-
1
-
-
84887615624
-
Modulation of the autonomic nervous system and behaviour by acute glial cell Gq protein-coupled receptor activation in vivo
-
Agulhon C., Boyt K.M., Xie A.X., Friocourt F., Roth B.L., McCarthy K.D. Modulation of the autonomic nervous system and behaviour by acute glial cell Gq protein-coupled receptor activation in vivo. J. Physiol. 2013, 591:5599-5609.
-
(2013)
J. Physiol.
, vol.591
, pp. 5599-5609
-
-
Agulhon, C.1
Boyt, K.M.2
Xie, A.X.3
Friocourt, F.4
Roth, B.L.5
McCarthy, K.D.6
-
2
-
-
68349103200
-
Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors
-
Alexander G.M., Rogan S.C., Abbas A.I., Armbruster B.N., Pei Y., Allen J.A., Nonneman R.J., Hartmann J., Moy S.S., Nicolelis M.A., et al. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 2009, 63:27-39.
-
(2009)
Neuron
, vol.63
, pp. 27-39
-
-
Alexander, G.M.1
Rogan, S.C.2
Abbas, A.I.3
Armbruster, B.N.4
Pei, Y.5
Allen, J.A.6
Nonneman, R.J.7
Hartmann, J.8
Moy, S.S.9
Nicolelis, M.A.10
-
3
-
-
79951512210
-
Strategies to discover unexpected targets for drugs active at G protein-coupled receptors
-
Allen J.A., Roth B.L. Strategies to discover unexpected targets for drugs active at G protein-coupled receptors. Annu. Rev. Pharmacol. Toxicol. 2011, 51:117-144.
-
(2011)
Annu. Rev. Pharmacol. Toxicol.
, vol.51
, pp. 117-144
-
-
Allen, J.A.1
Roth, B.L.2
-
4
-
-
81055145330
-
Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy
-
Allen J.A., Yost J.M., Setola V., Chen X., Sassano M.F., Chen M., Peterson S., Yadav P.N., Huang X.P., Feng B., et al. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc. Natl. Acad. Sci. USA 2011, 108:18488-18493.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 18488-18493
-
-
Allen, J.A.1
Yost, J.M.2
Setola, V.3
Chen, X.4
Sassano, M.F.5
Chen, M.6
Peterson, S.7
Yadav, P.N.8
Huang, X.P.9
Feng, B.10
-
5
-
-
79951992387
-
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
-
Aponte Y., Atasoy D., Sternson S.M. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nat. Neurosci. 2011, 14:351-355.
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 351-355
-
-
Aponte, Y.1
Atasoy, D.2
Sternson, S.M.3
-
6
-
-
41449091358
-
Genetic control of neuronal activity in mice conditionally expressing TRPV1
-
Arenkiel B.R., Klein M.E., Davison I.G., Katz L.C., Ehlers M.D. Genetic control of neuronal activity in mice conditionally expressing TRPV1. Nat. Methods 2008, 5:299-302.
-
(2008)
Nat. Methods
, vol.5
, pp. 299-302
-
-
Arenkiel, B.R.1
Klein, M.E.2
Davison, I.G.3
Katz, L.C.4
Ehlers, M.D.5
-
7
-
-
84904608117
-
Creation of Designer Biogenic Amine Receptors via Directed Molecular Evolution
-
Armbruster B., Roth B. Creation of Designer Biogenic Amine Receptors via Directed Molecular Evolution. Neuropsychopharmacology 2005, 30:S265.
-
(2005)
Neuropsychopharmacology
, vol.30
, pp. S265
-
-
Armbruster, B.1
Roth, B.2
-
8
-
-
34247640671
-
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
-
Armbruster B.N., Li X., Pausch M.H., Herlitze S., Roth B.L. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc. Natl. Acad. Sci. USA 2007, 104:5163-5168.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 5163-5168
-
-
Armbruster, B.N.1
Li, X.2
Pausch, M.H.3
Herlitze, S.4
Roth, B.L.5
-
9
-
-
84937416706
-
The promise and peril of chemical probes
-
Arrowsmith C.H., Audia J.E., Austin C., Baell J., Bennett J., Blagg J., Bountra C., Brennan P.E., Brown P.J., Bunnage M.E., et al. The promise and peril of chemical probes. Nat. Chem. Biol. 2015, 11:536-541.
-
(2015)
Nat. Chem. Biol.
, vol.11
, pp. 536-541
-
-
Arrowsmith, C.H.1
Audia, J.E.2
Austin, C.3
Baell, J.4
Bennett, J.5
Blagg, J.6
Bountra, C.7
Brennan, P.E.8
Brown, P.J.9
Bunnage, M.E.10
-
10
-
-
49049099862
-
A FLEX switch targets Channelrhodopsin-to multiple cell types for imaging and long-range circuit mapping
-
Atasoy D., Aponte Y., Su H.H., Sternson S.M. A FLEX switch targets Channelrhodopsin-to multiple cell types for imaging and long-range circuit mapping. J. Neurosci. 2008, 28:7025-7030.
