Phosphorylation of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis

Journal of Biological Chemistry

Volumn 285, Issue 17, 2010, Pages 12714-12725

  Veyron Churlet, Romain ^a   Zanella Cléon, Isabelle ^b   Cohen Gonsaud, Martin ^c,d   Molle, Virginie ^b   Kremer, Laurent ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b UNIVERSITÉ LYON 1   (France)

^c INSERM   (France)

^d CENTRE DE BIOCHIMIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOLOGY; BIOCHEMISTRY; BIOSYNTHESIS; ENZYME ACTIVITY; FLUORESCENCE SPECTROSCOPY; MASS SPECTROMETRY; PHOSPHORYLATION; TUBES (COMPONENTS);

CONDITIONAL EXPRESSIONS; ENVIRONMENTAL CONDITIONS; MASS SPECTROMETRIC ANALYSIS; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACID BIOSYNTHESIS; POST-TRANSLATIONAL MODIFICATIONS; SER/THR PROTEIN KINASE; SITE DIRECTED MUTAGENESIS;

FATTY ACIDS;

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; MABA PROTEIN; MYCOLIC ACID; PHOSPHOTHREONINE; PKNB PROTEIN; PROTEIN SERINE THREONINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FATTY ACID SYNTHESIS; LIQUID CHROMATOGRAPHY; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS;

CORYNEBACTERINEAE; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS;

EID: 77951212397     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.105189     Document Type: Article

References (59)

