A review on mechanisms of anti tumor activity of chalcones

Anti-Cancer Agents in Medicinal Chemistry

Volumn 16, Issue 2, 2016, Pages 200-211

  Sharma, Rahul ^a   Kumar, Rakesh ^a   Kodwani, Rishi ^a   Kapoor, Sukriti ^a   Khare, Anukriti ^a   Bansal, Ritu ^a   Khurana, Sonali ^a   Singh, Sandhya ^a   Thomas, Jennifer ^a   Roy, Bornika ^a   Phartyal, Rajendra ^a   Saluja, Shukla ^a   Kumar, Sanjay ^a  

^a UNIVERSITY OF DELHI   (India)

Author keywords

Anti angiogenesis; Anti cancer; Anti tubulin; Apoptosis; Chalcone; Cytoxicity; Signal transduction

Indexed keywords

CASPASE 10; CASPASE 2; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CHALCONE; CYCLOOXYGENASE 2; DEATH RECEPTOR 5; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FIBROBLAST GROWTH FACTOR; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE; LICOCHALCONE A; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; STAT PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TUBULIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; UNINDEXED DRUG; VASCULOTROPIN; XANTHOHUMOL; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CELL PROLIFERATION; CYTOTOXICITY; DOWN REGULATION; DPPH RADICAL SCAVENGING ASSAY; HUMAN; IC50; LEUKEMIA; MELANOMA; MITOCHONDRIAL PERMEABILITY; MOLECULAR HYBRIDIZATION; MOUTH SQUAMOUS CELL CARCINOMA; MTT ASSAY; NON SMALL CELL LUNG CANCER; PHAGOCYTOSIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH CANCER; STRUCTURE ACTIVITY RELATION; TUNEL ASSAY; UPREGULATION; ANIMAL; CELL CYCLE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; METABOLISM;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; CELL PROLIFERATION; CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 84959574023     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520615666150518093144     Document Type: Article

References (72)

1. Sharma, V.; Chaudhary, A.; Arora, S; Saxena, K.A.; Ishar, P.M. β-Ionone derived chalcones as potent antiproliferative agents. Eur. J. Med. Chem., 2013, 69, 310-315.
2. Omaima, M.A.; Kamelia, M.A.; Hamed, I.A.; Mohamed, M.A.; Eman, Y.A. Design, synthesis and anticancer activity of benzofuran derivatives targeting VEGFR-2 tyrosine kinase. RSC Adv., 2014, 4, 11569-11579.
3. Rai, S.U.; Isloor, A.M.; Shetty, P.; Pai, K.S.R.; Fun, H.K. Synthesis and in vitro biological evaluation of new pyrazole chalcones and hetrocyclic diamides as potential anticancer agent. Arab. J. Chem., 2015, 8, 317-321.
4. Champelovier, P.; Laporte, F.; Chauchet, X.; Boutonnat, J.; Hazane-Puch, F.; Boumendjel, A.; Vergnaud, S.; Garrel, C. Cellular and molecular mechanisms activating the cell death processes by chalcones: Critical structural effects. Toxicol. in Vitro, 2013, 27(8), 2305-2315.
5. Magedov, I.V.; Lefranc, F.; Frolova, L.V.; Banulus, L.M.; Peretti, A.S.; Rogelj, S.; Mathieu, V.; Kiss, R.; Kornienko, A. Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancer cells. Bioorg. Med. Chem. Lett., 2013, 23(11), 3277-3282.
6. Ivkovic, M.B.; Nikolic, K.; Ilic, B.B.; Zizak, S.Z.; Novakovic, B.R.; Cudina, A.O.; Vladimirov, M.S. Phenylpropiophenone derivatives as potential anticancer agents: synthesis, biological evaluation and quantitative structure-activity relationship study. Eur. J. Med. Chem., 2013, 63, 239-255.
7. Zhang, E.H.; Wang, R.F.; Guo, S.Z.; Liu, B. An update on antitumor activity of naturally occurring Chalcones. Evid. Based Complement. Alternat. Med., 2013, 1-22.
8. Bukhari, A.N.S.; Yasmin, T.; Benedict, J. V.; Lam, W.K.; Jantan, I.; Jalil, J.; Jasamai, M. Synthesis and evaluation of chalcones derivatives as inhibitors of Neutrophils’ chemotaxis, phagocytosis and production of reactive oxygen species. Chem. Biol. Drug Des., 2014, 83(2), 198-206.
