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Volumn 52, Issue 7, 2003, Pages 1738-1748

Mechanisms of the age-associated deterioration in glucose tolerance: Contribution of alterations in insulin secretion, action, and clearance

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

EID: 0038353641     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.7.1738     Document Type: Article
Times cited : (394)

References (54)
  • 1
    • 0021933723 scopus 로고
    • Pathogenesis of age-related glucose intolerance in man: Insulin resistance and decreased β-cell function
    • Chen M, Bergman RN, Pacini G, Porte D Jr: Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased β-cell function. J Clin Endocrinol Metab 60:13-20, 1985
    • (1985) J Clin Endocrinol Metab , vol.60 , pp. 13-20
    • Chen, M.1    Bergman, R.N.2    Pacini, G.3    Porte D., Jr.4
  • 2
    • 0026730037 scopus 로고
    • Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age
    • Coon PJ, Rogus EM, Drinkwater D, Muller DC, Goldberg AP: Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age. J Clin Endocrinol Metab 75:1125-1132, 1992
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 1125-1132
    • Coon, P.J.1    Rogus, E.M.2    Drinkwater, D.3    Muller, D.C.4    Goldberg, A.P.5
  • 3
    • 0018702014 scopus 로고
    • Glucose intolerance and aging: Evidence for tissue insensitivity to insulin
    • DeFronzo RA: Glucose intolerance and aging: evidence for tissue insensitivity to insulin. Diabetes 28:1095-1101, 1979
    • (1979) Diabetes , vol.28 , pp. 1095-1101
    • DeFronzo, R.A.1
  • 7
    • 0031797295 scopus 로고    scopus 로고
    • Age-related reduction in glucose elimination is accompanied by reduced glucose effectiveness and increased hepatic insulin extraction in man
    • Ahren B, Pacini G: Age-related reduction in glucose elimination is accompanied by reduced glucose effectiveness and increased hepatic insulin extraction in man. J Clin Endocrinol Metab 83:3350-3356, 1998
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3350-3356
    • Ahren, B.1    Pacini, G.2
  • 8
    • 0023939849 scopus 로고
    • Insulin sensitivity and beta-cell responsivity are not decreased in elderly subjects with normal OGTT
    • Pacini G, Valerio A, Beccaro F, Nosadini R, Cobelli C, Crepaldi G: Insulin sensitivity and beta-cell responsivity are not decreased in elderly subjects with normal OGTT. J Am Geriatr Soc 36:317-323, 1988
    • (1988) J Am Geriatr Soc , vol.36 , pp. 317-323
    • Pacini, G.1    Valerio, A.2    Beccaro, F.3    Nosadini, R.4    Cobelli, C.5    Crepaldi, G.6
  • 9
    • 0027309493 scopus 로고
    • Effects of age and body fat on insulin resistance in healthy men
    • Boden G, Chen X, DeSantis RA, Kendrick Z: Effects of age and body fat on insulin resistance in healthy men. Diabetes Care 16:728-733, 1993
    • (1993) Diabetes Care , vol.16 , pp. 728-733
    • Boden, G.1    Chen, X.2    DeSantis, R.A.3    Kendrick, Z.4
  • 13
    • 0027199747 scopus 로고
    • The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus
    • Elahi D, Muller DC, McAloon-Dyke M, Tobin D, Andres R: The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus. Exp Gerontol 28:393-409, 1993
    • (1993) Exp Gerontol , vol.28 , pp. 393-409
    • Elahi, D.1    Muller, D.C.2    McAloon-Dyke, M.3    Tobin, D.4    Andres, R.5
  • 14
    • 0025639010 scopus 로고
    • Reduced beta-cell secretion and insulin hepatic extraction in healthy elderly subjects
