-
1
-
-
0032452982
-
The envelope layers of mycobacteria with reference to their pathogenicity
-
Daffe M, Draper P. 1998. The envelope layers of mycobacteria with reference to their pathogenicity. Adv Microb Physiol 39:131-203.
-
(1998)
Adv Microb Physiol
, vol.39
, pp. 131-203
-
-
Daffe, M.1
Draper, P.2
-
2
-
-
0032126742
-
Mycolic acids: structure, biosynthesis and physiological functions
-
Barry CE 3rd, Lee RE, Mdluli K, Sampson AE, Schroeder BG, Slayden RA, Yuan Y. 1998. Mycolic acids: structure, biosynthesis and physiological functions. Prog Lipid Res 37:143-179.
-
(1998)
Prog Lipid Res
, vol.37
, pp. 143-179
-
-
Barry, C.E.1
Lee, R.E.2
Mdluli, K.3
Sampson, A.E.4
Schroeder, B.G.5
Slayden, R.A.6
Yuan, Y.7
-
4
-
-
45149110879
-
Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria
-
Ojha AK, Baughn AD, Sambandan D, Hsu T, Trivelli X, Guerardel Y, Alahari A, Kremer L, Jacobs WR Jr, Hatfull GF. 2008. Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria. Mol Microbiol 69:164-174.
-
(2008)
Mol Microbiol
, vol.69
, pp. 164-174
-
-
Ojha, A.K.1
Baughn, A.D.2
Sambandan, D.3
Hsu, T.4
Trivelli, X.5
Guerardel, Y.6
Alahari, A.7
Kremer, L.8
Jacobs, W.R.9
Hatfull, G.F.10
-
5
-
-
12844278679
-
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis
-
Takayama K, Wang C, Besra GS. 2005. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin Microbiol Rev 18:81-101.
-
(2005)
Clin Microbiol Rev
, vol.18
, pp. 81-101
-
-
Takayama, K.1
Wang, C.2
Besra, G.S.3
-
6
-
-
79952795109
-
The betaketoacyl-ACP synthase from Mycobacterium tuberculosis as potential drug targets
-
Singh V, Mani I, Chaudhary DK, Somvanshi P. 2011. The betaketoacyl-ACP synthase from Mycobacterium tuberculosis as potential drug targets. Curr Med Chem 18:1318-1324.
-
(2011)
Curr Med Chem
, vol.18
, pp. 1318-1324
-
-
Singh, V.1
Mani, I.2
Chaudhary, D.K.3
Somvanshi, P.4
-
8
-
-
34250198660
-
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development
-
Bhatt A, Molle V, Besra GS, Jacobs, WR Jr, Kremer L. 2007. The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development. Mol Microbiol 64:1442-1454.
-
(2007)
Mol Microbiol
, vol.64
, pp. 1442-1454
-
-
Bhatt, A.1
Molle, V.2
Besra, G.S.3
Jacobs, W.R.4
Kremer, L.5
-
9
-
-
0015373050
-
Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis
-
Takayama K, Wang L, David HL. 1972. Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis. Antimicrob Agents Chemother 2:29-35.
-
(1972)
Antimicrob Agents Chemother
, vol.2
, pp. 29-35
-
-
Takayama, K.1
Wang, L.2
David, H.L.3
-
10
-
-
45149113341
-
Extensively drug-resistant tuberculosis: current challenges and threats
-
Jain A, Mondal R. 2008. Extensively drug-resistant tuberculosis: current challenges and threats. FEMS Immunol Med Microbiol 53:145-150.
-
(2008)
FEMS Immunol Med Microbiol
, vol.53
, pp. 145-150
-
-
Jain, A.1
Mondal, R.2
-
11
-
-
0001279834
-
The chemistry of the lipids of tubercle bacilli. The isolation and properties of mycolic acid
-
Stodola FH, Lesuk A, Anderson RJ. 1938. The chemistry of the lipids of tubercle bacilli. The isolation and properties of mycolic acid. J Biol Chem 126:505-513.
-
(1938)
J Biol Chem
, vol.126
, pp. 505-513
-
-
Stodola, F.H.1
Lesuk, A.2
Anderson, R.J.3
-
12
-
-
0000883209
-
Structure of the mycolic acids of mycobacteria
-
Asselineau J, Lederer E. 1950. Structure of the mycolic acids of mycobacteria. Nature 166:782-783.
-
(1950)
Nature
, vol.166
, pp. 782-783
-
-
Asselineau, J.1
Lederer, E.2
-
13
-
-
0013798316
-
On the structure of the alpha-mycolic acids of the human test strain of Mycobacterium tuberculosis
-
Etemadi AH, Lederer E. 1965. On the structure of the alpha-mycolic acids of the human test strain of Mycobacterium tuberculosis. Bull Soc Chim Fr 9:2640-2645.
-
(1965)
Bull Soc Chim Fr
, vol.9
, pp. 2640-2645
-
-
Etemadi, A.H.1
Lederer, E.2
-
14
-
-
0019986729
-
Numerical classification of some Rhodococci, Corynebacteria and related organisms
-
Goodfellow M, Weaver CR, Minnikin DE. 1982. Numerical classification of some Rhodococci, Corynebacteria and related organisms. J Gen Microbiol 128:731-745.
-
(1982)
J Gen Microbiol
, vol.128
, pp. 731-745
-
-
Goodfellow, M.1
Weaver, C.R.2
Minnikin, D.E.3
-
15
-
-
0020033722
-
A survey of the structures of mycolic acids in Corynebacterium and related taxa
-
Collins MD, Goodfellow M, Minnikin DE. 1982. A survey of the structures of mycolic acids in Corynebacterium and related taxa. J Gen Microbiol 128:129-149.
-
(1982)
J Gen Microbiol
, vol.128
, pp. 129-149
-
-
Collins, M.D.1
Goodfellow, M.2
Minnikin, D.E.3
-
16
-
-
84862266687
-
Ultralong C100 mycolic acids support the assignment of Segniliparus as a new bacterial genus
-
Hong S, Cheng TY, Layre E, Sweet L, Young DC, Posey JE, Butler WR, Moody DB. 2012. Ultralong C100 mycolic acids support the assignment of Segniliparus as a new bacterial genus. PLoS One 7:e39017.
-
(2012)
PLoS One
, vol.7
-
-
Hong, S.1
Cheng, T.Y.2
Layre, E.3
Sweet, L.4
Young, D.C.5
Posey, J.E.6
Butler, W.R.7
Moody, D.B.8
-
17
-
-
0023005802
-
Determination of molecular species composition of C80 or longer-chain alpha-mycolic acids in Mycobacterium spp. by gas chromatography-mass spectrometry and mass chromatography
-
Kaneda K, Naito S, Imaizumi S, Yano I, Mizuno S, Tomiyasu I, Baba T, Kusunose E, Kusunose M. 1986. Determination of molecular species composition of C80 or longer-chain alpha-mycolic acids in Mycobacterium spp. by gas chromatography-mass spectrometry and mass chromatography. J Clin Microbiol 24:1060-1070.
-
(1986)
J Clin Microbiol
, vol.24
, pp. 1060-1070
-
-
Kaneda, K.1
Naito, S.2
Imaizumi, S.3
Yano, I.4
Mizuno, S.5
Tomiyasu, I.6
Baba, T.7
Kusunose, E.8
Kusunose, M.9
-
18
-
-
0037518719
-
Acide mycolique époxydique, un nouveau type d'acide mycolique
-
Daffe M, Lanéelle MA, Puzo G, Asselineau C. 1981. Acide mycolique époxydique, un nouveau type d'acide mycolique. Tetrahed Lett 22: 4515-4516.
-
(1981)
Tetrahed Lett
, vol.22
, pp. 4515-4516
-
-
Daffe, M.1
Lanéelle, M.A.2
Puzo, G.3
Asselineau, C.4
-
19
-
-
0000900934
-
The methoxymycolic and ketomycolic acids from human tubercle bacilli
-
Minnikin DE, Polgar N. 1967. The methoxymycolic and ketomycolic acids from human tubercle bacilli. Chem Commun 22:1172-1174.
-
(1967)
Chem Commun
, vol.22
, pp. 1172-1174
-
-
Minnikin, D.E.1
Polgar, N.2
-
20
-
-
0025080056
-
A novel mycolic acid in a Mycobacterium sp. from the environment
-
Luquin M, Roussel J, Lopez-Calahorra F, Laneelle G, Ausina V, Laneelle MA. 1990. A novel mycolic acid in a Mycobacterium sp. from the environment. Eur J Biochem 192:753-759.
-
(1990)
Eur J Biochem
, vol.192
, pp. 753-759
-
-
Luquin, M.1
Roussel, J.2
Lopez-Calahorra, F.3
Laneelle, G.4
Ausina, V.5
Laneelle, M.A.6
-
21
-
-
33750739586
-
Sur la structure des acides mycoliques dicarboxyliques insaturés isolés de Mycobacterium phlei
-
Markovits J, Pinte F, Etemadi AH. 1966. Sur la structure des acides mycoliques dicarboxyliques insaturés isolés de Mycobacterium phlei. CR Acad Sci (Paris) 263:960-962.
-
(1966)
CR Acad Sci (Paris)
, vol.263
, pp. 960-962
-
-
Markovits, J.1
Pinte, F.2
Etemadi, A.H.3
-
22
-
-
0021646109
-
Mycolic acid patterns of some species of Mycobacterium
-
Minnikin DE, Minnikin SM, Parlett JH, Goodfellow M, Magnusson M. 1984. Mycolic acid patterns of some species of Mycobacterium. Arch Microbiol 139:225-231.