9. Kitawat B.S.; Singh, M.; Kale, K.R. Solvent free synthesis, characterization, anticancer, antibacterial, antifungal, antioxidant and SAR studies of novel (E)-3-aryl-1-(3-alkyl-2-pyrazinyl)-2-propenone. New J. Chem, 2013, 37, 2541-2550.
10. Qian, Y.; Shang, Y.; Teng, Q.; Chang, J.; Fan, G.; Wei, X.; Li, R.; Li, H.; Yao, X.; Dai, F.; Zhou, B. Hydroxychalcones as potential antioxidants: Structure-activity relationship analysis and mechanisms consideration. Food Chem., 2011, 126(1), 241-248.
11. Sashidhara, V.K.; Kumar, M.; Modukuri, K.R.; Sonkar, R.; Bhatia, G.; Khanna, A.K.; Rai, S.; Shukla, R. Synthesis and antiinflammatory activity of novel biscoumarin-chalcone hybrids. Bioorg. Med. Chem. Lett., 2011, 21(15), 4480-4484.
12. Konduru, K.N.; Dey, S.; Sajid, M.; Owais, M.; Ahmed N. Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones. Eur. J. Med. Chem., 2013, 59, 23-30.
13. Pilatova, M.; Varinska, L.; Parjesi, P.; Sarissky, M.; Mirossay, L.; Solar, P.; Ostro, A.; Mojziz, J. In vitro antiproliferative and antiangiogenic effects of synthetic chalcone analogues. Toxicol. in Vitro, 2010, 24(5), 1347-1355.
14. Liu, X.F.; Zheng, C.J.; Sun, L.P.; Liu, X.K.; Piao, H.R. Synthesis of new chalcones derivatives bearing 2, 4-thiazolidinedione and benzoic acid moieties as potential antibacterial agents. Eur. J. Med. Chem., 2011, 46(8), 3469-3473.
15. Joshi, D.; Parikh, S.K. Synthesis and antimicrobial evaluation of 1, 3, 4-oxadiazole-based chalcone derivatives. Med. Chem. Res., 2014, 23(4), 1855-1864.
16. Ahmad, I.; Thakur, J.P.; Chanda, D.; Saikia, D.; Khan, F.; Dixit, S.; Kumar, A.; Konwar, R.; Negi, S.A.; Gupta, A. Syntheses of lipophilic chalcones and their conformationally restricted analogues as antitubercular agents. Bioorg. Med. Chem Lett., 2013, 23(5), 1322-1325.
17. Smit, J.F.; N’Da, D.D. Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides. Bioorg. Med. Chem., 2014, 22(3), 1128-1138.
18. De Mello, F.T.; Bitencourt, R.H.; Pedroso, B.R.; Aristides, M.S.; Lonardoni, V.M.; Silveria, G.T. Leishmanicidal activity of synthetic chalcones in Leishmania(Viannia) braziliensis. Exp. Parasitol., 2014, 136, 27-34.
19. Goto, N.K.; Lee, H.K. Anti-AIDS agents 68. The first total synthesis of a unique potent anti-HIV chalcone from genus desmos. Tetrahedron Lett., 2006, 47(47), 8263-8266.
20. Hsieh, C.T.; Hsieh, T.J.; El-Shazly, M.; Chuang, D.W.; Tsai, Y.H.; Yen, C.T.; Wu, S.F.; Wu, Y.C.; Chang, F.F. Synthesis of chalcones derivatives as potential anti-diabetic agents. Bioorg. Med. Chem. Lett., 2012, 22(12), 3912-3915.
21. Sharma, P.; Kumar, S.; Ali, F.; Anthal, S.; Gupta, K.V.; Khan, A. I.; Singh, S.; Sangwan P.S.; Suri A.K.; Gupta, D.B.; Gupta, K.D.; Dutt, P.; Vishwakarma R.A.; Satti, K.N. Synthesis and biological activity of some novel hetrocyclic chalcone derivatives. Med. Chem. Res., 2013, 22(8), 3969-3983.
