2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells

Chemico-Biological Interactions

Volumn 203, Issue 3, 2013, Pages 565-572

  Kim, Sun Young ^a   Lee, Ik Soo ^b   Moon, Aree ^a  

^a Duksung Women's University   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

2 Hydroxychalcone; Invasion; Triple negative breast cancer cells; Xanthohumol

Indexed keywords

2 HYDROXYCHALCONE; 4 METHOXYCHALCONE; ANTIMITOTIC AGENT; CHALCONE DERIVATIVE; CYTOTOXIC AGENT; GELATINASE A; GELATINASE B; HESPERIDIN METHYLCHALCONE; NEOHESPERIDIN DIHYDROCHALCONE; UNCLASSIFIED DRUG; XANTHOHUMOL;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; GELATINASE B GENE; GENE EXPRESSION REGULATION; PHENOTYPE; PROTEIN EXPRESSION; TRIPLE NEGATIVE BREAST CANCER; TUMOR GENE; TUMOR INVASION;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CHALCONES; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FLAVONOIDS; HUMANS; MICE; NEOPLASM INVASIVENESS; PROPIOPHENONES; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE;

EID: 84877016613     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.03.012     Document Type: Article

References (42)

1. A. Jemal, E. Ward, and M.J. Thun Recent trends in breast cancer incidence rates by age and tumor characteristics among US women Breast Cancer Res. 9 2007 R28
2. V. Chopin, R.A. Toillon, N. Jouy, and X. Le Bourhis P21(WAF1/CIP1) is dispensable for G1 arrest, but indispensable for apoptosis induced by sodium butyrate in MCF-7 breast cancer cells Oncogene 23 2004 21 29 (Pubitemid 38142236)
3. Y.A. DeClerck, N. Perez, H. Shimada, T.C. Boone, K.E. Langley, and S.M. Taylor Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases Cancer Res. 52 1992 701 708
4. V. Masson, L.R. de la Ballina, C. Munaut, B. Wielockx, M. Jost, C. Maillard, S. Blacher, K. Bajou, T. Itoh, S. Itohara, Z. Werb, C. Libert, J.M. Foidart, and A. Noël Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes FASEB J. 19 2005 234 236 (Pubitemid 40189266)
5. C. Sotiriou, S.Y. Neo, L.M. McShane, E.L. Korn, P.M. Long, A. Jazaeri, P. Martiat, S.B. Fox, A.L. Harris, and E.T. Liu Breast cancer classification and prognosis based on gene expression profiles from a population-based study Proc. Natl. Acad. Sci. USA 100 2003 10393 10398 (Pubitemid 37071889)
6. O. Ait-Mohamed, V. Battisti, V. Joliot, L. Fritsch, J. Pontis, S. Medjkane, C. Redeuilh, A. Lamouri, C. Fahy, M. Rholam, D. Atmani, and S. Ait-Si-Ali Acetonic extract of Buxus sempervirens induces cell cycle arrest, apoptosis and autophagy in breast cancer cells PLoS One 6 2011 e24537
7. M.J. Balunas, and A.D. Kinghorn Drug discovery from medicinal plants Life Sci. 78 2005 431 441 (Pubitemid 41653493)
8. D.J. Newman, and G.M. Cragg Natural products as sources of new drugs over the last 25 years J. Nat. Prod. 70 2007 461 477 (Pubitemid 46595760)
9. G. Di Carlo, N. Mascolo, A.A. Izzo, and F. Capasso Flavonoids: old and new aspects of a class of natural therapeutic drugs Life Sci. 65 1999 337 353 (Pubitemid 29325278)
10. Y. Han, M. Riwanto, M.L. Go, and P.L. Ee Modulation of breast cancer resistance protein (BCRP/ABCG2) by non-basic chalcone analogues Eur. J. Pharm. Sci. 35 2008 30 41