-
(2008)
J. Neurosci.
, vol.28
, pp. 7025-7030
-
-
Atasoy, D.1
Aponte, Y.2
Su, H.H.3
Sternson, S.M.4
-
11
-
-
84864711337
-
Deconstruction of a neural circuit for hunger
-
Atasoy D., Betley J.N., Su H.H., Sternson S.M. Deconstruction of a neural circuit for hunger. Nature 2012, 488:172-177.
-
(2012)
Nature
, vol.488
, pp. 172-177
-
-
Atasoy, D.1
Betley, J.N.2
Su, H.H.3
Sternson, S.M.4
-
12
-
-
84884145407
-
DREADDs in Drosophila: a pharmacogenetic approach for controlling behavior, neuronal signaling, and physiology in the fly
-
Becnel J., Johnson O., Majeed Z.R., Tran V., Yu B., Roth B.L., Cooper R.L., Kerut E.K., Nichols C.D. DREADDs in Drosophila: a pharmacogenetic approach for controlling behavior, neuronal signaling, and physiology in the fly. Cell Rep. 2013, 4:1049-1059.
-
(2013)
Cell Rep.
, vol.4
, pp. 1049-1059
-
-
Becnel, J.1
Johnson, O.2
Majeed, Z.R.3
Tran, V.4
Yu, B.5
Roth, B.L.6
Cooper, R.L.7
Kerut, E.K.8
Nichols, C.D.9
-
13
-
-
0028126689
-
Synthesis of n.c.a. carbon-11 labelled clozapine and its major metabolite clozapine-N-oxide and comparison of their biodistribution in mice
-
Bender D., Holschbach M., Stöcklin G. Synthesis of n.c.a. carbon-11 labelled clozapine and its major metabolite clozapine-N-oxide and comparison of their biodistribution in mice. Nucl. Med. Biol. 1994, 21:921-925.
-
(1994)
Nucl. Med. Biol.
, vol.21
, pp. 921-925
-
-
Bender, D.1
Holschbach, M.2
Stöcklin, G.3
-
14
-
-
84870987376
-
Automated design of ligands to polypharmacological profiles
-
Besnard J., Ruda G.F., Setola V., Abecassis K., Rodriguiz R.M., Huang X.P., Norval S., Sassano M.F., Shin A.I., Webster L.A., et al. Automated design of ligands to polypharmacological profiles. Nature 2012, 492:215-220.
-
(2012)
Nature
, vol.492
, pp. 215-220
-
-
Besnard, J.1
Ruda, G.F.2
Setola, V.3
Abecassis, K.4
Rodriguiz, R.M.5
Huang, X.P.6
Norval, S.7
Sassano, M.F.8
Shin, A.I.9
Webster, L.A.10
-
15
-
-
84929359280
-
Neurons for hunger and thirst transmit a negative-valence teaching signal
-
Betley J.N., Xu S., Cao Z.F., Gong R., Magnus C.J., Yu Y., Sternson S.M. Neurons for hunger and thirst transmit a negative-valence teaching signal. Nature 2015, 521:180-185.
-
(2015)
Nature
, vol.521
, pp. 180-185
-
-
Betley, J.N.1
Xu, S.2
Cao, Z.F.3
Gong, R.4
Magnus, C.J.5
Yu, Y.6
Sternson, S.M.7
-
16
-
-
0032568055
-
Design of allele-specific inhibitors to probe protein kinase signaling
-
Bishop A.C., Shah K., Liu Y., Witucki L., Kung C., Shokat K.M. Design of allele-specific inhibitors to probe protein kinase signaling. Curr. Biol. 1998, 8:257-266.
-
(1998)
Curr. Biol.
, vol.8
, pp. 257-266
-
-
Bishop, A.C.1
Shah, K.2
Liu, Y.3
Witucki, L.4
Kung, C.5
Shokat, K.M.6
-
17
-
-
0034699382
-
A chemical switch for inhibitor-sensitive alleles of any protein kinase
-
Bishop A.C., Ubersax J.A., Petsch D.T., Matheos D.P., Gray N.S., Blethrow J., Shimizu E., Tsien J.Z., Schultz P.G., Rose M.D., et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000, 407:395-401.
-
(2000)
Nature
, vol.407
, pp. 395-401
-
-
Bishop, A.C.1
Ubersax, J.A.2
Petsch, D.T.3
Matheos, D.P.4
Gray, N.S.5
Blethrow, J.6
Shimizu, E.7
Tsien, J.Z.8
Schultz, P.G.9
Rose, M.D.10
-
18
-
-
84899703098
-
Combined use of the canine adenovirus-and DREADD-technology to activate specific neural pathways in vivo
-
Boender A.J., de Jong J.W., Boekhoudt L., Luijendijk M.C., van der Plasse G., Adan R.A. Combined use of the canine adenovirus-and DREADD-technology to activate specific neural pathways in vivo. PLoS ONE 2014, 9:e95392.
-
(2014)
PLoS ONE
, vol.9
-
-
Boender, A.J.1
de Jong, J.W.2
Boekhoudt, L.3
Luijendijk, M.C.4
van der Plasse, G.5
Adan, R.A.6
-
19
-
-
84945533491
-
Gate control of mechanical itch by a subpopulation of spinal cord interneurons
-
Bourane S., Duan B., Koch S.C., Dalet A., Britz O., Garcia-Campmany L., Kim E., Cheng L., Ghosh A., Ma Q., Goulding M. Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Science 2015, 350:550-554.
