메뉴 건너뛰기




Volumn 6, Issue 3, 2016, Pages

Translating the science of aging into therapeutic interventions

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

EID: 84959528564     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a025908     Document Type: Article
Times cited : (53)

References (120)
  • 2
    • 84863403169 scopus 로고    scopus 로고
    • The caloric restriction paradigm: Implications for healthy human aging
    • Anderson RM, Weindruch R. 2012. The caloric restriction paradigm: Implications for healthy human aging. Am J Hum Biol 24: 101-106.
    • (2012) Am J Hum Biol , vol.24 , pp. 101-106
    • Anderson, R.M.1    Weindruch, R.2
  • 3
    • 77952941576 scopus 로고    scopus 로고
    • The cardiovascular effects of metformin: Further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus
    • Anfossi G, Russo I, Bonomo K, Trovati M. 2010. The cardiovascular effects of metformin: Further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus. Curr Vasc Pharmacol 8: 327-337.
    • (2010) Curr Vasc Pharmacol , vol.8 , pp. 327-337
    • Anfossi, G.1    Russo, I.2    Bonomo, K.3    Trovati, M.4
  • 4
    • 84881661464 scopus 로고    scopus 로고
    • The key role of growth hormone- insulin-IGF-1 signaling in aging and cancer
    • Anisimov VN, Bartke A. 2013. The key role of growth hormone- insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol 87: 201-223.
    • (2013) Crit Rev Oncol Hematol , vol.87 , pp. 201-223
    • Anisimov, V.N.1    Bartke, A.2
  • 12
    • 84914165449 scopus 로고    scopus 로고
    • Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls
    • Bannister CA, Holden SE, Jenkins-Jones S, Morgan CL, Halcox JP, Schernthaner G, Mukherjee J, Currie CJ. 2014. Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls. Diabetes Obes Metab 16: 1165-1173.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 1165-1173
    • Bannister, C.A.1    Holden, S.E.2    Jenkins-Jones, S.3    Morgan, C.L.4    Halcox, J.P.5    Schernthaner, G.6    Mukherjee, J.7    Currie, C.J.8
  • 13
    • 79251515182 scopus 로고    scopus 로고
    • Single-gene mutations and healthy ageing in mammals
    • Bartke A. 2011. Single-gene mutations and healthy ageing in mammals. Philos Trans R Soc Lond B Biol Sci 366: 28-34.
    • (2011) Philos Trans R Soc Lond B Biol Sci , vol.366 , pp. 28-34
    • Bartke, A.1
  • 17
    • 77955385716 scopus 로고    scopus 로고
    • Role of progerininduced telomere dysfunction in HGPS premature cellular senescence
    • Benson EK, Lee SW, Aaronson SA. 2010. Role of progerininduced telomere dysfunction in HGPS premature cellular senescence. J Cell Sci 123: 2605-2612.
    • (2010) J Cell Sci , vol.123 , pp. 2605-2612
    • Benson, E.K.1    Lee, S.W.2    Aaronson, S.A.3
  • 18
    • 0035138577 scopus 로고    scopus 로고
    • White blood cell count: An independent predictor of coronary heart disease mortality among a national cohort
    • Brown DW, Giles WH, Croft JB. 2001. White blood cell count: An independent predictor of coronary heart disease mortality among a national cohort. J Clin Epidemiol 54: 316-322.
    • (2001) J Clin Epidemiol , vol.54 , pp. 316-322
    • Brown, D.W.1    Giles, W.H.2    Croft, J.B.3
  • 24
    • 0037097039 scopus 로고    scopus 로고
    • Acarbose for prevention of type 2 diabetes mellitus: The STOP-NIDDM randomised trial
    • Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. 2002. Acarbose for prevention of type 2 diabetes mellitus: The STOP-NIDDM randomised trial. Lancet 359: 2072-2077.