-
(1984)
Arch Microbiol
, vol.139
, pp. 225-231
-
-
Minnikin, D.E.1
Minnikin, S.M.2
Parlett, J.H.3
Goodfellow, M.4
Magnusson, M.5
-
23
-
-
34548127698
-
Detection and identification of mycobacteria by mycolic acid analysis of sputum specimens and young cultures
-
Viader-Salvado JM, Molina-Torres CA, Guerrero-Olazaran M. 2007. Detection and identification of mycobacteria by mycolic acid analysis of sputum specimens and young cultures. J Microbiol Methods 70:479-483.
-
(2007)
J Microbiol Methods
, vol.70
, pp. 479-483
-
-
Viader-Salvado, J.M.1
Molina-Torres, C.A.2
Guerrero-Olazaran, M.3
-
24
-
-
84855231253
-
Mycolic acids as diagnostic markers for tuberculosis case detection in humans and drug efficacy in mice
-
Shui G, Bendt AK, Jappar IA, Lim HM, Laneelle M, Herve M, Via LE, Chua GH, Bratschi MW, Zainul Rahim SZ, Michelle AL, Hwang SH, Lee JS, Eum SY, Kwak HK, Daffe M, Dartois V, Michel G, Barry, CE 3rd, Wenk MR. 2012. Mycolic acids as diagnostic markers for tuberculosis case detection in humans and drug efficacy in mice. EMBO Mol Med 4:27-37.
-
(2012)
EMBO Mol Med
, vol.4
, pp. 27-37
-
-
Shui, G.1
Bendt, A.K.2
Jappar, I.A.3
Lim, H.M.4
Laneelle, M.5
Herve, M.6
Via, L.E.7
Chua, G.H.8
Bratschi, M.W.9
Zainul Rahim, S.Z.10
Michelle, A.L.11
Hwang, S.H.12
Lee, J.S.13
Eum, S.Y.14
Kwak, H.K.15
Daffe, M.16
Dartois, V.17
Michel, G.18
Barry, C.E.19
Wenk, M.R.20
more..
-
25
-
-
0037244370
-
The synthesis of a single enantiomer of a major alpha-mycolic acid of Mycobacterium tuberculosis
-
Al Dulayymi JR, Baird MS, Roberts E. 2003. The synthesis of a single enantiomer of a major alpha-mycolic acid of Mycobacterium tuberculosis. Chem Commun (Camb) Jan. 21:228-229.
-
(2003)
Chem Commun (Camb) Jan
, vol.21
, pp. 228-229
-
-
Al Dulayymi, J.R.1
Baird, M.S.2
Roberts, E.3
-
26
-
-
84862262996
-
Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis
-
Verschoor JA, Baird MS, Grooten J. 2012. Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis. Prog Lipid Res 51:325-339.
-
(2012)
Prog Lipid Res
, vol.51
, pp. 325-339
-
-
Verschoor, J.A.1
Baird, M.S.2
Grooten, J.3
-
27
-
-
0034073375
-
Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice
-
Dubnau E, Chan J, Raynaud C, Mohan VP, Laneelle MA, Yu K, Quemard A, Smith I, Daffe M. 2000. Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice. Mol Microbiol 36:630-637.
-
(2000)
Mol Microbiol
, vol.36
, pp. 630-637
-
-
Dubnau, E.1
Chan, J.2
Raynaud, C.3
Mohan, V.P.4
Laneelle, M.A.5
Yu, K.6
Quemard, A.7
Smith, I.8
Daffe, M.9
-
28
-
-
0033634971
-
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis
-
Glickman MS, Cox JS, Jacobs WR Jr. 2000. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Mol Cell 5:717-727.
-
(2000)
Mol Cell
, vol.5
, pp. 717-727
-
-
Glickman, M.S.1
Cox, J.S.2
Jacobs, W.R.3
-
29
-
-
34247572374
-
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice
-
Bhatt A, Fujiwara N, Bhatt K, Gurcha SS, Kremer L, Chen B, Chan J, Porcelli SA, Kobayashi K, Besra GS, JacobsWRJr. 2007. Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. Proc Natl Acad Sci USA 104:5157-5262.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5157-5262
-
-
Bhatt, A.1
Fujiwara, N.2
Bhatt, K.3
Gurcha, S.S.4
Kremer, L.5
Chen, B.6
Chan, J.7
Porcelli, S.A.8
Kobayashi, K.9
Besra, G.S.10
Jacobs, W.R.11
-
30
-
-
0031694056
-
The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis
-
Yuan Y, Zhu Y, Crane D, Barry CE 3rd. 1998. The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis. Mol Microbiol 29:1449-1458.
-
(1998)
Mol Microbiol
, vol.29
, pp. 1449-1458
-
-
Yuan, Y.1
Zhu, Y.2
Crane, D.3
Barry, C.E.4
-
31
-
-
2542544267
-
Construction, molecular modeling, and simulation of Mycobacterium tuberculosis cell walls
-
Hong X, Hopfinger AJ. 2004. Construction, molecular modeling, and simulation of Mycobacterium tuberculosis cell walls. Biomacromolecules 5:1052-1065.
-
(2004)
Biomacromolecules
, vol.5
, pp. 1052-1065
-
-
Hong, X.1
Hopfinger, A.J.2
-
32
-
-
0029048109
-
Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis
-
Yuan Y, Lee RE, Besra GS, Belisle JT, Barry CE 3rd. 1995. Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 92:6630-6634.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 6630-6634
-
-
Yuan, Y.1
Lee, R.E.2
Besra, G.S.3
Belisle, J.T.4
Barry, C.E.5
-
33
-
-
33645450141
-
Trehalose 6, 6'-dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice
-
Hunter RL, Olsen M, Jagannath C, Actor JK. 2006. Trehalose 6, 6'-dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice. Am J Pathol 168:1249-1261.
-
(2006)
Am J Pathol
, vol.168
, pp. 1249-1261
-
-
Hunter, R.L.1
Olsen, M.2
Jagannath, C.3
Actor, J.K.4
-
34
-
-
0014348458
-
Acute granulomatous response produced in mice by trehalose-6, 6-dimycolate
-
Bekierkunst A. 1968. Acute granulomatous response produced in mice by trehalose-6, 6-dimycolate. J Bacteriol 96:958-961.
-
(1968)
J Bacteriol
, vol.96
, pp. 958-961
-
-
Bekierkunst, A.1
-
35
-
-
0015121892
-
Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli
-
Bekierkunst A, Levij IS, Yarkoni E, Vilkas E, Lederer E. 1971. Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli. Infect Immun 4:245-255.
-
(1971)
Infect Immun
, vol.4
, pp. 245-255
-
-
Bekierkunst, A.1
Levij, I.S.2
Yarkoni, E.3
Vilkas, E.4
Lederer, E.5
-
36
-
-
0015230630
-
Suppression of urethaninduced lung adenomas in mice treated with trehalose-6, 6-dimycolate (cord factor) and living bacillus Calmette Guerin
-
Bekierkunst A, Levij IS, Yarkoni E. 1971. Suppression of urethaninduced lung adenomas in mice treated with trehalose-6, 6-dimycolate (cord factor) and living bacillus Calmette Guerin. Science 174:1240-1242.
-
(1971)
Science
, vol.174
, pp. 1240-1242
-
-
Bekierkunst, A.1
Levij, I.S.2
Yarkoni, E.3
-
37
-
-
0042424923
-
Cord factor trehalose 6, 6'-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages
-
Indrigo J, Hunter RL Jr, Actor JK. 2003. Cord factor trehalose 6, 6'-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages. Microbiology 149:2049-2059.
-
(2003)
Microbiology
, vol.149
, pp. 2049-2059
-
-
Indrigo, J.1
Hunter, R.L.2
Actor, J.K.3
-
38
-
-
52549125928
-
Mincle is an ITAM-coupled activating receptor that senses damaged cells
-
Yamasaki S, Ishikawa E, SakumaM, Hara H, Ogata K, Saito T. 2008. Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol 9:1179-1188.
-
(2008)
Nat Immunol
, vol.9
, pp. 1179-1188
-
-
Yamasaki, S.1
Ishikawa, E.2
Sakuma, M.3
Hara, H.4
Ogata, K.5
Saito, T.6
-
39
-
-
73949117849
-
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
-
Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S. 2009. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J Exp Med 206:2879-2888.
-
(2009)
J Exp Med
, vol.206
, pp. 2879-2888
-
-
Ishikawa, E.1
Ishikawa, T.2
Morita, Y.S.3
Toyonaga, K.4
Yamada, H.5
Takeuchi, O.6
Kinoshita, T.7
Akira, S.8
Yoshikai, Y.9
Yamasaki, S.10
-
40
-
-
84859512076
-
Exposure of mycobacteria to cell wall-inhibitory drugs decreases production of arabinoglycerolipid related to mycolyl-arabinogalactan-peptidoglycan metabolism
-
Rombouts Y, Brust B, Ojha AK, Maes E, Coddeville B, Elass-Rochard E, Kremer L, Guerardel Y. 2012. Exposure of mycobacteria to cell wall-inhibitory drugs decreases production of arabinoglycerolipid related to mycolyl-arabinogalactan-peptidoglycan metabolism. J Biol Chem 287: 11060-11069.
