Solid-phase synthesis of 2′-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 25-33

  Neves, Marta Perro ^a   Cravo, Sara ^a   Lima, Raquel T ^a   Vasconcelos, M Helena ^a   Nascimento, M São José ^a   Silva, Artur M S ^b   Pinto, Madalena ^a   Cidade, Honorina ^a   Corrêa, Arlene G ^c  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

^c FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

Author keywords

2 Hydroxychalcones; Antitumor; Apoptosis; Cell cycle; Solid phase

Indexed keywords

2' HYDROXYACETOPHENONE DERIVATIVE; 2' HYDROXYCHALCONE DERIVATIVE; 2',4' DIHYDROXY 3,4,5 TRIMETHOXY 3' PROPYLCHALCONE; 2',4' DIHYDROXY 3,4,5 TRIMETHOXYCHALCONE; 2,4,5 TRIMETHOXYCHALCONE DERIVATIVE; 4 BENZYLOXY 2',4' DIHYDROCHALCONE; 4 CHLORIDE SUBSTITUENT; 4 FLUORO 2',4' DIHYDROXYCHALCONE; ACETOPHENONE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZALDEHYDE DERIVATIVE; CHALCONE DERIVATIVE; CHLORINE DERIVATIVE; FLAVANONE DERIVATIVE; TRIFLUOROMETHYL SUBSTITUENT; UNCLASSIFIED DRUG;

ALDOL REACTION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CATALYSIS; CELL COUNT; CELL CYCLE REGULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; REACTION OPTIMIZATION; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZALDEHYDES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; SOLID-PHASE SYNTHESIS TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855202674     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.042     Document Type: Article

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