-
(2015)
Science
, vol.350
, pp. 550-554
-
-
Bourane, S.1
Duan, B.2
Koch, S.C.3
Dalet, A.4
Britz, O.5
Garcia-Campmany, L.6
Kim, E.7
Cheng, L.8
Ghosh, A.9
Ma, Q.10
Goulding, M.11
-
20
-
-
84878450313
-
A Gq-Ca2+ axis controls circuit-level encoding of circadian time in the suprachiasmatic nucleus
-
Brancaccio M., Maywood E.S., Chesham J.E., Loudon A.S., Hastings M.H. A Gq-Ca2+ axis controls circuit-level encoding of circadian time in the suprachiasmatic nucleus. Neuron 2013, 78:714-728.
-
(2013)
Neuron
, vol.78
, pp. 714-728
-
-
Brancaccio, M.1
Maywood, E.S.2
Chesham, J.E.3
Loudon, A.S.4
Hastings, M.H.5
-
21
-
-
84919876035
-
Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics
-
Brust R.D., Corcoran A.E., Richerson G.B., Nattie E., Dymecki S.M. Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics. Cell Rep. 2014, 9:2152-2165.
-
(2014)
Cell Rep.
, vol.9
, pp. 2152-2165
-
-
Brust, R.D.1
Corcoran, A.E.2
Richerson, G.B.3
Nattie, E.4
Dymecki, S.M.5
-
22
-
-
84939893166
-
Rat nucleus accumbens core astrocytes modulate reward and the motivation to self-administer ethanol after abstinence
-
Bull C., Freitas K.C., Zou S., Poland R.S., Syed W.A., Urban D.J., Minter S.C., Shelton K.L., Hauser K.F., Negus S.S., et al. Rat nucleus accumbens core astrocytes modulate reward and the motivation to self-administer ethanol after abstinence. Neuropsychopharmacology 2014, 39:2835-2845.
-
(2014)
Neuropsychopharmacology
, vol.39
, pp. 2835-2845
-
-
Bull, C.1
Freitas, K.C.2
Zou, S.3
Poland, R.S.4
Syed, W.A.5
Urban, D.J.6
Minter, S.C.7
Shelton, K.L.8
Hauser, K.F.9
Negus, S.S.10
-
23
-
-
84921683974
-
Central amygdala PKC-δ(+) neurons mediate the influence of multiple anorexigenic signals
-
Cai H., Haubensak W., Anthony T.E., Anderson D.J. Central amygdala PKC-δ(+) neurons mediate the influence of multiple anorexigenic signals. Nat. Neurosci. 2014, 17:1240-1248.
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 1240-1248
-
-
Cai, H.1
Haubensak, W.2
Anthony, T.E.3
Anderson, D.J.4
-
24
-
-
80054868459
-
Ligand discovery from a dopamine D3 receptor homology model and crystal structure
-
Carlsson J., Coleman R.G., Setola V., Irwin J.J., Fan H., Schlessinger A., Sali A., Roth B.L., Shoichet B.K. Ligand discovery from a dopamine D3 receptor homology model and crystal structure. Nat. Chem. Biol. 2011, 7:769-778.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 769-778
-
-
Carlsson, J.1
Coleman, R.G.2
Setola, V.3
Irwin, J.J.4
Fan, H.5
Schlessinger, A.6
Sali, A.7
Roth, B.L.8
Shoichet, B.K.9
-
25
-
-
84887407770
-
Genetic identification of a neural circuit that suppresses appetite
-
Carter M.E., Soden M.E., Zweifel L.S., Palmiter R.D. Genetic identification of a neural circuit that suppresses appetite. Nature 2013, 503:111-114.
-
(2013)
Nature
, vol.503
, pp. 111-114
-
-
Carter, M.E.1
Soden, M.E.2
Zweifel, L.S.3
Palmiter, R.D.4
-
26
-
-
1342265861
-
Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations
-
Chavkin C., Sud S., Jin W., Stewart J., Zjawiony J.K., Siebert D.J., Toth B.A., Hufeisen S.J., Roth B.L. Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. J. Pharmacol. Exp. Ther. 2004, 308:1197-1203.
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.308
, pp. 1197-1203
-
-
Chavkin, C.1
Sud, S.2
Jin, W.3
Stewart, J.4
Zjawiony, J.K.5
Siebert, D.J.6
Toth, B.A.7
Hufeisen, S.J.8
Roth, B.L.9
-
27
-
-
20144387125
-
A chemical-genetic approach to studying neurotrophin signaling
-
Chen X., Ye H., Kuruvilla R., Ramanan N., Scangos K.W., Zhang C., Johnson N.M., England P.M., Shokat K.M., Ginty D.D. A chemical-genetic approach to studying neurotrophin signaling. Neuron 2005, 46:13-21.