-
(2012)
J Biol Chem
, vol.287
, pp. 11060-11069
-
-
Rombouts, Y.1
Brust, B.2
Ojha, A.K.3
Maes, E.4
Coddeville, B.5
Elass-Rochard, E.6
Kremer, L.7
Guerardel, Y.8
-
41
-
-
84867277251
-
Structural determination and Toll-like receptor 2-dependent proinflammatory activity of dimycolyldiarabino-glycerol from Mycobacterium marinum
-
Elass-Rochard E, Rombouts Y, Coddeville B, Maes E, Blervaque R, Hot D, Kremer L, Guerardel Y. 2012. Structural determination and Toll-like receptor 2-dependent proinflammatory activity of dimycolyldiarabino-glycerol from Mycobacterium marinum. J Biol Chem 287: 34432-34444.
-
(2012)
J Biol Chem
, vol.287
, pp. 34432-34444
-
-
Elass-Rochard, E.1
Rombouts, Y.2
Coddeville, B.3
Maes, E.4
Blervaque, R.5
Hot, D.6
Kremer, L.7
Guerardel, Y.8
-
42
-
-
77952914135
-
Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms
-
Ojha AK, Trivelli X, Guerardel Y, Kremer L, Hatfull GF. 2010. Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms. J Biol Chem 285:17380-17389.
-
(2010)
J Biol Chem
, vol.285
, pp. 17380-17389
-
-
Ojha, A.K.1
Trivelli, X.2
Guerardel, Y.3
Kremer, L.4
Hatfull, G.F.5
-
43
-
-
0028588920
-
Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells
-
Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB. 1994. Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells. Nature 372:691-694.
-
(1994)
Nature
, vol.372
, pp. 691-694
-
-
Beckman, E.M.1
Porcelli, S.A.2
Morita, C.T.3
Behar, S.M.4
Furlong, S.T.5
Brenner, M.B.6
-
44
-
-
15844382344
-
The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen-associated host innate immune responses
-
Korf J, Stoltz A, Verschoor J, De Baetselier P, Grooten J. 2005. The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen-associated host innate immune responses. Eur J Immunol 35: 890-900.
-
(2005)
Eur J Immunol
, vol.35
, pp. 890-900
-
-
Korf, J.1
Stoltz, A.2
Verschoor, J.3
De Baetselier, P.4
Grooten, J.5
-
45
-
-
78851469937
-
Molecular structure of the Mycobacterium tuberculosis virulence factor, mycolic acid, determines the elicited inflammatory pattern
-
Vander Beken S, Al Dulayymi JR, Naessens T, Koza G, Maza-Iglesias M, Rowles R, Theunissen C, De Medts J, Lanckacker E, Baird MS, Grooten J. Molecular structure of the Mycobacterium tuberculosis virulence factor, mycolic acid, determines the elicited inflammatory pattern. Eur J Immunol 41:450-460.
-
Eur J Immunol
, vol.41
, pp. 450-460
-
-
Vander Beken, S.1
Al Dulayymi, J.R.2
Naessens, T.3
Koza, G.4
Maza-Iglesias, M.5
Rowles, R.6
Theunissen, C.7
De Medts, J.8
Lanckacker, E.9
Baird, M.S.10
Grooten, J.11
-
47
-
-
0036018143
-
Multi-subunit acetyl-CoA carboxylases
-
Cronan JE Jr, Waldrop GL. 2002. Multi-subunit acetyl-CoA carboxylases. Prog Lipid Res 41:407-435.
-
(2002)
Prog Lipid Res
, vol.41
, pp. 407-435
-
-
Cronan, J.E.1
Waldrop, G.L.2
-
48
-
-
0032508046
-
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
-
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544.
-
(1998)
Nature
, vol.393
, pp. 537-544
-
-
Cole, S.T.1
Brosch, R.2
Parkhill, J.3
Garnier, T.4
Churcher, C.5
Harris, D.6
Gordon, S.V.7
Eiglmeier, K.8
Gas, S.9
Barry, C.E.10
Tekaia, F.11
Badcock, K.12
Basham, D.13
Brown, D.14
Chillingworth, T.15
Connor, R.16
Davies, R.17
Devlin, K.18
Feltwell, T.19
Gentles, S.20
Hamlin, N.21
Holroyd, S.22
Hornsby, T.23
Jagels, K.24
Krogh, A.25
McLean, J.26
Moule, S.27
Murphy, L.28
Oliver, K.29
Osborne, J.30
Quail, M.A.31
Rajandream, M.A.32
Rogers, J.33
Rutter, S.34
Seeger, K.35
Skelton, J.36
Squares, R.37
Squares, S.38
Sulston, J.E.39
Taylor, K.40
Whitehead, S.41
Barrell, B.G.42
more..
-
49
-
-
0345701347
-
Genes required for mycobacterial growth defined by high density mutagenesis
-
Sassetti CM, Boyd DH, Rubin EJ. 2003. Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48:77-84.
-
(2003)
Mol Microbiol
, vol.48
, pp. 77-84
-
-
Sassetti, C.M.1
Boyd, D.H.2
Rubin, E.J.3
-
50
-
-
84855846742
-
AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain
-
Pawelczyk J, Brzostek A, Kremer L, Dziadek B, Rumijowska-Galewicz A, Fiolka M, Dziadek J. 2011. AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain. J Bacteriol 193:6960-6972.
-
(2011)
J Bacteriol
, vol.193
, pp. 6960-6972
-
-
Pawelczyk, J.1
Brzostek, A.2
Kremer, L.3
Dziadek, B.4
Rumijowska-Galewicz, A.5
Fiolka, M.6
Dziadek, J.7
-
51
-
-
33846632320
-
AccD6, a member of the Fas II locus, is a functional carboxyltransferase subunit of the acylcoenzyme A carboxylase in Mycobacterium tuberculosis
-
Daniel J, Oh TJ, Lee CM, Kolattukudy PE. 2007. AccD6, a member of the Fas II locus, is a functional carboxyltransferase subunit of the acylcoenzyme A carboxylase in Mycobacterium tuberculosis. J Bacteriol 189:911-917.
-
(2007)
J Bacteriol
, vol.189
, pp. 911-917
-
-
Daniel, J.1
Oh, T.J.2
Lee, C.M.3
Kolattukudy, P.E.4
-
52
-
-
33645239314
-
Identification and characterization of Rv3281 as a novel subunit of a biotin-dependent Acyl-CoA carboxylase in Mycobacterium tuberculosis H37Rv
-
Oh TJ, Daniel J, Kim HJ, Sirakova TD, Kolattukudy PE. 2006. Identification and characterization of Rv3281 as a novel subunit of a biotin-dependent Acyl-CoA carboxylase in Mycobacterium tuberculosis H37Rv. J Biol Chem 281:3899-3908.
-
(2006)
J Biol Chem
, vol.281
, pp. 3899-3908
-
-
Oh, T.J.1
Daniel, J.2
Kim, H.J.3
Sirakova, T.D.4
Kolattukudy, P.E.5
-
53
-
-
15744389881
-
The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components
-
Portevin D, de Sousa-D'Auria C, Montrozier H, Houssin C, Stella A, Laneelle MA, Bardou F, Guilhot C, Daffe M. 2005. The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components. J Biol Chem 280:8862-8874.
-
(2005)
J Biol Chem
, vol.280
, pp. 8862-8874
-
-
Portevin, D.1
de Sousa-D'Auria, C.2
Montrozier, H.3
Houssin, C.4
Stella, A.5
Laneelle, M.A.6
Bardou, F.7
Guilhot, C.8
Daffe, M.9
-
54
-
-
30744470169
-
Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis
-
Gago G, Kurth D, Diacovich L, Tsai SC, GramajoH. 2006. Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis. J Bacteriol 188:477-486.
-
(2006)
J Bacteriol
, vol.188
, pp. 477-486
-
-
Gago, G.1
Kurth, D.2
Diacovich, L.3
Tsai, S.C.4
Gramajo, H.5
-
55
-
-
33845415806
-
Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis
-
Holton SJ, King-Scott S, Nasser Eddine A, Kaufmann SH, Wilmanns M. 2006. Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis. FEBS Lett 580: 6898-6902.
-
(2006)
FEBS Lett
, vol.580
, pp. 6898-6902
-
-
Holton, S.J.1
King-Scott, S.2
Nasser Eddine, A.3
Kaufmann, S.H.4
Wilmanns, M.5
-
56
-
-
33644777600
-
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis
-
Lin TW, Melgar MM, Kurth D, Swamidass SJ, Purdon J, Tseng T, Gago G, Baldi P, Gramajo H, Tsai SC. 2006. Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proc Natl Acad Sci USA 103:3072-3077.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3072-3077
-
-
Lin, T.W.1
Melgar, M.M.2
Kurth, D.3
Swamidass, S.J.4
Purdon, J.5
Tseng, T.6
Gago, G.7
Baldi, P.8
Gramajo, H.9
Tsai, S.C.10
-
57
-
-
69949130235
-
ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria
-
Kurth DG, Gago GM, de la Iglesia A, Bazet Lyonnet B, Lin TW, Morbidoni HR, Tsai SC, Gramajo H. 2009. ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria. Microbiology 155:2664-2675.
