Phosphorylation of mycobacterial PCAA inhibits mycolic acid cyclopropanation: Consequences for intracellular survival and for phagosome maturation block

Journal of Biological Chemistry

Volumn 287, Issue 31, 2012, Pages 26187-26199

  Corrales, Rosa Milagros ^a   Molle, Virginie ^a   Leiba, Jade ^a   Mourey, Lionel ^b,c   De Chastellier, Chantal ^d   Kremer, Laurent ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPROPANATION; CYCLOPROPANE RING; HUMAN MACROPHAGES; HUMAN MONOCYTE-DERIVED MACROPHAGES; IN-VITRO; INTRACELLULAR SURVIVAL; METHYLTRANSFERASE ACTIVITY; MYCOBACTERIAL; MYCOLIC ACIDS; PATHOGENIC MYCOBACTERIA; PHAGOSOMES; REGULATORY MECHANISM; SYNTHASES; WILD TYPES;

DNA SEQUENCES; ENZYMES; GENES; MACROPHAGES; PROPANE;

PHOSPHORYLATION;

BACTERIAL PROTEIN; EPITOPE; METHYLTRANSFERASE; MYCOLIC ACID; PROTEIN PCAA; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; AUTOPHOSPHORYLATION; BACTERIAL VIRULENCE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; CYCLOPROPANATION; ENDOSOME; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MORPHOTYPE; NONHUMAN; PHAGOSOME; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; CONSERVED SEQUENCE; CYCLOPROPANES; HOST-PATHOGEN INTERACTIONS; HUMANS; MACROPHAGES; METHYLTRANSFERASES; MICROBIAL VIABILITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; PHAGOSOMES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES;

BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE;

EID: 84864381316     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.373209     Document Type: Article

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