-
2
-
-
84863403169
-
The caloric restriction paradigm: Implications for healthy human aging
-
Anderson RM, Weindruch R. 2012. The caloric restriction paradigm: Implications for healthy human aging. Am J Hum Biol 24: 101-106.
-
(2012)
Am J Hum Biol
, vol.24
, pp. 101-106
-
-
Anderson, R.M.1
Weindruch, R.2
-
3
-
-
77952941576
-
The cardiovascular effects of metformin: Further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus
-
Anfossi G, Russo I, Bonomo K, Trovati M. 2010. The cardiovascular effects of metformin: Further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus. Curr Vasc Pharmacol 8: 327-337.
-
(2010)
Curr Vasc Pharmacol
, vol.8
, pp. 327-337
-
-
Anfossi, G.1
Russo, I.2
Bonomo, K.3
Trovati, M.4
-
4
-
-
84881661464
-
The key role of growth hormone- insulin-IGF-1 signaling in aging and cancer
-
Anisimov VN, Bartke A. 2013. The key role of growth hormone- insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol 87: 201-223.
-
(2013)
Crit Rev Oncol Hematol
, vol.87
, pp. 201-223
-
-
Anisimov, V.N.1
Bartke, A.2
-
5
-
-
50849113473
-
Metformin slows down aging and extends life span of female SHR mice
-
Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Tyndyk ML, Yurova MV, Kovalenko IG, Poroshina TE, et al. 2008.Metformin slows down aging and extends life span of female SHR mice. Cell Cycle 7: 2769-2773.
-
(2008)
Cell Cycle
, vol.7
, pp. 2769-2773
-
-
Anisimov, V.N.1
Berstein, L.M.2
Egormin, P.A.3
Piskunova, T.S.4
Popovich, I.G.5
Zabezhinski, M.A.6
Tyndyk, M.L.7
Yurova, M.V.8
Kovalenko, I.G.9
Poroshina, T.E.10
-
6
-
-
74549131244
-
Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo
-
Anisimov VN, Egormin PA, Piskunova TS, Popovich IG, Tyndyk ML, Yurova MN, Zabezhinski MA, Anikin IV, Karkach AS, Romanyukha AA. 2010.Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo. Cell Cycle 9: 188-197.
-
(2010)
Cell Cycle
, vol.9
, pp. 188-197
-
-
Anisimov, V.N.1
Egormin, P.A.2
Piskunova, T.S.3
Popovich, I.G.4
Tyndyk, M.L.5
Yurova, M.N.6
Zabezhinski, M.A.7
Anikin, I.V.8
Karkach, A.S.9
Romanyukha, A.A.10
-
7
-
-
79959564452
-
If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
-
Anisimov VN, Berstein LM, Popovich IG, Zabezhinski MA, Egormin PA, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Kovalenko IG, et al. 2011. If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. Aging (Milano) 3: 148-157.
-
(2011)
Aging (Milano)
, vol.3
, pp. 148-157
-
-
Anisimov, V.N.1
Berstein, L.M.2
Popovich, I.G.3
Zabezhinski, M.A.4
Egormin, P.A.5
Piskunova, T.S.6
Semenchenko, A.V.7
Tyndyk, M.L.8
Yurova, M.N.9
Kovalenko, I.G.10
-
8
-
-
46449083569
-
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
-
Baker DJ, Perez-Terzic C, Jin F, Pitel KS, Niederlander NJ, Jeganathan K, Yamada S, Reyes S, Rowe L, Hiddinga HJ, et al. 2008. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol 10: 825-836.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 825-836
-
-
Baker, D.J.1
Perez-Terzic, C.2
Jin, F.3
Pitel, K.S.4
Niederlander, N.J.5
Jeganathan, K.6
Yamada, S.7
Reyes, S.8
Rowe, L.9
Hiddinga, H.J.10
-
9
-
-
80855138775
-
Clearance of p16Ink4a-positive senescent cells delays ageing- associated disorders
-
Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. 2011. Clearance of p16Ink4a-positive senescent cells delays ageing- associated disorders. Nature 479: 232-236.
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.J.1
Wijshake, T.2
Tchkonia, T.3
Lebrasseur, N.K.4
Childs, B.G.5
Van De Sluis, B.6
Kirkland, J.L.7
Van Deursen, J.M.8
-
10
-
-
33646014444
-
Phenotype of frailty: Characterization in the women’s health and aging studies
-
Bandeen-Roche K, Xue QL, Ferrucci L, Walston J, Guralnik JM, Chaves P, Zeger SL, Fried LP. 2006. Phenotype of frailty: Characterization in the women’s health and aging studies. J Gerontol A Biol Sci Med Sci 61: 262-266.
-
(2006)
J Gerontol a Biol Sci Med Sci
, vol.61
, pp. 262-266
-
-
Bandeen-Roche, K.1
Xue, Q.L.2
Ferrucci, L.3
Walston, J.4
Guralnik, J.M.5
Chaves, P.6
Zeger, S.L.7
Fried, L.P.8
-
11
-
-
77649213897
-
Measuring systemic inflammatory regulation in older adults: Evidence and utility
-
Bandeen-Roche K, Walston JD, Huang Y, Semba RD, Ferrucci L. 2009. Measuring systemic inflammatory regulation in older adults: Evidence and utility. Rejuvenation Res 12: 403-410.
-
(2009)
Rejuvenation Res
, vol.12
, pp. 403-410
-
-
Bandeen-Roche, K.1
Walston, J.D.2
Huang, Y.3
Semba, R.D.4
Ferrucci, L.5
-
12
-
-
84914165449
-
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls
-
Bannister CA, Holden SE, Jenkins-Jones S, Morgan CL, Halcox JP, Schernthaner G, Mukherjee J, Currie CJ. 2014. Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls. Diabetes Obes Metab 16: 1165-1173.
-
(2014)
Diabetes Obes Metab
, vol.16
, pp. 1165-1173
-
-
Bannister, C.A.1
Holden, S.E.2
Jenkins-Jones, S.3
Morgan, C.L.4
Halcox, J.P.5
Schernthaner, G.6
Mukherjee, J.7
Currie, C.J.8
-
13
-
-
79251515182
-
Single-gene mutations and healthy ageing in mammals
-
Bartke A. 2011. Single-gene mutations and healthy ageing in mammals. Philos Trans R Soc Lond B Biol Sci 366: 28-34.
-
(2011)
Philos Trans R Soc Lond B Biol Sci
, vol.366
, pp. 28-34
-
-
Bartke, A.1
-
14
-
-
17444370940
-
Protective effect of the inhibition of the renin-angiotensin system on aging
-
Basso N, Paglia N, Stella I, de Cavanagh EM, Ferder L, del Rosario Lores Arnaiz M, Inserra F. 2005. Protective effect of the inhibition of the renin-angiotensin system on aging. Regul Pept 128: 247-252.
-
(2005)
Regul Pept
, vol.128
, pp. 247-252
-
-
Basso, N.1
Paglia, N.2
Stella, I.3
De Cavanagh, E.M.4
Ferder, L.5
Del Rosario Lores Arnaiz, M.6
Inserra, F.7
-
15
-
-
34548414599
-
Protective effect of long-term angiotensin II inhibition
-
Basso N, Cini R, Pietrelli A, Ferder L, Terragno NA, Inserra F. 2007. Protective effect of long-term angiotensin II inhibition. Am J Physiol Heart Circ Physiol 293: H1351-H1358.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.293
-
-
Basso, N.1
Cini, R.2
Pietrelli, A.3
Ferder, L.4
Terragno, N.A.5
Inserra, F.6
-
16
-
-
84861852370
-
Are sirtuins viable targets for improving healthspan and lifespan?
