메뉴 건너뛰기




Volumn 18, Issue 5, 2013, Pages 698-711

MTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 4E BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MESSENGER RNA; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

EID: 84887415150     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.10.001     Document Type: Article
Times cited : (614)

References (65)
  • 2
    • 72949123583 scopus 로고    scopus 로고
    • Post-transcriptional regulons coordinate the initiation and resolution of inflammation
    • P. Anderson Post-transcriptional regulons coordinate the initiation and resolution of inflammation Nat. Rev. Immunol. 10 2010 24 35
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 24-35
    • Anderson, P.1
  • 5
    • 80155142474 scopus 로고    scopus 로고
    • Rapamycin passes the torch: A new generation of mTOR inhibitors
    • D. Benjamin, M. Colombi, C. Moroni, and M.N. Hall Rapamycin passes the torch: a new generation of mTOR inhibitors Nat. Rev. Drug Discov. 10 2011 868 880
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 868-880
    • Benjamin, D.1    Colombi, M.2    Moroni, C.3    Hall, M.N.4
  • 7
    • 84881098989 scopus 로고    scopus 로고
    • Feature Article: MTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
    • C. Betz, D. Stracka, C. Prescianotto-Baschong, M. Frieden, N. Demaurex, and M.N. Hall Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology Proc. Natl. Acad. Sci. USA 110 2013 12526 12534
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 12526-12534
    • Betz, C.1    Stracka, D.2    Prescianotto-Baschong, C.3    Frieden, M.4    Demaurex, N.5    Hall, M.N.6
  • 9
    • 33845744837 scopus 로고    scopus 로고
    • Initiation and beyond: Multiple functions of the human mitochondrial transcription machinery
    • N.D. Bonawitz, D.A. Clayton, and G.S. Shadel Initiation and beyond: multiple functions of the human mitochondrial transcription machinery Mol. Cell 24 2006 813 825
    • (2006) Mol. Cell , vol.24 , pp. 813-825
    • Bonawitz, N.D.1    Clayton, D.A.2    Shadel, G.S.3
  • 10
    • 0028802746 scopus 로고
    • A hierarchy of ATP-consuming processes in mammalian cells
    • F. Buttgereit, and M.D. Brand A hierarchy of ATP-consuming processes in mammalian cells Biochem. J. 312 1995 163 167
    • (1995) Biochem. J. , vol.312 , pp. 163-167
    • Buttgereit, F.1    Brand, M.D.2
  • 11
    • 84876574053 scopus 로고    scopus 로고
    • Nutrient signaling in protein homeostasis: An increase in quantity at the expense of quality
    • C.S. Conn, and S.B. Qian Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality Sci. Signal. 6 2013 ra24
    • (2013) Sci. Signal. , vol.6 , pp. 24
    • Conn, C.S.1    Qian, S.B.2
  • 12
    • 36749081539 scopus 로고    scopus 로고
    • MTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
    • J.T. Cunningham, J.T. Rodgers, D.H. Arlow, F. Vazquez, V.K. Mootha, and P. Puigserver mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex Nature 450 2007 736 740
    • (2007) Nature , vol.450 , pp. 736-740
    • Cunningham, J.T.1    Rodgers, J.T.2    Arlow, D.H.3    Vazquez, F.4    Mootha, V.K.5    Puigserver, P.6
  • 16
    • 77957656146 scopus 로고    scopus 로고
    • MiR-378() mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway
    • L.J. Eichner, M.C. Perry, C.R. Dufour, N. Bertos, M. Park, J. St-Pierre, and V. Giguère miR-378() mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway Cell Metab. 12 2010 352 361
    • (2010) Cell Metab. , vol.12 , pp. 352-361
    • Eichner, L.J.1    Perry, M.C.2    Dufour, C.R.3    Bertos, N.4    Park, M.5    St-Pierre, J.6    Giguère, V.7
  • 17
    • 78650448754 scopus 로고    scopus 로고
    • Chemical modulators of autophagy as biological probes and potential therapeutics
    • A. Fleming, T. Noda, T. Yoshimori, and D.C. Rubinsztein Chemical modulators of autophagy as biological probes and potential therapeutics Nat. Chem. Biol. 7 2011 9 17
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 9-17
    • Fleming, A.1    Noda, T.2    Yoshimori, T.3    Rubinsztein, D.C.4
  • 18
    • 77954932801 scopus 로고    scopus 로고
    • Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b
    • D. Fornuskova, L. Stiburek, L. Wenchich, K. Vinsova, H. Hansikova, and J. Zeman Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b Biochem. J. 428 2010 363 374
    • (2010) Biochem. J. , vol.428 , pp. 363-374
    • Fornuskova, D.1    Stiburek, L.2    Wenchich, L.3    Vinsova, K.4    Hansikova, H.5    Zeman, J.6
  • 19
    • 58649092475 scopus 로고    scopus 로고
    • MTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
    • J.M. García-Martínez, and D.R. Alessi mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1) Biochem. J. 416 2008 375 385
    • (2008) Biochem. J. , vol.416 , pp. 375-385
    • García-Martínez, J.M.1    Alessi, D.R.2