11. V.R. Yadav, S. Prasad, B. Sung, and B.B. Aggarwal The role of chalcones in suppression of NF-κB-mediated inflammation and cancer Int. Immunopharmacol. 11 2011 295 309
12. A. Modzelewska, C. Pettit, G. Achanta, N.E. Davidson, P. Huang, and S.R. Khan Anticancer activities of novel chalcone and bis-chalcone derivatives Bioorg. Med. Chem. 14 2006 3491 3495
13. M.V. Reddy, C.R. Su, W.F. Chiou, Y.N. Liu, R.Y. Chen, K.F. Bastow, K.H. Lee, and T.S. Wu Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents Bioorg. Med. Chem. 16 2008 7358 7370
14. X. Zi, and A.R. Simoneau Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice Cancer Res. 65 2005 3479 3486 (Pubitemid 40524635)
15. M.K. Pandey, S.K. Sandur, B. Sung, G. Sethi, A.B. Kunnumakkara, and B.B. Aggarwal Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaBregulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue J. Biol. Chem. 282 2007 17340 17350 (Pubitemid 47100316)
16. D.O. Moon, M.O. Kim, Y.H. Choi, J.W. Hyun, W.Y. Chang, and G.Y. Kim Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation Cancer Lett. 288 2010 204 213
17. K. Tabata, K. Motani, N. Takayanagi, R. Nishimura, S. Asami, Y. Kimura, M. Ukiya, D. Hasegawa, T. Akihisa, and T. Suzuki Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells Biol. Pharm. Bull. 28 2005 1404 1407 (Pubitemid 41379689)
18. B. Vanhoecke, L. Derycke, V. Van Marck, H. Depypere, D. De Keukeleire, and M. Bracke Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer Int. J. Cancer 117 2005 889 895 (Pubitemid 41688562)
19. R. Venè, R. Benelli, S. Minghelli, S. Astigiano, F. Tosetti, and N. Ferrari Xanthohumol impairs human prostate cancer cell growth and invasion and diminishes the incidence and progression of advanced tumors in TRAMP mice Mol. Med. 18 2012 1292 1302
20. R. Benelli, R. Venè, M. Ciarlo, S. Carlone, O. Barbieri, and N. Ferrari The AKT/NF-κB inhibitor xanthohumol is a potent anti-lymphocytic leukemia drug overcoming chemoresistance and cell infiltration Biochem. Pharmacol. 83 2012 1634 1642
21. R. Dell'Eva, C. Ambrosini, N. Vannini, G. Piaggio, A. Albini, and N. Ferrari AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies Cancer 110 2007 2007 2011 (Pubitemid 350036860)
22. E. Bertl, H. Becker, T. Eicher, C. Herhaus, G. Kapadia, H. Bartsch, and C. Gerhäuser Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents Biochem. Biophys. Res. Commun. 325 2004 287 295 (Pubitemid 39441191)
23. J.M. Choi, B.S. Yoon, S.K. Lee, J.K. Hwang, and R. Ryang Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death Biol. Pharm. Bull. 30 2007 324 330
24. I.T. Nizamutdinova, J.J. Jeong, G.H. Xu, S.H. Lee, S.S. Kang, Y.S. Kim, K.C. Chang, and H.J. Kim Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells Int. Immunopharmacol. 8 2008 670 678
25. K. Henmi, Y. Hiwatashi, E. Hikita, N. Toyama, and T. Hirano Methoxy- and fluoro-chalcone derivatives arrest cell cycle progression and induce apoptosis in human melanoma cell A375 Biol. Pharm. Bull. 32 2009 1109 1113
26. W. Qi, D. Ding, and R.J. Salvi Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures Hear. Res. 236 2008 52 60
27. I. Shin, S. Kim, H. Song, H.R. Kim, and A. Moon H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells J. Biol. Chem. 280 2005 14675 14683 (Pubitemid 40562814)
