Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 3, 2014, Pages 1128-1138

  Smit, Frans J ^a   N'Da, David D ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

4 Aminoquinoline; Chalcone; Chloroquine (CQ); Malaria; Plasmodium falciparum

Indexed keywords

1,10 CARBONYLDIIMIDAZOLE; 1,6 HEXANEDIAMINE; 4 AMINO 7 CHLOROQUINOLINE DERIVATIVE; 4 AMINOQUINOLINYLCHALCONE AMIDE DERIVATIVE; AMIDE; AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; CARBONYLDIIMIDAZOLE; CARBOXYLIC ACID; CHALCONE; CHALCONYL AMIDE DERIVATIVE; CHLOROQUINE; IMIDAZOLE DERIVATIVE; LICOCHALCONE A; N (2 AMINOETHYL) 7 CHLOROQUINOLIN 4 AMINE; N (2 AMINOPROPYL) 7 CHLOROQUINOLIN 4 AMINE; N (3 AMINOETHYL) 7 CHLOROQUINOLIN 4 AMINE; N (4 AMINOETHYL) 7 CHLOROQUINOLIN 4 AMINE; N (6 AMINOHEXYL) 7 CHLOROQUINOLIN 4 AMINE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; QUINOLINYLCHALCONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FETUS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG FIBROBLAST; MAMMAL CELL; NONHUMAN; PLASMODIUM FALCIPARUM;

MAMMALIA; PLASMODIUM FALCIPARUM;

4-AMINOQUINOLINE; CHALCONE; CHLOROQUINE (CQ); MALARIA; PLASMODIUM FALCIPARUM;

AMIDES; ANTIMALARIALS; CELL LINE; CELLS, CULTURED; CHALCONE; CHEMISTRY TECHNIQUES, SYNTHETIC; CHLOROQUINE; DIAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; INHIBITORY CONCENTRATION 50; PLASMODIUM FALCIPARUM;

EID: 84892812643     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.032     Document Type: Article

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