Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging

Aging Cell

Volumn 12, Issue 1, 2013, Pages 102-111

  González Navarro, Herminia ^a   Vinué, Ángela ^b   Sanz, María Jesús ^a,c   Delgado, Mercedes ^d   Pozo, Miguel Angel ^d   Serrano, Manuel ^e   Burks, Deborah J ^f   Andrés, Vicente ^g  

^a Biomedical Research Institute Hospital Clinic de Valencia INCLIVA   (Spain)

^b CSIC   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

^d INSTITUTO PLURIDISCIPLINAR   (Spain)

^e Centro Nacional de Investigations Oncológicas   (Spain)

^f CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^g CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

18F fluorodeoxyglucose PET; ARF; CDKN2A; CDKN2B; Diabetes; Insulin resistance; Insulin signaling; P15ink4b; P16ink4a; Pancreatic islet

Indexed keywords

ARF PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; FLUORODEOXYGLUCOSE F 18; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE; PHOSPHATIDYLINOSITOL 3 KINASE;

AGING; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ENZYME ACTIVATION; GENE LOCUS; GENOTYPE; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; MACROPHAGE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTECTION; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; SKELETAL MUSCLE; WILD TYPE;

ADP-RIBOSYLATION FACTORS; AGING; ANIMALS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE; GLUCOSE INTOLERANCE; INSULIN; INSULIN RESISTANCE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC;

MAMMALIA; MUS;

EID: 84872609955     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12023     Document Type: Article

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