    • (2002) Lancet , vol.359 , pp. 2072-2077
    • Chiasson, J.L.1    Josse, R.G.2    Gomis, R.3    Hanefeld, M.4    Karasik, A.5    Laakso, M.6
  • 28
    • 80054843547 scopus 로고    scopus 로고
    • Associations of anti-hypertensive treatments with Alzheimer’s disease, vascular dementia, and other dementias
    • Davies NM, Kehoe PG, Ben-Shlomo Y, Martin RM. 2011. Associations of anti-hypertensive treatments with Alzheimer’s disease, vascular dementia, and other dementias. J Alzheimers Dis 26: 699-708.
    • (2011) J Alzheimers Dis , vol.26 , pp. 699-708
    • Davies, N.M.1    Kehoe, P.G.2    Ben-Shlomo, Y.3    Martin, R.M.4
  • 29
    • 84903136322 scopus 로고    scopus 로고
    • Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease
    • De Felice FG, Ferreira ST. 2014. Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes 63: 2262-2272.
    • (2014) Diabetes , vol.63 , pp. 2262-2272
    • De Felice, F.G.1    Ferreira, S.T.2
  • 30
    • 25144513902 scopus 로고    scopus 로고
    • Development of 17a-estradiol as a neuroprotective therapeutic agent: Rationale and results from a phase I clinical study
    • Dykens JA, Moos WH, Howell N. 2005. Development of 17a-estradiol as a neuroprotective therapeutic agent: Rationale and results from a phase I clinical study. Ann NYAcad Sci 1052: 116-135.
    • (2005) Ann Nyacad Sci , vol.1052 , pp. 116-135
    • Dykens, J.A.1    Moos, W.H.2    Howell, N.3
  • 32
    • 0027320816 scopus 로고
    • Effects of angiotensin-converting enzyme inhibition on mitochondrial number in the aging mouse
    • Ferder L, Inserra F, Romano L, Ercole L, Pszenny V. 1993. Effects of angiotensin-converting enzyme inhibition on mitochondrial number in the aging mouse. Am J Physiol 265: C15-C18.
    • (1993) Am J Physiol , vol.265 , pp. C15-C18
    • Ferder, L.1    Inserra, F.2    Romano, L.3    Ercole, L.4    Pszenny, V.5
  • 36
    • 0033764352 scopus 로고    scopus 로고
    • Whose quality of life is it anyway?Why not ask seniors to tell us about it?
    • Fry PS. 2000.Whose quality of life is it anyway?Why not ask seniors to tell us about it? Int J Aging Hum Dev 50: 361-383.
    • (2000) Int J Aging Hum Dev , vol.50 , pp. 361-383
    • Fry, P.S.1
  • 37
    • 33645541890 scopus 로고    scopus 로고
    • Sources of life strengths as predictors of late-life mortality and survivorship
    • Fry PS, Debats DL. 2006. Sources of life strengths as predictors of late-life mortality and survivorship. Int J Aging Hum Dev 62: 303-334.
    • (2006) Int J Aging Hum Dev , vol.62 , pp. 303-334
    • Fry, P.S.1    Debats, D.L.2
  • 40
    • 51549095032 scopus 로고    scopus 로고
    • Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: Primary results of the Observational Study on Cognitive Function and Systolic Blood Pressure Reduction Open-Label Study
    • Hanon O, Berrou JP, Negre-Pages L, Goch JH, Nadhazi Z, Petrella R, Sedefdjian A, Sevenier F, Shlyakhto EV, Pathak A. 2008. Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: Primary results of the Observational Study on Cognitive Function and Systolic Blood Pressure Reduction Open-Label Study. J Hypertens 26: 1642-1650.
    • (2008) J Hypertens , vol.26 , pp. 1642-1650
    • Hanon, O.1    Berrou, J.P.2    Negre-Pages, L.3    Goch, J.H.4    Nadhazi, Z.5    Petrella, R.6    Sedefdjian, A.7    Sevenier, F.8    Shlyakhto, E.V.9    Pathak, A.10
  • 44
    • 84874357500 scopus 로고    scopus 로고
    • Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease
    • Hong J, Zhang Y, Lai S, Lv A, Su Q, Dong Y, Zhou Z, Tang W, Zhao J, Cui L, et al. 2013. Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diab Care 36: 1304-1311.
