PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 19, 2014, Pages 7090-7095

  Eren, Mesut ^a   Boe, Amanda E ^a   Murphy, Sheila B ^a   Place, Aaron T ^a   Nagpal, Varun ^a   Morales Nebreda, Luisa ^a   Urich, Daniela ^a   Quaggin, Susan E ^a   Scott Budinger, G R ^a   Mutlu, Gökhan M ^a   Miyata, Toshio ^b   Vaughan, Douglas E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

FGF23; IGFBP3; IL 6; TM5441

Indexed keywords

ALDOSTERONE; ALKALINE PHOSPHATASE; CALCIUM; COLECALCIFEROL; CREATININE; FIBROBLAST GROWTH FACTOR 23; INTERLEUKIN 6; PHOSPHATE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SOMATOMEDIN BINDING PROTEIN 3;

ALDOSTERONE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL OXYGEN SATURATION; ARTERIOSCLEROSIS; ARTICLE; CALCIFICATION; CELL AGING; CELL SURVIVAL; CONTROLLED STUDY; EMPHYSEMA; EXTRACELLULAR SPACE; FEMALE; GENOTYPE; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; TELOMERE; WEIGHT GAIN;

FGF23; IGFBP3; IL-6; TM5441;

AGING; ANIMALS; CELL AGING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EXTRACELLULAR SPACE; FEMALE; GLUCURONIDASE; HEMORRHAGIC DISORDERS; LONGEVITY; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEOLYSIS; SERPIN E2; TELOMERE;

EID: 84900505659     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321942111     Document Type: Article

References (47)

1. Rodier F, Campisi J (2011) Four faces of cellular senescence. J Cell Biol 192(4):547-556.
2. Campisi J, d'Adda di Fagagna F (2007) Cellular senescence: When bad things happen to good cells. Nat Rev Mol Cell Biol 8(9):729-740.
3. Coppé JP, Desprez PY, Krtolica A, Campisi J (2010) The senescence-associated secretory phenotype: The dark side of tumor suppression. Annu Rev Pathol 5:99-118.
4. Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J (2001) Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging. Proc Natl Acad Sci USA 98(21):12072-12077.
5. Mu XC, Higgins PJ (1995) Differential growth state-dependent regulation of plasminogen activator inhibitor type-1 expression in senescent IMR-90 human diploid fibroblasts. J Cell Physiol 165(3):647-657.
6. Kuilman T, Peeper DS (2009) Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer 9(2):81-94.
7. Dimri GP, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92(20):9363-9367.
8. Wahl GM, Carr AM (2001) The evolution of diverse biological responses to DNA damage: Insights from yeast and p53. Nat Cell Biol 3(12):E277-E286.
9. Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21 (CIP1), but not p16(INK4a). Mol Cell 14(4):501-513.
10. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88(5): 593-602.
11. Parrinello S, et al. (2003) Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 5(8):741-747.
12. Baker DJ, et al. (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479(7372):232-236.
13. Kuro-o M, et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390(6655):45-51.
14. Baker DJ, et al. (2008) Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol 10(7):825-836.
15. Liu H, et al. (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317(5839):803-806.
16. Doi S, et al. (2011) Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 286(10):8655-8665.
17. Kurosu H, et al. (2005) Suppression of aging in mice by the hormone Klotho. Science 309(5742):1829-1833.
18. Takeshita K, et al. (2002) Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse. Semin Thromb Hemost 28(6):545-554.
19. Kortlever RM, Higgins PJ, Bernards R (2006) Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol 8(8):877-884.
20. Boe AE, et al. (2013) Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nco-nitro-L-arginine methyl ester-induced hypertension and vascular senescence. Circulation 128(21):2318-2324.
21. Morishita K, et al. (2001) The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc. J Nutr 131(12):3182-3188.
22. Coviello-McLaughlin GM, Prowse KR (1997) Telomere length regulation during postnatal development and ageing in Mus spretus. Nucleic Acids Res 25(15):3051-3058.
23. Suga T, et al. (2000) Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life. Am J Respir Cell Mol Biol 22(1):26-33.
24. Voelkl J, et al. (2013) Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice. J Clin Invest 123(2):812-822.
25. Fischer SS, et al. (2010) Hyperaldosteronism in Klotho-deficient mice. Am J Physiol Renal Physiol 299(5):F1171-F1177.
26. Eren M, Painter CA, Atkinson JB, Declerck PJ, Vaughan DE (2002) Age-dependent spontaneous coronary arterial thrombosis in transgenic mice that express a stable form of human plasminogen activator inhibitor-1. Circulation 106(4):491-496.
27. Bernot D, et al. (2011) Plasminogen activator inhibitor 1 is an intracellular inhibitor of furin proprotein convertase. J Cell Sci 124(Pt 8):1224-1230.
28. Fukumoto S (2005) Post-translational modification of Fibroblast Growth Factor 23. Ther Apher Dial 9(4):319-322.
29. Thomas G (2002) Furin at the cutting edge: From protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol 3(10):753-766.
30. Tian S, Huang Q, Fang Y, Wu J (2011) FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs. Int J Mol Sci 12(2):1060-1065.
31. Razzaque MS (2009) The FGF23-Klotho axis: Endocrine regulation of phosphate ho-meostasis. Nat Rev Endocrinol 5(11):611-619.
32. Yamamoto M, et al. (2005) Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem 280(45):38029-38034.
33. Hu MC, et al. (2011) Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol 22(1):124-136.
34. Ohnishi M, Nakatani T, Lanske B, Razzaque MS (2009) Reversal of mineral ion ho-meostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int 75(11):1166-1172.
35. Lim K, et al. (2012) Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation 125(18):2243-2255.
36. Brown NJ, et al. (2000) Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. Kidney Int 58(3):1219-1227.
37. Elzi DJ, et al. (2012) Plasminogen activator inhibitor 1-insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence. Proc Natl Acad Sci USA 109(30):12052-12057.
38. Liu F, Wu S, Ren H, Gu J (2011) Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol 13(3):254-262.
39. López-Andrés N, et al. (2013) Absence of cardiotrophin 1 is associated with decreased age-dependent arterial stiffness and increased longevity in mice. Hypertension 61(1): 120-129.
40. Peeper DS (2011) Ageing: Old cells under attack. Nature 479(7372):186-187.
41. Tashiro Y, et al. (2012) Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice. Blood 119(26):6382-6393.
42. Izuhara Y, et al. (2008) Inhibition of plasminogen activator inhibitor-1: Its mechanism and effectiveness on coagulation and fibrosis. Arterioscler Thromb Vasc Biol 28(4):672-677.
43. Izuhara Y, et al. (2010) A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates. J Cereb Blood Flow Metab 30(5):904-912.
44. Miyata T, Yamaoka N, Kodama H, Murano K (2011) Inhibitor of plasminogen activator inhibitor-1. US Patent Appl 2, 011, 112, 140 A1 (May 12, 2011).
45. Mutlu GM, et al. (2004) Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling. Circ Res 94(8):1091-1100.
46. Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30(10):e47.
47. Callicott RJ, Womack JE (2006) Real-time PCR assay for measurement of mouse telomeres. Comp Med 56(1):17-22.