia. , vol.52 , Issue.5 , pp. 739-751
    • Henquin, J.C.1
  • 28
    • 33845533409 scopus 로고    scopus 로고
    • Probe-independent and direct quantification of insulin mRNA and growth hormone mRNA in enriched cell preparations
    • Van Lommel L, et al. Probe-independent and direct quantification of insulin mRNA and growth hormone mRNA in enriched cell preparations. Diabetes. 2006;55(12):3214-3220.
    • (2006) Diabetes. , vol.55 , Issue.12 , pp. 3214-3220
    • Van Lommel, L.1
  • 29
    • 84861914948 scopus 로고    scopus 로고
    • Maintenance of beta-cell maturity and plasticity in the adult pancreas: Developmental biology concepts in adult physiology
    • Szabat M, Lynn FC, Hoffman BG, Kieffer TJ, Allan DW, Johnson JD. Maintenance of beta-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes. 2012;61(6):1365-1371.
    • (2012) Diabetes. , vol.61 , Issue.6 , pp. 1365-1371
    • Szabat, M.1    Lynn, F.C.2    Hoffman, B.G.3    Kieffer, T.J.4    Allan, D.W.5    Johnson, J.D.6
  • 31
    • 77954277549 scopus 로고    scopus 로고
    • Cell replication is increased in donor organs from young patients after prolonged life support
    • In't Veld P, et al. Cell replication is increased in donor organs from young patients after prolonged life support. Diabetes. 2010;59(7):1702-1708.
    • (2010) Diabetes. , vol.59 , Issue.7 , pp. 1702-1708
    • In't Veld, P.1
  • 32
    • 79953752183 scopus 로고    scopus 로고
    • Glucose stimulates human cell replication in vivo in islets transplanted into NODsevere combined immunodeficiency (SCID) mice
    • Levitt HE, et al. Glucose stimulates human cell replication in vivo in islets transplanted into NODsevere combined immunodeficiency (SCID) mice. Diabetologia. 2011;54(3):572-582.
    • (2011) Diabetologia. , vol.54 , Issue.3 , pp. 572-582
    • Levitt, H.E.1
  • 33
    • 77955357730 scopus 로고    scopus 로고
    • Induction of human cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6
    • Fiaschi-Taesch NM, et al. Induction of human cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes. 2010; 59(8):1926-1936.
    • (2010) Diabetes. , vol.59 , Issue.8 , pp. 1926-1936
    • Fiaschi-Taesch, N.M.1
  • 34
    • 85047688791 scopus 로고    scopus 로고
    • Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human cell replication: A revised model of human cell G1/S control
    • Fiaschi-Taesch NM, et al. Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human cell replication: a revised model of human cell G1/S control. Diabetes. 2013;62(7):2460-2470.
    • (2013) Diabetes. , vol.62 , Issue.7 , pp. 2460-2470
    • Fiaschi-Taesch, N.M.1
  • 35
    • 62749167098 scopus 로고    scopus 로고
    • A new strategy to generate functional insulin-producing cell lines by somatic gene transfer into pancreatic progenitors
    • Ravassard P, et al. A new strategy to generate functional insulin-producing cell lines by somatic gene transfer into pancreatic progenitors. PLoS One. 2009;4(3):e4731.
    • (2009) PLoS One. , vol.4 , Issue.3
    • Ravassard, P.1
  • 36
    • 17844383999 scopus 로고    scopus 로고
    • Efficient restricted gene expression in beta cells by lentivirus-mediated gene transfer into pancreatic stem/progenitor cells
    • Castaing M, Guerci A, Mallet J, Czernichow P, Ravassard P, Scharfmann R. Efficient restricted gene expression in beta cells by lentivirus-mediated gene transfer into pancreatic stem/progenitor cells. Diabetologia. 2005;48(4):709-719.
    • (2005) Diabetologia. , vol.48 , Issue.4 , pp. 709-719
    • Castaing, M.1    Guerci, A.2    Mallet, J.3    Czernichow, P.4    Ravassard, P.5    Scharfmann, R.6
  • 37
    • 44749087001 scopus 로고    scopus 로고
    • In vitro proliferation of cells derived from adult human betacells revealed by cell-lineage tracing
    • Russ HA, Bar Y, Ravassard P, Efrat S. In vitro proliferation of cells derived from adult human betacells revealed by cell-lineage tracing. Diabetes. 2008; 57(6):1575-1583.
    • (2008) Diabetes. , vol.57 , Issue.6 , pp. 1575-1583
    • Russ, H.A.1    Bar, Y.2    Ravassard, P.3    Efrat, S.4
  • 38
    • 0030819379 scopus 로고    scopus 로고
    • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
    • Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol. 1997; 15(9):871-875.
    • (1997) Nat Biotechnol. , vol.15 , Issue.9 , pp. 871-875
    • Zufferey, R.1    Nagy, D.2    Mandel, R.J.3    Naldini, L.4    Trono, D.5
  • 40
    • 84856511715 scopus 로고    scopus 로고
    • L-leucine alters pancreatic cell differentiation and function via the mTor signaling pathway
    • Rachdi L, Aiello V, Duvillie B, Scharfmann R. L-leucine alters pancreatic cell differentiation and function via the mTor signaling pathway. Diabetes. 2012;61(2):409-417.
    • (2012) Diabetes. , vol.61 , Issue.2 , pp. 409-417
    • Rachdi, L.1    Aiello, V.2    Duvillie, B.3    Scharfmann, R.4
  • 41
    • 84893691755 scopus 로고    scopus 로고
    • Molecular analysis of diffuse intrinsic brainstem gliomas in adults
    • Reyes-Botero G, et al. Molecular analysis of diffuse intrinsic brainstem gliomas in adults. J Neurooncol. 2014;116(2):405-411.
    • (2014) J Neurooncol. , vol.116 , Issue.2 , pp. 405-411
    • Reyes-Botero, G.1
  • 42
    • 84856696056 scopus 로고    scopus 로고
    • The functional and molecular characterisation of human embryonic stem cellderived insulin-positive cells compared with adult pancreatic cells
    • Basford CL, et al. The functional and molecular characterisation of human embryonic stem cellderived insulin-positive cells compared with adult pancreatic cells. Diabetologia. 2012;55(2):358-371.
    • (2012) Diabetologia. , vol.55 , Issue.2 , pp. 358-371
    • Basford, C.L.1
  • 43
    • 84874626174 scopus 로고    scopus 로고
    • Epigenomic plasticity enables human pancreatic alpha to cell reprogramming
    • Bramswig NC, et al. Epigenomic plasticity enables human pancreatic alpha to cell reprogramming. J Clin Invest. 2013;123(3):1275-1284.
    • (2013) J Clin Invest. , vol.123 , Issue.3 , pp. 1275-1284
    • Bramswig, N.C.1


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