The products of the reaction between 6-amine-1,3-dimethyl uracil and bis-chalcones induce cytotoxicity with massive vacuolation in HeLa cervical cancer cell line

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 350-359

  Solano, José D ^a   González Sánchez, Ignacio ^a   Cerbón, Marco A ^a   Guzmán, Ángel ^b   Martínez Urbina, Miguel A ^b   Vilchis Reyes, Miguel A ^b   Martínez Zuñiga, Eduardo C ^c   Alvarado, Cuauhtémoc ^b   Quintero, Angelina ^a   Díaz, Eduardo ^b  

^a Universidad Nacional Autonoma de Mexico Facultad de Quimica   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MÉXICO   (Mexico)

Author keywords

Autophagy; Bis chalcones; Cytotoxicity; Pyrimidine derivatives; Spautin 1

Indexed keywords

1,3 DIMETHYL 5 (1 METHYL 1H PYRROL 2 YL) 9 [(1 METHYL 1H PYRROL 2 YL)METHYLENE) 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B]QUINOLINE 2,4(1H,3H) DIONE; 1,3 DIMETHYL 5 (1 METHYL 1H PYRROL 2 YL) 9 [(1 METHYL 1H PYRROL 2 YL)METHYLENE] 8,9 DIHYDRO 1H PYRANO[3',4':5,6] PYRIDO[2,3 D]PYRIMIDINE 2,4(3H,6H) DIONE; 1,3 DIMETHYL 5 (THIOPHEN 3 YL) 9 (THIOPHEN 3 YLMETHYLENE) 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B]QUINOLINE 2,4(1H,3H) DIONE; 1,3 DIMETHYL 5 (THIOPHEN 3 YL) 9 (THIOPHEN 3 YLMETHYLENE) 8,9 DIHYDRO 1H PYRANO[3',4':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4(3H,6H) DIONE; 6 AMINE 1,3 DIMETHYL URACIL; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; GALLIC ACID; MICROTUBULE ASSOCIATED PROTEIN 1; PROTEIN BCL 2; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BREAST CANCER; CANCER INHIBITION; CELL CYCLE ARREST; CELL STRUCTURE; CELL VACUOLE; CELL VIABILITY; CHEMICAL REACTION; COLORECTAL CANCER; CYTOTOXICITY; DNA FRAGMENTATION; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; IC 50; MYELOID LEUKEMIA; OXIDATIVE STRESS; POLYPLOIDY; PROTEIN SYNTHESIS; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; URACIL;

EID: 84872104254     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.021     Document Type: Article

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