Crystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin

Structure

Volumn 17, Issue 7, 2009, Pages 1004-1013

  Luckner, Sylvia R ^a   Machutta, Carl A ^b   Tonge, Peter J ^b   Kisker, Caroline ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

MICROBIO; PROTEINS

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ANTIBIOTIC AGENT; BACTERIAL ENZYME; CARBON; FATTY ACID; LIPID; LONG CHAIN FATTY ACID; MACROGOL; MYCOLIC ACID; THIOLACTOMYCIN;

ARTICLE; BACTERIAL CELL WALL; BACTERIAL SURVIVAL; BINDING AFFINITY; BIOSYNTHESIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTITUBERCULAR AGENTS; BINDING SITES; CELL WALL; CRYSTALLOGRAPHY, X-RAY; FATTY ACIDS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; THIOPHENES;

EID: 67649933582     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2009.04.012     Document Type: Article

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