-
1
-
-
0028156861
-
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
-
Banerjee, A., Dubnau, E., Quernard, A., Balasubramanian, V., Um, K. S., Wilson, T., Collins, D., de Lisle, G. & Jacobs, W. R., Jr (1994). inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263, 227-230.
-
(1994)
Science
, vol.263
, pp. 227-230
-
-
Banerjee, A.1
Dubnau, E.2
Quernard, A.3
Balasubramanian, V.4
Um, K.S.5
Wilson, T.6
Collins, D.7
de Lisle, G.8
Jacobs Jr, W.R.9
-
2
-
-
0031733687
-
The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance
-
Banerjee, A., Sugantino, M., Sacchettini, J. C. & Jacobs, W. R., Jr (1998). The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance. Microbiology 144, 2697-2704.
-
(1998)
Microbiology
, vol.144
, pp. 2697-2704
-
-
Banerjee, A.1
Sugantino, M.2
Sacchettini, J.C.3
Jacobs Jr, W.R.4
-
3
-
-
0036774617
-
Specialized transduction: An efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis
-
Bardarov, S., Bardarov, S., Pavelka, M. S., Sambandamurthy, V., Larsen, M., Tufariello, J., Chan, J., Hatfull, G. & Jacobs, W. R. (2002). Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. Microbiology 148, 3007-3017.
-
(2002)
Microbiology
, vol.148
, pp. 3007-3017
-
-
Bardarov, S.1
Bardarov, S.2
Pavelka, M.S.3
Sambandamurthy, V.4
Larsen, M.5
Tufariello, J.6
Chan, J.7
Hatfull, G.8
Jacobs, W.R.9
-
4
-
-
27744492218
-
Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis
-
Bhatt, A., Kremer, L., Dai, A. Z., Sacchettini, J. C. & Jacobs, W. R., Jr (2005). Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis. J Bacteriol 187, 7596-7606.
-
(2005)
J Bacteriol
, vol.187
, pp. 7596-7606
-
-
Bhatt, A.1
Kremer, L.2
Dai, A.Z.3
Sacchettini, J.C.4
Jacobs Jr, W.R.5
-
6
-
-
25444463559
-
Probing the mechanism of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase III mtFabH: Factors influencing catalysis and substrate specificity
-
Brown, A. K., Sridharan, S., Kremer, L., Lindenberg, S., Dover, L. G., Sacchettini, J. C. & Besra, G. S. (2005). Probing the mechanism of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity. J Biol Chem 280, 32539-32547.
-
(2005)
J Biol Chem
, vol.280
, pp. 32539-32547
-
-
Brown, A.K.1
Sridharan, S.2
Kremer, L.3
Lindenberg, S.4
Dover, L.G.5
Sacchettini, J.C.6
Besra, G.S.7
-
7
-
-
35448944356
-
Flavonoid inhibition as novel anti-mycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase-II
-
Brown, A. K., Papaemmanoul, A., Bhowruth, V., Bhatt, A., Dover, L. G. & Besra, G. S. (2007). Flavonoid inhibition as novel anti-mycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase-II. Microbiology 153, 3314-3322.
-
(2007)
Microbiology
, vol.153
, pp. 3314-3322
-
-
Brown, A.K.1
Papaemmanoul, A.2
Bhowruth, V.3
Bhatt, A.4
Dover, L.G.5
Besra, G.S.6
-
8
-
-
22244455775
-
Rv0216, a conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdog fold
-
Castell, A., Johansson, P., Unge, T., Jones, T. A. & Backbro, K. (2005). Rv0216, a conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdog fold. Protein Sci 14, 1850-1862.
-
(2005)
Protein Sci
, vol.14
, pp. 1850-1862
-
-
Castell, A.1
Johansson, P.2
Unge, T.3
Jones, T.A.4
Backbro, K.5
-
9
-
-
0032508046
-
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
-
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S. & other authors (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544.
-
(1998)
Nature
, vol.393
, pp. 537-544
-
-
Cole, S.T.1
Brosch, R.2
Parkhill, J.3
Garnier, T.4
Churcher, C.5
Harris, D.6
Gordon, S.V.7
Eiglmeier, K.8
Gas, S.9
-
10
-
-
0141861069
-
The RD1 proteins of Mycobacterium tuberculosis: Expression in Mycobacterium smegmatis and biochemical characterization
-
Daugelat, S., Kowall, J., Mattow, J., Bumann, D., Winter, R., Hurwitz, R. & Kaufmann, S. H. (2003). The RD1 proteins of Mycobacterium tuberculosis: expression in Mycobacterium smegmatis and biochemical characterization. Microbes Infect 5, 1082-1095.