28. M.S. Kim, E.J. Lee, H.R. Kim, and A. Moon P38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells Cancer Res. 63 2003 5454 5461 (Pubitemid 37139864)
29. O.C. Kousidou, A.E. Roussidis, A.D. Theocharis, and N.K. Karamanos Expression of MMPs and TIMPs genes in human breast cancer epithelial cells depends on cell culture conditions and is associated with their invasive potential Anticancer Res. 24 2004 4025 4030 (Pubitemid 40468702)
30. Y. Cha, Y. Kang, and A. Moon HER2 induces expression of leptin in human breast epithelial cells BMB Rep. 45 2012 719 723
31. B.D. Lehmann, J.A. Bauer, X. Chen, M.E. Sanders, A.B. Chakravarthy, Y. Shyr, and J.A. Pietenpol J. Clin. Invest. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies 127 2011 2750 2767
32. J.C. Reed Bcl-2 family proteins Oncogene 17 1998 3225 3236 (Pubitemid 29043975)
33. N. Ramos-DeSimone, E. Hahn-Dantona, J. Sipley, H. Nagase, D.L. French, and J.P. Quigley Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion J. Biol. Chem. 274 1999 13066 13076
34. Y.L. Hsu, P.L. Kuo, W.S. Tzeng, and C.C. Lin Chalcone inhibits the proliferation of human breast cancer cell by blocking cell cycle progression and inducing apoptosis Food Chem. Toxicol. 44 2006 704 713
35. L. Pan, H. Becker, and C. Gerhauser Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway Mol. Nutr. Food Res. 49 2005 837 843 (Pubitemid 41411567)
36. G. Saydam, H.H. Aydin, F. Sahin, O. Kucukoglu, E. Erciyas, E. Terzioglu, F. Buyukkececi, and S.B. Omay Cytotoxic and inhibitory effects of 4,4′-dihydroxy chalcone (RVC-588) on proliferation of human leukemic HL-60 cells Leuk. Res. 27 2003 57 64 (Pubitemid 35449717)
37. R. De Vincenzo, C. Ferlini, M. Distefano, C. Gaggini, A. Riva, E. Bombardelli, P. Morazzoni, P. Valenti, F. Belluti, F.O. Ranelletti, S. Mancuso, and G. Scambia In vitro evaluation of newly developed chalcone analogues in human cancer cells Cancer Chemother. Pharmacol. 46 2000 305 312
38. O. Sabzevari, G. Galati, M.Y. Moridani, A. Siraki, and P.J. O'Brien Molecular cytotoxic mechanisms of anticancer hydroxychalcones Chem. Biol. Interact. 148 2004 57 67 (Pubitemid 38824661)
39. K. Zhang, E.B. Yang, W.Y. Tang, K.P. Wong, and P. Mack Inhibition of glutathione reductase by plant polyphenols Biochem. Pharmacol. 54 1997 1047 1053 (Pubitemid 27475244)
40. K.H. Shen, J.K. Chang, Y.L. Hsu, and P.L. Kuo Chalcone arrests cell cycle progression and induces apoptosis through induction of mitochondrial pathway and inhibition of nuclear factor kappa B signalling in human bladder cancer cells Basic Clin. Pharmacol. Toxicol. 101 2007 254 261
41. B. Ngameni, M. Touaibia, R. Patnam, A. Belkaid, P. Sonna, B.T. Ngadjui, B. Annabi, and R. Roy Inhibition of MMP-2 secretion from brain tumor cells suggests chemopreventive properties of a furanocoumarin glycoside and of chalcones isolated from the twigs of Dorstenia turbinate Phytochemistry 67 2006 2573 2579 (Pubitemid 44711963)
42. S.S. Lakka, S.L. Jasti, C. Gondi, D. Boyd, N. Chandrasekar, D.H. Dinh, W.C. Olivero, M. Gujrati, and J.S. Rao Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro Oncogene 21 2002 5601 5608 (Pubitemid 34983550)