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Volumn 153, Issue 12, 2007, Pages 4166-4173

Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; CARRIER PROTEIN; DIHYDROXYACETONE SYNTHETASE; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE 2 BETA HYDROXYL ACYL ACP DEHYDRATASE; HYDROLASE; ISONIAZID; MYCOLIC ACID; SYNTHETASE; THIOLACTOMYCIN; UNCLASSIFIED DRUG;

EID: 37449032052     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2007/012419-0     Document Type: Article
Times cited : (48)

References (36)
  • 2
    • 0031733687 scopus 로고    scopus 로고
    • The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance
    • Banerjee, A., Sugantino, M., Sacchettini, J. C. & Jacobs, W. R., Jr (1998). The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance. Microbiology 144, 2697-2704.
    • (1998) Microbiology , vol.144 , pp. 2697-2704
    • Banerjee, A.1    Sugantino, M.2    Sacchettini, J.C.3    Jacobs Jr, W.R.4
  • 3
    • 0036774617 scopus 로고    scopus 로고
    • Specialized transduction: An efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis
    • Bardarov, S., Bardarov, S., Pavelka, M. S., Sambandamurthy, V., Larsen, M., Tufariello, J., Chan, J., Hatfull, G. & Jacobs, W. R. (2002). Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. Microbiology 148, 3007-3017.
    • (2002) Microbiology , vol.148 , pp. 3007-3017
    • Bardarov, S.1    Bardarov, S.2    Pavelka, M.S.3    Sambandamurthy, V.4    Larsen, M.5    Tufariello, J.6    Chan, J.7    Hatfull, G.8    Jacobs, W.R.9
  • 4
    • 27744492218 scopus 로고    scopus 로고
    • Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis
    • Bhatt, A., Kremer, L., Dai, A. Z., Sacchettini, J. C. & Jacobs, W. R., Jr (2005). Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis. J Bacteriol 187, 7596-7606.
    • (2005) J Bacteriol , vol.187 , pp. 7596-7606
    • Bhatt, A.1    Kremer, L.2    Dai, A.Z.3    Sacchettini, J.C.4    Jacobs Jr, W.R.5
  • 5
  • 6
    • 25444463559 scopus 로고    scopus 로고
    • Probing the mechanism of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase III mtFabH: Factors influencing catalysis and substrate specificity
    • Brown, A. K., Sridharan, S., Kremer, L., Lindenberg, S., Dover, L. G., Sacchettini, J. C. & Besra, G. S. (2005). Probing the mechanism of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity. J Biol Chem 280, 32539-32547.
    • (2005) J Biol Chem , vol.280 , pp. 32539-32547
    • Brown, A.K.1    Sridharan, S.2    Kremer, L.3    Lindenberg, S.4    Dover, L.G.5    Sacchettini, J.C.6    Besra, G.S.7
  • 7
    • 35448944356 scopus 로고    scopus 로고
    • Flavonoid inhibition as novel anti-mycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase-II
    • Brown, A. K., Papaemmanoul, A., Bhowruth, V., Bhatt, A., Dover, L. G. & Besra, G. S. (2007). Flavonoid inhibition as novel anti-mycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase-II. Microbiology 153, 3314-3322.
    • (2007) Microbiology , vol.153 , pp. 3314-3322
    • Brown, A.K.1    Papaemmanoul, A.2    Bhowruth, V.3    Bhatt, A.4    Dover, L.G.5    Besra, G.S.6
  • 8
    • 22244455775 scopus 로고    scopus 로고
    • Rv0216, a conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdog fold
    • Castell, A., Johansson, P., Unge, T., Jones, T. A. & Backbro, K. (2005). Rv0216, a conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdog fold. Protein Sci 14, 1850-1862.
    • (2005) Protein Sci , vol.14 , pp. 1850-1862
    • Castell, A.1    Johansson, P.2    Unge, T.3    Jones, T.A.4    Backbro, K.5
  • 10
    • 0141861069 scopus 로고    scopus 로고
    • The RD1 proteins of Mycobacterium tuberculosis: Expression in Mycobacterium smegmatis and biochemical characterization
    • Daugelat, S., Kowall, J., Mattow, J., Bumann, D., Winter, R., Hurwitz, R. & Kaufmann, S. H. (2003). The RD1 proteins of Mycobacterium tuberculosis: expression in Mycobacterium smegmatis and biochemical characterization. Microbes Infect 5, 1082-1095.
