Probing the mechanism of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase III mtFabH: Factors influencing catalysis and substrate specificity

Journal of Biological Chemistry

Volumn 280, Issue 37, 2005, Pages 32539-32547

  Brown, Alistair K ^a,b   Sridharan, Sudharsan ^c   Kremer, Laurent ^d   Lindenberg, Sandra ^b   Dover, Lynn G ^b   Sacchettini, James C ^c   Besra, Gurdyal S ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c TEXAS A AND M UNIVERSITY   (United States)

^d UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLATION; CATALYSIS; ESCHERICHIA COLI; FATTY ACIDS; PROTEINS; SUBSTRATES;

ABROGATING ACTIVITIES; HYDROXY FATTY ACIDS; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS;

BACTERIA;

3 HYDROXY FATTY ACID; ACYL CARRIER PROTEIN; ACYL COENZYME A; BACTERIAL ENZYME; BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE III; CARRIER PROTEIN; FATTY ACID; FATTY ACID SYNTHASE; MALONYL ACYL CARRIER PROTEIN; MEROMYCOLIC ACID; PROTEIN MTFABH; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL CELL WALL; CATALYSIS; DECARBOXYLATION; DEPROTECTION REACTION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENE MUTATION; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ACYL CARRIER PROTEIN; ARGININE; BINDING SITES; CARBON; CATALYSIS; CATALYTIC DOMAIN; CELL WALL; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ELECTRONS; ESCHERICHIA COLI; FATTY ACIDS; GENES, DOMINANT; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; SUBSTRATE SPECIFICITY; TIME FACTORS; X-RAYS;

ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS;

EID: 25444463559     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413216200     Document Type: Article

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