-
(2009)
Microbiology
, vol.155
, pp. 2664-2675
-
-
Kurth, D.G.1
Gago, G.M.2
de la Iglesia, A.3
Bazet Lyonnet, B.4
Lin, T.W.5
Morbidoni, H.R.6
Tsai, S.C.7
Gramajo, H.8
-
58
-
-
83055178874
-
Expression, purification and preliminary crystallographic analysis of Rv2247, the beta subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis
-
Niu C, Yin J, Cherney MM, James MN. 2011. Expression, purification and preliminary crystallographic analysis of Rv2247, the beta subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 67:1637-1640.
-
(2011)
Acta Crystallogr Sect F Struct Biol Cryst Commun
, vol.67
, pp. 1637-1640
-
-
Niu, C.1
Yin, J.2
Cherney, M.M.3
James, M.N.4
-
59
-
-
0037411269
-
Structural and functional organization of the animal fatty acid synthase
-
Smith S, Witkowski A, Joshi AK. 2003. Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res 42: 289-317.
-
(2003)
Prog Lipid Res
, vol.42
, pp. 289-317
-
-
Smith, S.1
Witkowski, A.2
Joshi, A.K.3
-
60
-
-
0017354918
-
Control mechanisms in the synthesis of saturated fatty acids
-
Bloch K, Vance D. 1977. Control mechanisms in the synthesis of saturated fatty acids. Annu Rev Biochem 46:263-298.
-
(1977)
Annu Rev Biochem
, vol.46
, pp. 263-298
-
-
Bloch, K.1
Vance, D.2
-
61
-
-
0026659794
-
Purification and characterization of an unusually large fatty acid synthase from Mycobacterium tuberculosis var. bovis BCG
-
Kikuchi S, Rainwater DL, Kolattukudy PE. 1992. Purification and characterization of an unusually large fatty acid synthase from Mycobacterium tuberculosis var. bovis BCG. Arch Biochem Biophys 295:318-326.
-
(1992)
Arch Biochem Biophys
, vol.295
, pp. 318-326
-
-
Kikuchi, S.1
Rainwater, D.L.2
Kolattukudy, P.E.3
-
62
-
-
3042606702
-
Characterization of Mycobacterium smegmatis expressing the Mycobacterium tuberculosis fatty acid synthase I (fas1) gene
-
Zimhony O, Vilcheze C, Jacobs WR Jr. 2004. Characterization of Mycobacterium smegmatis expressing the Mycobacterium tuberculosis fatty acid synthase I (fas1) gene. J Bacteriol 186:4051-4055.
-
(2004)
J Bacteriol
, vol.186
, pp. 4051-4055
-
-
Zimhony, O.1
Vilcheze, C.2
Jacobs, W.R.3
-
63
-
-
35348978364
-
Product-regulation mechanisms for fatty acid biosynthesis catalyzed by Mycobacterium smegmatis FAS I
-
Papaioannou N, Cheon HS, Lian Y, Kishi Y. 2007. Product-regulation mechanisms for fatty acid biosynthesis catalyzed by Mycobacterium smegmatis FAS I. Chembiochem 8:1775-1780.
-
(2007)
Chembiochem
, vol.8
, pp. 1775-1780
-
-
Papaioannou, N.1
Cheon, H.S.2
Lian, Y.3
Kishi, Y.4
-
64
-
-
84874115655
-
7.5-A Cryo-EM structure of the mycobacterial fatty acid synthase
-
Boehringer D, Ban N, LeibundgutM. 2013. 7.5-A Cryo-EM structure of the mycobacterial fatty acid synthase. J Mol Biol 425:841-849.
-
(2013)
J Mol Biol
, vol.425
, pp. 841-849
-
-
Boehringer, D.1
Ban, N.2
Leibundgut, M.3
-
65
-
-
0034623067
-
Identification and substrate specificity of beta-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis
-
Choi KH, Kremer L, Besra GS, Rock CO. 2000. Identification and substrate specificity of beta-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J Biol Chem 275: 28201-28207.
-
(2000)
J Biol Chem
, vol.275
, pp. 28201-28207
-
-
Choi, K.H.1
Kremer, L.2
Besra, G.S.3
Rock, C.O.4
-
66
-
-
0035827542
-
Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III
-
Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT. 2001. Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III. J Biol Chem 276:20516-20522.
-
(2001)
J Biol Chem
, vol.276
, pp. 20516-20522
-
-
Scarsdale, J.N.1
Kazanina, G.2
He, X.3
Reynolds, K.A.4
Wright, H.T.5
-
67
-
-
25444463559
-
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity
-
Brown AK, Sridharan S, Kremer L, Lindenberg S, Dover LG, Sacchettini JC, Besra GS. 2005. Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity. J Biol Chem 280:32539-32547.
-
(2005)
J Biol Chem
, vol.280
, pp. 32539-32547
-
-
Brown, A.K.1
Sridharan, S.2
Kremer, L.3
Lindenberg, S.4
Dover, L.G.5
Sacchettini, J.C.6
Besra, G.S.7
-
68
-
-
0035958944
-
Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II
-
Kremer L, Nampoothiri KM, Lesjean S, Dover LG, Graham S, Betts J, Brennan PJ, Minnikin DE, Locht C, Besra GS. 2001. Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II. J Biol Chem 276:27967-27974.
-
(2001)
J Biol Chem
, vol.276
, pp. 27967-27974
-
-
Kremer, L.1
Nampoothiri, K.M.2
Lesjean, S.3
Dover, L.G.4
Graham, S.5
Betts, J.6
Brennan, P.J.7
Minnikin, D.E.8
Locht, C.9
Besra, G.S.10
-
69
-
-
0037013187
-
The solution structure of acyl carrier protein from Mycobacterium tuberculosis
-
Wong HC, Liu G, Zhang YM, Rock CO, Zheng J. 2002. The solution structure of acyl carrier protein from Mycobacterium tuberculosis. J Biol Chem 277:15874-15880.
-
(2002)
J Biol Chem
, vol.277
, pp. 15874-15880
-
-
Wong, H.C.1
Liu, G.2
Zhang, Y.M.3
Rock, C.O.4
Zheng, J.5
-
70
-
-
0034595879
-
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis
-
Kremer L, Douglas JD, Baulard AR, Morehouse C, Guy MR, Alland D, Dover LG, Lakey JH, Jacobs WR Jr, Brennan PJ, Minnikin DE, Besra GS. 2000. Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis. J Biol Chem 275:16857-16864.
-
(2000)
J Biol Chem
, vol.275
, pp. 16857-16864
-
-
Kremer, L.1
Douglas, J.D.2
Baulard, A.R.3
Morehouse, C.4
Guy, M.R.5
Alland, D.6
Dover, L.G.7
Lakey, J.H.8
Jacobs, W.R.9
Brennan, P.J.10
Minnikin, D.E.11
Besra, G.S.12
-
71
-
-
0035861550
-
Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB
-
Schaeffer ML, Agnihotri G, Volker C, Kallender H, Brennan PJ, Lonsdale JT. 2001. Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB. J Biol Chem 276:47029-47037.
-
(2001)
J Biol Chem
, vol.276
, pp. 47029-47037
-
-
Schaeffer, M.L.1
Agnihotri, G.2
Volker, C.3
Kallender, H.4
Brennan, P.J.5
Lonsdale, J.T.6
-
72
-
-
0036606073
-
Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis
-
Kremer L, Dover LG, Carrere S, Nampoothiri KM, Lesjean S, Brown AK, Brennan PJ, Minnikin DE, Locht C, Besra GS. 2002. Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis. Biochem J 364:423-430.
-
(2002)
Biochem J
, vol.364
, pp. 423-430
-
-
Kremer, L.1
Dover, L.G.2
Carrere, S.3
Nampoothiri, K.M.4
Lesjean, S.5
Brown, A.K.6
Brennan, P.J.7
Minnikin, D.E.8
Locht, C.9
Besra, G.S.10
-
73
-
-
67649933582
-
Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin
-
Luckner SR, Machutta CA, Tonge PJ, Kisker C. 2009. Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin. Structure 17:1004-1013.
-
(2009)
Structure
, vol.17
, pp. 1004-1013
-
-
Luckner, S.R.1
Machutta, C.A.2
Tonge, P.J.3
Kisker, C.4
-
74
-
-
33846412588
-
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB)
-
Sridharan S, Wang L, Brown AK, Dover LG, Kremer L, Besra GS, Sacchettini JC. 2007. X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB). J Mol Biol 366:469-480.
-
(2007)
J Mol Biol
, vol.366
, pp. 469-480
-
-
Sridharan, S.1
Wang, L.2
Brown, A.K.3
Dover, L.G.4
Kremer, L.5
Besra, G.S.6
Sacchettini, J.C.7
-
75
-
-
0036448224
-
The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis
-
Slayden RA, Barry CE 3rd. 2002. The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis. Tuberculosis (Edinb) 82:149-160.
-
(2002)
Tuberculosis (Edinb)
, vol.82
, pp. 149-160
-
-
Slayden, R.A.1
Barry, C.E.2
-
76
-
-
27744492218
-
Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis
-
Bhatt A, Kremer L, Dai AZ, Sacchettini JC, Jacobs WR Jr. 2005. Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis. J Bacteriol 187:7596-7606.
-
(2005)
J Bacteriol
, vol.187
, pp. 7596-7606
-
-
Bhatt, A.1
Kremer, L.2
Dai, A.Z.3
Sacchettini, J.C.4
Jacobs, W.R.5
-
77
-
-
84874775139
-
Thiolactomycin-based betaketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy
-
Kapilashrami K, Bommineni GR, Machutta CA, Kim P, Lai CT, Simmerling C, Picart F, Tonge PJ. 2013. Thiolactomycin-based betaketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy. J Biol Chem 288:6045-6052.
