Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14+ monocytes in frail older adults

Mechanisms of Ageing and Development

Volumn 130, Issue 3, 2009, Pages 161-166

  Qu, Tao ^a   Walston, Jeremy D ^a   Yang, Huanle ^a   Fedarko, Neal S ^a   Xue, Qian Li ^a   Beamer, Brock A ^a   Ferrucci, Luigi ^b   Rose, Noel R ^a   Leng, Sean X ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Aging; Frailty; Gene expression; Geriatrics; Monocyte mediated inflammatory pathways; Stress responsive genes

Indexed keywords

CD14 ANTIGEN; CHEMOKINE LIGAND 1; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR 10; FAS ASSOCIATED VIA DEATH DOMAIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCOCORTICOID RECEPTOR DNA BINDING FACTOR 1; HYDROGEN PEROXIDE INDUCED CLONE 5; INTERLEUKIN 11; LIPOPOLYSACCHARIDE; LYMPHOTOXIN; MITOGEN ACTIVATED PROTEIN KINASE 10; MITOGEN ACTIVATED PROTEIN KINASE 7; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

AGE DISTRIBUTION; AGED; AGING; ARTICLE; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; FEMALE; FRAIL ELDERLY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MONOCYTE; PRIORITY JOURNAL; RACE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX RATIO; STRESS; UPREGULATION; VALIDATION PROCESS;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD14; CASE-CONTROL STUDIES; CELLS, CULTURED; FEMALE; FRAIL ELDERLY; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; MONOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; STRESS, PHYSIOLOGICAL; UP-REGULATION;

EID: 59049097390     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2008.10.005     Document Type: Article

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