Structural determination and toll-like receptor 2-dependent proinflammatory activity of dimycolyl-diarabino-glycerol from Mycobacterium marinum

Journal of Biological Chemistry

Volumn 287, Issue 41, 2012, Pages 34432-34444

  Elass Rochard, Elisabeth ^a   Rombouts, Yoann ^a   Coddeville, Bernadette ^a   Maes, Emmanuel ^a   Blervaque, Renaud ^b   Hot, David ^b   Kremer, Laurent ^c   Guérardel, Yann ^a  

^a UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE   (France)

^b INSERM U1019   (France)

^c UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; ADHESION MOLECULES; ALKALINE PHOSPHATASE; BIOLOGICAL PROPERTIES; CELL SURFACES; CELL WALLS; CHEMOKINES; GENES ENCODING; GLYCO LIPIDS; GLYCOCONJUGATES; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMAN MACROPHAGES; INFLAMMATORY RESPONSE; LIPID COMPOSITION; MASS SPECTROMETRY ANALYSIS; METALLOPROTEINASES; MYCOBACTERIAL INFECTION; MYCOLIC ACIDS; PATHOGENIC MYCOBACTERIA; PROINFLAMMATORY; PROINFLAMMATORY CYTOKINES; REGULATED GENES; REPORTER GENE; SECRETED ALKALINE PHOSPHATASE; STRUCTURAL DETERMINATION; TOLL-LIKE RECEPTORS;

CELLS; CHEMICAL DETECTION; CYTOLOGY; FACTOR ANALYSIS; GENES; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHATASES; PROPANE; PURIFICATION;

GLYCEROL;

ACYLGLYCEROL; ALKALINE PHOSPHATASE; AROMATASE; CD1D ANTIGEN; CD40 ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR2; CYCLOPROPANE; DIMYCOLYLDIARABINOGLYCEROL; HEME OXYGENASE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 8; MANGANESE SUPEROXIDE DISMUTASE; METALLOPROTEINASE; MYCOLIC ACID; NEUTRALIZING ANTIBODY; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PENTRAXIN 3; THIOREDOXIN REDUCTASE 1; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL WALL; CELL STRAIN HEK293; CYTOKINE RELEASE; ENZYME PURIFICATION; GENETIC REGULATION; GENETIC TRANSFECTION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; INFLAMMATION; LIPID COMPOSITION; MACROPHAGE; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MYCOBACTERIOSIS; MYCOBACTERIUM MARINUM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RECEPTOR UPREGULATION; REPORTER GENE;

ANTIGENS, CD40; CYTOKINES; GLYCOLIPIDS; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; MACROPHAGES; MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS; MYCOBACTERIUM MARINUM; TOLL-LIKE RECEPTOR 2;

EID: 84867277251     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.378083     Document Type: Article

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