-
(2013)
J Biol Chem
, vol.288
, pp. 6045-6052
-
-
Kapilashrami, K.1
Bommineni, G.R.2
Machutta, C.A.3
Kim, P.4
Lai, C.T.5
Simmerling, C.6
Picart, F.7
Tonge, P.J.8
-
78
-
-
57649115444
-
A novel interaction linking the FAS-II and phthiocerol dimycocerosate (PDIM) biosynthetic pathways
-
Kruh NA, JG Borgaro JG, Ruzsicska BP, Xu H, Tonge PJ. 2008. A novel interaction linking the FAS-II and phthiocerol dimycocerosate (PDIM) biosynthetic pathways. J Biol Chem 283:31719-31725.
-
(2008)
J Biol Chem
, vol.283
, pp. 31719-31725
-
-
Kruh, N.A.1
Borgaro, J.G.2
Ruzsicska, B.P.3
Xu, H.4
Tonge, P.J.5
-
79
-
-
0036228187
-
MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II
-
Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, Emorine L, Charpentier X, Daffe M, Quemard A. 2002. MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II. Microbiology 148:951-960.
-
(2002)
Microbiology
, vol.148
, pp. 951-960
-
-
Marrakchi, H.1
Ducasse, S.2
Labesse, G.3
Montrozier, H.4
Margeat, E.5
Emorine, L.6
Charpentier, X.7
Daffe, M.8
Quemard, A.9
-
80
-
-
35548929836
-
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis
-
Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A. 2007. The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. Proc Natl Acad Sci USA 104:14628-14633.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 14628-14633
-
-
Sacco, E.1
Covarrubias, A.S.2
O'Hare, H.M.3
Carroll, P.4
Eynard, N.5
Jones, T.A.6
Parish, T.7
Daffe, M.8
Backbro, K.9
Quemard, A.10
-
81
-
-
37449032052
-
Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex
-
Brown AK, Bhatt A, Singh S, Saparia E, Evans AF, Besra GS. 2007. Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex. Microbiology 153:4166-4173.
-
(2007)
Microbiology
, vol.153
, pp. 4166-4173
-
-
Brown, A.K.1
Bhatt, A.2
Singh, S.3
Saparia, E.4
Evans, A.F.5
Besra, G.S.6
-
82
-
-
0029000868
-
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis
-
Quemard A, Sacchettini JC, Dessen A, Vilcheze C, Bittman R, Jacobs WR Jr, Blanchard JS. 1995. Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. Biochemistry 34:8235-8241.
-
(1995)
Biochemistry
, vol.34
, pp. 8235-8241
-
-
Quemard, A.1
Sacchettini, J.C.2
Dessen, A.3
Vilcheze, C.4
Bittman, R.5
Jacobs, W.R.6
Blanchard, J.S.7
-
83
-
-
0028156861
-
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
-
Banerjee A, Dubnau E, Quemard A, Balasubramanian V, Um KS, Wilson T, Collins D, de Lisle G, Jacobs WR Jr. 1994. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263:227-230.
-
(1994)
Science
, vol.263
, pp. 227-230
-
-
Banerjee, A.1
Dubnau, E.2
Quemard, A.3
Balasubramanian, V.4
Um, K.S.5
Wilson, T.6
Collins, D.7
de Lisle, G.8
Jacobs, W.R.9
-
84
-
-
0036299101
-
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis
-
Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A. 2002. Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis. J Mol Biol 320:249-261.
-
(2002)
J Mol Biol
, vol.320
, pp. 249-261
-
-
Cohen-Gonsaud, M.1
Ducasse, S.2
Hoh, F.3
Zerbib, D.4
Labesse, G.5
Quemard, A.6
-
85
-
-
84868125770
-
Mutations in the essential FAS II beta-hydroxyacyl ACP dehydratase complex confer resistance to thiacetazone in Mycobacterium tuberculosis and Mycobacterium kansasii
-
Belardinelli JM, Morbidoni HR. 2012. Mutations in the essential FAS II beta-hydroxyacyl ACP dehydratase complex confer resistance to thiacetazone in Mycobacterium tuberculosis and Mycobacterium kansasii. Mol Microbiol 86:568-579.
-
(2012)
Mol Microbiol
, vol.86
, pp. 568-579
-
-
Belardinelli, J.M.1
Morbidoni, H.R.2
-
86
-
-
84871905006
-
Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues
-
Coxon GD, Craig D, Corrales RM, Vialla E, Gannoun-Zaki L, Kremer L. 2013. Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues. PLoS One 8:e53162.
-
(2013)
PLoS One
, vol.8
-
-
Coxon, G.D.1
Craig, D.2
Corrales, R.M.3
Vialla, E.4
Gannoun-Zaki, L.5
Kremer, L.6
-
87
-
-
84869029377
-
A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone
-
Grzegorzewicz AE, Kordulakova J, Jones V, Born SE, Belardinelli JM, Vaquie A, Gundi VA, Madacki J, Slama N, Laval F, Vaubourgeix J, Crew RM, Gicquel B, Daffe M, Morbidoni HR, Brennan PJ, Quemard A, McNeil MR, Jackson M. 2012. A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone. J Biol Chem 287:38434-38441.
-
(2012)
J Biol Chem
, vol.287
, pp. 38434-38441
-
-
Grzegorzewicz, A.E.1
Kordulakova, J.2
Jones, V.3
Born, S.E.4
Belardinelli, J.M.5
Vaquie, A.6
Gundi, V.A.7
Madacki, J.8
Slama, N.9
Laval, F.10
Vaubourgeix, J.11
Crew, R.M.12
Gicquel, B.13
Daffe, M.14
Morbidoni, H.R.15
Brennan, P.J.16
Quemard, A.17
McNeil, M.R.18
Jackson, M.19
-
88
-
-
84872036531
-
Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis
-
Gannoun-Zaki L, Alibaud L, Kremer L. 2013. Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 57:629-632.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 629-632
-
-
Gannoun-Zaki, L.1
Alibaud, L.2
Kremer, L.3
-
89
-
-
0000255856
-
Genetics of mycolic acid biosynthesis
-
Hatfull GF, Jacobs WR Jr (ed), ASM Press, Washington, DC
-
Kremer L, Baulard AR, Besra GS. 2000. Genetics of mycolic acid biosynthesis, p 173-190. In Hatfull GF, Jacobs WR Jr (ed), Molecular Genetics of Mycobacteria. ASM Press, Washington, DC.
-
(2000)
Molecular Genetics of Mycobacteria
, pp. 173-190
-
-
Kremer, L.1
Baulard, A.R.2
Besra, G.S.3
-
90
-
-
0037192859
-
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis
-
Huang CC, Smith CV, Glickman MS, Jacobs WR Jr, Sacchettini JC. 2002. Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. J Biol Chem 277:11559-11569.
-
(2002)
J Biol Chem
, vol.277
, pp. 11559-11569
-
-
Huang, C.C.1
Smith, C.V.2
Glickman, M.S.3
Jacobs, W.R.4
Sacchettini, J.C.5
-
91
-
-
33645212866
-
Further insight into S-adenosylmethioninedependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis
-
Boissier F, Bardou F, Guillet V, Uttenweiler-Joseph S, Daffe M, Quemard A, Mourey L. 2006. Further insight into S-adenosylmethioninedependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis. J Biol Chem 281:4434-4445.
-
(2006)
J Biol Chem
, vol.281
, pp. 4434-4445
-
-
Boissier, F.1
Bardou, F.2
Guillet, V.3
Uttenweiler-Joseph, S.4
Daffe, M.5
Quemard, A.6
Mourey, L.7
-
92
-
-
65749086909
-
Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis
-
Barkan D, Liu Z, Sacchettini JC, Glickman MS. 2009. Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis. Chem Biol 16:499-509.
-
(2009)
Chem Biol
, vol.16
, pp. 499-509
-
-
Barkan, D.1
Liu, Z.2
Sacchettini, J.C.3
Glickman, M.S.4
-
93
-
-
0028972283
-
The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2
-
George KM, Yuan Y, Sherman DR, Barry CE 3rd. 1995. The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2. J Biol Chem 270:27292-27298.
-
(1995)
J Biol Chem
, vol.270
, pp. 27292-27298
-
-
George, K.M.1
Yuan, Y.2
Sherman, D.R.3
Barry, C.E.4
-
94
-
-
0029803546
-
A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis
-
Yuan Y, Barry CE 3rd. 1996. A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 93:12828-12833.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12828-12833
-
-
Yuan, Y.1
Barry, C.E.2
-
95
-
-
0037424531
-
The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid
-
Glickman MS. 2003. The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid. J Biol Chem 278:7844-7849.
-
(2003)
J Biol Chem
, vol.278
, pp. 7844-7849
-
-
Glickman, M.S.1
-
96
-
-
0035910583
-
The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase
-
Glickman MS, Cahill SM, Jacobs WR Jr. 2001. The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase. J Biol Chem 276:2228-2233.
-
(2001)
J Biol Chem
, vol.276
, pp. 2228-2233
-
-
Glickman, M.S.1
Cahill, S.M.2
Jacobs, W.R.3
-
97
-
-
77954406755
-
Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates
-
Barkan D, Rao V, Sukenick GD, Glickman MS. 2010. Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates. J Bacteriol 192:3661-3668.