-
Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R. 2012. Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov 11: 443-461.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 443-461
-
-
Baur, J.A.1
Ungvari, Z.2
Minor, R.K.3
Le Couteur, D.G.4
De Cabo, R.5
-
17
-
-
77955385716
-
Role of progerininduced telomere dysfunction in HGPS premature cellular senescence
-
Benson EK, Lee SW, Aaronson SA. 2010. Role of progerininduced telomere dysfunction in HGPS premature cellular senescence. J Cell Sci 123: 2605-2612.
-
(2010)
J Cell Sci
, vol.123
, pp. 2605-2612
-
-
Benson, E.K.1
Lee, S.W.2
Aaronson, S.A.3
-
18
-
-
0035138577
-
White blood cell count: An independent predictor of coronary heart disease mortality among a national cohort
-
Brown DW, Giles WH, Croft JB. 2001. White blood cell count: An independent predictor of coronary heart disease mortality among a national cohort. J Clin Epidemiol 54: 316-322.
-
(2001)
J Clin Epidemiol
, vol.54
, pp. 316-322
-
-
Brown, D.W.1
Giles, W.H.2
Croft, J.B.3
-
20
-
-
0041878545
-
Elevated levels of tumor necrosis factor a and mortality in centenarians
-
Bruunsgaard H, Andersen-Ranberg K, Hjelmborg JB, Pedersen BK, Jeune B. 2003. Elevated levels of tumor necrosis factor a and mortality in centenarians. Am J Med 115: 278-283.
-
(2003)
Am J Med
, vol.115
, pp. 278-283
-
-
Bruunsgaard, H.1
Ersen-Ranberg, K.2
Hjelmborg, J.B.3
Pedersen, B.K.4
Jeune, B.5
-
21
-
-
84961637065
-
Senescent cells contribute to the physiological remodeling of aged lungs
-
Calhoun C, Shivshankar P, Saker M, Sloane LB, Livi CB, Sharp ZD, Orihuela CJ, Adnot S, White ES, Richardson A, et al. 2015. Senescent cells contribute to the physiological remodeling of aged lungs. J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glu241.
-
(2015)
J Gerontol a Biol Sci Med Sci
-
-
Calhoun, C.1
Shivshankar, P.2
Saker, M.3
Sloane, L.B.4
Livi, C.B.5
Sharp, Z.D.6
Orihuela, C.J.7
Adnot, S.8
White, E.S.9
Richardson, A.10
-
22
-
-
0042510462
-
Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study)
-
Cesari M, Penninx BW, Newman AB, Kritchevsky SB, Nicklas BJ, Sutton-Tyrrell K, Tracy RP, Rubin SM, Harris TB, Pahor M. 2003. Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study). Am J Cardiol 92: 522-528.
-
(2003)
Am J Cardiol
, vol.92
, pp. 522-528
-
-
Cesari, M.1
Penninx, B.W.2
Newman, A.B.3
Kritchevsky, S.B.4
Nicklas, B.J.5
Sutton-Tyrrell, K.6
Tracy, R.P.7
Rubin, S.M.8
Harris, T.B.9
Pahor, M.10
-
23
-
-
84876698868
-
DNAdamage drives accelerated bone aging via an NF-kB-dependent mechanism
-
Chen Q, Liu K, Robinson AR, Clauson CL, Blair HC, Robbins PD, Niedernhofer LJ, Ouyang H. 2013.DNAdamage drives accelerated bone aging via an NF-kB-dependent mechanism. J Bone Miner Res 28: 1214-1228.
-
(2013)
J Bone Miner Res
, vol.28
, pp. 1214-1228
-
-
Chen, Q.1
Liu, K.2
Robinson, A.R.3
Clauson, C.L.4
Blair, H.C.5
Robbins, P.D.6
Niedernhofer, L.J.7
Ouyang, H.8
-
24
-
-
0037097039
-
Acarbose for prevention of type 2 diabetes mellitus: The STOP-NIDDM randomised trial
-
Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. 2002. Acarbose for prevention of type 2 diabetes mellitus: The STOP-NIDDM randomised trial. Lancet 359: 2072-2077.
-
(2002)
Lancet
, vol.359
, pp. 2072-2077
-
-
Chiasson, J.L.1
Josse, R.G.2
Gomis, R.3
Hanefeld, M.4
Karasik, A.5
Laakso, M.6
-
25
-
-
84912064761
-
A three-dimensional human neural cell culture model of Alzheimer’s disease
-
Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D’Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, et al. 2014. A three-dimensional human neural cell culture model of Alzheimer’s disease. Nature 515: 274-278.
-
(2014)
Nature
, vol.515
, pp. 274-278
-
-
Choi, S.H.1
Kim, Y.H.2
Hebisch, M.3
Sliwinski, C.4
Lee, S.5
D’avanzo, C.6
Chen, H.7
Hooli, B.8
Asselin, C.9
Muffat, J.10
-
26
-
-
13944261231
-
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
-
Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. 2005. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433: 760-764.
-
(2005)
Nature
, vol.433
, pp. 760-764
-
-
Conboy, I.M.1
Conboy, M.J.2
Wagers, A.J.3
Girma, E.R.4
Weissman, I.L.5
Rando, T.A.6
-
27
-
-
33750918489
-
The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes
-
Crandall J, Schade D, Ma Y, Fujimoto WY, Barrett-Connor E, Fowler S, Dagogo-Jack S, Andres R. 2006. The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes. J Gerontol A Biol Sci Med Sci 61: 1075-1081.
-
(2006)
J Gerontol a Biol Sci Med Sci
, vol.61
, pp. 1075-1081
-
-
Crandall, J.1
Schade, D.2
Ma, Y.3
Fujimoto, W.Y.4
Barrett-Connor, E.5
Fowler, S.6
Dagogo-Jack, S.7
Res, R.8
-
28
-
-
80054843547
-
Associations of anti-hypertensive treatments with Alzheimer’s disease, vascular dementia, and other dementias
-
Davies NM, Kehoe PG, Ben-Shlomo Y, Martin RM. 2011. Associations of anti-hypertensive treatments with Alzheimer’s disease, vascular dementia, and other dementias. J Alzheimers Dis 26: 699-708.
-
(2011)
J Alzheimers Dis
, vol.26
, pp. 699-708
-
-
Davies, N.M.1
Kehoe, P.G.2
Ben-Shlomo, Y.3
Martin, R.M.4
-
29
-
-
84903136322
-
Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease
-
De Felice FG, Ferreira ST. 2014. Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes 63: 2262-2272.
-
(2014)
Diabetes
, vol.63
, pp. 2262-2272
-
-
De Felice, F.G.1
Ferreira, S.T.2
-
30
-
-
25144513902
-
Development of 17a-estradiol as a neuroprotective therapeutic agent: Rationale and results from a phase I clinical study
-
Dykens JA, Moos WH, Howell N. 2005. Development of 17a-estradiol as a neuroprotective therapeutic agent: Rationale and results from a phase I clinical study. Ann NYAcad Sci 1052: 116-135.
-
(2005)
Ann Nyacad Sci
, vol.1052
, pp. 116-135
-
-
Dykens, J.A.1
Moos, W.H.2
Howell, N.3
-
31
-
-
84900505659
-
PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice
-
Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales- Nebreda L, Urich D, Quaggin SE, Budinger GR, Mutlu GM, et al. 2014. PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. ProcNatl Acad Sci 111: 7090-7095.