    • (2013) Diab Care , vol.36 , pp. 1304-1311
    • Hong, J.1    Zhang, Y.2    Lai, S.3    Lv, A.4    Su, Q.5    Dong, Y.6    Zhou, Z.7    Tang, W.8    Zhao, J.9    Cui, L.10
  • 45
    • 65649152524 scopus 로고    scopus 로고
    • Associations of depression with C-reactive protein, IL-1, and IL-6: A metaanalysis
    • Howren MB, Lamkin DM, Suls J. 2009. Associations of depression with C-reactive protein, IL-1, and IL-6: A metaanalysis. Psychosom Med 71: 171-186.
    • (2009) Psychosom Med , vol.71 , pp. 171-186
    • Howren, M.B.1    Lamkin, D.M.2    Suls, J.3
  • 46
    • 1442301080 scopus 로고    scopus 로고
    • Inflammatory markers and risk of developing type 2 diabetes in women
    • Hu FB, Meigs JB, Li TY, Rifai N, Manson JE. 2004. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes 53: 693-700.
    • (2004) Diabetes , vol.53 , pp. 693-700
    • Hu, F.B.1    Meigs, J.B.2    Li, T.Y.3    Rifai, N.4    Manson, J.E.5
  • 47
    • 79952773620 scopus 로고    scopus 로고
    • Angiotensin II receptor blockers and risk of cancer in patients with systemic hypertension
    • Huang CC, Chan WL, Chen YC, Chen TJ, Lin SJ, Chen JW, Leu HB. 2011. Angiotensin II receptor blockers and risk of cancer in patients with systemic hypertension. Am J Cardiol 107: 1028-1033.
    • (2011) Am J Cardiol , vol.107 , pp. 1028-1033
    • Huang, C.C.1    Chan, W.L.2    Chen, Y.C.3    Chen, T.J.4    Lin, S.J.5    Chen, J.W.6    Leu, H.B.7
  • 49
    • 17144384777 scopus 로고    scopus 로고
    • Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with type 2 diabetes
    • Johnson JA, Simpson SH, Toth EL, Majumdar SR. 2005. Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with type 2 diabetes. Diabet Med 22: 497-502.
    • (2005) Diabet Med , vol.22 , pp. 497-502
    • Johnson, J.A.1    Simpson, S.H.2    Toth, E.L.3    Majumdar, S.R.4
  • 50
    • 84912030559 scopus 로고    scopus 로고
    • Diabetes and cancer: Epidemiology and potential mechanisms
    • Joost HG. 2014. Diabetes and cancer: Epidemiology and potential mechanisms. Diab Vasc Dis Res 11: 390-394.
    • (2014) Diab Vasc Dis Res , vol.11 , pp. 390-394
    • Joost, H.G.1
  • 51
    • 67649743686 scopus 로고    scopus 로고
    • Inflammation, coagulation, and the pathway to frailty
    • Kanapuru B, Ershler WB. 2009. Inflammation, coagulation, and the pathway to frailty. Am J Med 122: 605-613.
    • (2009) Am J Med , vol.122 , pp. 605-613
    • Kanapuru, B.1    Ershler, W.B.2
  • 52
    • 84877251996 scopus 로고    scopus 로고
    • Metformin- mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells
    • Karnevi E, Said K, Andersson R, Rosendahl AH. 2013.Metformin- mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells. BMC Cancer 13: 235.
    • (2013) BMC Cancer , vol.13
    • Karnevi, E.1    Said, K.2    Ersson, R.3    Rosendahl, A.H.4
  • 54
    • 84899562732 scopus 로고    scopus 로고
    • Drugs that modulate aging: The promising yet difficult path ahead
    • Kennedy BK, Pennypacker JK. 2014. Drugs that modulate aging: The promising yet difficult path ahead. Transl Res 163: 456-465.
    • (2014) Transl Res , vol.163 , pp. 456-465
    • Kennedy, B.K.1    Pennypacker, J.K.2
  • 55
    • 84872047225 scopus 로고    scopus 로고
    • Translating advances from the basic biology of aging into clinical application
    • Kirkland JL. 2013a. Translating advances from the basic biology of aging into clinical application. Exp Gerontol 48: 1-5.