    • (2003) Microbes Infect , vol.5 , pp. 1082-1095
    • Daugelat, S.1    Kowall, J.2    Mattow, J.3    Bumann, D.4    Winter, R.5    Hurwitz, R.6    Kaufmann, S.H.7
  • 11
    • 1942421808 scopus 로고    scopus 로고
    • Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae
    • Dover, L. G., Cerdeno-Tarraga, A. M., Pallen, M. J., Parkhill, J. & Besra, G. S. (2004). Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae. FEMS Microbial Rev 28, 225-250.
    • (2004) FEMS Microbial Rev , vol.28 , pp. 225-250
    • Dover, L.G.1    Cerdeno-Tarraga, A.M.2    Pallen, M.J.3    Parkhill, J.4    Besra, G.S.5
  • 12
    • 33644991496 scopus 로고    scopus 로고
    • Global epidemiology of tuberculosis
    • Dye, C. (2006). Global epidemiology of tuberculosis. Lancet 367, 938-940.
    • (2006) Lancet , vol.367 , pp. 938-940
    • Dye, C.1
  • 13
    • 7244242397 scopus 로고    scopus 로고
    • Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis
    • Gande, R., Gibson, K. J., Brown, A. K., Krumbach, K., Dover, L. G., Sahm, H., Shioyama, S., Oikawa, T., Besra, G. S. & Eggeling, L. (2004). Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. J Biol Chem 279, 44847-44857.
    • (2004) J Biol Chem , vol.279 , pp. 44847-44857
    • Gande, R.1    Gibson, K.J.2    Brown, A.K.3    Krumbach, K.4    Dover, L.G.5    Sahm, H.6    Shioyama, S.7    Oikawa, T.8    Besra, G.S.9    Eggeling, L.10
  • 14
    • 0029807273 scopus 로고    scopus 로고
    • Tuberculosis control: The relevance of classic principles in an era of acquired immunodeficiency syndrome and multidrug resistance
    • Kaye, K. & Frieden, T. R. (1996). Tuberculosis control: the relevance of classic principles in an era of acquired immunodeficiency syndrome and multidrug resistance. Epidemiol Rev 18, 52-63.
    • (1996) Epidemiol Rev , vol.18 , pp. 52-63
    • Kaye, K.1    Frieden, T.R.2
  • 15
    • 0021498897 scopus 로고
    • Purification of NADPH-dependent enoyl-CoA reductase involved in the malonyl-CoA dependent fatty acid elongation system of Mycobacterium smegmatis
    • Kikuchi, S. & Kusaka, T. (1984). Purification of NADPH-dependent enoyl-CoA reductase involved in the malonyl-CoA dependent fatty acid elongation system of Mycobacterium smegmatis. J Biochem (Tokyo) 96, 841-848.
    • (1984) J Biochem (Tokyo) , vol.96 , pp. 841-848
    • Kikuchi, S.1    Kusaka, T.2
  • 16
    • 0034595879 scopus 로고    scopus 로고
    • Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis
    • Kremer, L., Douglas, J. D., Baulard, A. R., Morehouse, C., Guy, M. R., Alland, D., Dover, L. G., Lakey, J. H., Jacobs, W. R., Jr & other authors (2000). Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis. J Biol Chem 275, 16857-16864.
    • (2000) J Biol Chem , vol.275 , pp. 16857-16864
    • Kremer, L.1    Douglas, J.D.2    Baulard, A.R.3    Morehouse, C.4    Guy, M.R.5    Alland, D.6    Dover, L.G.7    Lakey, J.H.8    Jacobs Jr, W.R.9
  • 17
    • 0035958944 scopus 로고    scopus 로고
    • Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA: AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II
    • Kremer, L., Nampoothiri, K. M., Lesjean, S., Dover, L. G., Graham, S., Betts, J., Brennan, P. J., Minnikin, D. E., Locht, C. & Besra, G. S. (2001). Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA: AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II. J Biol Chem 276, 27967-27974.
