A synthetic chalcone as a potent inducer of glutathione biosynthesis

Journal of Medicinal Chemistry

Volumn 55, Issue 3, 2012, Pages 1382-1388

  Kachadourian, Remy ^a,b   Day, Brian J ^a,b,c   Pugazhenti, Subbiah ^b,d   Franklin, Christopher C ^c   Genoux Bastide, Estelle ^e   Mahaffey, Gregory ^d   Gauthier, Charlotte ^f   Di Pietro, Attilio ^f   Boumendjel, Ahcène ^e  

^a DEPARTMENT OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e VERIMAG   (France)

^f UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' DIHYDROXYCHALCONE; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; CHALCONE DERIVATIVE; CHLORINE; FLUORINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HALOGEN; HOLOENZYME; HYDROXYL GROUP; PHENYL GROUP; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NF E2; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BREAST CANCER; CELL LEVEL; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; ENZYME SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION INITIATION;

ANTIOXIDANTS; CELL LINE, TUMOR; CHALCONES; GENES, REPORTER; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HOLOENZYMES; HUMANS; INTRACELLULAR SPACE; LUCIFERASES; NF-E2 TRANSCRIPTION FACTOR, P45 SUBUNIT; RESPONSE ELEMENTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 84856854110     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2016073     Document Type: Article

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