    • (2013) Exp Gerontol , vol.48 , pp. 1-5
    • Kirkland, J.L.1
  • 56
    • 84941285507 scopus 로고    scopus 로고
    • Inflammation and cellular senescence: Potential contribution to chronic diseases and disabilities with aging
    • Kirkland JL. 2013b. Inflammation and cellular senescence: Potential contribution to chronic diseases and disabilities with aging. Public Policy Aging Rep 23: 12-15.
    • (2013) Public Policy Aging Rep , vol.23 , pp. 12-15
    • Kirkland, J.L.1
  • 57
    • 64949128319 scopus 로고    scopus 로고
    • Healthspan, translation, and new outcomes for animal studies of aging
    • Kirkland JL, Peterson C. 2009. Healthspan, translation, and new outcomes for animal studies of aging. J Gerontol A Biol Sci Med Sci 64: 209-212.
    • (2009) J Gerontol a Biol Sci Med Sci , vol.64 , pp. 209-212
    • Kirkland, J.L.1    Peterson, C.2
  • 58
    • 84941264776 scopus 로고    scopus 로고
    • Clinical strategies and animal models for developing senolytic agents
    • Kirkland JL, Tchkonia T. 2014. Clinical strategies and animal models for developing senolytic agents. Exp Gerontol 68: 19-25.
    • (2014) Exp Gerontol , vol.68 , pp. 19-25
    • Kirkland, J.L.1    Tchkonia, T.2
  • 59
    • 78851470539 scopus 로고    scopus 로고
    • Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials
    • Lamanna C, Monami M, Marchionni N, Mannucci E. 2011. Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials. Diabetes Obes Metab 13: 221-228.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 221-228
    • Lamanna, C.1    Monami, M.2    Marchionni, N.3    Mannucci, E.4
  • 61
    • 84874611570 scopus 로고    scopus 로고
    • Rapalogs and mTOR inhibitors as anti-aging therapeutics
    • Lamming DW, Ye L, Sabatini DM, Baur JA. 2013. Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest 123: 980-989.
    • (2013) J Clin Invest , vol.123 , pp. 980-989
    • Lamming, D.W.1    Ye, L.2    Sabatini, D.M.3    Baur, J.A.4
  • 64
    • 78651451726 scopus 로고    scopus 로고
    • Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: A representative population prospective cohort study of 800,000 individuals
    • Lee MS, Hsu CC, Wahlqvist ML, Tsai HN, Chang YH, Huang YC. 2011. Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: A representative population prospective cohort study of 800,000 individuals. BMC Cancer 11: 20.
    • (2011) BMC Cancer , vol.11
    • Lee, M.S.1    Hsu, C.C.2    Wahlqvist, M.L.3    Tsai, H.N.4    Chang, Y.H.5    Huang, Y.C.6
  • 67
    • 74949131237 scopus 로고    scopus 로고
    • Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis
    • Li NC, Lee A, Whitmer RA, Kivipelto M, Lawler E, Kazis LE, Wolozin B. 2010. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis. BMJ 340: b5465.
    • (2010) BMJ , vol.340
    • Li, N.C.1    Lee, A.2    Whitmer, R.A.3    Kivipelto, M.4    Lawler, E.5    Kazis, L.E.6    Wolozin, B.7
  • 68
    • 69549097703 scopus 로고    scopus 로고
    • Newusers of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
    • Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM. 2009.Newusers of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes. Diab Care 32: 1620-1625.
    • (2009) Diab Care , vol.32 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3    Alessi, D.R.4    Morris, A.D.5    Evans, J.M.6
  • 69
    • 0030699961 scopus 로고    scopus 로고
    • Long-term ACE inhibition doubles lifespan of hypertensive rats
    • Linz W, Jessen T, Becker RH, Scholkens BA,Wiemer G. 1997. Long-term ACE inhibition doubles lifespan of hypertensive rats. Circulation 96: 3164-3172.