    • Pacini G, Beccaro F, Valerio A, Nosadini R, Crepaldi G: Reduced beta-cell secretion and insulin hepatic extraction in healthy elderly subjects. J Am Geriatr Soc 38:1283-1289, 1990
    • (1990) J Am Geriatr Soc , vol.38 , pp. 1283-1289
    • Pacini, G.1    Beccaro, F.2    Valerio, A.3    Nosadini, R.4    Crepaldi, G.5
  • 17
    • 0027361147 scopus 로고
    • Serum insulin distributions and reproducibility of the relationship between 2-hour insulin and plasma glucose levels in Asian Indian, Creole, and Chinese Mauritians
    • Dowse GK, Zimmet PZ, Alberti KGMM, Brigham L, Carlin JB, Tuomilehto J, Knight LT, Gareeboo H: Serum insulin distributions and reproducibility of the relationship between 2-hour insulin and plasma glucose levels in Asian Indian, Creole, and Chinese Mauritians. Metabolism 42:1232-1241, 1993
    • (1993) Metabolism , vol.42 , pp. 1232-1241
    • Dowse, G.K.1    Zimmet, P.Z.2    Alberti, K.G.M.M.3    Brigham, L.4    Carlin, J.B.5    Tuomilehto, J.6    Knight, L.T.7    Gareeboo, H.8
  • 19
    • 0027419106 scopus 로고
    • Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations
    • Nauck MA, Bartels E, Orskov C, Ebert R, Creutzfeldt W: Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. J Clin Endocrinol Metab 76:912-917, 1993
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 912-917
    • Nauck, M.A.1    Bartels, E.2    Orskov, C.3    Ebert, R.4    Creutzfeldt, W.5
  • 20
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ: Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study. Lancet 359:824-830, 2002
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 23
    • 0027285747 scopus 로고
    • Endurance exercise training reduces glucose-stimulated insulin levels in 60- to 70-year-old men and women
    • Kirwan JP, Kohrt WM, Wojta DM, Bourey RE, Holloszy JO: Endurance exercise training reduces glucose-stimulated insulin levels in 60- to 70-year-old men and women. J Gerontol Med Sci 48:M84-M90, 1993
    • (1993) J Gerontol Med Sci , vol.48
    • Kirwan, J.P.1    Kohrt, W.M.2    Wojta, D.M.3    Bourey, R.E.4    Holloszy, J.O.5
  • 24
    • 85003195436 scopus 로고
    • Cortisol induced insulin resistance in man: Impaired suppression of glucose production and stimulation of glucose utilization due to a post-receptor defect of insulin action
    • Rizza R, Mandarino L, Gerich J: Cortisol induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a post-receptor defect of insulin action. J Clin Endocrinol Metab 54:131-138, 1982
    • (1982) J Clin Endocrinol Metab , vol.54 , pp. 131-138
    • Rizza, R.1    Mandarino, L.2    Gerich, J.3
  • 25
    • 0019970112 scopus 로고
    • Effect of growth hormone on insulin action in man: Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization
    • Rizza RA, Mandarino LJ, Gerich JE: Effect of growth hormone on insulin action in man: mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes 31:663-669, 1982
    • (1982) Diabetes , vol.31 , pp. 663-669
    • Rizza, R.A.1    Mandarino, L.J.2    Gerich, J.E.3
  • 28
    • 0024834748 scopus 로고
    • Toward physiological understanding of glucose tolerance: The minimal model approach. Lilly Award Lecture
    • Bergman RN: Toward physiological understanding of glucose tolerance: the minimal model approach. Lilly Award Lecture. Diabetes 38:1512-1527, 1989
    • (1989) Diabetes , vol.38 , pp. 1512-1527
    • Bergman, R.N.1
  • 29
    • 0036318476 scopus 로고    scopus 로고
    • Accurate assessment of B-cell function: The hyperbolic correction