22. Wan, M.; Xu, L.; Hua, L.; Li, A.; Li, S.; Lu, W.; Pang, Y.; Cao, C.; Liu, X.; Jia, P. Synthesis and evaluation of novel isoxazolyl chalcones as potential anticancer agents. Bioorg. Chem., 2014, 54, 38-43.
23. Chauhan, S.S.; Singh, K.A.; Meena, S.; Lohani, M.; Singh, A.; Arya, K.R.; Cheruvu, H.S.; Sarkar, J.; Gayen, R.J.; Datta, D. Chauhan P. M. Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells. Bioorg. Med. Chem. Lett., 2014, 24(13), 2820-2824.
24. Vasconcelos De, A.; Campos, F.V.; Nedel, F.; Seixas, K.F.; Dellagostin, A.O.; Smith, R.K.; Pereira De Pereira, M.C.; Stefanello, M.F.; Collares, T.; Barschak, G.A. Cytotoxic and apoptotic effects of chalcone derivatives of 2-acetylthiophene on human colon adenocarcinoma cells. Cell Biochem. Funct., 2013, 31(4), 289-297.
25. Nelson, G.; Mohammad, A.A.; Atkinson, T.; Gurrapu, S.; Kumar, S.J.; Bicknese, C.; Johnson, L.J.; Williams, M. Synthesis and evaluation of p-N,N-dialkyl substituted chalcones as anticancer agents. Med. Chem. Res., 2013, 22(10), 4610-4614.
26. Shin, Y.S.; Kim, J.H.; Yoon, H.; Choi, Y.K.; Koh, D.; Lim, Y.; Lee, H.Y. Novel antimitotic activity of 2-hydroxy-4-methoxy-2',3'-benzochalcone (HymnPro) through the inhibition of tubulin polymerization. J. Agric. Food Chem., 2013, 61(51), 12588-12597.
27. Ismail, B.; Ghezali, L.; Gueye, R.; Limami, Y.; Pouget, C.; Leger, D.Y.; Martin F.; Beneytout J.L.; Duroux J.L.; Diab-Assaf M.; Fagnere, C.; Liagre, B. Novel methylsulfonyl chalcones as potential antiproliferative drugs for human prostate cancer: Involvement of the intrinsic pathway of apoptosis. Int. J. Oncol., 2013, 43(4), 1160-1168.
28. Fang, X.; Yang, B.; Cheng, Z.; Yang, M.; Su, N.; Lizhen, Z.; Zhou, J. Synthesis and anti tumor activity of novel nitrogen mustardlinked chalcones. Arch. Pharm. Chem. Life Sci., 2013, 346(4), 292-299.
29. Shenvi, S.; Kumar, K.; Hatti, S.K.; Rijesh, K.; Diwakar, L.; Reddy, C.G. Synthesis, anticancer and antioxidant activities of 2,4,5-trimethoxy chalcones and analogues from asaronaldehydestructure-activity relationship. Eur. J. of Med. Chem., 2013, 62, 435-442.
30. Raj, C.G.D.; Balladaka, K.S.; Subramanya, H.; Swamy, S.; Yalega, S.R.; Veerakyathappa, B.; Yogisharadhya, R.; Ramappa, R. In vitro biological activity of new heterocyclic chalcone derivatives. Med. Chem. Res., 2013, 22(5), 2079-2087.
31. Jin, C.; Liang, Y.J.; He, H.; Fu, L. Synthesis and antitumor activity of novel chalcone derivatives. Biomed. Pharmacother., 2013, 67(3), 215-217.
32. Solano, J.D.; González-Sánchez, I.; Cerbón, M.A.; Guzmán, Á.; Martínez-Urbina, M.A.; Vilchis-Reyes, M.A., Martínez-Zuñiga, E.C.; Alvarado, C.; Quintero, A.; Díaz, E. The products of the reaction between 6-amine-1, 3-dimethyluracil and bis-chalcones induce cytotoxicity with massive vacuolation in HeLa cervical cancer cell line. Eur. J. Med. Chem., 2013, 60, 350-359.
33. Ethiraj, R.K.; Nithya, P.; Krishnakumar, V.; Mathew, J.A.; Khan, N.F. Synthesis and cytotoxicity study of pyrazoline derivatives of methoxy substitued naphthyl chalcones. Res. Chem. Intermed., 2013, 39(4), 1833-1841.