    • (1997) Circulation , vol.96 , pp. 3164-3172
    • Linz, W.1    Jessen, T.2    Becker, R.H.3
  • 70
    • 0034106595 scopus 로고    scopus 로고
    • Longterm angiotensin II type 1 receptor blockade with fonsartan doubles lifespan of hypertensive rats
    • Linz W, Heitsch H, Scholkens BA, Wiemer G. 2000. Longterm angiotensin II type 1 receptor blockade with fonsartan doubles lifespan of hypertensive rats. Hypertension 35: 908-913.
    • (2000) Hypertension , vol.35 , pp. 908-913
    • Linz, W.1    Heitsch, H.2    Scholkens, B.A.3    Wiemer, G.4
  • 72
    • 80052397117 scopus 로고    scopus 로고
    • Potent anti-proliferative effects of metformin on trastuzumab- resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions
    • Liu B, Fan Z, Edgerton SM, Yang X, Lind SE, Thor AD. 2011. Potent anti-proliferative effects of metformin on trastuzumab- resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions. Cell Cycle 10: 2959-2966.
    • (2011) Cell Cycle , vol.10 , pp. 2959-2966
    • Liu, B.1    Fan, Z.2    Edgerton, S.M.3    Yang, X.4    Lind, S.E.5    Thor, A.D.6
  • 73
    • 77955347748 scopus 로고    scopus 로고
    • An index of self-rated health deficits in relation to frailty and adverse outcomes in older adults
    • Lucicesare A, Hubbard RE, Searle SD, Rockwood K. 2010. An index of self-rated health deficits in relation to frailty and adverse outcomes in older adults. Aging Clin Exp Res 22: 255-260.
    • (2010) Aging Clin Exp Res , vol.22 , pp. 255-260
    • Lucicesare, A.1    Hubbard, R.E.2    Searle, S.D.3    Rockwood, K.4
  • 78
    • 84899073317 scopus 로고    scopus 로고
    • Criteria for clinically relevantweakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: The Foundation for the National Institutes of Health (FNIH) Sarcopenia Project
    • McLean RR, Shardell MD, Alley DE, Cawthon PM, Fragala MS, Harris TB, Kenny AM, Peters KW, Ferrucci L, Guralnik JM, et al. 2014. Criteria for clinically relevantweakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: The Foundation for the National Institutes of Health (FNIH) Sarcopenia Project. J Gerontol A Biol Sci Med Sci 69: 576-583.
    • (2014) J Gerontol a Biol Sci Med Sci , vol.69 , pp. 576-583
    • McLean, R.R.1    Shardell, M.D.2    Alley, D.E.3    Cawthon, P.M.4    Fragala, M.S.5    Harris, T.B.6    Kenny, A.M.7    Peters, K.W.8    Ferrucci, L.9    Guralnik, J.M.10
  • 85
    • 77955279767 scopus 로고    scopus 로고
    • Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease
    • O’Connor PM, Lapointe TK, Beck PL, Buret AG. 2010. Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease. Inflamm Bowel Dis 16: 1411-1420.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1411-1420
    • O’connor, P.M.1    Lapointe, T.K.2    Beck, P.L.3    Buret, A.G.4
  • 86
    • 0025198608 scopus 로고
    • In search of Methuselah: Estimating the upper limits to human longevity
    • Olshansky SJ, Carnes BA, Cassel C. 1990. In search of Methuselah: Estimating the upper limits to human longevity. Science 250: 634-640.
    • (1990) Science , vol.250 , pp. 634-640
    • Olshansky, S.J.1    Carnes, B.A.2    Cassel, C.3
  • 89
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. 2001. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. J Amer Med Assoc 286: 327-334.
    • (2001) J Amer Med Assoc , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 90
    • 59049097390 scopus 로고    scopus 로고
    • Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14þ monocytes in frail older adults
    • Qu T, Walston JD, Yang H, Fedarko NS, Xue QL, Beamer BA, Ferrucci L, Rose NR, Leng SX. 2009. Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14þ monocytes in frail older adults. Mech Ageing Dev 130: 161-166.
