Design, synthesis and biological evaluation of novel chalcone derivatives as antitubulin agents

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 10, 2012, Pages 3212-3218

  Zhang, Hui ^a   Liu, Jia Jia ^a   Sun, Jian ^a   Yang, Xian Hui ^a   Zhao, Ting Ting ^a   Lu, Xiang ^a   Gong, Hai Bin ^b   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

Antiproliferative activity; Chalcone; Molecular docking; Tubulin inhibitory activity

Indexed keywords

1 (4 BROMOROPHENYL) 3 [3 CHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL]PROP 2 EN 1 ONE; 1 (4 BROMOROPHENYL) 3 [3,5 DIBROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL]PROP 2 EN 1 ONE; 1 (4 BROMOROPHENYL) 3 [3,5 DICHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL]PROP 2 EN 1 ONE; 1 (4 CHLOROPHENYL) 3 [3,5 DIBROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL]PROP 2 EN 1 ONE; 1 (4 CHLOROPHENYL) 3 [3,5 DICHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL]PROP 2 EN 1 ONE; 3 [3 BROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 BROMOPHENYL)PROP 2 EN 1 ONE; 3 [3 BROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 CHLOROPHENYL)PROP 2 EN 1 ONE; 3 [3 BROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 [3 BROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3 BROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 TOLYL)PROP 2 EN 1 ONE; 3 [3 CHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 CHLOROPHENYL)PROP 2 EN 1 ONE; 3 [3 CHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 [3 CHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3 CHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 TOLYL)PROP 2 EN 1 ONE; 3 [3,5 DIBROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 [3,5 DIBROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3,5 DIBROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1,4 TOLYLPROP 2 EN 1 ONE; 3 [3,5 DICHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 [3,5 DICHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3,5 DICHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]PHENYL] 1,4 TOLYLPROP 2 EN 1 ONE; CHALCONE DERIVATIVE; COLCHICINE; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CANCER INHIBITION; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONE; DRUG DESIGN; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; TUBULIN MODULATORS;

EID: 84860428576     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.055     Document Type: Article

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