-
(2005)
Neuron
, vol.46
, pp. 13-21
-
-
Chen, X.1
Ye, H.2
Kuruvilla, R.3
Ramanan, N.4
Scangos, K.W.5
Zhang, C.6
Johnson, N.M.7
England, P.M.8
Shokat, K.M.9
Ginty, D.D.10
-
28
-
-
84925136303
-
The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs
-
Chen X., Choo H., Huang X.P., Yang X., Stone O., Roth B.L., Jin J. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem. Neurosci. 2015, 6:476-484.
-
(2015)
ACS Chem. Neurosci.
, vol.6
, pp. 476-484
-
-
Chen, X.1
Choo, H.2
Huang, X.P.3
Yang, X.4
Stone, O.5
Roth, B.L.6
Jin, J.7
-
29
-
-
19744364796
-
Structural bioinformatics-based design of selective, irreversible kinase inhibitors
-
Cohen M.S., Zhang C., Shokat K.M., Taunton J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 2005, 308:1318-1321.
-
(2005)
Science
, vol.308
, pp. 1318-1321
-
-
Cohen, M.S.1
Zhang, C.2
Shokat, K.M.3
Taunton, J.4
-
30
-
-
0042805254
-
Artificial metalloenzymes for enantioselective catalysis based on biotin-avidin
-
Collot J., Gradinaru J., Humbert N., Skander M., Zocchi A., Ward T.R. Artificial metalloenzymes for enantioselective catalysis based on biotin-avidin. J. Am. Chem. Soc. 2003, 125:9030-9031.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 9030-9031
-
-
Collot, J.1
Gradinaru, J.2
Humbert, N.3
Skander, M.4
Zocchi, A.5
Ward, T.R.6
-
31
-
-
48449105746
-
Engineering GPCR signaling pathways with RASSLs
-
Conklin B.R., Hsiao E.C., Claeysen S., Dumuis A., Srinivasan S., Forsayeth J.R., Guettier J.M., Chang W.C., Pei Y., McCarthy K.D., et al. Engineering GPCR signaling pathways with RASSLs. Nat. Methods 2008, 5:673-678.
-
(2008)
Nat. Methods
, vol.5
, pp. 673-678
-
-
Conklin, B.R.1
Hsiao, E.C.2
Claeysen, S.3
Dumuis, A.4
Srinivasan, S.5
Forsayeth, J.R.6
Guettier, J.M.7
Chang, W.C.8
Pei, Y.9
McCarthy, K.D.10
-
32
-
-
0001169515
-
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins
-
Costa T., Herz A. Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins. Proc. Natl. Acad. Sci. USA 1989, 86:7321-7325.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 7321-7325
-
-
Costa, T.1
Herz, A.2
-
33
-
-
0031940393
-
Controlling signaling with a specifically designed Gi-coupled receptor
-
Coward P., Wada H.G., Falk M.S., Chan S.D., Meng F., Akil H., Conklin B.R. Controlling signaling with a specifically designed Gi-coupled receptor. Proc. Natl. Acad. Sci. USA 1998, 95:352-357.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 352-357
-
-
Coward, P.1
Wada, H.G.2
Falk, M.S.3
Chan, S.D.4
Meng, F.5
Akil, H.6
Conklin, B.R.7
-
34
-
-
84861943484
-
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
-
Dar A.C., Das T.K., Shokat K.M., Cagan R.L. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature 2012, 486:80-84.
-
(2012)
Nature
, vol.486
, pp. 80-84
-
-
Dar, A.C.1
Das, T.K.2
Shokat, K.M.3
Cagan, R.L.4
-
35
-
-
16844363204
-
The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?
-
Davies M.A., Compton-Toth B.A., Hufeisen S.J., Meltzer H.Y., Roth B.L. The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?. Psychopharmacology (Berl.) 2005, 178:451-460.
-
(2005)
Psychopharmacology (Berl.)
, vol.178
, pp. 451-460
-
-
Davies, M.A.1
Compton-Toth, B.A.2
Hufeisen, S.J.3
Meltzer, H.Y.4
Roth, B.L.5
-
36
-
-
0019137579
-
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor
-
De Lean A., Stadel J.M., Lefkowitz R.J. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J. Biol. Chem. 1980, 255:7108-7117.
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 7108-7117
-
-
De Lean, A.1
Stadel, J.M.2
Lefkowitz, R.J.3
-
37
-
-
0018001339
-
Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves
-
DeLean A., Munson P.J., Rodbard D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol. 1978, 235:E97-E102.
-
(1978)
Am. J. Physiol.
, vol.235
, pp. E97-E102
-
-
DeLean, A.1
Munson, P.J.2
Rodbard, D.3
-
38
-
-
84903753279
-
Remote control of induced dopaminergic neurons in parkinsonian rats
-
Dell'Anno M.T., Caiazzo M., Leo D., Dvoretskova E., Medrihan L., Colasante G., Giannelli S., Theka I., Russo G., Mus L., et al. Remote control of induced dopaminergic neurons in parkinsonian rats. J. Clin. Invest. 2014, 124:3215-3229.