    • (2009) Mech Ageing Dev , vol.130 , pp. 161-166
    • Qu, T.1    Walston, J.D.2    Yang, H.3    Fedarko, N.S.4    Xue, Q.L.5    Beamer, B.A.6    Ferrucci, L.7    Rose, N.R.8    Leng, S.X.9
  • 92
    • 84938061050 scopus 로고    scopus 로고
    • How longevity research can lead to therapies for Alzheimer’s disease: The rapamycin story
    • Richardson A, Galvan V, Lin AL, Oddo S. 2014. How longevity research can lead to therapies for Alzheimer’s disease: The rapamycin story. Exp Gerontol 68: 51-58.
    • (2014) Exp Gerontol , vol.68 , pp. 51-58
    • Richardson, A.1    Galvan, V.2    Lin, A.L.3    Oddo, S.4
  • 93
    • 78549254172 scopus 로고    scopus 로고
    • Frailty defined by deficit accumulation and geriatric medicine defined by frailty
    • Rockwood K, Mitnitski A. 2011. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med 27: 17-26.
    • (2011) Clin Geriatr Med , vol.27 , pp. 17-26
    • Rockwood, K.1    Mitnitski, A.2
  • 94
    • 33744925926 scopus 로고    scopus 로고
    • Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70
    • Rockwood K, Mitnitski A, Song X, Steen B, Skoog I. 2006. Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc 54: 975-979.
    • (2006) J am Geriatr Soc , vol.54 , pp. 975-979
    • Rockwood, K.1    Mitnitski, A.2    Song, X.3    Steen, B.4    Skoog, I.5
  • 95
    • 84868652782 scopus 로고    scopus 로고
    • Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: A cohort study
    • Roumie CL, Hung AM, Greevy RA, Grijalva CG, Liu X, Murff HJ, Elasy TA, Griffin MR. 2012. Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: A cohort study. Ann Intern Med 157: 601-610.
    • (2012) Ann Intern Med , vol.157 , pp. 601-610
    • Roumie, C.L.1    Hung, A.M.2    Greevy, R.A.3    Grijalva, C.G.4    Liu, X.5    Murff, H.J.6    Elasy, T.A.7    Griffin, M.R.8
  • 99
    • 74049140048 scopus 로고    scopus 로고
    • Inflammation and cancer: Interweaving microRNA, free radical, cytokine and p53 pathways
    • Schetter AJ, Heegaard NH, Harris CC. 2010. Inflammation and cancer: Interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis 31: 37-49.
    • (2010) Carcinogenesis , vol.31 , pp. 37-49
    • Schetter, A.J.1    Heegaard, N.H.2    Harris, C.C.3
  • 104
    • 0345700727 scopus 로고    scopus 로고
    • Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF. 2003. Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52: 812-817.
    • (2003) Diabetes , vol.52 , pp. 812-817
    • Spranger, J.1    Kroke, A.2    Mohlig, M.3    Hoffmann, K.4    Bergmann, M.M.5    Ristow, M.6    Boeing, H.7    Pfeiffer, A.F.8
  • 105
    • 67650482883 scopus 로고    scopus 로고
    • Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer
    • Srikrishna G, Freeze HH. 2009. Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer. Neoplasia 11: 615-628.
    • (2009) Neoplasia , vol.11 , pp. 615-628
    • Srikrishna, G.1    Freeze, H.H.2
  • 106
    • 67650088426 scopus 로고    scopus 로고
    • The basics of preclinical drug development for neurodegenerative disease indications
    • Steinmetz KL, Spack EG. 2009. The basics of preclinical drug development for neurodegenerative disease indications. BMC Neurol 9: pS2.
    • (2009) BMC Neurol , vol.9
    • Steinmetz, K.L.1    Spack, E.G.2
  • 108
    • 84893401717 scopus 로고    scopus 로고
    • Autophagy induction by SIRT6 through attenuation of insulinlike growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence
    • Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, et al. 2014. Autophagy induction by SIRT6 through attenuation of insulinlike growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol 192: 958-968.
    • (2014) J Immunol , vol.192 , pp. 958-968
    • Takasaka, N.1    Araya, J.2    Hara, H.3    Ito, S.4    Kobayashi, K.5    Kurita, Y.6    Wakui, H.7    Yoshii, Y.8    Yumino, Y.9    Fujii, S.10
  • 109
    • 64949168686 scopus 로고    scopus 로고
    • Can we develop genetically tractable models to assess healthspan (Rather than life span) in animal models?