    • (2001) J Biol Chem , vol.276 , pp. 27967-27974
    • Kremer, L.1    Nampoothiri, K.M.2    Lesjean, S.3    Dover, L.G.4    Graham, S.5    Betts, J.6    Brennan, P.J.7    Minnikin, D.E.8    Locht, C.9    Besra, G.S.10
  • 18
    • 34249675745 scopus 로고    scopus 로고
    • The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan
    • Lea-Smith, D. J., Pyke, J. S., Tull, D., McConville, M. J., Coppel, R. L. & Crellin, P. K. (2007). The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan. J Biol Chem 282, 11000-11008.
    • (2007) J Biol Chem , vol.282 , pp. 11000-11008
    • Lea-Smith, D.J.1    Pyke, J.S.2    Tull, D.3    McConville, M.J.4    Coppel, R.L.5    Crellin, P.K.6
  • 19
    • 0027417563 scopus 로고
    • Cloning and sequencing of the gene which encodes the highly inducible acetamidase of Mycobacterium smegmatis
    • Mahenthiralingam, E., Draper, P., Davis, E. O. & Colston, M. J. (1993). Cloning and sequencing of the gene which encodes the highly inducible acetamidase of Mycobacterium smegmatis. J Gen Microbiol 139, 575-583.
    • (1993) J Gen Microbiol , vol.139 , pp. 575-583
    • Mahenthiralingam, E.1    Draper, P.2    Davis, E.O.3    Colston, M.J.4
  • 21
    • 0002259015 scopus 로고
    • Lipids: Complex lipids, their chemistry, biosynthesis and roles
    • Edited by C. Ratledge & J. Stanford. London, UK: Academic Press
    • Minnikin, D. E. (1982). Lipids: complex lipids, their chemistry, biosynthesis and roles. In The Biology of the Mycobacteria: Physiology, Identification and Classification. Edited by C. Ratledge & J. Stanford. London, UK: Academic Press.
    • (1982) The Biology of the Mycobacteria: Physiology, Identification and Classification
    • Minnikin, D.E.1
  • 22
    • 2342418470 scopus 로고    scopus 로고
    • Tuberculosis in New York city: Recent lessons and a look ahead
    • Paolo, W. F., Jr & Nosanchuk, J. D. (2004). Tuberculosis in New York city: recent lessons and a look ahead. Lancet Infect Dis 4, 287-293.
    • (2004) Lancet Infect Dis , vol.4 , pp. 287-293
    • Paolo Jr, W.F.1    Nosanchuk, J.D.2
  • 23
    • 34248364296 scopus 로고    scopus 로고
    • Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but
    • Parish, T., Roberts, G., Laval, F., Schaeffer, M., Daffe, M. & Duncan, K. (2007). Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG. J Bacteriol 189, 3721-3728.
    • (2007) Escherichia coli fabG. J Bacteriol , vol.189 , pp. 3721-3728
    • Parish, T.1    Roberts, G.2    Laval, F.3    Schaeffer, M.4    Daffe, M.5    Duncan, K.6
  • 24
    • 0347719360 scopus 로고    scopus 로고
    • A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms
    • Portevin, D., De Sousa-D'Auria, C., Houssin, C., Grimaldi, C., Chami, M., Daffe, M. & Guilhot C. (2004). A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms. Proc Natl Acad Sci U S A 101, 314-319.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 314-319
    • Portevin, D.1    De Sousa-D'Auria, C.2    Houssin, C.3    Grimaldi, C.4    Chami, M.5    Daffe, M.6    Guilhot, C.7
  • 25
    • 15744389881 scopus 로고    scopus 로고
    • The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: Identification of the carboxylation product and determination of the acyl-CoA carboxylase components
    • Portevin, D., de Sousa-D'Auria, C., Montrozier, H., Houssin, C., Stella, A., Laneelle, M. A., Bardou, F., Guilhot C. & Daffe, M. (2005). The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components. J Biol Chem 280, 8862-8874.