-
(2003)
Microbes Infect
, vol.5
, pp. 1082-1095
-
-
Daugelat, S.1
Kowall, J.2
Mattow, J.3
Bumann, D.4
Winter, R.5
Hurwitz, R.6
Kaufmann, S.H.7
-
11
-
-
1942421808
-
Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae
-
Dover, L. G., Cerdeno-Tarraga, A. M., Pallen, M. J., Parkhill, J. & Besra, G. S. (2004). Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae. FEMS Microbial Rev 28, 225-250.
-
(2004)
FEMS Microbial Rev
, vol.28
, pp. 225-250
-
-
Dover, L.G.1
Cerdeno-Tarraga, A.M.2
Pallen, M.J.3
Parkhill, J.4
Besra, G.S.5
-
12
-
-
33644991496
-
Global epidemiology of tuberculosis
-
Dye, C. (2006). Global epidemiology of tuberculosis. Lancet 367, 938-940.
-
(2006)
Lancet
, vol.367
, pp. 938-940
-
-
Dye, C.1
-
13
-
-
7244242397
-
Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis
-
Gande, R., Gibson, K. J., Brown, A. K., Krumbach, K., Dover, L. G., Sahm, H., Shioyama, S., Oikawa, T., Besra, G. S. & Eggeling, L. (2004). Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. J Biol Chem 279, 44847-44857.
-
(2004)
J Biol Chem
, vol.279
, pp. 44847-44857
-
-
Gande, R.1
Gibson, K.J.2
Brown, A.K.3
Krumbach, K.4
Dover, L.G.5
Sahm, H.6
Shioyama, S.7
Oikawa, T.8
Besra, G.S.9
Eggeling, L.10
-
14
-
-
0029807273
-
Tuberculosis control: The relevance of classic principles in an era of acquired immunodeficiency syndrome and multidrug resistance
-
Kaye, K. & Frieden, T. R. (1996). Tuberculosis control: the relevance of classic principles in an era of acquired immunodeficiency syndrome and multidrug resistance. Epidemiol Rev 18, 52-63.
-
(1996)
Epidemiol Rev
, vol.18
, pp. 52-63
-
-
Kaye, K.1
Frieden, T.R.2
-
15
-
-
0021498897
-
Purification of NADPH-dependent enoyl-CoA reductase involved in the malonyl-CoA dependent fatty acid elongation system of Mycobacterium smegmatis
-
Kikuchi, S. & Kusaka, T. (1984). Purification of NADPH-dependent enoyl-CoA reductase involved in the malonyl-CoA dependent fatty acid elongation system of Mycobacterium smegmatis. J Biochem (Tokyo) 96, 841-848.
-
(1984)
J Biochem (Tokyo)
, vol.96
, pp. 841-848
-
-
Kikuchi, S.1
Kusaka, T.2
-
16
-
-
0034595879
-
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis
-
Kremer, L., Douglas, J. D., Baulard, A. R., Morehouse, C., Guy, M. R., Alland, D., Dover, L. G., Lakey, J. H., Jacobs, W. R., Jr & other authors (2000). Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis. J Biol Chem 275, 16857-16864.
-
(2000)
J Biol Chem
, vol.275
, pp. 16857-16864
-
-
Kremer, L.1
Douglas, J.D.2
Baulard, A.R.3
Morehouse, C.4
Guy, M.R.5
Alland, D.6
Dover, L.G.7
Lakey, J.H.8
Jacobs Jr, W.R.9
-
17
-
-
0035958944
-
Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA: AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II
-
Kremer, L., Nampoothiri, K. M., Lesjean, S., Dover, L. G., Graham, S., Betts, J., Brennan, P. J., Minnikin, D. E., Locht, C. & Besra, G. S. (2001). Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA: AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II. J Biol Chem 276, 27967-27974.
-
(2001)
J Biol Chem
, vol.276
, pp. 27967-27974
-
-
Kremer, L.1
Nampoothiri, K.M.2
Lesjean, S.3
Dover, L.G.4
Graham, S.5
Betts, J.6
Brennan, P.J.7
Minnikin, D.E.8
Locht, C.9
Besra, G.S.10
-
18
-
-
34249675745
-
The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan
-
Lea-Smith, D. J., Pyke, J. S., Tull, D., McConville, M. J., Coppel, R. L. & Crellin, P. K. (2007). The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan. J Biol Chem 282, 11000-11008.
-
(2007)
J Biol Chem
, vol.282
, pp. 11000-11008
-
-
Lea-Smith, D.J.1
Pyke, J.S.2
Tull, D.3
McConville, M.J.4
Coppel, R.L.5
Crellin, P.K.6
-
19
-
-
0027417563
-
Cloning and sequencing of the gene which encodes the highly inducible acetamidase of Mycobacterium smegmatis
-
Mahenthiralingam, E., Draper, P., Davis, E. O. & Colston, M. J. (1993). Cloning and sequencing of the gene which encodes the highly inducible acetamidase of Mycobacterium smegmatis. J Gen Microbiol 139, 575-583.
