The chalcone 20-hydroxy-40,50-dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells

IUBMB Life

Volumn 65, Issue 6, 2013, Pages 533-543

  Yang, Lina ^a   Su, Ling ^a   Cao, Congmei ^b   Xu, Linyan ^a   Zhong, Diansheng ^c   Xu, Lijia ^b   Liu, Xiangguo ^a  

^a SHANDONG UNIVERSITY   (China)

^b INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^c TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; C FLIP; Chalcone; DR5; ROS

Indexed keywords

2' HYDROXY 4',5' DIMETHOXYCHALCONE; ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 4; ANTIOXIDANT; CHALCONE DERIVATIVE; COMPLEMENTARY DNA; DEATH RECEPTOR 5; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; REACTIVE OXYGEN METABOLITE; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 2'-HYDROXY-4',5'-DIMETHOXYCHALCONE; ANTINEOPLASTIC AGENT; ATF4 PROTEIN, HUMAN; CFLAR PROTEIN, HUMAN; CHALCONE; DDIT3 PROTEIN, HUMAN; FLICE INHIBITORY PROTEIN; HERBACEOUS AGENT; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER PREVENTION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CELL GROWTH; CELL SURVIVAL; CHEMICAL STRUCTURE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG ISOLATION; ENZYME ASSAY; GENE EXPRESSION; GROWTH INHIBITION; HERB; HUMAN; HUMAN CELL; LUNG CANCER; LUNG NON SMALL CELL CANCER; MEDICINAL PLANT; PROTON NUCLEAR MAGNETIC RESONANCE; SARCANDRA HAINANENSIS; TRADITIONAL MEDICINE; WESTERN BLOTTING; CELL CYCLE CHECKPOINT; DRUG EFFECTS; DRUG SCREENING; ENDOPLASMIC RETICULUM STRESS; GENETICS; LUNG TUMOR; METABOLISM; NON SMALL CELL LUNG CANCER; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR CELL LINE; UPREGULATION; C-FLIP; DR5; DRUG EFFECT; ROS;

ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CHALCONE; CHALCONES; DRUG SCREENING ASSAYS, ANTITUMOR; DRUGS, CHINESE HERBAL; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMANS; LUNG NEOPLASMS; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

APOPTOSIS; C-FLIP; CHALCONE; DR5; ROS;

EID: 84881504249     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1161     Document Type: Article

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