34. Ethiraj, R.K.; Jesil, M.A.; Khan, N.F. Potential cytotoxic and apoptosis inducing agents: Synthesis and evaluation of methoxysubstituted chalcones against human lung and cervical cancer. Med. Chem. Res., 2013, 22(11), 5408-5417.
35. Solomon, R.V.; Lee, H. Anti-breast cancer activity of heteroaryl chalcone derivatives. Biomed. Pharmacother., 2012, 66(3), 213-220.
36. Dias, A.T.; Duarte, L.C.; Lima, F.C.; Proenca, F.M.; Pereira-Wilson, C. Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonols quercetin. Eur. J. Med. Chem., 2013, 65, 500-510.
37. Sharma, V.; Chaudhary, A.; Chasoo G.; Arora R.; Arora, S; Saxena, K.A.; Ishar, M.P. β-Ionone derived apoptosis inducing endoperoxides: Discovery of potent leads for anticancer agents. Eur. J. Med. Chem., 2014, 87, 228-236.
38. Kumar, D.; Kumar, M.N.; Tantak, P.M.; Ogura, M.; Kusaka, E.; Ito, T.; Synthesis and identification of a-cyano bis (indolyl) chalcones as novel anticancer agents. Bioorg. Med. Chem. Lett., 2014, 24(22), 5170-5174.
39. Lee, M.J.; Lee, S.M.; Koh, D.; Lee, H.Y.; Lim, Y.; Shin, Y.S.; A new synthetic 2′-hydroxy-2,4,6-trimethoxy-5′,6′-naphthochalcone induces G2/M cell cycle arrest and apoptosis by disrupting the microtubular network of human colon cancer cells. Cancer Lett., 2014, 354(2), 348-354.
40. Neves, P.M.; Cravo, S.; Lima, T.R.; Vasconcelos, H.M.; Nascimento, S.M.; Silva, M.A.; Pinto, M.; Cidade, H.; Correa, A. G. Solid-phase synthesis of 2'-hydroxy chalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines. Bioorg. Med Chem., 2012, 20(1), 25-33.
41. Singh, P.; Raj, R.; Kumar, V.; Mahajan, M.P.; Bedi, P.M.; Kaur, T.; Saxena, A.K. 1, 2, 3-Triazole tethered β-lactam-chalcone bifunctional hybrids: synthesis and anticancer evaluation. Eur. J. Med. Chem., 2012, 47(1), 594-600.
42. Wu, W.; Ye, H.; Wan, L.; Han, X.; Wang, G.; Hu, J.; Tang, M.; Duan, X.; Fan, Y.; He, S.; Huang, L.; Pei, H.; Wang, X.; Li, X.; Xie, C.; Zhang, R.; Yuan, Z.; Mao, Y.; Wei, Y.; Chen, L. Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS -mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo. Carcinogenesis, 2013, 34(7), 1636-1643.
43. Sakai, T.; Eskander, R.N.; Guo, Y.; Kim, K.J.; Mefford, J.; Hopkins, J.; Bhatia, N.N.; Zi, X.; Hoang, B.H. Flavokawain, B, A Kava chalcone, induces apoptosis in synovial sarcoma cell lines. J. Orthop. Res., 2012, 30(7), 1045-1050.
44. Winter, E.; Chiaradia, D.L.; Silva, H.A.; Nunes, J.R.; Yunes, A. R.; Creczynski-Pasa, B.T. Involvement of extrinsic and intrinsic apoptotic pathways together with endoplasmic reticulum stress in cell death induced by naphthyl chalcones in a leukemic cell line: Advantages of multi-target action. Toxicol. In Vitro, 2014, 28(5), 769-777.
45. Wei, H.; Zhang, X.; Wu, G.; Yang, X.; Pan, S.; Wang, Y.; Ruan, J. Chalcone derivatives from the fern Cyclosorus parasiticus and their anti-proliferative activity. Food Chem. Toxicol., 2013, 60, 147-152.
46. Yang, L.; Su, L.; Cao, C.; Xu, L.; Zhong, D.; Xu, L.; Liu, X. The Chalcone 2’ -hydroxy -4’, 5’-dimethoxy chalcone activates death receptor 5 pathway and leads to apoptosis in human non small cell lung cancer cells. IUBMB, Life, 2013, 65(6), 533-543.