-
(2014)
Procnatl Acad Sci
, vol.111
, pp. 7090-7095
-
-
Eren, M.1
Boe, A.E.2
Murphy, S.B.3
Place, A.T.4
Nagpal, V.5
Morales-Nebreda, L.6
Urich, D.7
Quaggin, S.E.8
Budinger, G.R.9
Mutlu, G.M.10
-
32
-
-
0027320816
-
Effects of angiotensin-converting enzyme inhibition on mitochondrial number in the aging mouse
-
Ferder L, Inserra F, Romano L, Ercole L, Pszenny V. 1993. Effects of angiotensin-converting enzyme inhibition on mitochondrial number in the aging mouse. Am J Physiol 265: C15-C18.
-
(1993)
Am J Physiol
, vol.265
, pp. C15-C18
-
-
Ferder, L.1
Inserra, F.2
Romano, L.3
Ercole, L.4
Pszenny, V.5
-
33
-
-
0033024330
-
Serum IL-6 level and the development of disability in older persons
-
Ferrucci L, Harris TB, Guralnik JM, Tracy RP, Corti MC, Cohen HJ, Penninx B, Pahor M, Wallace R, Havlik RJ. 1999. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc 47: 639-646.
-
(1999)
J am Geriatr Soc
, vol.47
, pp. 639-646
-
-
Ferrucci, L.1
Harris, T.B.2
Guralnik, J.M.3
Tracy, R.P.4
Corti, M.C.5
Cohen, H.J.6
Penninx, B.7
Pahor, M.8
Wallace, R.9
Havlik, R.J.10
-
34
-
-
2442699834
-
Frailty in older adults: Evidence for a phenotype
-
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, et al. 2001. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56: M146-M156
-
(2001)
J Gerontol a Biol Sci Med Sci
, vol.56
, pp. M146-M156
-
-
Fried, L.P.1
Tangen, C.M.2
Walston, J.3
Newman, A.B.4
Hirsch, C.5
Gottdiener, J.6
Seeman, T.7
Tracy, R.8
Kop, W.J.9
Burke, G.10
-
35
-
-
69949102187
-
Nonlinear multisystem physiological dysregulation associated with frailty in older women: Implications for etiology and treatment
-
Fried LP, Xue QL, Cappola AR, Ferrucci L, Chaves P, Varadhan R, Guralnik JM, Leng SX, Semba RD, Walston JD, et al. 2009. Nonlinear multisystem physiological dysregulation associated with frailty in older women: Implications for etiology and treatment. J Gerontol A Biol Sci Med Sci 64: 1049-1057.
-
(2009)
J Gerontol a Biol Sci Med Sci
, vol.64
, pp. 1049-1057
-
-
Fried, L.P.1
Xue, Q.L.2
Cappola, A.R.3
Ferrucci, L.4
Chaves, P.5
Varadhan, R.6
Guralnik, J.M.7
Leng, S.X.8
Semba, R.D.9
Walston, J.D.10
-
36
-
-
0033764352
-
Whose quality of life is it anyway?Why not ask seniors to tell us about it?
-
Fry PS. 2000.Whose quality of life is it anyway?Why not ask seniors to tell us about it? Int J Aging Hum Dev 50: 361-383.
-
(2000)
Int J Aging Hum Dev
, vol.50
, pp. 361-383
-
-
Fry, P.S.1
-
37
-
-
33645541890
-
Sources of life strengths as predictors of late-life mortality and survivorship
-
Fry PS, Debats DL. 2006. Sources of life strengths as predictors of late-life mortality and survivorship. Int J Aging Hum Dev 62: 303-334.
-
(2006)
Int J Aging Hum Dev
, vol.62
, pp. 303-334
-
-
Fry, P.S.1
Debats, D.L.2
-
38
-
-
84879564109
-
Salicylate (Salsalate) in patients with type 2 diabetes: A randomized trial
-
Goldfine AB, Fonseca V, Jablonski KA, Chen YD, Tipton L, Staten MA, Shoelson SE. 2013. Salicylate (salsalate) in patients with type 2 diabetes: A randomized trial. Ann Intern Med 159: 1-12.
-
(2013)
Ann Intern Med
, vol.159
, pp. 1-12
-
-
Goldfine, A.B.1
Fonseca, V.2
Jablonski, K.A.3
Chen, Y.D.4
Tipton, L.5
Staten, M.A.6
Shoelson, S.E.7
-
39
-
-
84885402674
-
Substantial health and economic returns from delayed aging may warrant a new focus for medical research
-
Goldman DP, Cutler D, Rowe JW, Michaud PC, Sullivan J, Peneva D, Olshansky SJ. 2013. Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff (Millwood) 32: 1698-1705.
-
(2013)
Health Aff (Millwood)
, vol.32
, pp. 1698-1705
-
-
Goldman, D.P.1
Cutler, D.2
Rowe, J.W.3
Michaud, P.C.4
Sullivan, J.5
Peneva, D.6
Olshansky, S.J.7
-
40
-
-
51549095032
-
Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: Primary results of the Observational Study on Cognitive Function and Systolic Blood Pressure Reduction Open-Label Study
-
Hanon O, Berrou JP, Negre-Pages L, Goch JH, Nadhazi Z, Petrella R, Sedefdjian A, Sevenier F, Shlyakhto EV, Pathak A. 2008. Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: Primary results of the Observational Study on Cognitive Function and Systolic Blood Pressure Reduction Open-Label Study. J Hypertens 26: 1642-1650.
-
(2008)
J Hypertens
, vol.26
, pp. 1642-1650
-
-
Hanon, O.1
Berrou, J.P.2
Negre-Pages, L.3
Goch, J.H.4
Nadhazi, Z.5
Petrella, R.6
Sedefdjian, A.7
Sevenier, F.8
Shlyakhto, E.V.9
Pathak, A.10
-
41
-
-
0033134682
-
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
-
Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH Jr, Heimovitz H, Cohen HJ, Wallace R. 1999. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 106: 506-512.
-
(1999)
Am J Med
, vol.106
, pp. 506-512
-
-
Harris, T.B.1
Ferrucci, L.2
Tracy, R.P.3
Corti, M.C.4
Wacholder, S.5
Ettinger, W.H.6
Heimovitz, H.7
Cohen, H.J.8
Wallace, R.9
-
42
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, et al. 2009. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460: 392-395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
-
43
-
-
84895825386
-
Acarbose, 17-a-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
-
Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, et al. 2014. Acarbose, 17-a-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell 13: 273-282.
-
(2014)
Aging Cell
, vol.13
, pp. 273-282
-
-
Harrison, D.E.1
Strong, R.2
Allison, D.B.3
Ames, B.N.4
Astle, C.M.5
Atamna, H.6
Fernandez, E.7
Flurkey, K.8
Javors, M.A.9
Nadon, N.L.10
-
44
-
-
84874357500
-
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease
-
Hong J, Zhang Y, Lai S, Lv A, Su Q, Dong Y, Zhou Z, Tang W, Zhao J, Cui L, et al. 2013. Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diab Care 36: 1304-1311.
-
(2013)
Diab Care
, vol.36
, pp. 1304-1311
-
-
Hong, J.1
Zhang, Y.2
Lai, S.3
Lv, A.4
Su, Q.5
Dong, Y.6
Zhou, Z.7
Tang, W.8
Zhao, J.9
Cui, L.10
-
45
-
-
65649152524
-
Associations of depression with C-reactive protein, IL-1, and IL-6: A metaanalysis
-
Howren MB, Lamkin DM, Suls J. 2009. Associations of depression with C-reactive protein, IL-1, and IL-6: A metaanalysis. Psychosom Med 71: 171-186.