1. Frieden, T. R., Sterling, T. R., Munsiff, S. S., Watt, C. J., and Dye, C. (2003) Lancet 362, 887-899
2. Flynn, J. L., and Chan, J. (2003) Curr. Opin. Immunol. 15, 450-455
3. Daffé, M., and Draper, P. (1998) Adv. Microb. Physiol. 39, 131-203
4. Kremer, L., Baulard, A. R., and Besra, G. S. (2000) in Molecular Genetics of Mycobacteria (Hatfull, G. F., and Jacobs, W. R., Jr., eds) pp. 173-190, ASM Press, Washington, DC
5. Takayama, K., Wang, C., and Besra, G. S. (2005) Clin. Microbiol. Rev. 18, 81-101
6. Ojha, A. K., Baughn, A. D., Sambandan, D., Hsu, T., Trivelli, X., Guerardel, Y., Alahari, A., Kremer, L., Jacobs, W. R., Jr., and Hatfull, G. F. (2008) Mol. Microbiol. 69, 164-174
7. Brennan, P. J., and Nikaido, H. (1995) Annu. Rev. Biochem. 64, 29-63
8. Bhatt, A., Molle, V., Besra, G. S., Jacobs, W. R., Jr., and Kremer, L. (2007) Mol. Microbiol. 64, 1442-1454
9. Dubnau, E., Chan, J., Raynaud, C., Mohan, V. P., Lanéelle, M. A., Yu, K., Quémard, A., Smith, I., and Daffé, M. (2000) Mol. Microbiol. 36, 630-637
10. Glickman, M. S., Cox, J. S., and Jacobs, W. R., Jr. (2000) Mol. Cell 5, 717-727
11. Rao, V., Gao, F., Chen, B., Jacobs, W. R., Jr., and Glickman, M. S. (2006) J. Clin. Invest. 116, 1660-1667
12. Dao, D. N., Sweeney, K., Hsu, T., Gurcha, S. S., Nascimento, I. P., Roshevsky, D., Besra, G. S., Chan, J., Porcelli, S. A., and Jacobs, W. R. (2008) PLoS Pathog. 4, e1000081
13. Bhatt, A., Fujiwara, N., Bhatt, K., Gurcha, S. S., Kremer, L., Chen, B., Chan, J., Porcelli, S. A., Kobayashi, K., Besra, G. S., and Jacobs, W. R., Jr. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 5157-5162
14. Zimhony, O., Vilchèze, C., and Jacobs, W. R., Jr. (2004) J. Bacteriol. 186, 4051-4055
15. Bloch, K. (1975) Methods Enzymol. 35, 84-90
16. Choi, K. H., Kremer, L., Besra, G. S., and Rock, C. O. (2000) J. Biol. Chem. 275, 28201-28207
17. Scarsdale, J. N., Kazanina, G., He, X., Reynolds, K. A., and Wright, H. T. (2001) J. Biol. Chem. 276, 20516-20522
18. Brown, A. K., Sridharan, S., Kremer, L., Lindenberg, S., Dover, L. G., Sacchettini, J. C., and Besra, G. S. (2005) J. Biol. Chem. 280, 32539-32547
19. Banerjee, A., Sugantino, M., Sacchettini, J. C., and Jacobs, W. R., Jr. (1998) Microbiology 144, 2697-2704
20. Marrakchi, H., Ducasse, S., Labesse, G., Montrozier, H., Margeat, E., Emorine, L., Charpentier, X., Daffé, M., and Quémard, A. (2002) Microbiology 148, 951-960
21. Brown, A. K., Bhatt, A., Singh, A., Saparia, E., Evans, A. F., and Besra, G. S. (2007) Microbiology 153, 4166-4173
22. Sacco, E., Covarrubias, A. S., O'Hare, H. M., Carroll, P., Eynard, N., Jones, T. A., Parish, T., Daffé, M., Bäckbro, K., and Quémard, A. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 14628-14633
23. Vilchèze, C., Wang, F., Arai, M., Hazbón, M. H., Colangeli, R., Kremer, L., Weisbrod, T. R., Alland, D., Sacchettini, J. C., and Jacobs, W. R., Jr. (2006) Nat. Med. 12, 1027-1029
24. Schaeffer, M. L., Agnihotri, G., Volker, C., Kallender, H., Brennan, P. J., and Lonsdale, J. T. (2001) J. Biol. Chem. 276, 47029-47037
25. Kremer, L., Dover, L. G., Carrère, S., Nampoothiri, K. M., Lesjean, S., Brown, A. K., Brennan, P. J., Minnikin, D. E., Locht, C., and Besra, G. S. (2002) Biochem. J. 364, 423-430
26. Molle, V., Brown, A. K., Besra, G. S., Cozzone, A. J., and Kremer, L. (2006) J. Biol. Chem. 281, 30094-30103
27. Stock, J. B., Ninfa, A. J., and Stock, A. M. (1989) Microbiol. Rev. 53, 450-490
28. Wehenkel, A., Bellinzoni, M., Graña, M., Duran, R., Villarino, A., Fernandez, P., Andre-Leroux, G., England, P., Takiff, H., Cerveñansky, C., Cole, S. T., and Alzari, P. M. (2008) Biochim. Biophys. Acta 1784, 193-202
29. Walburger, A., Koul, A., Ferrari, G., Nguyen, L., Prescianotto-Baschong, C., Huygen, K., Klebl, B., Thompson, C., Bacher, G., and Pieters, J. (2004) Science 304, 1800-1804
30. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., 3rd, Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M. A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S., and Barrell, B. G. (1998) Nature 393, 537-544
31. Av-Gay, Y., and Everett, M. (2000) Trends Microbiol. 8, 238-244
32. Veyron-Churlet, R., Molle, V., Taylor, R. C., Brown, A. K., Besra, G. S., Zanella-Cléon, I., Fütterer, K., and Kremer, L. (2009) J. Biol. Chem. 284, 6414-6424
33. Canova, M. J., Kremer, L., and Molle, V. (2008) Plasmid 60, 149-153
34. Molle, V., Kremer, L., Girard-Blanc, C., Besra, G. S., Cozzone, A. J., and Prost, J. F. (2003) Biochemistry 42, 15300-15309
35. Fiuza, M., Canova, M. J., Zanella-Cléon, I., Becchi, M., Cozzone, A. J., Mateos, L. M., Kremer, L., Gil, J. A., and Molle, V. (2008) J. Biol. Chem. 283, 18099-18112
36. Böhm, G., Muhr, R., and Jaenicke, R. (1992) Protein Eng. 5, 191-195
37. Daugelat, S., Kowall, J., Mattow, J., Bumann, D., Winter, R., Hurwitz, R., and Kaufmann, S. H. (2003) Microbes Infect. 5, 1082-1095
38. Kremer, L., Dover, L. G., Morbidoni, H. R., Vilchèze, C., Maughan, W. N., Baulard, A., Tu, S. C., Honoré, N., Deretic, V., Sacchettini, J. C., Locht, C., Jacobs, W. R., Jr., and Besra, G. S. (2003) J. Biol. Chem. 278, 20547-20554
39. Canova, M. J., Kremer, L., and Molle, V. (2009) J. Bacteriol. 191, 2876-2883
40. Oppermann, U., Filling, C., Hult, M., Shafqat, N., Wu, X., Lindh, M., Shafqat, J., Nordling, E., Kallberg, Y., Persson, B., and Jörnvall, H. (2003) Chem. Biol. Interact. 143-144, 247-253
41. Cohen-Gonsaud, M., Ducasse, S., Hoh, F., Zerbib, D., Labesse, G., and Quemard, A. (2002) J. Mol. Biol. 320, 249-261
42. Oppermann, U. C., Filling, C., and Jörnvall, H. (2001) Chem. Biol. Interact. 130-132, 699-705
43. Filling, C., Berndt, K. D., Benach, J., Knapp, S., Prozorovski, T., Nordling, E., Ladenstein, R., Jörnvall, H., and Oppermann, U. (2002) J. Biol. Chem. 277, 25677-25684
44. Cohen-Gonsaud, M., Ducasse-Cabanot, S., Quemard, A., and Labesse, G. (2005) Proteins 60, 392-400
45. Kang, C. M., Nyayapathy, S., Lee, J. Y., Suh, J. W., and Husson, R. N. (2008) Microbiology 154, 725-735
46. Singh, A., Gupta, R., Vishwakarma, R. A., Narayanan, P. R., Paramasivan, C. N., Ramanathan, V. D., and Tyagi, A. K. (2005) J. Bacteriol. 187, 4173-4186
47. Gupta, M., Sajid, A., Arora, G., Tandon, V., and Singh, Y. (2009) J. Biol. Chem. 284, 34723-34734
48. Kumar, P., Kumar, D., Parikh, A., Rananaware, D., Gupta, M., Singh, Y., and Nandicoori, V. K. (2009) J. Biol. Chem. 284, 11090-11099
49. Sharma, K., Gupta, M., Pathak, M., Gupta, N., Koul, A., Sarangi, S., Baweja, R., and Singh, Y. (2006) J. Bacteriol. 188, 2936-2944
50. Dasgupta, A., Datta, P., Kundu, M., and Basu, J. (2006) Microbiology 152, 493-504
51. Kang, C. M., Abbott, D. W., Park, S. T., Dascher, C. C., Cantley, L. C., and Husson, R. N. (2005) Genes Dev. 19, 1692-1704
52. Parikh, A., Verma, S. K., Khan, S., Prakash, B., and Nandicoori, V. K. (2009) J. Mol. Biol. 386, 451-464
53. Thakur, M., and Chakraborti, P. K. (2006) J. Biol. Chem. 281, 40107-40113
54. Thakur, M., and Chakraborti, P. K. (2008) Biochem. J. 415, 27-33
55. Molle, V., and Kremer, L. (2010) Mol. Microbiol. 75, 1064-1077
56. Parish, T., Roberts, G., Laval, F., Schaeffer, M., Daffé, M., and Duncan, K. (2007) J. Bacteriol. 189, 3721-3728
57. Veyron-Churlet, R., Guerrini, O., Mourey, L., Daffé, M., and Zerbib, D. (2004) Mol. Microbiol. 54, 1161-1172
58. Grundner, C., Gay, L. M., and Alber, T. (2005) Protein Sci. 14, 1918-1921
59. Molle, V., Reynolds, R. C., Alderwick, L. J., Besra, G. S., Cozzone, A. J., Fütterer, K., and Kremer, L. (2008) Biochem. J. 410, 309-317