    • Tatar M. 2009. Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models? J Gerontol A Biol Sci Med Sci 64: 161-163.
    • (2009) J Gerontol a Biol Sci Med Sci , vol.64 , pp. 161-163
    • Tatar, M.1
  • 111
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretoryphenotype: Therapeutic opportunities
    • Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. 2013. Cellular senescence and the senescent secretoryphenotype: Therapeutic opportunities. J Clin Invest 123: 966-972.
    • (2013) J Clin Invest , vol.123 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    Van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 112
    • 75149186480 scopus 로고    scopus 로고
    • Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells
    • Tosca L, Rame C, Chabrolle C, Tesseraud S, Dupont J. 2010. Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells. Reproduction 139: 409-418.
    • (2010) Reproduction , vol.139 , pp. 409-418
    • Tosca, L.1    Rame, C.2    Chabrolle, C.3    Tesseraud, S.4    Dupont, J.5
  • 113
    • 84865717087 scopus 로고    scopus 로고
    • Diabetes, metformin use, and colon cancer: A population-based cohort study in Taiwan
    • Tseng CH. 2012. Diabetes, metformin use, and colon cancer: A population-based cohort study in Taiwan. Eur J Endocrinol 167: 409-416.
    • (2012) Eur J Endocrinol , vol.167 , pp. 409-416
    • Tseng, C.H.1
  • 114
    • 33645538914 scopus 로고    scopus 로고
    • C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population- based, prospective study
    • Tuomisto K, Jousilahti P, Sundvall J, Pajunen P, Salomaa V. 2006. C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population- based, prospective study. Thromb Haemost 95: 511-518.
    • (2006) Thromb Haemost , vol.95 , pp. 511-518
    • Tuomisto, K.1    Jousilahti, P.2    Sundvall, J.3    Pajunen, P.4    Salomaa, V.5
  • 116
    • 0037111615 scopus 로고    scopus 로고
    • Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the Cardiovascular Health Study
    • Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH, Gottdiener J, Fried LP. 2002. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the Cardiovascular Health Study. Arch Intern Med 162: 2333-2341.
    • (2002) Arch Intern Med , vol.162 , pp. 2333-2341
    • Walston, J.1    McBurnie, M.A.2    Newman, A.3    Tracy, R.P.4    Kop, W.J.5    Hirsch, C.H.6    Gottdiener, J.7    Fried, L.P.8
  • 117
    • 33744913541 scopus 로고    scopus 로고
    • Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/ National Institute on Aging research conference on frailty in older adults
    • Walston J, Hadley E, Ferrucci L, Guralnick JM, Newman AB, Studenski SA, Ershler WB, Harris T, Fried LP. 2006. Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/ National Institute on Aging research conference on frailty in older adults. J Am Geriatr Soc 54: 991-1001.
    • (2006) J am Geriatr Soc , vol.54 , pp. 991-1001
    • Walston, J.1    Hadley, E.2    Ferrucci, L.3    Guralnick, J.M.4    Newman, A.B.5    Studenski, S.A.6    Ershler, W.B.7    Harris, T.8    Fried, L.P.9
  • 120
    • 8544240116 scopus 로고    scopus 로고
    • Effect of acarbose treatment on the risk of silent myocardial infarctions in patients with impaired glucose tolerance: Results of the randomised STOP-NIDDM trial electrocardiography substudy
    • Zeymer U, Schwarzmaier-D’assie A, Petzinna D, Chiasson JL. 2004. Effect of acarbose treatment on the risk of silent myocardial infarctions in patients with impaired glucose tolerance: Results of the randomised STOP-NIDDM trial electrocardiography substudy. Eur J Cardiovasc Prev Rehabil 11: 412-415.
    • (2004) Eur J Cardiovasc Prev Rehabil , vol.11 , pp. 412-415
    • Zeymer, U.1    Schwarzmaier-D’assie, A.2    Petzinna, D.3    Chiasson, J.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.