-
(2009)
Psychosom Med
, vol.71
, pp. 171-186
-
-
Howren, M.B.1
Lamkin, D.M.2
Suls, J.3
-
46
-
-
1442301080
-
Inflammatory markers and risk of developing type 2 diabetes in women
-
Hu FB, Meigs JB, Li TY, Rifai N, Manson JE. 2004. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes 53: 693-700.
-
(2004)
Diabetes
, vol.53
, pp. 693-700
-
-
Hu, F.B.1
Meigs, J.B.2
Li, T.Y.3
Rifai, N.4
Manson, J.E.5
-
47
-
-
79952773620
-
Angiotensin II receptor blockers and risk of cancer in patients with systemic hypertension
-
Huang CC, Chan WL, Chen YC, Chen TJ, Lin SJ, Chen JW, Leu HB. 2011. Angiotensin II receptor blockers and risk of cancer in patients with systemic hypertension. Am J Cardiol 107: 1028-1033.
-
(2011)
Am J Cardiol
, vol.107
, pp. 1028-1033
-
-
Huang, C.C.1
Chan, W.L.2
Chen, Y.C.3
Chen, T.J.4
Lin, S.J.5
Chen, J.W.6
Leu, H.B.7
-
48
-
-
84878854824
-
Clinical ascertainment of health outcomes among adults treated for childhood cancer
-
Hudson MM, Ness KK, Gurney JG, Mulrooney DA, Chemaitilly W, Krull KR, Green DM, Armstrong GT, Nottage KA, Jones KE, et al. 2013. Clinical ascertainment of health outcomes among adults treated for childhood cancer. J Am Med Assoc 309: 2371-2381.
-
(2013)
J am Med Assoc
, vol.309
, pp. 2371-2381
-
-
Hudson, M.M.1
Ness, K.K.2
Gurney, J.G.3
Mulrooney, D.A.4
Chemaitilly, W.5
Krull, K.R.6
Green, D.M.7
Armstrong, G.T.8
Nottage, K.A.9
Jones, K.E.10
-
49
-
-
17144384777
-
Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with type 2 diabetes
-
Johnson JA, Simpson SH, Toth EL, Majumdar SR. 2005. Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with type 2 diabetes. Diabet Med 22: 497-502.
-
(2005)
Diabet Med
, vol.22
, pp. 497-502
-
-
Johnson, J.A.1
Simpson, S.H.2
Toth, E.L.3
Majumdar, S.R.4
-
50
-
-
84912030559
-
Diabetes and cancer: Epidemiology and potential mechanisms
-
Joost HG. 2014. Diabetes and cancer: Epidemiology and potential mechanisms. Diab Vasc Dis Res 11: 390-394.
-
(2014)
Diab Vasc Dis Res
, vol.11
, pp. 390-394
-
-
Joost, H.G.1
-
51
-
-
67649743686
-
Inflammation, coagulation, and the pathway to frailty
-
Kanapuru B, Ershler WB. 2009. Inflammation, coagulation, and the pathway to frailty. Am J Med 122: 605-613.
-
(2009)
Am J Med
, vol.122
, pp. 605-613
-
-
Kanapuru, B.1
Ershler, W.B.2
-
52
-
-
84877251996
-
Metformin- mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells
-
Karnevi E, Said K, Andersson R, Rosendahl AH. 2013.Metformin- mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells. BMC Cancer 13: 235.
-
(2013)
BMC Cancer
, vol.13
-
-
Karnevi, E.1
Said, K.2
Ersson, R.3
Rosendahl, A.H.4
-
53
-
-
84900338737
-
Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors
-
Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. 2014. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 344: 630-634.
-
(2014)
Science
, vol.344
, pp. 630-634
-
-
Katsimpardi, L.1
Litterman, N.K.2
Schein, P.A.3
Miller, C.M.4
Loffredo, F.S.5
Wojtkiewicz, G.R.6
Chen, J.W.7
Lee, R.T.8
Wagers, A.J.9
Rubin, L.L.10
-
54
-
-
84899562732
-
Drugs that modulate aging: The promising yet difficult path ahead
-
Kennedy BK, Pennypacker JK. 2014. Drugs that modulate aging: The promising yet difficult path ahead. Transl Res 163: 456-465.
-
(2014)
Transl Res
, vol.163
, pp. 456-465
-
-
Kennedy, B.K.1
Pennypacker, J.K.2
-
55
-
-
84872047225
-
Translating advances from the basic biology of aging into clinical application
-
Kirkland JL. 2013a. Translating advances from the basic biology of aging into clinical application. Exp Gerontol 48: 1-5.
-
(2013)
Exp Gerontol
, vol.48
, pp. 1-5
-
-
Kirkland, J.L.1
-
56
-
-
84941285507
-
Inflammation and cellular senescence: Potential contribution to chronic diseases and disabilities with aging
-
Kirkland JL. 2013b. Inflammation and cellular senescence: Potential contribution to chronic diseases and disabilities with aging. Public Policy Aging Rep 23: 12-15.
-
(2013)
Public Policy Aging Rep
, vol.23
, pp. 12-15
-
-
Kirkland, J.L.1
-
57
-
-
64949128319
-
Healthspan, translation, and new outcomes for animal studies of aging
-
Kirkland JL, Peterson C. 2009. Healthspan, translation, and new outcomes for animal studies of aging. J Gerontol A Biol Sci Med Sci 64: 209-212.
-
(2009)
J Gerontol a Biol Sci Med Sci
, vol.64
, pp. 209-212
-
-
Kirkland, J.L.1
Peterson, C.2
-
58
-
-
84941264776
-
Clinical strategies and animal models for developing senolytic agents
-
Kirkland JL, Tchkonia T. 2014. Clinical strategies and animal models for developing senolytic agents. Exp Gerontol 68: 19-25.
-
(2014)
Exp Gerontol
, vol.68
, pp. 19-25
-
-
Kirkland, J.L.1
Tchkonia, T.2
-
59
-
-
78851470539
-
Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials
-
Lamanna C, Monami M, Marchionni N, Mannucci E. 2011. Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials. Diabetes Obes Metab 13: 221-228.
-
(2011)
Diabetes Obes Metab
, vol.13
, pp. 221-228
-
-
Lamanna, C.1
Monami, M.2
Marchionni, N.3
Mannucci, E.4
-
60
-
-
84859117806
-
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
-
Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, et al. 2012. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335: 1638-1643.
-
(2012)
Science
, vol.335
, pp. 1638-1643
-
-
Lamming, D.W.1
Ye, L.2
Katajisto, P.3
Goncalves, M.D.4
Saitoh, M.5
Stevens, D.M.6
Davis, J.G.7
Salmon, A.B.8
Richardson, A.9
Ahima, R.S.10
-
62
-
-
75149179169
-
Metformin associatedwith lower cancer mortality in type 2 diabetes: ZODIAC-16
-
Landman GW, Kleefstra N, van Hateren KJ, Groenier KH, Gans RO, Bilo HJ. 2010.Metformin associatedwith lower cancer mortality in type 2 diabetes: ZODIAC-16. Diab Care 33: 322-326.