47. Szliszka, E.; Jaworska, D.; Kłósek, M.; Czuba Z.P.; Krol, W. Targeting death receptor TRAIL -R2 by chalcones for TRAILinduced apoptosis in cancer cells. Int. J. Mol. Sci., 2012, 13(11), 15343-15359.
48. Wyns, C.; Steendam, V.K.; Vanhoecke, B.; Deforce, D.; Bracke, M.; Heyerick, A. Prenylated chalcone xanthomol associates with histones in breast cancer cells -a novel target identified by a monoclonal antibody. Mol. Nutr. Food Res., 2012, 56(11), 1688-1696.
49. Orlikova, B.; Tasdemir, D.; Golais, F; Dicato, M.; Diederich, M. Dietary chalcones with chemopreventive and chemotherapeutic potential. Gen. Nutr., 2011, 6(2), 125-147.
50. Katsori, M.A.; Litina, H.D. Chalcones in cancer: Understanding their role in terms of QSAR. Curr. Med. Chem., 2009, 16(9), 1062-1081.
51. Spatafora, C.; Tringali, C. Natural-derived polyphenols as potential anticancer agents. Anticancer Agents Med. Chem., 2012, 12(8), 902-918
52. Dyrager, C.; Wickstrom, M.; Friden-Saxin, M.; Friberg, A.; Dahlen, K.; Wallen, A.E.; Gullbo, J.; Grotli, M.; Luthman, K. Inhibitors and promoters of tubulin polymerization: Synthesis and biological evaluation of chalones and related dienones as potential anticancer agents. Bioorg. Med. Chem., 2011, 19(8), 2659-2665.
53. Hseu, Y.C.; Lee, M.S.; Wu, C.R.; Cho, H.J.; Lin, K.Y.; Lai, G.H.; Wang, S.Y.; Kuo, Y.H.; Kumar, K.J.; Yang, H.L. The chalcone flawokawain B induced G2/M cell cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. J. Agric. Food Chem., 2012, 60(9), 2385-2397.
54. Vitorovic-Todorovic, D.M.; Eric-Nikolic, A.; Kolundzija, B.; Hamel, E.; Ristic, S.; Juranic, O.I.; Drakulic, J.B. (E)-4-Aryl-4-oxo-2-butenoic acid amides, chalcone-aroylacrylic acid chimeras: Design, anti-proliferative activity and inhibition of tubulin polymerization. Eur. J. Med. Chem., 2013, 62, 40-50.
55. Kamal, A.; Mallareddy, A.; Suresh, P.; Shaik, B T.; Lakshma Nayak, V.; Kishor, C.; Shetti, R.V.; Sankara Rao, N.; Tamboli, R.J.; Ramakrishna, S.; Addlagatta, A. Synthesis of chalcone amidobenzothiazole conjugates as anti-mitotic and apoptotic inducing agents. Bioorg. Med. Chem., 2012, 20(11), 3480-3492.
56. Zhang, H.; Liu, J.J.; Sun, J.; Yang, X.H.; Zhao, T.T.; Lu, X.; Gong, H.B.; Zhu, H.L. Design, synthesis and biological evaluation of novel chalcone derivatives as anti tubulin agents. Bioorg. Med. Chem., 2012, 20(10), 3212-3218.
57. Varinska, L.; Wijhe, V.M.; Belleri, M.; Mitola, S.; Perjesi, P.; Presta, M.; Koolwijk, P.; Ivanova, L.; Mojzis, J. Anti angiogenic activity of flavonoid precursor 4-hydroxy chalcone. Eur. J. Pharmacol., 2012, 691(1-3), 125-133.
58. Sharma, S.; Kaur, C.; Budhiraja, A.; Nepali, K.; Gupta, K.M.; Saxena, K.A.; Bedi, P.M.; Chalcone based azacarboline analogues as novel antitubulin agents: Design, synthesis, biological evaluation and molecular modeling studies. Eur. J. Med. Chem., 2014, 85, 648-660.
59. Kolundzija, B.; Markovic, V.; Stanojkovic, T.; Joksovic, L.; Matic, I.; Todorovic, N.; Nikolic, M.; Joksovic, D.M. Novel anthraquinone based chalcones analogues containing an imine fragment: Synthesis, cytotoxicity and anti-angiogenic activity. Bioorg. Med. Chem. Lett., 2014, 24(1), 65-71.