  • 23
    • 84866873298 scopus 로고    scopus 로고
    • PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1
    • C.K. Goo, H.Y. Lim, Q.S. Ho, H.P. Too, M.V. Clement, and K.P. Wong PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1 PLoS ONE 7 2012 e45806
    • (2012) PLoS ONE , vol.7 , pp. 45806
    • Goo, C.K.1    Lim, H.Y.2    Ho, Q.S.3    Too, H.P.4    Clement, M.V.5    Wong, K.P.6
  • 28
    • 47949104258 scopus 로고    scopus 로고
    • Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
    • T. Ikenoue, K. Inoki, Q. Yang, X. Zhou, and K.L. Guan Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling EMBO J. 27 2008 1919 1931
    • (2008) EMBO J. , vol.27 , pp. 1919-1931
    • Ikenoue, T.1    Inoki, K.2    Yang, Q.3    Zhou, X.4    Guan, K.L.5
  • 29
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • K. Inoki, Y. Li, T. Xu, and K.L. Guan Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling Genes Dev. 17 2003 1829 1834
    • (2003) Genes Dev. , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 32
    • 0025029035 scopus 로고
    • Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily
    • S.C. Kozma, S. Ferrari, P. Bassand, M. Siegmann, N. Totty, and G. Thomas Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily Proc. Natl. Acad. Sci. USA 87 1990 7365 7369
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7365-7369
    • Kozma, S.C.1    Ferrari, S.2    Bassand, P.3    Siegmann, M.4    Totty, N.5    Thomas, G.6
  • 33
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • M. Laplante, and D.M. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 34
    • 78650723802 scopus 로고    scopus 로고
    • Identification of differential translation in genome wide studies
    • O. Larsson, N. Sonenberg, and R. Nadon Identification of differential translation in genome wide studies Proc. Natl. Acad. Sci. USA 107 2010 21487 21492
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 21487-21492
    • Larsson, O.1    Sonenberg, N.2    Nadon, R.3
  • 35
    • 79955753537 scopus 로고    scopus 로고
    • Anota: Analysis of differential translation in genome-wide studies
    • O. Larsson, N. Sonenberg, and R. Nadon anota: Analysis of differential translation in genome-wide studies Bioinformatics 27 2011 1440 1441
    • (2011) Bioinformatics , vol.27 , pp. 1440-1441
    • Larsson, O.1    Sonenberg, N.2    Nadon, R.3
  • 37
    • 0025314596 scopus 로고
    • Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap
    • A. Lazaris-Karatzas, K.S. Montine, and N. Sonenberg Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap Nature 345 1990 544 547
    • (1990) Nature , vol.345 , pp. 544-547
    • Lazaris-Karatzas, A.1    Montine, K.S.2    Sonenberg, N.3
  • 38
    • 0033803048 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    • J.J. Lehman, P.M. Barger, A. Kovacs, J.E. Saffitz, D.M. Medeiros, and D.P. Kelly Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis J. Clin. Invest. 106 2000 847 856
    • (2000) J. Clin. Invest. , vol.106 , pp. 847-856
    • Lehman, J.J.1    Barger, P.M.2    Kovacs, A.3    Saffitz, J.E.4    Medeiros, D.M.5    Kelly, D.P.6
  • 40
    • 34447502083 scopus 로고    scopus 로고
    • Determination of metabolic flux ratios from 13C-experiments and gas chromatography-mass spectrometry data: Protocol and principles
    • A. Nanchen, T. Fuhrer, and U. Sauer Determination of metabolic flux ratios from 13C-experiments and gas chromatography-mass spectrometry data: protocol and principles Methods Mol. Biol. 358 2007 177 197
    • (2007) Methods Mol. Biol. , vol.358 , pp. 177-197
    • Nanchen, A.1    Fuhrer, T.2    Sauer, U.3
  • 41
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
    • A. Pause, G.J. Belsham, A.C. Gingras, O. Donzé, T.A. Lin, J.C. Lawrence Jr., and N. Sonenberg Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function Nature 371 1994 762 767
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.C.3    Donzé, O.4    Lin, T.A.5    Lawrence, Jr.J.C.6    Sonenberg, N.7
  • 42
    • 54849431380 scopus 로고    scopus 로고
    • Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
    • P. Polak, N. Cybulski, J.N. Feige, J. Auwerx, M.A. Rüegg, and M.N. Hall Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration Cell Metab. 8 2008 399 410
    • (2008) Cell Metab. , vol.8 , pp. 399-410
    • Polak, P.1    Cybulski, N.2    Feige, J.N.3    Auwerx, J.4    Rüegg, M.A.5    Hall, M.N.6
  • 44
    • 0030854715 scopus 로고    scopus 로고
    • Cellular energy utilization and molecular origin of standard metabolic rate in mammals
    • D.F. Rolfe, and G.C. Brown Cellular energy utilization and molecular origin of standard metabolic rate in mammals Physiol. Rev. 77 1997 731 758
    • (1997) Physiol. Rev. , vol.77 , pp. 731-758
    • Rolfe, D.F.1    Brown, G.C.2
  • 46
    • 2442648845 scopus 로고    scopus 로고