    • Bergman RN, Ader M, Huecking K, Van Citters G: Accurate assessment of B-cell function: the hyperbolic correction. Diabetes 51 (Suppl. 1):S212-S220, 2002
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Bergman, R.N.1    Ader, M.2    Huecking, K.3    Van Citters, G.4
  • 30
    • 0029968711 scopus 로고    scopus 로고
    • Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males
    • Vermeulen A, Kaufman JM, Giagulli VA: Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 81:1821-1826, 1996
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1821-1826
    • Vermeulen, A.1    Kaufman, J.M.2    Giagulli, V.A.3
  • 32
    • 0023193582 scopus 로고
    • Validation of a new method for the determination of free fatty acid turnover
    • Miles JM, Ellman MG, McClean KL, Jensen MD: Validation of a new method for the determination of free fatty acid turnover. Am J Physiol 252:E431-E438, 1987
    • (1987) Am J Physiol , vol.252
    • Miles, J.M.1    Ellman, M.G.2    McClean, K.L.3    Jensen, M.D.4
  • 33
    • 0028794829 scopus 로고
    • Measurement of abdominal and visceral fat with computed tomography and dual-energy x-ray absorptiometry
    • Jensen MD, Kanaley JA, Reed JE, Sheedy PF: Measurement of abdominal and visceral fat with computed tomography and dual-energy x-ray absorptiometry. Am J Clin Nutr 61:274-278, 1995
    • (1995) Am J Clin Nutr , vol.61 , pp. 274-278
    • Jensen, M.D.1    Kanaley, J.A.2    Reed, J.E.3    Sheedy, P.F.4
  • 34
    • 0029019420 scopus 로고
    • Oxidative capacity of human muscle fiber types: Effects of age and training status
    • Proctor DN, Sinning WE, Walro JM, Sieck GC, Lemon PW: Oxidative capacity of human muscle fiber types: effects of age and training status. J Appl Physiol 78:2033-2038, 1995
    • (1995) J Appl Physiol , vol.78 , pp. 2033-2038
    • Proctor, D.N.1    Sinning, W.E.2    Walro, J.M.3    Sieck, G.C.4    Lemon, P.W.5
  • 35
    • 0030962960 scopus 로고    scopus 로고
    • Dynamic muscle strength alterations to detraining and retraining in elderly men
    • Taafe DR, Marcus R: Dynamic muscle strength alterations to detraining and retraining in elderly men. Clin Physiol 17:311-324, 1997
    • (1997) Clin Physiol , vol.17 , pp. 311-324
    • Taafe, D.R.1    Marcus, R.2
  • 36
    • 0036110469 scopus 로고    scopus 로고
    • The oral glucose minimal model: Estimation of insulin sensitivity from a meal test
    • Dalla Man C, Caumo A, Cobelli C: The oral glucose minimal model: estimation of insulin sensitivity from a meal test. IEEE Trans Biomed Eng 49:419-429, 2002
    • (2002) IEEE Trans Biomed Eng , vol.49 , pp. 419-429
    • Dalla Man, C.1    Caumo, A.2    Cobelli, C.3
  • 37
    • 0035149713 scopus 로고    scopus 로고
    • Oral glucose tolerance test minimal model indexes of β-cell function and insulin sensitivity
    • Breda E, Cavaghan MK, Toffolo G, Polonsky KS, Cobelli C: Oral glucose tolerance test minimal model indexes of β-cell function and insulin sensitivity. Diabetes 50:150-158, 2001
    • (2001) Diabetes , vol.50 , pp. 150-158
    • Breda, E.1    Cavaghan, M.K.2    Toffolo, G.3    Polonsky, K.S.4    Cobelli, C.5
  • 40
    • 0029123756 scopus 로고
    • Estimation of β-cell sensitivity from intravenous glucose tolerance tests C-peptide data
    • Toffolo G, De Grandi F, Cobelli C: Estimation of β-cell sensitivity from intravenous glucose tolerance tests C-peptide data. Diabetes 44:845-854, 1995
    • (1995) Diabetes , vol.44 , pp. 845-854
    • Toffolo, G.1    De Grandi, F.2    Cobelli, C.3
  • 41
    • 0032870338 scopus 로고    scopus 로고
