Clinical strategies and animal models for developing senolytic agents

Experimental Gerontology

Volumn 68, Issue , 2015, Pages 19-25

  Kirkland, James L ^a   Tchkonia, Tamara ^a  

^a MAYO CLINIC   (United States)

Author keywords

Cellular senescence; Healthspan; Senescence associated secretory phenotype; Senolytic

Indexed keywords

AGENTS AFFECTING METABOLISM; SENOLYTIC AGENT; UNCLASSIFIED DRUG;

ACCELERATED AGING LIKE CONDITION; AEROSOL; AGING; ARTICLE; CELL AGING; CELLULAR SENESCENCE; COMORBIDITY; DISEASE ASSOCIATION; DISEASE MODEL; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; DRUG DEVELOPMENT; DRUG EFFECT; DRUG EFFICACY; DRUG INDICATION; FIBROSING ALVEOLITIS; FRAILTY; GENE MUTATION; GENERAL ASPECTS OF DISEASE; HUMAN; LOCALIZED DRUG DELIVERY; LOSS OF RESILIENCE; NONHUMAN; OFF TARGET EFFECT; OSTEOARTHRITIS; PHENOTYPE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; TOPICAL DRUG DELIVERY; ANIMAL; ANIMAL MODEL; CHRONIC DISEASE; DISABLED PERSON; DRUG EFFECTS; PROCEDURES;

AGING; ANIMALS; CELL AGING; CHRONIC DISEASE; DISABLED PERSONS; DRUG DISCOVERY; HUMANS; MODELS, ANIMAL;

EID: 84941264776     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.10.012     Document Type: Article

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