Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 71, Issue 2, 2016, Pages 153-160

  Calhoun, Cheresa ^a   Shivshankar, Pooja ^a   Saker, Mirna ^b   Sloane, Lauren B ^a   Livi, Carolina B ^a,c   Sharp, Zelton D ^a,c,d   Orihuela, Carlos J ^e   Adnot, Serge ^b   White, Eric S ^f   Richardson, Arlan ^a   Jourdan Le Saux, Claude ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^c Sam and Ann Barshop Institute of Aging and Longevity Studies ^*  (United States)

^d Cancer and Therapy Research Center   (United States)

^e University of Texas Health Science Center   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Aging; mTOR pathway; Rapamycin; Remodeling; Senescence

Indexed keywords

ACTIN; BIOLOGICAL MARKER; COLLAGEN; MTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TENASCIN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; AGING; AIRWAY REMODELING; ANIMAL; C57BL MOUSE; CELL AGING; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; LUNG; MALE; METABOLISM; MIDDLE AGED; MOUSE; PHYSIOLOGY; PROTEOMICS; SIGNAL TRANSDUCTION;

ACTINS; ADULT; AGED; AGING; AIRWAY REMODELING; ANIMALS; BIOMARKERS; CELL AGING; COLLAGEN; EXTRACELLULAR MATRIX; FIBROBLASTS; HUMANS; LUNG; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PROTEOMICS; SIGNAL TRANSDUCTION; TENASCIN; TOR SERINE-THREONINE KINASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84961637065     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu241     Document Type: Article

References (30)

1. Wahba WM. Influence of aging on lung function-clinical significance of changes from age twenty. Anesth Analg. 1983;62:764-776. PMID: 6346955.
2. Faner R, Rojas M, Macnee W, Agustí A. Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2012;186:306-313. doi:10.1164/rccm.201202-0282PP
3. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol. 2011;192:547-556. doi:10.1083/jcb.201009094
4. Tsuji T, Aoshiba K, Nagai A. Alveolar cell senescence in patients with pulmonary emphysema. Am J Respir Crit Care Med. 2006;174:886-893. PMID: 16888288.
5. Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, Le Saux CJ. Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice. Am J Respir Cell Mol Biol. 2012;47:28-36. doi:10.1165/rcmb.2011-0349OC
6. Jourdan Le Saux C, Davy P, Brampton C, et al. A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS One. 2013;8(3):e58423. doi:10.1371/journal.pone.0058423
7. Newgard CB, Sharpless NE. Coming of age: molecular drivers of aging and therapeutic opportunities. J Clin Invest. 2013;123:946-950. doi:10.1172/JCI68833
8. Wilkinson JE, Burmeister L, Brooks SV, et al. Rapamycin slows aging in mice. Aging Cell. 2012;11:675-682. doi:10.1111/j.1474-9726.2012.00832.x
9. Miller RA, Harrison DE, Astle CM, et al. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell. 2014;13:468-477. doi:10.1111/acel.12194
10. Korfhagen TR, Le Cras TD, Davidson CR, et al. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009;41:562-572. doi:10.1165/rcmb.2008-0377OC
11. Kramer EL, Hardie WD, Mushaben EM, et al. Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease. J Appl Physiol. 2011;111:1760-1767. doi:10.1152/japplphysiol.00737
12. Harrison DE, Strong R, Sharp ZD, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460:392-395. doi:10.1038/nature08221
13. Booth AJ, Hadley R, Cornett AM, et al. Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. Am J Respir Crit Care Med. 2012;186:866-876. doi:10.1164/rccm.201204-0754OC
14. Li W, Zhou J, Chen L, Luo Z, Zhao Y. Lysyl oxidase, a critical intra-and extra-cellular target in the lung for cigarette smoke pathogenesis. Int J Environ Res Public Health. 2011;8:161-184. doi:10.3390/ijerph8010161
15. Mazzon E, Cuzzocrea S. Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation. Respir Res. 2007;8:75. PMID: 17971210.
16. Sueblinvong V, Neujahr DC, Mills ST, et al. Predisposition for disrepair in the aged lung. Am J Med Sci. 2012;344:41-51. doi:10.1097/MAJ.0b013e318234c132
17. Velarde MC, Demaria M, Campisi J. Senescent cells and their secretory phenotype as targets for cancer therapy. Interdiscip Top Gerontol. 2013;38:17-27. doi:10.1159/000343572
18. Zhang R, Poustovoitov MV, Ye X, et al. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell. 2005;8:19-30. PMID: 15621527.
19. Zhang Y, Bokov A, Gelfond J, et al. Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2014;69:119-130. doi:10.1093/gerona/glt056
20. Lowsky DJ, Olshansky SJ, Bhattacharya J, Goldman DP. Heterogeneity in healthy aging. J Gerontol A Biol Sci Med Sci. 2014;69:640-649. doi:10.1093/gerona/glt162
21. Amdam GV. Social context, stress, and plasticity of aging. Aging Cell. 2011;10:18-27. doi:10.1111/j.1474-9726.2010.00647.x
22. Sharma G, Goodwin J. Effect of aging on respiratory system physiology and immunology. Clin Interv Aging. 2006;1:253-260. PMID: 18046878.
23. Adams PD. Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell. 2009;36:2-14. doi:10.1016/j. molcel.2009.09.021
24. Aoshiba K, Nagai A. Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009;6:596-601. doi:10.1513/pats.200904-017RM
25. Minagawa S, Araya J, Numata T, et al. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;300:L391-L401. doi:10.1152/ajplung.00097.2010
26. Muñoz-Espín D, Cañamero M, Maraver A, et al. Programmed cell senescence during mammalian embryonic development. Cell. 2013;155:1104-1118. doi:10.1016/j.cell.2013
27. Storer M, Mas A, Robert-Moreno A, et al. Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell. 2013;155:1119-1130. doi:10.1016/j.cell.2013.10.041
28. Olyaei AJ, de Mattos AM, Bennett WM. Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategies. Curr Opin Crit Care. 2001;7:384-389. doi:10.1159/000321857
29. Pham PT, Pham PC, Danovitch GM, et al. Sirolimus-associated pulmonary toxicity. Transplantation. 2004;77:1215-1220. PMID: 15114088.
30. Goncharova EA. mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects. FASEB J. 2013;27:1796-1807. doi:10.1096/fj.12-222224