    • β-cell function during insulin-modified intravenous glucose tolerance test successfully assessed by the C-peptide minimal model
    • Toffolo G, Cefalu WT, Cobelli C: β-cell function during insulin-modified intravenous glucose tolerance test successfully assessed by the C-peptide minimal model. Metabolism 48:1162-1166, 1999
    • (1999) Metabolism , vol.48 , pp. 1162-1166
    • Toffolo, G.1    Cefalu, W.T.2    Cobelli, C.3
  • 42
    • 0026504160 scopus 로고
    • Estimation of insulin secretion rates from C-peptide levels: Comparison of individual and standard kinetic parameters for C-peptide clearance
    • Van Cauter E, Mestrez F, Sturis J, Polonsky KS: Estimation of insulin secretion rates from C-peptide levels: comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41:368-377, 1992
    • (1992) Diabetes , vol.41 , pp. 368-377
    • Van Cauter, E.1    Mestrez, F.2    Sturis, J.3    Polonsky, K.S.4
  • 43
    • 0019810028 scopus 로고
    • Physiologic evaluation of factors controlling glucose tolerance in man
    • Bergman RN, Phillips SP, Cobelli C: Physiologic evaluation of factors controlling glucose tolerance in man. J Clin Invest 68:1456-1467, 1981
    • (1981) J Clin Invest , vol.68 , pp. 1456-1467
    • Bergman, R.N.1    Phillips, S.P.2    Cobelli, C.3
  • 48
    • 0021962194 scopus 로고
    • The metabolic clearance of insulin and the feedback inhibition of insulin secretion are altered with aging
    • Fink RI, Revers RR, Kolterman OG, Olefsky JM: The metabolic clearance of insulin and the feedback inhibition of insulin secretion are altered with aging. Diabetes 34:275-280, 1985
    • (1985) Diabetes , vol.34 , pp. 275-280
    • Fink, R.I.1    Revers, R.R.2    Kolterman, O.G.3    Olefsky, J.M.4
  • 50
    • 0030786810 scopus 로고    scopus 로고
    • Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals
    • Meneilly GS, Ryan AS, Veldhuis JD, Elahi D: Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals. J Clin Endocrinol Metab 82:4088-4093, 1997
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 4088-4093
    • Meneilly, G.S.1    Ryan, A.S.2    Veldhuis, J.D.3    Elahi, D.4
  • 51
    • 0033305319 scopus 로고    scopus 로고
    • Disruption of the pulsatile and entropic modes of insulin release during an unvarying glucose stimulus in elderly individuals
    • Meneilly GS, Veldhuis JD, Elahi D: Disruption of the pulsatile and entropic modes of insulin release during an unvarying glucose stimulus in elderly individuals. J Clin Endocrinol Metab 84:1938-1943, 1999
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1938-1943
    • Meneilly, G.S.1    Veldhuis, J.D.2    Elahi, D.3
  • 52
    • 0020121342 scopus 로고
    • Differential rates of release of newly synthesized and of stored insulin from pancreatic islets
    • Halban PE: Differential rates of release of newly synthesized and of stored insulin from pancreatic islets. Endocrinology 110:1183-1188, 1982
    • (1982) Endocrinology , vol.110 , pp. 1183-1188
    • Halban, P.E.1
  • 54
    • 0035461929 scopus 로고    scopus 로고
    • Decrease in β-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig
    • Kjems LL, Kirby BM, Welsh EM, Veldhuis JD, Straume M, McIntyre SS, Yang D, Lefebvre P, Butler PC: Decrease in β-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig. Diabetes 50:2001-2012, 2001
    • (2001) Diabetes , vol.50 , pp. 2001-2012
    • Kjems, L.L.1    Kirby, B.M.2    Welsh, E.M.3    Veldhuis, J.D.4    Straume, M.5    McIntyre, S.S.6    Yang, D.7    Lefebvre, P.8    Butler, P.C.9


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