-
(1993)
J Gen Microbiol
, vol.139
, pp. 575-583
-
-
Mahenthiralingam, E.1
Draper, P.2
Davis, E.O.3
Colston, M.J.4
-
20
-
-
0032486197
-
Inhibition of a Mycobacterium tuberculosis β-ketoacyl ACP synthase by isoniazid
-
Mdluli, K., Slayden, R. A., Zhu, Y., Ramaswamy, S., Pan, X., Mead, D., Crane, D. D., Musser, J. M. & Barry, C. E., III (1998). Inhibition of a Mycobacterium tuberculosis β-ketoacyl ACP synthase by isoniazid. Science 280, 1607-1610.
-
(1998)
Science
, vol.280
, pp. 1607-1610
-
-
Mdluli, K.1
Slayden, R.A.2
Zhu, Y.3
Ramaswamy, S.4
Pan, X.5
Mead, D.6
Crane, D.D.7
Musser, J.M.8
Barry III, C.E.9
-
21
-
-
0002259015
-
Lipids: Complex lipids, their chemistry, biosynthesis and roles
-
Edited by C. Ratledge & J. Stanford. London, UK: Academic Press
-
Minnikin, D. E. (1982). Lipids: complex lipids, their chemistry, biosynthesis and roles. In The Biology of the Mycobacteria: Physiology, Identification and Classification. Edited by C. Ratledge & J. Stanford. London, UK: Academic Press.
-
(1982)
The Biology of the Mycobacteria: Physiology, Identification and Classification
-
-
Minnikin, D.E.1
-
22
-
-
2342418470
-
Tuberculosis in New York city: Recent lessons and a look ahead
-
Paolo, W. F., Jr & Nosanchuk, J. D. (2004). Tuberculosis in New York city: recent lessons and a look ahead. Lancet Infect Dis 4, 287-293.
-
(2004)
Lancet Infect Dis
, vol.4
, pp. 287-293
-
-
Paolo Jr, W.F.1
Nosanchuk, J.D.2
-
23
-
-
34248364296
-
Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but
-
Parish, T., Roberts, G., Laval, F., Schaeffer, M., Daffe, M. & Duncan, K. (2007). Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG. J Bacteriol 189, 3721-3728.
-
(2007)
Escherichia coli fabG. J Bacteriol
, vol.189
, pp. 3721-3728
-
-
Parish, T.1
Roberts, G.2
Laval, F.3
Schaeffer, M.4
Daffe, M.5
Duncan, K.6
-
24
-
-
0347719360
-
A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms
-
Portevin, D., De Sousa-D'Auria, C., Houssin, C., Grimaldi, C., Chami, M., Daffe, M. & Guilhot C. (2004). A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms. Proc Natl Acad Sci U S A 101, 314-319.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 314-319
-
-
Portevin, D.1
De Sousa-D'Auria, C.2
Houssin, C.3
Grimaldi, C.4
Chami, M.5
Daffe, M.6
Guilhot, C.7
-
25
-
-
15744389881
-
The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: Identification of the carboxylation product and determination of the acyl-CoA carboxylase components
-
Portevin, D., de Sousa-D'Auria, C., Montrozier, H., Houssin, C., Stella, A., Laneelle, M. A., Bardou, F., Guilhot C. & Daffe, M. (2005). The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components. J Biol Chem 280, 8862-8874.
-
(2005)
J Biol Chem
, vol.280
, pp. 8862-8874
-
-
Portevin, D.1
de Sousa-D'Auria, C.2
Montrozier, H.3
Houssin, C.4
Stella, A.5
Laneelle, M.A.6
Bardou, F.7
Guilhot, C.8
Daffe, M.9
-
26
-
-
0034681451
-
Human peroxisomal multifunctional enzyme type 2. Site-directed mutagenesis studies show the importance of two protic residues for 2-enoyl-CoA hydratase 2 activity
-
Qin, Y. M., Haapalainen, A. M., Kilpelainen, S. H., Marttila, M. S., Koski, M. K., Glumoff, T., Novikov, D. K. & Hiltunen, J. K. (2000). Human peroxisomal multifunctional enzyme type 2. Site-directed mutagenesis studies show the importance of two protic residues for 2-enoyl-CoA hydratase 2 activity. J Biol Chem 275, 4965-4972.
-
(2000)
J Biol Chem
, vol.275
, pp. 4965-4972
-
-
Qin, Y.M.1
Haapalainen, A.M.2
Kilpelainen, S.H.3
Marttila, M.S.4
Koski, M.K.5
Glumoff, T.6
Novikov, D.K.7
Hiltunen, J.K.8
-
28
-
-
0345701347
-
Genes required for mycobacterial growth defined by high density mutagenesis
-
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003). Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48, 77-84.
-
(2003)
Mol Microbiol
, vol.48
, pp. 77-84
-
-
Sassetti, C.M.1
Boyd, D.H.2
Rubin, E.J.3
-
29
-
-
0035861550
-
Purification and biochemical characterization of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthases KasA and KasB
-
Schaeffer, M. L., Agnihotri, G., Volker, C., Kallender, H., Brennan, P. J. & Lonsdale, J. T. (2001). Purification and biochemical characterization of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthases KasA and KasB. J Biol Chem 276, 47029-47037.
-
(2001)
J Biol Chem
, vol.276
, pp. 47029-47037
-
-
Schaeffer, M.L.1
Agnihotri, G.2
Volker, C.3
Kallender, H.4
Brennan, P.J.5
Lonsdale, J.T.6
-
30
-
-
0036020524
-
Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis
-
Schroeder, E. K., de Souza, N., Santos, D. S., Blanchard, J. S. & Basso, L. A. (2002). Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis. Curr Pharm Biotechnol 3, 197-225.
-
(2002)
Curr Pharm Biotechnol
, vol.3
, pp. 197-225
-
-
Schroeder, E.K.1
de Souza, N.2
Santos, D.S.3
Blanchard, J.S.4
Basso, L.A.5
-
31
-
-
0037411269
-
Structural and functional organization of the animal fatty acid synthase
-
Smith, S., Witkowski, A. & Joshi, A. K. (2003). Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res 42, 289-317.
-
(2003)
Prog Lipid Res
, vol.42
, pp. 289-317
-
-
Smith, S.1
Witkowski, A.2
Joshi, A.K.3
-
32
-
-
0025081151
-
Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis
-
Snapper, S. B., Melton, R. E., Mustafa, S., Kieser, T. & Jacobs, W. R., Jr (1990). Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol Microbiol 4, 1911-1919.
-
(1990)
Mol Microbiol
, vol.4
, pp. 1911-1919
-
-
Snapper, S.B.1
Melton, R.E.2
Mustafa, S.3
Kieser, T.4
Jacobs Jr, W.R.5
-
33
-
-
0025922291
-
-
Stover, C. K., de la Cruz, V. F., Fuerst, T. R., Burlein, J. E., Benson, L. A., Bennett, L. T., Bansal, G. P., Young, J. F., Lee, M. H. & other authors (1991). New use of BCG for recombinant vaccines. Nature 351, 456-460.
-
Stover, C. K., de la Cruz, V. F., Fuerst, T. R., Burlein, J. E., Benson, L. A., Bennett, L. T., Bansal, G. P., Young, J. F., Lee, M. H. & other authors (1991). New use of BCG for recombinant vaccines. Nature 351, 456-460.
-
-
-
-
34
-
-
12844278679
-
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis
-
Takayama, K., Wang, C. & Basra, G. S. (2005). Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin Microbiol Rev 18, 81-101.
-
(2005)
Clin Microbiol Rev
, vol.18
, pp. 81-101
-
-
Takayama, K.1
Wang, C.2
Basra, G.S.3
-
35
-
-
0038410325
-
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis
-
Vilcheze, C., Morbidoni, H. R., Welsbrod, T. R., Iwamoto, H., Kuo, M., Sacchettini, J. C. & Jacobs, W. R., Jr (2000). Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis. J Bacteriol 182, 4059-4067.
-
(2000)
J Bacteriol
, vol.182
, pp. 4059-4067
-
-
Vilcheze, C.1
Morbidoni, H.R.2
Welsbrod, T.R.3
Iwamoto, H.4
Kuo, M.5
Sacchettini, J.C.6
Jacobs Jr, W.R.7
-
36
-
-
33645119729
-
Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs-worldwide, 2000-2004
-
Wright, A., Bai, G., Barrera, L., Boulahbal, F., Martin-Casabona, N., Gilpin, C., Drobniewski, F., Havelková, M., Lepe, R. & other authors (2006). Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs-worldwide, 2000-2004. MMWR Morb Mortal Wkly Rep 55, 301-305.
-
(2006)
MMWR Morb Mortal Wkly Rep
, vol.55
, pp. 301-305
-
-
Wright, A.1
Bai, G.2
Barrera, L.3
Boulahbal, F.4
Martin-Casabona, N.5
Gilpin, C.6
Drobniewski, F.7
Havelková, M.8
Lepe, R.9
|