S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of Mycobacterium tuberculosis mycolic acid methyltransferases

Journal of Biological Chemistry

Volumn 284, Issue 29, 2009, Pages 19321-19330

  Vaubourgeix, Julien ^a,b   Bardou, Fabienne ^a,b   Boissier, Fanny ^a,b,d   Julien, Sylviane ^a,b   Constant, Patricia ^a,b   Ploux, Olivier ^c   Daffé, Mamadou ^a,b   Quémard, Annaïk ^a,b   Mourey, Lionel ^a,b  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c PSL RESEARCH UNIVERSITY   (France)

^d Institut de Biochimie et Genetique Cellulaires   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACID MOIETY; BIOLOGICALLY ACTIVE MOLECULES; COFACTOR; HIGH RESOLUTION CRYSTAL STRUCTURE; IN-VITRO; LIPID CHAINS; M. TUBERCULOSIS; METHYL GROUP; METHYLTRANSFERASES; MODE OF ACTION; MYCOBACTERIAL CELLS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; REACTION PRODUCTS; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; SPECIFIC COMPONENT;

AMINES; AMINO ACIDS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CELL MEMBRANES; CHEMICAL MODIFICATION; ENZYMES; HYDROCARBONS; ORGANIC ACIDS;

X RAY CRYSTALLOGRAPHY;

BACTERIAL ENZYME; METHYLTRANSFERASE INHIBITOR; MYCOLIC ACID METHYLTRANSFERASE; S ADENOSYL N DECYL AMINOETHYL; S ADENOSYLHOMOCYSTEINE; SINEFUNGIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE; CATALYTIC DOMAIN; CELL DIVISION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; SPECIES SPECIFICITY;

BACILLI (CLASS); MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 67749120736     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809599200     Document Type: Article

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