A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone

Journal of Biological Chemistry

Volumn 287, Issue 46, 2012, Pages 38434-38441

  Grzegorzewicz, Anna E ^a   Korduláková, Jana ^b   Jones, Victoria ^a   Born, Sarah E M ^a   Belardinelli, Juan M ^c   Vaquié, Adrien ^a   Gundi, Vijay A K B ^a   Madacki, Jan ^b   Slama, Nawel ^d,e   Laval, Françoise ^d,e   Vaubourgeix, Julien ^d,e,g   Crew, Rebecca M ^a   Gicquel, Brigitte ^f   Daffé, Mamadou ^d,e   Morbidoni, Hector R ^c   Brennan, Patrick J ^a   Quémard, Annaik ^d,e   McNeil, Michael R ^a   Jackson, Mary ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b Physics and Informatics   (Slovakia)

^c FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^d INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^e UNIVERSITÉ PAUL SABATIER   (France)

^f INSTITUT PASTEUR   (France)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHETIC PATHWAY; CARRIER PROTEINS; CLINICAL TREATMENTS; GENES ENCODING; M. TUBERCULOSIS; METHYLTRANSFERASES; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACID BIOSYNTHESIS; MYCOLIC ACIDS; OVER-EXPRESSION; PRODRUGS; SYNTHASES; TYPE II;

BIOCHEMISTRY; BIOSYNTHESIS; FATTY ACIDS; GENES;

TUBES (COMPONENTS);

BACTERIAL ENZYME; FATTY ACID SYNTHASE; HADA PROTEIN; HADB PROTEIN; HADC PROTEIN; METHYLTRANSFERASE; MMAA2 PROTEIN; MMAA4 PROTEIN; MYCOLIC ACID; THIOACETAZONE; TIOCARLIDE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DRUG STRUCTURE; FATTY ACID SYNTHESIS; GENE OVEREXPRESSION; HADA GENE; HADB GENE; HADC GENE; MISSENSE MUTATION; MMAA2 GENE; MMAA4 GENE; MUTATOR GENE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ALLELES; ANTITUBERCULAR AGENTS; CELL WALL; CHROMATOGRAPHY, LIQUID; FATTY ACID SYNTHETASE COMPLEX; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENOME, BACTERIAL; LIPIDS; MASS SPECTROMETRY; MODELS, CHEMICAL; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; PHENYLTHIOUREA; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; THIOACETAZONE; TIME FACTORS;

MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS;

EID: 84869029377     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.400994     Document Type: Article

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