-
(2010)
J Bacteriol
, vol.192
, pp. 3661-3668
-
-
Barkan, D.1
Rao, V.2
Sukenick, G.D.3
Glickman, M.S.4
-
98
-
-
38349138934
-
Investigating the function of the putative mycolic acid methyltransferase UmaA: divergence between the Mycobacterium smegmatis and Mycobacterium tuberculosis proteins
-
Laval F, Haites R, Movahedzadeh F, Lemassu A, Wong CY, Stoker N, Billman-Jacobe H, Daffe M. 2008. Investigating the function of the putative mycolic acid methyltransferase UmaA: divergence between the Mycobacterium smegmatis and Mycobacterium tuberculosis proteins. J Biol Chem 283:1419-1427.
-
(2008)
J Biol Chem
, vol.283
, pp. 1419-1427
-
-
Laval, F.1
Haites, R.2
Movahedzadeh, F.3
Lemassu, A.4
Wong, C.Y.5
Stoker, N.6
Billman-Jacobe, H.7
Daffe, M.8
-
99
-
-
46449096343
-
Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production
-
Dao DN, Sweeney K, Hsu T, Gurcha SS, Nascimento IP, Roshevsky D, Besra GS, Chan J, Porcelli SA, Jacobs WR. 2008. Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production. PLoS Pathog 4:e1000081.
-
(2008)
PLoS Pathog
, vol.4
-
-
Dao, D.N.1
Sweeney, K.2
Hsu, T.3
Gurcha, S.S.4
Nascimento, I.P.5
Roshevsky, D.6
Besra, G.S.7
Chan, J.8
Porcelli, S.A.9
Jacobs, W.R.10
-
100
-
-
60649090254
-
Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis
-
Alahari A, Alibaud L, Trivelli X, Gupta R, Lamichhane G, Reynolds RC, Bishai WR, Guerardel Y, Kremer L. 2009. Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis. Mol Microbiol 71:1263-1277.
-
(2009)
Mol Microbiol
, vol.71
, pp. 1263-1277
-
-
Alahari, A.1
Alibaud, L.2
Trivelli, X.3
Gupta, R.4
Lamichhane, G.5
Reynolds, R.C.6
Bishai, W.R.7
Guerardel, Y.8
Kremer, L.9
-
101
-
-
0031015320
-
Mycobacterium bovis BCG genes involved in the biosynthesis of cyclopropyl keto-and hydroxy-mycolic acids
-
Dubnau E, Laneelle MA, Soares S, Benichou A, Vaz T, Prome D, Prome JC, Daffe M, Quemard A. 1997. Mycobacterium bovis BCG genes involved in the biosynthesis of cyclopropyl keto-and hydroxy-mycolic acids. Mol Microbiol 23:313-322.
-
(1997)
Mol Microbiol
, vol.23
, pp. 313-322
-
-
Dubnau, E.1
Laneelle, M.A.2
Soares, S.3
Benichou, A.4
Vaz, T.5
Prome, D.6
Prome, J.C.7
Daffe, M.8
Quemard, A.9
-
102
-
-
0031667049
-
Mutations in the cmaB gene are responsible for the absence of methoxymycolic acid in Mycobacterium bovis BCG Pasteur
-
Dubnau E, Marrakchi H, Smith I, Daffe M, Quemard A. 1998. Mutations in the cmaB gene are responsible for the absence of methoxymycolic acid in Mycobacterium bovis BCG Pasteur. Mol Microbiol 29:1526-1528.
-
(1998)
Mol Microbiol
, vol.29
, pp. 1526-1528
-
-
Dubnau, E.1
Marrakchi, H.2
Smith, I.3
Daffe, M.4
Quemard, A.5
-
103
-
-
0037470224
-
Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis. Structural analysis of fatty acids of a mutant strain devoid of methoxy-and ketomycolates
-
Dinadayala P, Laval F, Raynaud C, Lemassu A, Laneelle MA, Laneelle G, Daffe M. 2003. Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis. Structural analysis of fatty acids of a mutant strain devoid of methoxy-and ketomycolates. J Biol Chem 278:7310-7319.
-
(2003)
J Biol Chem
, vol.278
, pp. 7310-7319
-
-
Dinadayala, P.1
Laval, F.2
Raynaud, C.3
Lemassu, A.4
Laneelle, M.A.5
Laneelle, G.6
Daffe, M.7
-
104
-
-
0034040723
-
A point mutation in the mma3 gene is responsible for impaired methoxymycolic acid production in Mycobacterium bovis BCG strains obtained after 1927
-
Behr MA, Schroeder BG, Brinkman JN, Slayden RA, Barry CE 3rd. 2000. A point mutation in the mma3 gene is responsible for impaired methoxymycolic acid production in Mycobacterium bovis BCG strains obtained after 1927. J Bacteriol 182:3394-3399.
-
(2000)
J Bacteriol
, vol.182
, pp. 3394-3399
-
-
Behr, M.A.1
Schroeder, B.G.2
Brinkman, J.N.3
Slayden, R.A.4
Barry, C.E.5
-
105
-
-
14244260489
-
Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule
-
Rao V, Fujiwara N, Porcelli SA, Glickman MS. 2005. Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule. J Exp Med 201: 535-543.
-
(2005)
J Exp Med
, vol.201
, pp. 535-543
-
-
Rao, V.1
Fujiwara, N.2
Porcelli, S.A.3
Glickman, M.S.4
-
106
-
-
84864381316
-
Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block
-
Corrales RM, Molle V, Leiba J, Mourey L, de Chastellier C, Kremer L. 2012. Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block. J Biol Chem 287:26187-26199.
-
(2012)
J Biol Chem
, vol.287
, pp. 26187-26199
-
-
Corrales, R.M.1
Molle, V.2
Leiba, J.3
Mourey, L.4
de Chastellier, C.5
Kremer, L.6
-
107
-
-
33745217856
-
Transcyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis-induced inflammation and virulence
-
Rao V, Gao F, Chen B, Jacobs WR Jr, Glickman MS. 2006. Transcyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis-induced inflammation and virulence. J Clin Invest 116:1660-1667.
-
(2006)
J Clin Invest
, vol.116
, pp. 1660-1667
-
-
Rao, V.1
Gao, F.2
Chen, B.3
Jacobs, W.R.4
Glickman, M.S.5
-
108
-
-
84863815961
-
Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice
-
Barkan D, Hedhli D, Yan HG, Huygen K, Glickman MS. 2012. Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice. Infect Immun 80:1958-1968.
-
(2012)
Infect Immun
, vol.80
, pp. 1958-1968
-
-
Barkan, D.1
Hedhli, D.2
Yan, H.G.3
Huygen, K.4
Glickman, M.S.5
-
109
-
-
67749120736
-
S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of Mycobacterium tuberculosis mycolic acid methyltransferases
-
Vaubourgeix J, Bardou F, Boissier F, Julien S, Constant P, Ploux O, Daffe M, Quemard A, Mourey L. 2009. S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of Mycobacterium tuberculosis mycolic acid methyltransferases. J Biol Chem 284:19321-19330.
-
(2009)
J Biol Chem
, vol.284
, pp. 19321-19330
-
-
Vaubourgeix, J.1
Bardou, F.2
Boissier, F.3
Julien, S.4
Constant, P.5
Ploux, O.6
Daffe, M.7
Quemard, A.8
Mourey, L.9
-
110
-
-
43249131427
-
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria
-
Alahari A, Trivelli X, Guerardel Y, Dover LG, Besra GS, Sacchettini JC, Reynolds RC, Coxon GD, Kremer L. 2007. Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria. PLoS One 2:e1343.
-
(2007)
PLoS One
, vol.2
-
-
Alahari, A.1
Trivelli, X.2
Guerardel, Y.3
Dover, L.G.4
Besra, G.S.5
Sacchettini, J.C.6
Reynolds, R.C.7
Coxon, G.D.8
Kremer, L.9
-
111
-
-
77954369363
-
Temperature-dependent regulation of mycolic acid cyclopropanation in saprophytic mycobacteria: role of the Mycobacterium smegmatis 1351 gene (MSMEG_1351) in cis-cyclopropanation of alpha-mycolates
-
Alibaud L, Alahari A, Trivelli X, Ojha AK, Hatfull GF, Guerardel Y, Kremer L. 2010. Temperature-dependent regulation of mycolic acid cyclopropanation in saprophytic mycobacteria: role of the Mycobacterium smegmatis 1351 gene (MSMEG_1351) in cis-cyclopropanation of alpha-mycolates. J Biol Chem 285:21698-21707.
-
(2010)
J Biol Chem
, vol.285
, pp. 21698-21707
-
-
Alibaud, L.1
Alahari, A.2
Trivelli, X.3
Ojha, A.K.4
Hatfull, G.F.5
Guerardel, Y.6
Kremer, L.7
-
112
-
-
0347719360
-
A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms
-
Portevin D, De Sousa-D'Auria C, Houssin C, Grimaldi C, Chami M, Daffe M, Guilhot C. 2004. A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms. Proc Natl Acad Sci USA 101:314-319.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 314-319
-
-
Portevin, D.1
De Sousa-D'Auria, C.2
Houssin, C.3
Grimaldi, C.4
Chami, M.5
Daffe, M.6
Guilhot, C.7
-
113
-
-
7244242397
-
Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis
-
Gande R, Gibson KJ, Brown AK, Krumbach K, Dover LG, Sahm H, Shioyama S, Oikawa T, Besra GS, Eggeling L. 2004. Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. J Biol Chem 279:44847-44857.
-
(2004)
J Biol Chem
, vol.279
, pp. 44847-44857
-
-
Gande, R.1
Gibson, K.J.2
Brown, A.K.3
Krumbach, K.4
Dover, L.G.5
Sahm, H.6
Shioyama, S.7
Oikawa, T.8
Besra, G.S.9
Eggeling, L.10
-
114
-
-
34447529329
-
The two carboxylases of Corynebacterium glutamicum essential for fatty acid and mycolic acid synthesis
-
Gande R, Dover LG, Krumbach K, Besra GS, Sahm H, Oikawa T, Eggeling L. 2007. The two carboxylases of Corynebacterium glutamicum essential for fatty acid and mycolic acid synthesis. J Bacteriol 189:5257-5264.
-
(2007)
J Bacteriol
, vol.189
, pp. 5257-5264
-
-
Gande, R.1
Dover, L.G.2
Krumbach, K.3
Besra, G.S.4
Sahm, H.5
Oikawa, T.6
Eggeling, L.7
-
115
-
-
1842577641
-
Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria
-
Trivedi OA, Arora P, Sridharan V, Tickoo R, Mohanty D, Gokhale RS. 2004. Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria. Nature 428:441-445.
-
(2004)
Nature
, vol.428
, pp. 441-445
-
-
Trivedi, O.A.1
Arora, P.2
Sridharan, V.3
Tickoo, R.4
Mohanty, D.5
Gokhale, R.S.6
-
116
-
-
33644777600
-
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis
-
Lin TW, Melgar MM, Kurth D, Swamidass SJ, Purdon J, Tseng T, Gago G, Baldi P, Gramajo H, Tsai SC. 2006. Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proc Natl Acad Sci USA 103: 3072-3077.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3072-3077
-
-
Lin, T.W.1
Melgar, M.M.2
Kurth, D.3
Swamidass, S.J.4
Purdon, J.5
Tseng, T.6
Gago, G.7
Baldi, P.8
Gramajo, H.9
Tsai, S.C.10
-
117
-
-
65749100586
-
The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis
-
Gavalda S, Leger M, van der Rest B, Stella A, Bardou F, Montrozier H, Chalut C, Burlet-Schiltz O, Marrakchi H, Daffe M, Quemard A. 2009. The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis. J Biol Chem 284:19255-19264.
-
(2009)
J Biol Chem
, vol.284
, pp. 19255-19264
-
-
Gavalda, S.1
Leger, M.2
van der Rest, B.3
Stella, A.4
Bardou, F.5
Montrozier, H.6
Chalut, C.7
Burlet-Schiltz, O.8
Marrakchi, H.9
Daffe, M.10
Quemard, A.11
-
118
-
-
65749086527
-
The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis
-
Leger M, Gavalda S, Guillet V, van der Rest B, Slama N, Montrozier H, Mourey L, Quemard A, Daffe M, Marrakchi H. 2009. The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis. Chem Biol 16:510-519.
-
(2009)
Chem Biol
, vol.16
, pp. 510-519
-
-
Leger, M.1
Gavalda, S.2
Guillet, V.3
van der Rest, B.4
Slama, N.5
Montrozier, H.6
Mourey, L.7
Quemard, A.8
Daffe, M.9
Marrakchi, H.10
-
119
-
-
84866904411
-
Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13
-
Bergeret F, Gavalda S, Chalut C, Malaga W, Quemard A, Pedelacq JD, Daffe M, Guilhot C, Mourey L, Bon C. 2012. Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13. J Biol Chem 287:33675-33690.
-
(2012)
J Biol Chem
, vol.287
, pp. 33675-33690
-
-
Bergeret, F.1
Gavalda, S.2
Chalut, C.3
Malaga, W.4
Quemard, A.5
Pedelacq, J.D.6
Daffe, M.7
Guilhot, C.8
Mourey, L.9
Bon, C.10
-
120
-
-
84880924467
-
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis
-
Wilson R, Kumar P, Parashar V, Vilcheze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, Shenai S, Colangeli R, Jacobs WR Jr, Neiditch MB, Kremer L, Alland D. 2013. Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. Nat Chem Biol 9:499-506.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 499-506
-
-
Wilson, R.1
Kumar, P.2
Parashar, V.3
Vilcheze, C.4
Veyron-Churlet, R.5
Freundlich, J.S.6
Barnes, S.W.7
Walker, J.R.8
Szymonifka, M.J.9
Marchiano, E.10
Shenai, S.11
Colangeli, R.12
Jacobs, W.R.13
Neiditch, M.B.14
Kremer, L.15
Alland, D.16
-
121
-
-
34249675745
-
The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan
-
Lea-Smith DJ, Pyke JS, Tull D, McConville MJ, Coppel RL, Crellin PK. 2007. The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan. J Biol Chem 282:11000-11008.
-
(2007)
J Biol Chem
, vol.282
, pp. 11000-11008
-
-
Lea-Smith, D.J.1
Pyke, J.S.2
Tull, D.3
McConville, M.J.4
Coppel, R.L.5
Crellin, P.K.6
-
122
-
-
84878211646
-
Assay development for identifying inhibitors of the mycobacterial FadD32 activity
-
Galandrin S, Guillet V, Rane RS, Leger M, Radha N, Eynard N, Das K, Balganesh TS, Mourey L, Daffe M, Marrakchi H. 2013. Assay development for identifying inhibitors of the mycobacterial FadD32 activity. J Biomol Screen 18:576-587.
-
(2013)
J Biomol Screen
, vol.18
, pp. 576-587
-
-
Galandrin, S.1
Guillet, V.2
Rane, R.S.3
Leger, M.4
Radha, N.5
Eynard, N.6
Das, K.7
Balganesh, T.S.8
Mourey, L.9
Daffe, M.10
Marrakchi, H.11
-
123
-
-
84872033341
-
4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo
-
Leblanc C, Prudhomme T, Tabouret G, Ray A, Burbaud S, Cabantous S, Mourey L, Guilhot C, Chalut C. 2012. 4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo. PLoS Pathog 8: e1003097.
-
(2012)
PLoS Pathog
, vol.8
-
-
Leblanc, C.1
Prudhomme, T.2
Tabouret, G.3
Ray, A.4
Burbaud, S.5
Cabantous, S.6
Mourey, L.7
Guilhot, C.8
Chalut, C.9
-
124
-
-
84860181497
-
MmpL genes are associated with mycolic acid metabolism in mycobacteria and corynebacteria
-
Varela C, Rittmann D, Singh A, Krumbach K, Bhatt K, Eggeling L, Besra GS, Bhatt A. 2012. MmpL genes are associated with mycolic acid metabolism in mycobacteria and corynebacteria. Chem Biol 19:498-506.
-
(2012)
Chem Biol
, vol.19
, pp. 498-506
-
-
Varela, C.1
Rittmann, D.2
Singh, A.3
Krumbach, K.4
Bhatt, K.5
Eggeling, L.6
Besra, G.S.7
Bhatt, A.8
-
125
-
-
84455173193
-
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212
-
La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, Botta M, De Logu A, Rubin EJ, De Rossi E. 2012. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob Agents Chemother 56:324-331.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 324-331
-
-
La Rosa, V.1
Poce, G.2
Canseco, J.O.3
Buroni, S.4
Pasca, M.R.5
Biava, M.6
Raju, R.M.7
Porretta, G.C.8
Alfonso, S.9
Battilocchio, C.10
Javid, B.11
Sorrentino, F.12
Ioerger, T.R.13
Sacchettini, J.C.14
Manetti, F.15
Botta, M.16
De Logu, A.17
Rubin, E.J.18
De Rossi, E.19
-
126
-
-
84863404695
-
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis
-
Tahlan K, Wilson R, Kastrinsky DB, Arora K, Nair V, Fischer E, Barnes SW, Walker JR, Alland D, Barry CE 3rd, Boshoff HI. 2012. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob Agents Chemother 56:1797-1809.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 1797-1809
-
-
Tahlan, K.1
Wilson, R.2
Kastrinsky, D.B.3
Arora, K.4
Nair, V.5
Fischer, E.6
Barnes, S.W.7
Walker, J.R.8
Alland, D.9
Barry, C.E.10
Boshoff, H.I.11
-
127
-
-
84858677107
-
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
-
Grzegorzewicz AE, Pham H, Gundi VA, Scherman MS, North EJ, Hess T, Jones V, Gruppo V, Born SE, Kordulakova J, Chavadi SS, Morisseau C, Lenaerts AJ, Lee RE, McNeil MR, Jackson M. 2012. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol 8:334-341.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 334-341
-
-
Grzegorzewicz, A.E.1
Pham, H.2
Gundi, V.A.3
Scherman, M.S.4
North, E.J.5
Hess, T.6
Jones, V.7
Gruppo, V.8
Born, S.E.9
Kordulakova, J.10
Chavadi, S.S.11
Morisseau, C.12
Lenaerts, A.J.13
Lee, R.E.14
McNeil, M.R.15
Jackson, M.16
-
128
-
-
0031007903
-
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis
-
Belisle JT, Vissa VD, Sievert T, Takayama K, Brennan PJ, Besra GS. 1997. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 276:1420-1422.