-
(2010)
Diab Care
, vol.33
, pp. 322-326
-
-
Landman, G.W.1
Kleefstra, N.2
Van Hateren, K.J.3
Groenier, K.H.4
Gans, R.O.5
Bilo, H.J.6
-
63
-
-
84856695688
-
Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model
-
Lavasani M, Robinson AR, Lu A, Song M, Feduska JM, Ahani B, Tilstra JS, Feldman CH, Robbins PD, Niedernhofer LJ, et al. 2012. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun 3: 608.
-
(2012)
Nat Commun
, vol.3
, pp. 608
-
-
Lavasani, M.1
Robinson, A.R.2
Lu, A.3
Song, M.4
Feduska, J.M.5
Ahani, B.6
Tilstra, J.S.7
Feldman, C.H.8
Robbins, P.D.9
Niedernhofer, L.J.10
-
64
-
-
78651451726
-
Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: A representative population prospective cohort study of 800,000 individuals
-
Lee MS, Hsu CC, Wahlqvist ML, Tsai HN, Chang YH, Huang YC. 2011. Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: A representative population prospective cohort study of 800,000 individuals. BMC Cancer 11: 20.
-
(2011)
BMC Cancer
, vol.11
-
-
Lee, M.S.1
Hsu, C.C.2
Wahlqvist, M.L.3
Tsai, H.N.4
Chang, Y.H.5
Huang, Y.C.6
-
65
-
-
84863229916
-
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy
-
Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, et al. 2012. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med 4: p124ra127.
-
(2012)
Sci Transl Med
, vol.4
-
-
Lee, C.1
Raffaghello, L.2
Brandhorst, S.3
Safdie, F.M.4
Bianchi, G.5
Martin-Montalvo, A.6
Pistoia, V.7
Wei, M.8
Hwang, S.9
Merlino, A.10
-
66
-
-
34347338725
-
Inflammation and frailty in older women
-
Leng SX, Xue QL, Tian J, Walston JD, Fried LP. 2007. Inflammation and frailty in older women. J Am Geriatr Soc 55: 864-871.
-
(2007)
J am Geriatr Soc
, vol.55
, pp. 864-871
-
-
Leng, S.X.1
Xue, Q.L.2
Tian, J.3
Walston, J.D.4
Fried, L.P.5
-
67
-
-
74949131237
-
Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis
-
Li NC, Lee A, Whitmer RA, Kivipelto M, Lawler E, Kazis LE, Wolozin B. 2010. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis. BMJ 340: b5465.
-
(2010)
BMJ
, vol.340
-
-
Li, N.C.1
Lee, A.2
Whitmer, R.A.3
Kivipelto, M.4
Lawler, E.5
Kazis, L.E.6
Wolozin, B.7
-
68
-
-
69549097703
-
Newusers of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
-
Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM. 2009.Newusers of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes. Diab Care 32: 1620-1625.
-
(2009)
Diab Care
, vol.32
, pp. 1620-1625
-
-
Libby, G.1
Donnelly, L.A.2
Donnan, P.T.3
Alessi, D.R.4
Morris, A.D.5
Evans, J.M.6
-
69
-
-
0030699961
-
Long-term ACE inhibition doubles lifespan of hypertensive rats
-
Linz W, Jessen T, Becker RH, Scholkens BA,Wiemer G. 1997. Long-term ACE inhibition doubles lifespan of hypertensive rats. Circulation 96: 3164-3172.
-
(1997)
Circulation
, vol.96
, pp. 3164-3172
-
-
Linz, W.1
Jessen, T.2
Becker, R.H.3
-
70
-
-
0034106595
-
Longterm angiotensin II type 1 receptor blockade with fonsartan doubles lifespan of hypertensive rats
-
Linz W, Heitsch H, Scholkens BA, Wiemer G. 2000. Longterm angiotensin II type 1 receptor blockade with fonsartan doubles lifespan of hypertensive rats. Hypertension 35: 908-913.
-
(2000)
Hypertension
, vol.35
, pp. 908-913
-
-
Linz, W.1
Heitsch, H.2
Scholkens, B.A.3
Wiemer, G.4
-
71
-
-
77953096154
-
Exceptional parental longevity associated with lower risk of Alzheimer’s disease and memory decline
-
Lipton RB, Hirsch J, Katz MJ, Wang C, Sanders AE, Verghese J, Barzilai N, Derby CA. 2010. Exceptional parental longevity associated with lower risk of Alzheimer’s disease and memory decline. J Am Geriatr Soc 58: 1043-1049.
-
(2010)
J am Geriatr Soc
, vol.58
, pp. 1043-1049
-
-
Lipton, R.B.1
Hirsch, J.2
Katz, M.J.3
Wang, C.4
Sanders, A.E.5
Verghese, J.6
Barzilai, N.7
Derby, C.A.8
-
72
-
-
80052397117
-
Potent anti-proliferative effects of metformin on trastuzumab- resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions
-
Liu B, Fan Z, Edgerton SM, Yang X, Lind SE, Thor AD. 2011. Potent anti-proliferative effects of metformin on trastuzumab- resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions. Cell Cycle 10: 2959-2966.
-
(2011)
Cell Cycle
, vol.10
, pp. 2959-2966
-
-
Liu, B.1
Fan, Z.2
Edgerton, S.M.3
Yang, X.4
Lind, S.E.5
Thor, A.D.6
-
73
-
-
77955347748
-
An index of self-rated health deficits in relation to frailty and adverse outcomes in older adults
-
Lucicesare A, Hubbard RE, Searle SD, Rockwood K. 2010. An index of self-rated health deficits in relation to frailty and adverse outcomes in older adults. Aging Clin Exp Res 22: 255-260.
-
(2010)
Aging Clin Exp Res
, vol.22
, pp. 255-260
-
-
Lucicesare, A.1
Hubbard, R.E.2
Searle, S.D.3
Rockwood, K.4
-
74
-
-
84858342119
-
Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1b and enhancing NMDA signaling
-
Majumder S, Caccamo A, Medina DX, Benavides AD, Javors MA, Kraig E, Strong R, Richardson A, Oddo S. 2012. Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1b and enhancing NMDA signaling. Aging Cell 11: 326-335.
-
(2012)
Aging Cell
, vol.11
, pp. 326-335
-
-
Majumder, S.1
Caccamo, A.2
Medina, D.X.3
Benavides, A.D.4
Javors, M.A.5
Kraig, E.6
Strong, R.7
Richardson, A.8
Oddo, S.9
-
75
-
-
84919756169
-
MTOR inhibition improves immune function in the elderly
-
Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S, et al. 2014. mTOR inhibition improves immune function in the elderly. Sci Transl Med 6: 268ra179.
-
(2014)
Sci Transl Med
, vol.6
-
-
Mannick, J.B.1
Del Giudice, G.2
Lattanzi, M.3
Valiante, N.M.4
Praestgaard, J.5
Huang, B.6
Lonetto, M.A.7
Maecker, H.T.8
Kovarik, J.9
Carson, S.10
-
76
-
-
20044383742
-
Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: The Women’s Health Initiative Observational Study
-
Margolis KL, Manson JE, Greenland P, Rodabough RJ, Bray PF, Safford M, Grimm RH Jr, Howard BV, Assaf AR, Prentice R. 2005. Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: The Women’s Health Initiative Observational Study. Arch Intern Med 165: 500-508.