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 3215-3229
-
-
Dell'Anno, M.T.1
Caiazzo, M.2
Leo, D.3
Dvoretskova, E.4
Medrihan, L.5
Colasante, G.6
Giannelli, S.7
Theka, I.8
Russo, G.9
Mus, L.10
-
39
-
-
84943456292
-
Palatability Can Drive Feeding Independent of AgRP Neurons
-
Denis R.G., Joly-Amado A., Webber E., Langlet F., Schaeffer M., Padilla S.L., Cansell C., Dehouck B., Castel J., Delbès A.S., et al. Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metab. 2015, 22:646-657.
-
(2015)
Cell Metab.
, vol.22
, pp. 646-657
-
-
Denis, R.G.1
Joly-Amado, A.2
Webber, E.3
Langlet, F.4
Schaeffer, M.5
Padilla, S.L.6
Cansell, C.7
Dehouck, B.8
Castel, J.9
Delbès, A.S.10
-
40
-
-
33947401068
-
Beta-arrestins and cell signaling
-
DeWire S.M., Ahn S., Lefkowitz R.J., Shenoy S.K. Beta-arrestins and cell signaling. Annu. Rev. Physiol. 2007, 69:483-510.
-
(2007)
Annu. Rev. Physiol.
, vol.69
, pp. 483-510
-
-
DeWire, S.M.1
Ahn, S.2
Lefkowitz, R.J.3
Shenoy, S.K.4
-
41
-
-
77749320196
-
Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs
-
Dong S., Rogan S.C., Roth B.L. Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs. Nat. Protoc. 2010, 5:561-573.
-
(2010)
Nat. Protoc.
, vol.5
, pp. 561-573
-
-
Dong, S.1
Rogan, S.C.2
Roth, B.L.3
-
42
-
-
84953836550
-
Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value
-
Eldridge M.A.G., Lerchner W., Saunders R.C., Kaneko H., Krausz K.W., Gonzalez F.J., Ji B., Higuchi M., Minamimoto T., Richmond B.J. Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value. Nat. Neurosci. 2016, 19:37-39.
-
(2016)
Nat. Neurosci.
, vol.19
, pp. 37-39
-
-
Eldridge, M.A.G.1
Lerchner, W.2
Saunders, R.C.3
Kaneko, H.4
Krausz, K.W.5
Gonzalez, F.J.6
Ji, B.7
Higuchi, M.8
Minamimoto, T.9
Richmond, B.J.10
-
43
-
-
84953774679
-
Comprehensive characterization of the Published Kinase Inhibitor Set
-
Elkins J.M., Fedele V., Szklarz M., Abdul Azeez K.R., Salah E., Mikolajczyk J., Romanov S., Sepetov N., Huang X.P., Roth B.L., et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat. Biotechnol. 2015, 34:95-103.
-
(2015)
Nat. Biotechnol.
, vol.34
, pp. 95-103
-
-
Elkins, J.M.1
Fedele, V.2
Szklarz, M.3
Abdul Azeez, K.R.4
Salah, E.5
Mikolajczyk, J.6
Romanov, S.7
Sepetov, N.8
Huang, X.P.9
Roth, B.L.10
-
44
-
-
84946781241
-
Chemogenetics-Transformational and Translational Platform
-
English J.G., Roth B.L. Chemogenetics-Transformational and Translational Platform. JAMA Neurol. 2015, 72:1361-1366.
-
(2015)
JAMA Neurol.
, vol.72
, pp. 1361-1366
-
-
English, J.G.1
Roth, B.L.2
-
45
-
-
84875210398
-
A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons
-
Farrell M.S., Pei Y., Wan Y., Yadav P.N., Daigle T.L., Urban D.J., Lee H.M., Sciaky N., Simmons A., Nonneman R.J., et al. A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology 2013, 38:854-862.
-
(2013)
Neuropsychopharmacology
, vol.38
, pp. 854-862
-
-
Farrell, M.S.1
Pei, Y.2
Wan, Y.3
Yadav, P.N.4
Daigle, T.L.5
Urban, D.J.6
Lee, H.M.7
Sciaky, N.8
Simmons, A.9
Nonneman, R.J.10
-
46
-
-
84893954062
-
Molecular control of δ-opioid receptor signalling
-
Fenalti G., Giguere P.M., Katritch V., Huang X.P., Thompson A.A., Cherezov V., Roth B.L., Stevens R.C. Molecular control of δ-opioid receptor signalling. Nature 2014, 506:191-196.
-
(2014)
Nature
, vol.506
, pp. 191-196
-
-
Fenalti, G.1
Giguere, P.M.2
Katritch, V.3
Huang, X.P.4
Thompson, A.A.5
Cherezov, V.6
Roth, B.L.7
Stevens, R.C.8
-
47
-
-
78650679270
-
Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization
-
Ferguson S.M., Eskenazi D., Ishikawa M., Wanat M.J., Phillips P.E., Dong Y., Roth B.L., Neumaier J.F. Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. Nat. Neurosci. 2011, 14:22-24.
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 22-24
-
-
Ferguson, S.M.1
Eskenazi, D.2
Ishikawa, M.3
Wanat, M.J.4
Phillips, P.E.5
Dong, Y.6
Roth, B.L.7
Neumaier, J.F.8
-
48
-
-
84880421209
-
Direct-pathway striatal neurons regulate the retention of decision-making strategies
-
Ferguson S.M., Phillips P.E., Roth B.L., Wess J., Neumaier J.F. Direct-pathway striatal neurons regulate the retention of decision-making strategies. J. Neurosci. 2013, 33:11668-11676.