60. Rizvi, F.U.S.; Siddiqui, L.H.; Nisar, M.; Khan, N.; Khan, I. Discovery and molecular docking of quinolyl-thienyl chalcones as anti-angiogenic agents targeting VEGFR-3 tyrosine kinase. Bioorg. Med. Chem. Lett., 2012, 22(2), 942-944.
61. Kim, Y.S.; Lee, I.S.; Moon, A. 2-hydoxy chalcone and xanthohumol inhibit invasion of triple negative breast cancer cells. Chem. Biol. Interact., 2013, 203(3), 565-572.
62. Wang, X.; Goode, L.E.; Fredericksen, S.Z.; Vierkant, A.R.; Pankratz, S.V.; Liu-Mares, W.; Rider N.D.; Vachon, M.C.; Cerhan, R.J.; Olson, E.J.; Couch, J.F. Association of genetic variation in genes implicated in the β-catenin destruction complex with risk of breast cancer. Cancer Epidemiol. Biomarkers Prev., 2008, 17(8), 2101-2108.
63. Sen, R.; Baltimore, D. Inducibility of κ immunoglobin enhancerbinding protein NF-κB by a post translational mechanism. Cell, 1986, 47(6), 921-928.
64. Rao, E.V.; Sharma, K.V.; Yun, J.; Kim, Y.; Jung, S. Anti proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells. Bioorg. Med. Chem., 2014, 22(13), 3386-3392.
65. Hsuan-Su, L.; Shih, Y.W. Anti tumor effect of flavone chalcone: Inhibition of invasion and migration through the FAK/ JNK signaling pathway in human gastric adenocarcinoma AGS cells. Mol. Cell Biochem., 2014, 391(1-2),47-58.
66. Pinz, S.; Unser, S.; Brueggemann, S.; Besl, E.; Al-Rifai, N.; Petkes, H.; Amslinger, S.; Rascle, A. The synthetic α-Bromo-2’, 3, 4, 4’ -Tetramethoxychalcone (α-Br-TMC) inhibits the JAK/STAT signaling pathway. PloSOne, 2014,9(3), e90275.
67. Wang, Z.; Wang, N.; Han, S.; Wang, D.; Mo, S.; Yu, L.; Huang, H.; Tsui, K.; Shen, J.; Chen, J. Dietary compound isoliquiritigenin inhibits breast cancer Neo-angiogeneis via VEGF/ VEGFR -2 signaling pathway. Plos One, 2013, 8(7), e68566.
68. Abdel-Aziz, M.; Park, S.E.; Abuo-Rahma, G.E.A.A.; Sayed, A.M.; Kwon, Y. Novel -4-piprazinyl-ciprofloxacin-chalcone hybrids: Synthesis, physiochemical properties, anti cancer and topoisomerase I and II inhibitory activity. Eur. J. Med. Chem., 2013, 69, 427-438.
69. Kim, S.H.; Lee, E.; Baek, H.K.; Kwon, B.H.; Woo, H.; Lee, E.S.; Kwon, Y.; Na, Y. Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti cancer agents. Bioorg. Med. Chem. Lett., 2013, 23(11), 3320-3324.
70. Kachadourian, R.; Day, J.B.; Pugazhenti, S.; Franklin, C.C.; Estelle, G.B.; Mahaffey, G.; Gauthier, C.; Pietro, D.A.; Boumendjel, A.A synthetic Chalcone as a potent inducer of glutathione biosynthesis. J. Med. Chem., 2012, 55(3), 1382-1388.
71. Yu, L.; Zhang, F.; Hu, Z.; Ding, H.; Tang, H.; Ma, Z.; Zhao, X. Novel prenylated bi-chalcone and chalcone from Humulus lupulus and their quinone reductase induction activities. Fitoterapia, 2014, 93, 115-120.
72. Isa, N.M.; Abdelwahab, S.I.; Mohan, S.; Abdul, A.B.; Sukari, M.A.; Taha, M.M.E.; Syam, S.; Cheah, P.; Ahmad, S.; Mustafa, M.R. In vitro anti inflammatory, cytotoxic and anti oxidant activities of boesenbergia A, a chalcone isolated from Boesenbergia rotunda(L.) (fingerroot). Braz. J. Med. Biol. Res., 2012, 45(6), 524-530.