    • The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
    • D. Ruggero, L. Montanaro, L. Ma, W. Xu, P. Londei, C. Cordon-Cardo, and P.P. Pandolfi The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis Nat. Med. 10 2004 484 486
    • (2004) Nat. Med. , vol.10 , pp. 484-486
    • Ruggero, D.1    Montanaro, L.2    Ma, L.3    Xu, W.4    Londei, P.5    Cordon-Cardo, C.6    Pandolfi, P.P.7
  • 47
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • D.D. Sarbassov, S.M. Ali, D.H. Kim, D.A. Guertin, R.R. Latek, H. Erdjument-Bromage, P. Tempst, and D.M. Sabatini Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton Curr. Biol. 14 2004 1296 1302
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 48
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • D.D. Sarbassov, D.A. Guertin, S.M. Ali, and D.M. Sabatini Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 307 2005 1098 1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 49
    • 33748752151 scopus 로고    scopus 로고
    • The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
    • S.M. Schieke, D. Phillips, J.P. McCoy Jr., A.M. Aponte, R.F. Shen, R.S. Balaban, and T. Finkel The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity J. Biol. Chem. 281 2006 27643 27652
    • (2006) J. Biol. Chem. , vol.281 , pp. 27643-27652
    • Schieke, S.M.1    Phillips, D.2    McCoy, Jr.J.P.3    Aponte, A.M.4    Shen, R.F.5    Balaban, R.S.6    Finkel, T.7
  • 51
    • 34548251464 scopus 로고    scopus 로고
    • Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle
    • P. She, T.M. Reid, S.K. Bronson, T.C. Vary, A. Hajnal, C.J. Lynch, and S.M. Hutson Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle Cell Metab. 6 2007 181 194
    • (2007) Cell Metab. , vol.6 , pp. 181-194
    • She, P.1    Reid, T.M.2    Bronson, S.K.3    Vary, T.C.4    Hajnal, A.5    Lynch, C.J.6    Hutson, S.M.7
  • 52
    • 0038036024 scopus 로고    scopus 로고
    • Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells
    • J. St-Pierre, J. Lin, S. Krauss, P.T. Tarr, R. Yang, C.B. Newgard, and B.M. Spiegelman Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells J. Biol. Chem. 278 2003 26597 26603
    • (2003) J. Biol. Chem. , vol.278 , pp. 26597-26603
    • St-Pierre, J.1    Lin, J.2    Krauss, S.3    Tarr, P.T.4    Yang, R.5    Newgard, C.B.6    Spiegelman, B.M.7
  • 53
    • 79953171531 scopus 로고    scopus 로고
    • PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation
    • J. Sun, C.S. Conn, Y. Han, V. Yeung, and S.B. Qian PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation J. Biol. Chem. 286 2011 6791 6800
    • (2011) J. Biol. Chem. , vol.286 , pp. 6791-6800
    • Sun, J.1    Conn, C.S.2    Han, Y.3    Yeung, V.4    Qian, S.B.5
  • 54
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • A.R. Tee, B.D. Manning, P.P. Roux, L.C. Cantley, and J. Blenis Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb Curr. Biol. 13 2003 1259 1268
    • (2003) Curr. Biol. , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 57
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 58
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • P.S. Ward, and C.B. Thompson Metabolic reprogramming: a cancer hallmark even warburg did not anticipate Cancer Cell 21 2012 297 308
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 60
    • 79955779584 scopus 로고    scopus 로고
    • MTOR links oncogenic signaling to tumor cell metabolism
    • J.L. Yecies, and B.D. Manning mTOR links oncogenic signaling to tumor cell metabolism J. Mol. Med. 89 2011 221 228
    • (2011) J. Mol. Med. , vol.89 , pp. 221-228
    • Yecies, J.L.1    Manning, B.D.2
  • 61
    • 68049137608 scopus 로고    scopus 로고
    • Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin
    • K. Yu, L. Toral-Barza, C. Shi, W.G. Zhang, J. Lucas, B. Shor, J. Kim, J. Verheijen, K. Curran, and D.J. Malwitz Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin Cancer Res. 69 2009 6232 6240
    • (2009) Cancer Res. , vol.69 , pp. 6232-6240
    • Yu, K.1    Toral-Barza, L.2    Shi, C.3    Zhang, W.G.4    Lucas, J.5    Shor, B.6    Kim, J.7    Verheijen, J.8    Curran, K.9    Malwitz, D.J.10
  • 62
    • 84865503043 scopus 로고    scopus 로고
    • Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2
    • M. Yuan, E. Pino, L. Wu, M. Kacergis, and A.A. Soukas Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2 J. Biol. Chem. 287 2012 29579 29588
    • (2012) J. Biol. Chem. , vol.287 , pp. 29579-29588
    • Yuan, M.1    Pino, E.2    Wu, L.3    Kacergis, M.4    Soukas, A.A.5
  • 64
  • 65
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • R. Zoncu, A. Efeyan, and D.M. Sabatini mTOR: from growth signal integration to cancer, diabetes and ageing Nat. Rev. Mol. Cell Biol. 12 2011 21 35
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.