-
(2013)
J. Neurosci.
, vol.33
, pp. 11668-11676
-
-
Ferguson, S.M.1
Phillips, P.E.2
Roth, B.L.3
Wess, J.4
Neumaier, J.F.5
-
49
-
-
0018946505
-
Genetic control of chalcone isomerase activity in flowers of Dianthus caryophyllus
-
Forkmann G., Dangelmayr B. Genetic control of chalcone isomerase activity in flowers of Dianthus caryophyllus. Biochem. Genet. 1980, 18:519-527.
-
(1980)
Biochem. Genet.
, vol.18
, pp. 519-527
-
-
Forkmann, G.1
Dangelmayr, B.2
-
50
-
-
84858769326
-
Generation of a synthetic memory trace
-
Garner A.R., Rowland D.C., Hwang S.Y., Baumgaertel K., Roth B.L., Kentros C., Mayford M. Generation of a synthetic memory trace. Science 2012, 335:1513-1516.
-
(2012)
Science
, vol.335
, pp. 1513-1516
-
-
Garner, A.R.1
Rowland, D.C.2
Hwang, S.Y.3
Baumgaertel, K.4
Roth, B.L.5
Kentros, C.6
Mayford, M.7
-
51
-
-
0028856707
-
Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes
-
Gether U., Lin S., Kobilka B.K. Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes. J. Biol. Chem. 1995, 270:28268-28275.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 28268-28275
-
-
Gether, U.1
Lin, S.2
Kobilka, B.K.3
-
52
-
-
77950930288
-
Molecular and cellular approaches for diversifying and extending optogenetics
-
Gradinaru V., Zhang F., Ramakrishnan C., Mattis J., Prakash R., Diester I., Goshen I., Thompson K.R., Deisseroth K. Molecular and cellular approaches for diversifying and extending optogenetics. Cell 2010, 141:154-165.
-
(2010)
Cell
, vol.141
, pp. 154-165
-
-
Gradinaru, V.1
Zhang, F.2
Ramakrishnan, C.3
Mattis, J.4
Prakash, R.5
Diester, I.6
Goshen, I.7
Thompson, K.R.8
Deisseroth, K.9
-
53
-
-
72649084796
-
A chemical-genetic approach to study G protein regulation of beta cell function in vivo
-
Guettier J.M., Gautam D., Scarselli M., Ruiz de Azua I., Li J.H., Rosemond E., Ma X., Gonzalez F.J., Armbruster B.N., Lu H., et al. A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proc. Natl. Acad. Sci. USA 2009, 106:19197-19202.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 19197-19202
-
-
Guettier, J.M.1
Gautam, D.2
Scarselli, M.3
Ruiz de Azua, I.4
Li, J.H.5
Rosemond, E.6
Ma, X.7
Gonzalez, F.J.8
Armbruster, B.N.9
Lu, H.10
-
54
-
-
0242449394
-
Enzymes by design: chemogenetic assembly of transamination active sites containing lysine residues for covalent catalysis
-
Häring D., Distefano M.D. Enzymes by design: chemogenetic assembly of transamination active sites containing lysine residues for covalent catalysis. Bioconjug. Chem. 2001, 12:385-390.
-
(2001)
Bioconjug. Chem.
, vol.12
, pp. 385-390
-
-
Häring, D.1
Distefano, M.D.2
-
55
-
-
84947736998
-
Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice
-
Hayashi Y., Kashiwagi M., Yasuda K., Ando R., Kanuka M., Sakai K., Itohara S. Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice. Science 2015, 350:957-961.
-
(2015)
Science
, vol.350
, pp. 957-961
-
-
Hayashi, Y.1
Kashiwagi, M.2
Yasuda, K.3
Ando, R.4
Kanuka, M.5
Sakai, K.6
Itohara, S.7
-
56
-
-
39549099297
-
Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass
-
Hsiao E.C., Boudignon B.M., Chang W.C., Bencsik M., Peng J., Nguyen T.D., Manalac C., Halloran B.P., Conklin B.R., Nissenson R.A. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc. Natl. Acad. Sci. USA 2008, 105:1209-1214.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 1209-1214
-
-
Hsiao, E.C.1
Boudignon, B.M.2
Chang, W.C.3
Bencsik, M.4
Peng, J.5
Nguyen, T.D.6
Manalac, C.7
Halloran, B.P.8
Conklin, B.R.9
Nissenson, R.A.10
-
57
-
-
84939795137
-
Structural insights into μ-opioid receptor activation
-
Huang W., Manglik A., Venkatakrishnan A.J., Laeremans T., Feinberg E.N., Sanborn A.L., Kato H.E., Livingston K.E., Thorsen T.S., Kling R.C., et al. Structural insights into μ-opioid receptor activation. Nature 2015, 524:315-321.
