Aging-dependent demethylation of regulatory elements correlates with chromatin state and improved β cell function

Cell Metabolism

Volumn 22, Issue 4, 2015, Pages 619-632

  Avrahami, Dana ^a,d   Li, Changhong ^b   Zhang, Jia ^a   Schug, Jonathan ^a   Avrahami, Ran ^a   Rao, Shilpa ^a   Stadler, Michael B ^c   Burger, Lukas ^c   Schübeler, Dirk ^c   Glaser, Benjamin ^d   Kaestner, Klaus H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYCLIN D3; DNA; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 3BETA; HOX PROTEIN; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MKI67 PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; POLO LIKE KINASE 1; PROTEIN; RFX PROTEIN; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTOME; UNCLASSIFIED DRUG; CHROMATIN; HISTONE; PROTEIN BINDING; TRANSCRIPTION FACTOR;

AGE; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CELL AGING; CELL CONTACT; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL MATURATION; CELL POPULATION; CELL PROLIFERATION; CELL SPECIFICITY; CELL STIMULATION; CHROMATIN; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENZYME REPRESSION; EPIGENETICS; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE SILENCING; GENOME; GLUCOSE METABOLISM; HISTONE MODIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEOSOME; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ACETYLATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REGULATORY SEQUENCE; RNA ANALYSIS; RNA SEQUENCE; SIGNAL TRANSDUCTION; STEADY STATE; TRANSCRIPTION INITIATION SITE; UPREGULATION; AGING; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CPG ISLAND; CYTOLOGY; ENHANCER REGION; GENETICS; METABOLISM; SECRETION (PROCESS);

AGING; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN; CPG ISLANDS; DNA METHYLATION; ENHANCER ELEMENTS, GENETIC; HISTONES; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; TRANSCRIPTION FACTORS;

EID: 84943451551     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.07.025     Document Type: Article

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