-
(1997)
Science
, vol.276
, pp. 1420-1422
-
-
Belisle, J.T.1
Vissa, V.D.2
Sievert, T.3
Takayama, K.4
Brennan, P.J.5
Besra, G.S.6
-
129
-
-
0036090968
-
Evidence for a partial redundancy of the fibronectinbinding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis
-
Puech V, Guilhot C, Perez E, Tropis M, Armitige LY, Gicquel B, Daffe M. 2002. Evidence for a partial redundancy of the fibronectinbinding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis. Mol Microbiol 44:1109-1122.
-
(2002)
Mol Microbiol
, vol.44
, pp. 1109-1122
-
-
Puech, V.1
Guilhot, C.2
Perez, E.3
Tropis, M.4
Armitige, L.Y.5
Gicquel, B.6
Daffe, M.7
-
130
-
-
84858962177
-
EccA1, a component of the Mycobacterium marinum ESX-1 protein virulence factor secretion pathway, regulates mycolic acid lipid synthesis
-
Joshi SA, Ball DA, SunMG, Carlsson F, Watkins BY, Aggarwal N, McCracken JM, Huynh KK, Brown EJ. 2012. EccA1, a component of the Mycobacterium marinum ESX-1 protein virulence factor secretion pathway, regulates mycolic acid lipid synthesis. Chem Biol 19:372-380.
-
(2012)
Chem Biol
, vol.19
, pp. 372-380
-
-
Joshi, S.A.1
Ball, D.A.2
Sun, M.G.3
Carlsson, F.4
Watkins, B.Y.5
Aggarwal, N.6
McCracken, J.M.7
Huynh, K.K.8
Brown, E.J.9
-
131
-
-
9644257517
-
Protein-protein interactions within the fatty acid synthase-II system of Mycobacterium tuberculosis are essential for mycobacterial viability
-
Veyron-Churlet R, Guerrini O, Mourey L, Daffe M, Zerbib D. 2004. Protein-protein interactions within the fatty acid synthase-II system of Mycobacterium tuberculosis are essential for mycobacterial viability. Mol Microbiol 54:1161-1172.
-
(2004)
Mol Microbiol
, vol.54
, pp. 1161-1172
-
-
Veyron-Churlet, R.1
Guerrini, O.2
Mourey, L.3
Daffe, M.4
Zerbib, D.5
-
132
-
-
26844537406
-
The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions
-
Veyron-Churlet R, Bigot S, Guerrini O, Verdoux S, Malaga W, Daffe D, Zerbib D. 2005. The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions. J Mol Biol 353: 847-858.
-
(2005)
J Mol Biol
, vol.353
, pp. 847-858
-
-
Veyron-Churlet, R.1
Bigot, S.2
Guerrini, O.3
Verdoux, S.4
Malaga, W.5
Daffe, D.6
Zerbib, D.7
-
133
-
-
84055182559
-
The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes
-
Cantaloube S, Veyron-Churlet R, Haddache N, Daffe M, Zerbib D. 2011. The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes. PLoS One 6:e29564.
-
(2011)
PLoS One
, vol.6
-
-
Cantaloube, S.1
Veyron-Churlet, R.2
Haddache, N.3
Daffe, M.4
Zerbib, D.5
-
134
-
-
77957243487
-
Transcriptional regulation of lipid homeostasis in mycobacteria
-
Salzman V, Mondino S, Sala C, Cole ST, Gago G, Gramajo H. 2010. Transcriptional regulation of lipid homeostasis in mycobacteria. Mol Microbiol 78:64-77.
-
(2010)
Mol Microbiol
, vol.78
, pp. 64-77
-
-
Salzman, V.1
Mondino, S.2
Sala, C.3
Cole, S.T.4
Gago, G.5
Gramajo, H.6
-
135
-
-
0034194181
-
The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis
-
Av-Gay Y, Everett M. 2000. The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis. Trends Microbiol 8:238-244.
-
(2000)
Trends Microbiol
, vol.8
, pp. 238-244
-
-
Av-Gay, Y.1
Everett, M.2
-
136
-
-
77349099314
-
Division and cell envelope regulation by Ser/Thr phosphorylation: mycobacterium shows the way
-
Molle V, Kremer L. 2010. Division and cell envelope regulation by Ser/Thr phosphorylation: mycobacterium shows the way. Mol Microbiol 75:1064-1077.
-
(2010)
Mol Microbiol
, vol.75
, pp. 1064-1077
-
-
Molle, V.1
Kremer, L.2
-
137
-
-
33749570515
-
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation
-
Molle V, Brown AK, Besra GS, Cozzone AJ, Kremer L. 2006. The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation. J Biol Chem 281:30094-30103.
-
(2006)
J Biol Chem
, vol.281
, pp. 30094-30103
-
-
Molle, V.1
Brown, A.K.2
Besra, G.S.3
Cozzone, A.J.4
Kremer, L.5
-
138
-
-
65249174626
-
The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue
-
Veyron-Churlet R, Molle V, Taylor RC, Brown AK, Besra GS, Zanella-Cleon I, Futterer K, Kremer L. 2009. The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue. J Biol Chem 284:6414-6424.
-
(2009)
J Biol Chem
, vol.284
, pp. 6414-6424
-
-
Veyron-Churlet, R.1
Molle, V.2
Taylor, R.C.3
Brown, A.K.4
Besra, G.S.5
Zanella-Cleon, I.6
Futterer, K.7
Kremer, L.8
-
139
-
-
77951212397
-
Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis
-
Veyron-Churlet R, Zanella-Cleon I, Cohen-Gonsaud M, Molle V, Kremer L. 2010. Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis. J Biol Chem 285:12714-12725.
-
(2010)
J Biol Chem
, vol.285
, pp. 12714-12725
-
-
Veyron-Churlet, R.1
Zanella-Cleon, I.2
Cohen-Gonsaud, M.3
Molle, V.4
Kremer, L.5
-
140
-
-
78650031727
-
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis
-
Molle V, Gulten G, Vilcheze C, Veyron-Churlet R, Zanella-Cleon I, Sacchettini JC, Jacobs WR Jr, Kremer L. 2010. Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Mol Microbiol 78:1591-1605.
-
(2010)
Mol Microbiol
, vol.78
, pp. 1591-1605
-
-
Molle, V.1
Gulten, G.2
Vilcheze, C.3
Veyron-Churlet, R.4
Zanella-Cleon, I.5
Sacchettini, J.C.6
Jacobs, W.R.7
Kremer, L.8
-
141
-
-
80052270882
-
Negative regulation by Ser/Thr phosphorylation of HadAB and HadBC dehydratases from Mycobacterium tuberculosis type II fatty acid synthase system
-
Slama N, Leiba J, Eynard N, Daffe M, Kremer L, Quemard A, Molle V. 2011. Negative regulation by Ser/Thr phosphorylation of HadAB and HadBC dehydratases from Mycobacterium tuberculosis type II fatty acid synthase system. Biochem Biophys Res Commun 412:401-406.
-
(2011)
Biochem Biophys Res Commun
, vol.412
, pp. 401-406
-
-
Slama, N.1
Leiba, J.2
Eynard, N.3
Daffe, M.4
Kremer, L.5
Quemard, A.6
Molle, V.7
-
142
-
-
0024669395
-
Mycolic acid metabolic filiation and location in Mycobacterium aurum and Mycobacterium phlei
-
Lacave C, Laneelle MA, Daffe M, Montrozier H, Laneelle G. 1989. Mycolic acid metabolic filiation and location in Mycobacterium aurum and Mycobacterium phlei. Eur J Biochem 181:459-466.
-
(1989)
Eur J Biochem
, vol.181
, pp. 459-466
-
-
Lacave, C.1
Laneelle, M.A.2
Daffe, M.3
Montrozier, H.4
Laneelle, G.5
-
143
-
-
84865253965
-
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening
-
Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT. 2012. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol 7:1377-1384.
-
(2012)
ACS Chem Biol
, vol.7
, pp. 1377-1384
-
-
Stanley, S.A.1
Grant, S.S.2
Kawate, T.3
Iwase, N.4
Shimizu, M.5
Wivagg, C.6
Silvis, M.7
Kazyanskaya, E.8
Aquadro, J.9
Golas, A.10
Fitzgerald, M.11
Dai, H.12
Zhang, L.13
Hung, D.T.14
-
144
-
-
3142774125
-
Revisiting sputum smear microscopy
-
Trebucq A. 2004. Revisiting sputum smear microscopy. Int J Tuberc Lung Dis 8:805.
-
(2004)
Int J Tuberc Lung Dis
, vol.8
, pp. 805
-
-
Trebucq, A.1
-
145
-
-
0242552007
-
Cell-wall alterations as an attribute of Mycobacterium tuberculosis in latent infection
-
Seiler P, Ulrichs T, Bandermann S, Pradl L, Jorg S, Krenn V, Morawietz L, Kaufmann SH, Aichele P. 2003. Cell-wall alterations as an attribute of Mycobacterium tuberculosis in latent infection. J Infect Dis 188:1326-1331.
-
(2003)
J Infect Dis
, vol.188
, pp. 1326-1331
-
-
Seiler, P.1
Ulrichs, T.2
Bandermann, S.3
Pradl, L.4
Jorg, S.5
Krenn, V.6
Morawietz, L.7
Kaufmann, S.H.8
Aichele, P.9
|