-
(2015)
Nature
, vol.524
, pp. 315-321
-
-
Huang, W.1
Manglik, A.2
Venkatakrishnan, A.J.3
Laeremans, T.4
Feinberg, E.N.5
Sanborn, A.L.6
Kato, H.E.7
Livingston, K.E.8
Thorsen, T.S.9
Kling, R.C.10
-
58
-
-
84948440927
-
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
-
Huang X.P., Karpiak J., Kroeze W.K., Zhu H., Chen X., Moy S.S., Saddoris K.A., Nikolova V.D., Farrell M.S., Wang S., et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature 2015, 527:477-483.
-
(2015)
Nature
, vol.527
, pp. 477-483
-
-
Huang, X.P.1
Karpiak, J.2
Kroeze, W.K.3
Zhu, H.4
Chen, X.5
Moy, S.S.6
Saddoris, K.A.7
Nikolova, V.D.8
Farrell, M.S.9
Wang, S.10
-
59
-
-
84947806033
-
Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear
-
Isosaka T., Matsuo T., Yamaguchi T., Funabiki K., Nakanishi S., Kobayakawa R., Kobayakawa K. Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear. Cell 2015, 163:1153-1164.
-
(2015)
Cell
, vol.163
, pp. 1153-1164
-
-
Isosaka, T.1
Matsuo, T.2
Yamaguchi, T.3
Funabiki, K.4
Nakanishi, S.5
Kobayakawa, R.6
Kobayakawa, K.7
-
60
-
-
84875843482
-
Chronic activation of a designer G(q)-coupled receptor improves β cell function
-
Jain S., Ruiz de Azua I., Lu H., White M.F., Guettier J.M., Wess J. Chronic activation of a designer G(q)-coupled receptor improves β cell function. J. Clin. Invest. 2013, 123:1750-1762.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 1750-1762
-
-
Jain, S.1
Ruiz de Azua, I.2
Lu, H.3
White, M.F.4
Guettier, J.M.5
Wess, J.6
-
61
-
-
0028588470
-
Rapid formation of clozapine in guinea-pigs and man following clozapine-N-oxide administration
-
Jann M.W., Lam Y.W., Chang W.H. Rapid formation of clozapine in guinea-pigs and man following clozapine-N-oxide administration. Arch. Int. Pharmacodyn. Ther. 1994, 328:243-250.
-
(1994)
Arch. Int. Pharmacodyn. Ther.
, vol.328
, pp. 243-250
-
-
Jann, M.W.1
Lam, Y.W.2
Chang, W.H.3
-
62
-
-
84938359988
-
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
-
Kang Y., Zhou X.E., Gao X., He Y., Liu W., Ishchenko A., Barty A., White T.A., Yefanov O., Han G.W., et al. Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature 2015, 523:561-567.
-
(2015)
Nature
, vol.523
, pp. 561-567
-
-
Kang, Y.1
Zhou, X.E.2
Gao, X.3
He, Y.4
Liu, W.5
Ishchenko, A.6
Barty, A.7
White, T.A.8
Yefanov, O.9
Han, G.W.10
-
63
-
-
84899960884
-
Allosteric sodium in class A GPCR signaling
-
Katritch V., Fenalti G., Abola E.E., Roth B.L., Cherezov V., Stevens R.C. Allosteric sodium in class A GPCR signaling. Trends Biochem. Sci. 2014, 39:233-244.
-
(2014)
Trends Biochem. Sci.
, vol.39
, pp. 233-244
-
-
Katritch, V.1
Fenalti, G.2
Abola, E.E.3
Roth, B.L.4
Cherezov, V.5
Stevens, R.C.6
-
64
-
-
84901659538
-
Chemical-genetic attenuation of focal neocortical seizures
-
Kätzel D., Nicholson E., Schorge S., Walker M.C., Kullmann D.M. Chemical-genetic attenuation of focal neocortical seizures. Nat. Commun. 2014, 5:3847.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3847
-
-
Kätzel, D.1
Nicholson, E.2
Schorge, S.3
Walker, M.C.4
Kullmann, D.M.5
-
65
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
Keiser M.J., Setola V., Irwin J.J., Laggner C., Abbas A.I., Hufeisen S.J., Jensen N.H., Kuijer M.B., Matos R.C., Tran T.B., et al. Predicting new molecular targets for known drugs. Nature 2009, 462:175-181.
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
Setola, V.2
Irwin, J.J.3
Laggner, C.4
Abbas, A.I.5
Hufeisen, S.J.6
Jensen, N.H.7
Kuijer, M.B.8
Matos, R.C.9
Tran, T.B.10
-
66
-
-
28744432508
-
Tailoring the active site of chemzymes by using a chemogenetic-optimization procedure: towards substrate-specific artificial hydrogenases based on the biotin-avidin technology
-
Klein G., Humbert N., Gradinaru J., Ivanova A., Gilardoni F., Rusbandi U.E., Ward T.R. Tailoring the active site of chemzymes by using a chemogenetic-optimization procedure: towards substrate-specific artificial hydrogenases based on the biotin-avidin technology. Angew. Chem. Int. Ed. Engl. 2005, 44:7764-7767.
-
(2005)
Angew. Chem. Int. Ed. Engl.