    • (2005) J Biol Chem , vol.280 , pp. 8862-8874
    • Portevin, D.1    de Sousa-D'Auria, C.2    Montrozier, H.3    Houssin, C.4    Stella, A.5    Laneelle, M.A.6    Bardou, F.7    Guilhot, C.8    Daffe, M.9
  • 26
    • 0034681451 scopus 로고    scopus 로고
    • Human peroxisomal multifunctional enzyme type 2. Site-directed mutagenesis studies show the importance of two protic residues for 2-enoyl-CoA hydratase 2 activity
    • Qin, Y. M., Haapalainen, A. M., Kilpelainen, S. H., Marttila, M. S., Koski, M. K., Glumoff, T., Novikov, D. K. & Hiltunen, J. K. (2000). Human peroxisomal multifunctional enzyme type 2. Site-directed mutagenesis studies show the importance of two protic residues for 2-enoyl-CoA hydratase 2 activity. J Biol Chem 275, 4965-4972.
    • (2000) J Biol Chem , vol.275 , pp. 4965-4972
    • Qin, Y.M.1    Haapalainen, A.M.2    Kilpelainen, S.H.3    Marttila, M.S.4    Koski, M.K.5    Glumoff, T.6    Novikov, D.K.7    Hiltunen, J.K.8
  • 28
    • 0345701347 scopus 로고    scopus 로고
    • Genes required for mycobacterial growth defined by high density mutagenesis
    • Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003). Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48, 77-84.
    • (2003) Mol Microbiol , vol.48 , pp. 77-84
    • Sassetti, C.M.1    Boyd, D.H.2    Rubin, E.J.3
  • 29
    • 0035861550 scopus 로고    scopus 로고
    • Purification and biochemical characterization of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthases KasA and KasB
    • Schaeffer, M. L., Agnihotri, G., Volker, C., Kallender, H., Brennan, P. J. & Lonsdale, J. T. (2001). Purification and biochemical characterization of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthases KasA and KasB. J Biol Chem 276, 47029-47037.
    • (2001) J Biol Chem , vol.276 , pp. 47029-47037
    • Schaeffer, M.L.1    Agnihotri, G.2    Volker, C.3    Kallender, H.4    Brennan, P.J.5    Lonsdale, J.T.6
  • 31
    • 0037411269 scopus 로고    scopus 로고
    • Structural and functional organization of the animal fatty acid synthase
    • Smith, S., Witkowski, A. & Joshi, A. K. (2003). Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res 42, 289-317.
    • (2003) Prog Lipid Res , vol.42 , pp. 289-317
    • Smith, S.1    Witkowski, A.2    Joshi, A.K.3
  • 32
    • 0025081151 scopus 로고
    • Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis
    • Snapper, S. B., Melton, R. E., Mustafa, S., Kieser, T. & Jacobs, W. R., Jr (1990). Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol Microbiol 4, 1911-1919.
    • (1990) Mol Microbiol , vol.4 , pp. 1911-1919
    • Snapper, S.B.1    Melton, R.E.2    Mustafa, S.3    Kieser, T.4    Jacobs Jr, W.R.5
  • 33
    • 0025922291 scopus 로고    scopus 로고
    • Stover, C. K., de la Cruz, V. F., Fuerst, T. R., Burlein, J. E., Benson, L. A., Bennett, L. T., Bansal, G. P., Young, J. F., Lee, M. H. & other authors (1991). New use of BCG for recombinant vaccines. Nature 351, 456-460.
    • Stover, C. K., de la Cruz, V. F., Fuerst, T. R., Burlein, J. E., Benson, L. A., Bennett, L. T., Bansal, G. P., Young, J. F., Lee, M. H. & other authors (1991). New use of BCG for recombinant vaccines. Nature 351, 456-460.
  • 34
    • 12844278679 scopus 로고    scopus 로고
    • Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis
    • Takayama, K., Wang, C. & Basra, G. S. (2005). Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin Microbiol Rev 18, 81-101.
    • (2005) Clin Microbiol Rev , vol.18 , pp. 81-101
    • Takayama, K.1    Wang, C.2    Basra, G.S.3
  • 35
    • 0038410325 scopus 로고    scopus 로고
    • Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis
    • Vilcheze, C., Morbidoni, H. R., Welsbrod, T. R., Iwamoto, H., Kuo, M., Sacchettini, J. C. & Jacobs, W. R., Jr (2000). Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis. J Bacteriol 182, 4059-4067.
    • (2000) J Bacteriol , vol.182 , pp. 4059-4067
    • Vilcheze, C.1    Morbidoni, H.R.2    Welsbrod, T.R.3    Iwamoto, H.4    Kuo, M.5    Sacchettini, J.C.6    Jacobs Jr, W.R.7


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