The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis

Journal of Biological Chemistry

Volumn 284, Issue 29, 2009, Pages 19255-19264

  Gavalda, Sabine ^a,b   Léger, Mathieu ^a,b   van der Rest, Benoît ^a,b   Stella, Alexandre ^b,c   Bardou, Fabienne ^a,b   Montrozier, Henri ^a,b   Chalut, Christian ^a,b   Burlet Schiltz, Odile ^b,c   Marrakchi, Hedia ^a,b   Daffé, Mamadou ^a,b   Quémard, Annaïk ^a,b  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c Departement Biologie du Cancer   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEINS; ANTI-MYCOBACTERIAL; DRUG SCREENING; FATTY ACYL CHAINS; IN-VITRO; IN-VITRO ASSAYS; KETOACIDS; KETOSYNTHASE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; N-TERMINAL; POLYKETIDE SYNTHASE; RADIOLABELING; STRATEGIC TOOL; TRYPTIC DIGESTS;

ACIDS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CHROMATOGRAPHIC ANALYSIS; ENZYMES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLANTS (BOTANY); STRATEGIC PLANNING;

CLUSTERING ALGORITHMS;

ACYL CARRIER PROTEIN; ADENOSINE PHOSPHATE; BACTERIAL PROTEIN; MYCOLIC ACID; POLYKETIDE SYNTHASE 13; PROTEIN FADD32; SERINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME PURIFICATION; ENZYME SUBSTRATE; FATTY ACID SYNTHESIS; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ACYL CARRIER PROTEIN; BACTERIAL PROTEINS; BINDING SITES; BIOSYNTHETIC PATHWAYS; CHROMATOGRAPHY, LIQUID; COENZYME A LIGASES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; PEPTIDE FRAGMENTS; POLYKETIDE SYNTHASES; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY;

MYCOBACTERIUM TUBERCULOSIS;

EID: 65749100586     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.006940     Document Type: Article

References (27)

1. Marrakchi, H., Bardou, F., Lanéelle, M. A., and Daffé, M. (2008) in The Mycobacterial Cell Envelope (Daffé, M., and Reyrat, J.-M., eds) pp. 41-62, ASM Press, Washington, DC
2. Zuber, B., Chami, M., Houssin, C., Dubochet, J., Griffiths, G., and Daffé, M. (2008) J. Bacteriol. 190, 5672-5680
3. Hoffmann, C., Leis, A., Niederweis, M., Plitzko, J. M., and Engelhardt, H. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 3963-3967
4. Daffé, M., and Draper, P. (1998) Adv. Microb. Physiol. 39, 131-203
5. Walker, R. W., Prome, J. C., and Lacave, C. S. (1973) Biochim. Biophys. Acta 326, 52-62
6. Shimakata, T., Iwaki, M., and Kusaka, T. (1984) Arch. Biochem. Biophys. 229, 329-339
7. Portevin, D., De Sousa-D'Auria, C., Houssin, C., Grimaldi, C., Chami, M., Daffé, M., and Guilhot, C. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 314-319
8. Portevin, D., de Sousa-D'Auria, C., Montrozier, H., Houssin, C., Stella, A., Lanéelle, M. A., Bardou, F., Guilhot, C., and Daffé, M. (2005) J. Biol. Chem. 280, 8862-8874
9. Gande, R., Gibson, K. J., Brown, A. K., Krumbach, K., Dover, L. G., Sahm, H., Shioyama, S., Oikawa, T., Besra, G. S., and Eggeling, L. (2004) J. Biol. Chem. 279, 44847-44857
10. Gande, R., Dover, L. G., Krumbach, K., Besra, G. S., Sahm, H., Oikawa, T., and Eggeling, L. (2007) J. Bacteriol. 189, 5257-5264
11. Oh, T. J., Daniel, J., Kim, H. J., Sirakova, T. D., and Kolattukudy, P. E. (2006) J. Biol. Chem. 281, 3899-3908
12. Trivedi, O. A., Arora, P., Sridharan, V., Tickoo, R., Mohanty, D., and Gokhale, R. S. (2004) Nature 428, 441-445
13. Lea-Smith, D. J., Pyke, J. S., Tull, D., McConville, M. J., Coppel, R. L., and Crellin, P. K. (2007) J. Biol. Chem. 282, 11000-11008
14. Chalut, C., Botella, L., de Sousa-D'Auria, C., Houssin, C., and Guilhot, C. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 8511-8516
15. Nakano, M. M., Corbell, N., Besson, J., and Zuber, P. (1992) Mol. Gen. Genet. 232, 313-321
16. Morsczeck, C., Berger, S., and Plum, G. (2001) Biochim. Biophys. Acta 1521, 59-65
17. Studier, F. W. (2005) Protein Expr. Purif. 41, 207-234
18. Padmakumar, R., Gantla, S., and Banerjee, R. (1993) Anal. Biochem. 214, 318-320
19. Adams, R., and Kamm, O. (1941) in Organic Syntheses Coll., Vol. 1, p. 250, Wiley, New York
20. Goldman, P., and Vagelos, P. R. (1961) J. Biol. Chem. 236, 2620-2623
21. Shimakata, T., Tsubokura, K., and Kusaka, T. (1986) Arch. Biochem. Biophys. 247, 302-311
22. Altschul, S. F., Madden, T. L., Schäffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997) Nucleic Acids Res. 25, 3389-3402
23. Ahibo-Coffy, A., Aurelle, H., Lacave, C., Prome, J. C., Puzo, G., and Savagnac, A. (1978) Chem. Phys. Lipids 22, 185-195
24. Revill, W. P., Bibb, M. J., and Hopwood, D. A. (1996) J. Bacteriol. 178, 5660-5667
25. Schmoock, G., Pfennig, F., Jewiarz, J., Schlumbohm, W., Laubinger, W., Schauwecker, F., and Keller, U. (2005) J. Biol. Chem. 280, 4339-4349
26. Quadri, L. E., Sello, J., Keating, T. A., Weinreb, P. H., and Walsh, C. T. (1998) Chem. Biol. 5, 631-645
27. Gehring, A. M., Mori, I., Perry, R. D., and Walsh, C. T. (1998) Biochemistry 37, 11637-11650