, vol.44
, pp. 7764-7767
-
-
Klein, G.1
Humbert, N.2
Gradinaru, J.3
Ivanova, A.4
Gilardoni, F.5
Rusbandi, U.E.6
Ward, T.R.7
-
67
-
-
84868012864
-
GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure
-
Kong D., Tong Q., Ye C., Koda S., Fuller P.M., Krashes M.J., Vong L., Ray R.S., Olson D.P., Lowell B.B. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell 2012, 151:645-657.
-
(2012)
Cell
, vol.151
, pp. 645-657
-
-
Kong, D.1
Tong, Q.2
Ye, C.3
Koda, S.4
Fuller, P.M.5
Krashes, M.J.6
Vong, L.7
Ray, R.S.8
Olson, D.P.9
Lowell, B.B.10
-
68
-
-
84863744270
-
Recurrent network activity drives striatal synaptogenesis
-
Kozorovitskiy Y., Saunders A., Johnson C.A., Lowell B.B., Sabatini B.L. Recurrent network activity drives striatal synaptogenesis. Nature 2012, 485:646-650.
-
(2012)
Nature
, vol.485
, pp. 646-650
-
-
Kozorovitskiy, Y.1
Saunders, A.2
Johnson, C.A.3
Lowell, B.B.4
Sabatini, B.L.5
-
69
-
-
79953307878
-
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
-
Krashes M.J., Koda S., Ye C., Rogan S.C., Adams A.C., Cusher D.S., Maratos-Flier E., Roth B.L., Lowell B.B. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J. Clin. Invest. 2011, 121:1424-1428.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 1424-1428
-
-
Krashes, M.J.1
Koda, S.2
Ye, C.3
Rogan, S.C.4
Adams, A.C.5
Cusher, D.S.6
Maratos-Flier, E.7
Roth, B.L.8
Lowell, B.B.9
-
70
-
-
84885089652
-
Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP
-
Krashes M.J., Shah B.P., Koda S., Lowell B.B. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab. 2013, 18:588-595.
-
(2013)
Cell Metab.
, vol.18
, pp. 588-595
-
-
Krashes, M.J.1
Shah, B.P.2
Koda, S.3
Lowell, B.B.4
-
71
-
-
84929285245
-
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
-
Kroeze W.K., Sassano M.F., Huang X.P., Lansu K., McCorvy J.D., Giguère P.M., Sciaky N., Roth B.L. PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nat. Struct. Mol. Biol. 2015, 22:362-369.
-
(2015)
Nat. Struct. Mol. Biol.
, vol.22
, pp. 362-369
-
-
Kroeze, W.K.1
Sassano, M.F.2
Huang, X.P.3
Lansu, K.4
McCorvy, J.D.5
Giguère, P.M.6
Sciaky, N.7
Roth, B.L.8
-
72
-
-
84889564886
-
Activation and allosteric modulation of a muscarinic acetylcholine receptor
-
Kruse A.C., Ring A.M., Manglik A., Hu J., Hu K., Eitel K., Hübner H., Pardon E., Valant C., Sexton P.M., et al. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 2013, 504:101-106.
-
(2013)
Nature
, vol.504
, pp. 101-106
-
-
Kruse, A.C.1
Ring, A.M.2
Manglik, A.3
Hu, J.4
Hu, K.5
Eitel, K.6
Hübner, H.7
Pardon, E.8
Valant, C.9
Sexton, P.M.10
-
73
-
-
0032541483
-
Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination
-
Lee G., Saito I. Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination. Gene 1998, 216:55-65.
-
(1998)
Gene
, vol.216
, pp. 55-65
-
-
Lee, G.1
Saito, I.2
-
74
-
-
33947693328
-
Reversible silencing of neuronal excitability in behaving mice by a genetically targeted, ivermectin-gated Cl- channel
-
Lerchner W., Xiao C., Nashmi R., Slimko E.M., van Trigt L., Lester H.A., Anderson D.J. Reversible silencing of neuronal excitability in behaving mice by a genetically targeted, ivermectin-gated Cl- channel. Neuron 2007, 54:35-49.
-
(2007)
Neuron
, vol.54
, pp. 35-49
-
-
Lerchner, W.1
Xiao, C.2
Nashmi, R.3
Slimko, E.M.4
van Trigt, L.5
Lester, H.A.6
Anderson, D.J.7
-
75
-
-
84884687446
-
A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo
-
Li J.H., Jain S., McMillin S.M., Cui Y., Gautam D., Sakamoto W., Lu H., Jou W., McGuinness O.P., Gavrilova O., Wess J. A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo. Endocrinology 2013, 154:3539-3551.
-
(2013)
Endocrinology
, vol.154
, pp. 3539-3551
-
-
Li, J.H.1
Jain, S.2
McMillin, S.M.3
Cui, Y.4
Gautam, D.5
Sakamoto, W.6
Lu, H.7
Jou, W.8
McGuinness, O.P.9
Gavrilova, O.10
Wess, J.11
-
76
-
-
0032008085
-
Engineering Src family protein kinases with unnatural nucleotide specificity
-
Liu Y., Shah K., Yang F., Witucki L., Shokat K.M. Engineering Src family protein kinases with unnatural nucleotide specificity. Chem. Biol. 1998, 5:91-101.
-
(1998)
Chem. Biol.
, vol.5
, pp. 91-101
-
-
Liu, