Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

Genes and Development

Volumn 29, Issue 17, 2015, Pages 1875-1889

  Nicolay, Brandon N ^a   Danielian, Paul S ^b,c   Kottakis, Filippos ^a,c   Lapek, John D ^a,c   Sanidas, Ioannis ^a,c   Miles, Wayne O ^a   Dehnad, Mantre ^a   Tschöp, Katrin ^a   Gierut, Jessica J ^a   Manning, Amity L ^a   Morris, Robert ^a   Haigis, Kevin ^a   Bardeesy, Nabeel ^a   Lees, Jacqueline A ^b   Haas, Wilhelm ^a   Dyson, Nicholas J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

13C glucose; Metabolism; Mitochondria; OXPHOS; PRB; Proteomics

Indexed keywords

GLUCOSE; GLUCOSE C 13; MITOCHONDRIAL PROTEIN; PROTEIN PRB; PROTEOME; PYRUVIC ACID; RNA; TRANSCRIPTION FACTOR E2F; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; RETINOBLASTOMA PROTEIN; TRANSCRIPTOME;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CITRIC ACID CYCLE; COLON; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; RB1 GENE; ANIMAL; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS;

ANIMALS; CELLS, CULTURED; COLON; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; HUMANS; LUNG; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATIVE PHOSPHORYLATION; PROTEOMICS; RETINOBLASTOMA PROTEIN; STRESS, PHYSIOLOGICAL; TRANSCRIPTOME;

EID: 84940843287     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.264127.115     Document Type: Article

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