Chalcone based azacarboline analogues as novel antitubulin agents: Design, synthesis, biological evaluation and molecular modelling studies

European Journal of Medicinal Chemistry

Volumn 85, Issue , 2014, Pages 648-660

  Sharma, Sahil ^a   Kaur, Charanjit ^a   Budhiraja, Abhishek ^b   Nepali, Kunal ^a   Gupta, Manish K ^c,d   Saxena, A K ^e   Bedi, P M S ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

^b SHOOLINI UNIVERSITY   (India)

^c ISF COLLEGE OF PHARMACY   (India)

^d Knowledge Park II   (India)

^e CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Carboline; Cell line; Chalcone; Constrained; Cytotoxic; Molecular modelling studies; Tubulin

Indexed keywords

3 (1H) PYRROL 2 YL 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (1H) PYRROL 2 YL 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (2 AMINOACETYLPHENYL) 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (3 AMINOACETYLPHENYL) 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (3,4 DIMETHOXYPHENYL) 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (3,4 DIMETHOXYPHENYL) 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (3,4,5 TRIMETHOXYPHENYL) 5 CHLORO 9 ACETYL PYRIDAZINO [3,4 B]INDOLE; 3 (3,4,5 TRIMETHOXYPHENYL) 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (4 BROMOPHENYL) 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (4 BROMOPHENYL) 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (4 CHLOROPHENYL) 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (4 CHLOROPHENYL) 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (4 FLUOROPHENYL) 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (4 METHOXYPHENYL) 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (4 METHOXYPHENYL) 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (4 NITROPHENYL) 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (4 NITROPHENYL) 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 NAPHTH 1 YL 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 NAPHTH 1 YL 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 NAPHTH 2 YL 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 NAPHTH 2 YL 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 PHENYL 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 PHENYL 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 THIOPHEN 2 YL 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; ANTINEOPLASTIC AGENT; CARBOLINE DERIVATIVE; CHALCONE DERIVATIVE; DOXORUBICIN; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG; CHALCONE; TUBULIN MODULATOR; 3 (1H)PYRROL 2 YL 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (1H)PYRROL 2 YL 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 (3,4,5 TRIMETHOXYPHENYL) 5 CHLORO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 ARYL 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 NAPHTH 1 YL 5 BROMO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; 3 NAPHTH 2 YL 5 BROMO 9 ACETYL PYRIDAZINO[3,4 B]INDOLE; INDOLE DERIVATIVE; UNINDEXED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL LINE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HCT116 CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROGEN BOND; HYDROPHOBICITY; IC 50; IMMUNOFLUORESCENCE; IN VITRO STUDY; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; MOLECULAR INTERACTION; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; SYNTHESIS; TUMOR CELL LINE; CYTOTOXICITY; DRUG SCREENING; IC50; IMMUNOFLUORESCENCE TEST; MOLECULAR MODEL;

ANTINEOPLASTIC AGENTS; CARBOLINES; CELL LINE, TUMOR; CHALCONE; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 84906081062     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.08.005     Document Type: Article

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