-
(2005)
Arch Intern Med
, vol.165
, pp. 500-508
-
-
Margolis, K.L.1
Manson, J.E.2
Greenland, P.3
Rodabough, R.J.4
Bray, P.F.5
Safford, M.6
Grimm, R.H.7
Howard, B.V.8
Assaf, A.R.9
Prentice, R.10
-
77
-
-
84881347302
-
Metformin improves healthspan and lifespan in mice
-
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, et al. 2013. Metformin improves healthspan and lifespan in mice. Nat Commun 4: 2192.
-
(2013)
Nat Commun
, vol.4
, pp. 2192
-
-
Martin-Montalvo, A.1
Mercken, E.M.2
Mitchell, S.J.3
Palacios, H.H.4
Mote, P.L.5
Scheibye-Knudsen, M.6
Gomes, A.P.7
Ward, T.M.8
Minor, R.K.9
Blouin, M.J.10
-
78
-
-
84899073317
-
Criteria for clinically relevantweakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: The Foundation for the National Institutes of Health (FNIH) Sarcopenia Project
-
McLean RR, Shardell MD, Alley DE, Cawthon PM, Fragala MS, Harris TB, Kenny AM, Peters KW, Ferrucci L, Guralnik JM, et al. 2014. Criteria for clinically relevantweakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: The Foundation for the National Institutes of Health (FNIH) Sarcopenia Project. J Gerontol A Biol Sci Med Sci 69: 576-583.
-
(2014)
J Gerontol a Biol Sci Med Sci
, vol.69
, pp. 576-583
-
-
McLean, R.R.1
Shardell, M.D.2
Alley, D.E.3
Cawthon, P.M.4
Fragala, M.S.5
Harris, T.B.6
Kenny, A.M.7
Peters, K.W.8
Ferrucci, L.9
Guralnik, J.M.10
-
79
-
-
84924866970
-
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
-
Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, et al. 2014. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell 13: 787-796.
-
(2014)
Aging Cell
, vol.13
, pp. 787-796
-
-
Mercken, E.M.1
Mitchell, S.J.2
Martin-Montalvo, A.3
Minor, R.K.4
Almeida, M.5
Gomes, A.P.6
Scheibye-Knudsen, M.7
Palacios, H.H.8
Licata, J.J.9
Zhang, Y.10
-
80
-
-
79955047394
-
Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-b-induced senescence of human bronchial epithelial cells
-
Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, et al. 2011. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-b-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 300: L391-L401.
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.300
, pp. L391-L401
-
-
Minagawa, S.1
Araya, J.2
Numata, T.3
Nojiri, S.4
Hara, H.5
Yumino, Y.6
Kawaishi, M.7
Odaka, M.8
Morikawa, T.9
Nishimura, S.L.10
-
81
-
-
84895925833
-
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
-
Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, Minor RK, Vlasuk GP, Ellis JL, Sinclair DA, et al. 2014. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Rep 6: 836-843.
-
(2014)
Cell Rep
, vol.6
, pp. 836-843
-
-
Mitchell, S.J.1
Martin-Montalvo, A.2
Mercken, E.M.3
Palacios, H.H.4
Ward, T.M.5
Abulwerdi, G.6
Minor, R.K.7
Vlasuk, G.P.8
Ellis, J.L.9
Sinclair, D.A.10
-
82
-
-
79951708837
-
Metformin and cancer occurrence in insulin- treated type 2 diabetic patients
-
Monami M, Colombi C, Balzi D, Dicembrini I, Giannini S, Melani C, Vitale V, Romano D, Barchielli A, Marchionni N, et al. 2011.Metformin and cancer occurrence in insulin- treated type 2 diabetic patients. Diab Care 34: 129-131.
-
(2011)
Diab Care
, vol.34
, pp. 129-131
-
-
Monami, M.1
Colombi, C.2
Balzi, D.3
Dicembrini, I.4
Giannini, S.5
Melani, C.6
Vitale, V.7
Romano, D.8
Barchielli, A.9
Marchionni, N.10
-
84
-
-
84929046486
-
Frailty in childhood cancer survivors
-
Ness KK, Armstrong GT, Kundu M, Wilson CL, Tchkonia T, Kirkland JL. 2014. Frailty in childhood cancer survivors. Cancer 121: 1540-1547.
-
(2014)
Cancer
, vol.121
, pp. 1540-1547
-
-
Ness, K.K.1
Armstrong, G.T.2
Kundu, M.3
Wilson, C.L.4
Tchkonia, T.5
Kirkland, J.L.6
-
85
-
-
77955279767
-
Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease
-
O’Connor PM, Lapointe TK, Beck PL, Buret AG. 2010. Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease. Inflamm Bowel Dis 16: 1411-1420.
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 1411-1420
-
-
O’connor, P.M.1
Lapointe, T.K.2
Beck, P.L.3
Buret, A.G.4
-
86
-
-
0025198608
-
In search of Methuselah: Estimating the upper limits to human longevity
-
Olshansky SJ, Carnes BA, Cassel C. 1990. In search of Methuselah: Estimating the upper limits to human longevity. Science 250: 634-640.
-
(1990)
Science
, vol.250
, pp. 634-640
-
-
Olshansky, S.J.1
Carnes, B.A.2
Cassel, C.3
-
87
-
-
10344231441
-
Inflammatory markers and the risk of coronary heart disease in men and women
-
Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, Curhan GC, Rifai N, Cannuscio CC, Stampfer MJ, et al. 2004. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 351: 2599-2610.
-
(2004)
N Engl J Med
, vol.351
, pp. 2599-2610
-
-
Pai, J.K.1
Pischon, T.2
Ma, J.3
Manson, J.E.4
Hankinson, S.E.5
Joshipura, K.6
Curhan, G.C.7
Rifai, N.8
Cannuscio, C.C.9
Stampfer, M.J.10
-
88
-
-
79955560688
-
Use of angiotensin receptor blockers and the risk of cancer
-
Pasternak B, Svanstrom H, Callreus T, Melbye M, Hviid A. 2011. Use of angiotensin receptor blockers and the risk of cancer. Circulation 123: 1729-1736.
-
(2011)
Circulation
, vol.123
, pp. 1729-1736
-
-
Pasternak, B.1
Svanstrom, H.2
Callreus, T.3
Melbye, M.4
Hviid, A.5
-
89
-
-
0035908632
-
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
-
Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. 2001. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. J Amer Med Assoc 286: 327-334.
-
(2001)
J Amer Med Assoc
, vol.286
, pp. 327-334
-
-
Pradhan, A.D.1
Manson, J.E.2
Rifai, N.3
Buring, J.E.4
Ridker, P.M.5
-
90
-
-
59049097390
-
Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14þ monocytes in frail older adults
-
Qu T, Walston JD, Yang H, Fedarko NS, Xue QL, Beamer BA, Ferrucci L, Rose NR, Leng SX. 2009. Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14þ monocytes in frail older adults. Mech Ageing Dev 130: 161-166.
-
(2009)
Mech Ageing Dev
, vol.130
, pp. 161-166
-
-
Qu, T.1
Walston, J.D.2
Yang, H.3
Fedarko, N.S.4
Xue, Q.L.5
Beamer, B.A.6
Ferrucci, L.7
Rose, N.R.8
Leng, S.X.9
-
91
-
-
84883764605
-
Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling
-
Quinn BJ, Dallos M, Kitagawa H, Kunnumakkara AB, Memmott RM, Hollander MC, Gills JJ, Dennis PA. 2013. Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling. Cancer Prev Res (Phila) 6: 801-810.
