Synthesis and evaluation of novel isoxazolyl chalcones as potential anticancer agents

Bioorganic Chemistry

Volumn 54, Issue , 2014, Pages 38-43

  Wan, Maosheng ^a   Xu, Linyan ^a   Hua, Li ^b   Li, Ailing ^b   Li, Shuqing ^b   Lu, Wenjing ^a   Pang, Yue ^a   Cao, Chengbo ^a   Liu, Xiangguo ^a   Jiao, Peifu ^c  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Drug and Food Vocational College   (China)

^c Qilu Normal University   (China)

Author keywords

Apoptosis; Death receptor 5; Human non small cell lung cancer cells; Isoxazolyl chalcones; Synthesis

Indexed keywords

1 [5 METHYL 3 (4 NITROPHENYL)ISOXAZOL 4 YL] 3 (2 NITROPHENYL)PROP 2 EN 1 ONE; 1 [5 METHYL 3 (4 NITROPHENYL)ISOXAZOL 4 YL] 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 [5 METHYL 3 (4 NITROPHENYL)ISOXAZOL 4 YL] 3 (THIOPHEN 2YL)PROP 2 EN 1 ONE; 1 [5 METHYL 3 (4 NITROPHENYL)ISOXAZOL 4 YL] 3 PHENYLPROP 2 EN 1 ONE; 3 (2 BROMOPHENYL) 1 [5 METHYL 3 (4 NITROPHENYL)ISOXAZOL 4YL]ROP 2 EN 1 ONE; 3 (2 CHLOROPHENYL) 1 [5 METHYL 3 (4 NITROPHENYL)ISOXAZOL 4YL]PROP 2 EN 1 ONE; 3 (4 BROMOPHENYL) 1 [5 METHYL 3 (4 NITROPHENYL)ISOXAZOL 4YL]PROP 2 EN 1 ONE; 3 (4 CHLOROPHENYL) 1 [5 METHYL 3 (4 NITROPHENYL)ISOXAZOL 4YL]PROP 2 EN 1 ONE; 5 METHYL 3 (4 NITROPHENYL) 4 ACETYL ISO OXAZOLE; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ELECTRON; HUMAN; HUMAN CELL; IC 50; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; CELL CYCLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; SYNTHESIS; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOXAZOLES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84898954512     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2014.03.004     Document Type: Article

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