Synthesis, anticancer and antioxidant activities of 2,4,5-trimethoxy chalcones and analogues from asaronaldehyde: Structure-activity relationship

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 435-442

  Shenvi, Suvarna ^a   Kumar, Krishna ^a   Hatti, Kaushik S ^a   Rijesh, K ^a   Diwakar, Latha ^a   Reddy, G Chandrasekara ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

Anticancer; Antioxidant; Chalcones; Flavones; Flavonols; In silico

Indexed keywords

1 (2 HYDROXY,5 CHLOROPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 1 (2,4,6 TRIMETHOXYPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 1 (2,5 DICETOXYPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 1 (3 METHOXY,4 HYDROXYPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (3 NITRO,4 CHLOROPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 1 (3 NITROPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (3 TRIFLUROPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (3,5 DIBENZYLOXYPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 1 (4 FLUROPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4 HYDROXYPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4 IMIDAZOLYLPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4 METHYLPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4 MORPHILINOPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 1 PHENYL 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 2 (2,4,5 TRIMETHOXYPHENYL) 3,6 DIHYDROXY CHROMEN 4 ONE; 2 (2,4,5 TRIMETHOXYPHENYL) 6 CHLORO CHROMEN 4 ONE; 2 (2,4,5 TRIMETHOXYPHENYL) 6 CHLORO,3 HYDROXY CHROMEN 4 ONE; 2 (2,4,5 TRIMETHOXYPHENYL) 6 HYDROXY CHROMAN 4 ONE; 2 (2,4,5 TRIMETHOXYPHENYL) 6 HYDROXY CHROMEN 4 ONE; 2 (2,4,5 TRIMETHOXYPHENYL) 7 HYDROXY CHROMEN 4 ONE; ALDEHYDE DERIVATIVE; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; BETA ASARONE; CHALCONE DERIVATIVE; UNCLASSIFIED DRUG;

ACORUS CALAMUS; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ASSAY; COMPUTER MODEL; CONTROLLED STUDY; DRUG SYNTHESIS; ERYTHROCYTE; FEMALE; HEMOLYSIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ALDEHYDES; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873481261     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.018     Document Type: Article

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