-
(2013)
Cancer Prev Res (Phila)
, vol.6
, pp. 801-810
-
-
Quinn, B.J.1
Dallos, M.2
Kitagawa, H.3
Kunnumakkara, A.B.4
Memmott, R.M.5
Hollander, M.C.6
Gills, J.J.7
Dennis, P.A.8
-
92
-
-
84938061050
-
How longevity research can lead to therapies for Alzheimer’s disease: The rapamycin story
-
Richardson A, Galvan V, Lin AL, Oddo S. 2014. How longevity research can lead to therapies for Alzheimer’s disease: The rapamycin story. Exp Gerontol 68: 51-58.
-
(2014)
Exp Gerontol
, vol.68
, pp. 51-58
-
-
Richardson, A.1
Galvan, V.2
Lin, A.L.3
Oddo, S.4
-
93
-
-
78549254172
-
Frailty defined by deficit accumulation and geriatric medicine defined by frailty
-
Rockwood K, Mitnitski A. 2011. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med 27: 17-26.
-
(2011)
Clin Geriatr Med
, vol.27
, pp. 17-26
-
-
Rockwood, K.1
Mitnitski, A.2
-
94
-
-
33744925926
-
Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70
-
Rockwood K, Mitnitski A, Song X, Steen B, Skoog I. 2006. Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc 54: 975-979.
-
(2006)
J am Geriatr Soc
, vol.54
, pp. 975-979
-
-
Rockwood, K.1
Mitnitski, A.2
Song, X.3
Steen, B.4
Skoog, I.5
-
95
-
-
84868652782
-
Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: A cohort study
-
Roumie CL, Hung AM, Greevy RA, Grijalva CG, Liu X, Murff HJ, Elasy TA, Griffin MR. 2012. Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: A cohort study. Ann Intern Med 157: 601-610.
-
(2012)
Ann Intern Med
, vol.157
, pp. 601-610
-
-
Roumie, C.L.1
Hung, A.M.2
Greevy, R.A.3
Grijalva, C.G.4
Liu, X.5
Murff, H.J.6
Elasy, T.A.7
Griffin, M.R.8
-
96
-
-
84905496408
-
Idiopathic pulmonary fibrosis: Evolving concepts
-
Ryu JH, Moua T, Daniels CE, Hartman TE, Yi ES, Utz JP, Limper AH. 2014. Idiopathic pulmonary fibrosis: Evolving concepts. Mayo Clin Proc 89: 1130-1142.
-
(2014)
Mayo Clin Proc
, vol.89
, pp. 1130-1142
-
-
Ryu, J.H.1
Moua, T.2
Daniels, C.E.3
Hartman, T.E.4
Yi, E.S.5
Utz, J.P.6
Limper, A.H.7
-
97
-
-
84856528344
-
Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells
-
Salani B, Maffioli S, Hamoudane M, Parodi A, Ravera S, Passalacqua M, Alama A, Nhiri M, Cordera R, Maggi D. 2012. Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells. FASEB J 26: 788-798.
-
(2012)
FASEB J
, vol.26
, pp. 788-798
-
-
Salani, B.1
Maffioli, S.2
Hamoudane, M.3
Parodi, A.4
Ravera, S.5
Passalacqua, M.6
Alama, A.7
Nhiri, M.8
Cordera, R.9
Maggi, D.10
-
98
-
-
69549095825
-
Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats
-
Santos EL, de Picoli Souza K, da Silva ED, Batista EC, Martins PJ, D’Almeida V, Pesquero JB. 2009. Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats. Biochem Pharmacol 78: 951-958.
-
(2009)
Biochem Pharmacol
, vol.78
, pp. 951-958
-
-
Santos, E.L.1
De Picoli Souza, K.2
Da Silva, E.D.3
Batista, E.C.4
Martins, P.J.5
D’almeida, V.6
Pesquero, J.B.7
-
99
-
-
74049140048
-
Inflammation and cancer: Interweaving microRNA, free radical, cytokine and p53 pathways
-
Schetter AJ, Heegaard NH, Harris CC. 2010. Inflammation and cancer: Interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis 31: 37-49.
-
(2010)
Carcinogenesis
, vol.31
, pp. 37-49
-
-
Schetter, A.J.1
Heegaard, N.H.2
Harris, C.C.3
-
100
-
-
43049098611
-
Effect of metformin on IGF-1 and IGFBP-1 levels in obese patients with polycystic ovary syndrome
-
Seibel SA, Chou KH, Capp E, Spritzer PM, von Eye Corleta H. 2008. Effect of metformin on IGF-1 and IGFBP-1 levels in obese patients with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 138: 122-124.
-
(2008)
Eur J Obstet Gynecol Reprod Biol
, vol.138
, pp. 122-124
-
-
Seibel, S.A.1
Chou, K.H.2
Capp, E.3
Spritzer, P.M.4
Von Eye Corleta, H.5
-
101
-
-
84862297965
-
Accelerating drug discovery for Alzheimer’s disease: Best practices for preclinical animal studies
-
Shineman DW, Basi GS, Bizon JL, Colton CA, Greenberg BD, Hollister BA, Lincecum J, Leblanc GG, Lee LB, Luo F, et al. 2011. Accelerating drug discovery for Alzheimer’s disease: Best practices for preclinical animal studies. Alzheimers Res Ther 3: 28.
-
(2011)
Alzheimers Res Ther
, vol.3
-
-
Shineman, D.W.1
Basi, G.S.2
Bizon, J.L.3
Colton, C.A.4
Greenberg, B.D.5
Hollister, B.A.6
Lincecum, J.7
Leblanc, G.G.8
Lee, L.B.9
Luo, F.10
-
102
-
-
84900323323
-
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
-
Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, et al. 2014. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science 344: 649-652.
-
(2014)
Science
, vol.344
, pp. 649-652
-
-
Sinha, M.1
Jang, Y.C.2
Oh, J.3
Khong, D.4
Wu, E.Y.5
Manohar, R.6
Miller, C.7
Regalado, S.G.8
Loffredo, F.S.9
Pancoast, J.R.10
-
103
-
-
77951908829
-
Metformin supplementation and life span in Fischer-344 rats
-
Smith DL Jr, Elam CF Jr, Mattison JA, Lane MA, Roth GS, Ingram DK, Allison DB. 2010. Metformin supplementation and life span in Fischer-344 rats. J Gerontol A Biol Sci Med Sci 65: 468-474.
-
(2010)
J Gerontol a Biol Sci Med Sci
, vol.65
, pp. 468-474
-
-
Smith, D.L.1
Elam, C.F.2
Mattison, J.A.3
Lane, M.A.4
Roth, G.S.5
Ingram, D.K.6
Allison, D.B.7
-
104
-
-
0345700727
-
Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
-
Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF. 2003. Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52: 812-817.
-
(2003)
Diabetes
, vol.52
, pp. 812-817
-
-
Spranger, J.1
Kroke, A.2
Mohlig, M.3
Hoffmann, K.4
Bergmann, M.M.5
Ristow, M.6
Boeing, H.7
Pfeiffer, A.F.8
-
105
-
-
67650482883
-
Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer
-
Srikrishna G, Freeze HH. 2009. Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer. Neoplasia 11: 615-628.
-
(2009)
Neoplasia
, vol.11
, pp. 615-628
-
-
Srikrishna, G.1
Freeze, H.H.2
-
106
-
-
67650088426
-
The basics of preclinical drug development for neurodegenerative disease indications
-
Steinmetz KL, Spack EG. 2009. The basics of preclinical drug development for neurodegenerative disease indications. BMC Neurol 9: pS2.
-
(2009)
BMC Neurol
, vol.9
-
-
Steinmetz, K.L.1
Spack, E.G.2
-
107
-
-
52449114485
-
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
-
Strong R, Miller RA, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E. 2008.Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7: 641-650.
