Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13

Journal of Biological Chemistry

Volumn 287, Issue 40, 2012, Pages 33675-33690

  Bergeret, Fabien ^a,b   Gavalda, Sabine ^a,b   Chalut, Christian ^a,b   Malaga, Wladimir ^a,b   Quémard, Annaïk ^a,b   Pedelacq, Jean Denis ^a,b   Daffé, Mamadou ^a,b   Guilhot, Christophe ^a,b   Mourey, Lionel ^a,b   Bon, Cécile ^a,b  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACYL-COA; CORE STRUCTURE; CRYSTALLOGRAPHIC ANALYSIS; DEDICATED CHANNELS; DOMAIN-DOMAIN INTERACTIONS; ESSENTIAL COMPONENT; HIGH RESOLUTION CRYSTAL STRUCTURE; IN-LINE; INTER-DOMAIN CONNECTIONS; LONG CHAINS; MYCOBACTERIAL; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; POLYKETIDE SYNTHASES; STRUCTURAL CHARACTERIZATION; STRUCTURAL STUDIES; SYNTHASES; VIRULENCE FACTORS;

BIOCHEMISTRY; FATTY ACIDS;

PLANTS (BOTANY);

ACYLTRANSFERASE; FATTY ACID SYNTHASE; POLYKETIDE SYNTHASE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; BIOCHEMISTRY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CHEMISTRY, PHARMACEUTICAL; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; POLYKETIDE SYNTHASES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84866904411     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.325639     Document Type: Article

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