-
(2008)
Aging Cell
, vol.7
, pp. 641-650
-
-
Strong, R.1
Miller, R.A.2
Astle, C.M.3
Floyd, R.A.4
Flurkey, K.5
Hensley, K.L.6
Javors, M.A.7
Leeuwenburgh, C.8
Nelson, J.F.9
Ongini, E.10
-
108
-
-
84893401717
-
Autophagy induction by SIRT6 through attenuation of insulinlike growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence
-
Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, et al. 2014. Autophagy induction by SIRT6 through attenuation of insulinlike growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol 192: 958-968.
-
(2014)
J Immunol
, vol.192
, pp. 958-968
-
-
Takasaka, N.1
Araya, J.2
Hara, H.3
Ito, S.4
Kobayashi, K.5
Kurita, Y.6
Wakui, H.7
Yoshii, Y.8
Yumino, Y.9
Fujii, S.10
-
109
-
-
64949168686
-
Can we develop genetically tractable models to assess healthspan (Rather than life span) in animal models?
-
Tatar M. 2009. Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models? J Gerontol A Biol Sci Med Sci 64: 161-163.
-
(2009)
J Gerontol a Biol Sci Med Sci
, vol.64
, pp. 161-163
-
-
Tatar, M.1
-
110
-
-
78349299099
-
Fat tissue, aging, and cellular senescence
-
Tchkonia T, Morbeck DE, von Zglinicki T, van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen MD, Kirkland JL. 2010. Fat tissue, aging, and cellular senescence. Aging Cell 9: 667-684.
-
(2010)
Aging Cell
, vol.9
, pp. 667-684
-
-
Tchkonia, T.1
Morbeck, D.E.2
Von Zglinicki, T.3
Van Deursen, J.4
Lustgarten, J.5
Scrable, H.6
Khosla, S.7
Jensen, M.D.8
Kirkland, J.L.9
-
111
-
-
84874603171
-
Cellular senescence and the senescent secretoryphenotype: Therapeutic opportunities
-
Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. 2013. Cellular senescence and the senescent secretoryphenotype: Therapeutic opportunities. J Clin Invest 123: 966-972.
-
(2013)
J Clin Invest
, vol.123
, pp. 966-972
-
-
Tchkonia, T.1
Zhu, Y.2
Van Deursen, J.3
Campisi, J.4
Kirkland, J.L.5
-
112
-
-
75149186480
-
Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells
-
Tosca L, Rame C, Chabrolle C, Tesseraud S, Dupont J. 2010. Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells. Reproduction 139: 409-418.
-
(2010)
Reproduction
, vol.139
, pp. 409-418
-
-
Tosca, L.1
Rame, C.2
Chabrolle, C.3
Tesseraud, S.4
Dupont, J.5
-
113
-
-
84865717087
-
Diabetes, metformin use, and colon cancer: A population-based cohort study in Taiwan
-
Tseng CH. 2012. Diabetes, metformin use, and colon cancer: A population-based cohort study in Taiwan. Eur J Endocrinol 167: 409-416.
-
(2012)
Eur J Endocrinol
, vol.167
, pp. 409-416
-
-
Tseng, C.H.1
-
114
-
-
33645538914
-
C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population- based, prospective study
-
Tuomisto K, Jousilahti P, Sundvall J, Pajunen P, Salomaa V. 2006. C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population- based, prospective study. Thromb Haemost 95: 511-518.
-
(2006)
Thromb Haemost
, vol.95
, pp. 511-518
-
-
Tuomisto, K.1
Jousilahti, P.2
Sundvall, J.3
Pajunen, P.4
Salomaa, V.5
-
115
-
-
79953225169
-
Weight loss, exercise, or both and physical function in obese older adults
-
Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, Napoli N, Qualls C, Shah K. 2011.Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med 364: 1218-1229.
-
(2011)
N Engl J Med
, vol.364
, pp. 1218-1229
-
-
Villareal, D.T.1
Chode, S.2
Parimi, N.3
Sinacore, D.R.4
Hilton, T.5
Armamento-Villareal, R.6
Napoli, N.7
Qualls, C.8
Shah, K.9
-
116
-
-
0037111615
-
Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the Cardiovascular Health Study
-
Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH, Gottdiener J, Fried LP. 2002. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the Cardiovascular Health Study. Arch Intern Med 162: 2333-2341.
-
(2002)
Arch Intern Med
, vol.162
, pp. 2333-2341
-
-
Walston, J.1
McBurnie, M.A.2
Newman, A.3
Tracy, R.P.4
Kop, W.J.5
Hirsch, C.H.6
Gottdiener, J.7
Fried, L.P.8
-
117
-
-
33744913541
-
Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/ National Institute on Aging research conference on frailty in older adults
-
Walston J, Hadley E, Ferrucci L, Guralnick JM, Newman AB, Studenski SA, Ershler WB, Harris T, Fried LP. 2006. Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/ National Institute on Aging research conference on frailty in older adults. J Am Geriatr Soc 54: 991-1001.
-
(2006)
J am Geriatr Soc
, vol.54
, pp. 991-1001
-
-
Walston, J.1
Hadley, E.2
Ferrucci, L.3
Guralnick, J.M.4
Newman, A.B.5
Studenski, S.A.6
Ershler, W.B.7
Harris, T.8
Fried, L.P.9
-
118
-
-
64449084857
-
Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults
-
Walston JD, Matteini AM, Nievergelt C, Lange LA, Fallin DM, Barzilai N, Ziv E, Pawlikowska L, Kwok P, Cummings SR, et al. 2009. Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. Exp Gerontol 44: 350-355.
-
(2009)
Exp Gerontol
, vol.44
, pp. 350-355
-
-
Walston, J.D.1
Matteini, A.M.2
Nievergelt, C.3
Lange, L.A.4
Fallin, D.M.5
Barzilai, N.6
Ziv, E.7
Pawlikowska, L.8
Kwok, P.9
Cummings, S.R.10
-
119
-
-
84873056313
-
Chronic metformin associated cardioprotection against infarction: Not just a glucose lowering phenomenon
-
Whittington HJ, Hall AR, McLaughlin CP, Hausenloy DJ, Yellon DM, Mocanu MM. 2013. Chronic metformin associated cardioprotection against infarction: Not just a glucose lowering phenomenon. Cardiovasc Drugs Ther 27: 5-16.
-
(2013)
Cardiovasc Drugs Ther
, vol.27
, pp. 5-16
-
-
Whittington, H.J.1
Hall, A.R.2
McLaughlin, C.P.3
Hausenloy, D.J.4
Yellon, D.M.5
Mocanu, M.M.6
-
120
-
-
8544240116
-
Effect of acarbose treatment on the risk of silent myocardial infarctions in patients with impaired glucose tolerance: Results of the randomised STOP-NIDDM trial electrocardiography substudy
-
Zeymer U, Schwarzmaier-D’assie A, Petzinna D, Chiasson JL. 2004. Effect of acarbose treatment on the risk of silent myocardial infarctions in patients with impaired glucose tolerance: Results of the randomised STOP-NIDDM trial electrocardiography substudy. Eur J Cardiovasc Prev Rehabil 11: 412-415.
-
(2004)
Eur J Cardiovasc Prev Rehabil
, vol.11
, pp. 412-415
-
-
Zeymer, U.1
Schwarzmaier-D’assie, A.2
Petzinna, D.3
Chiasson, J.L.4
|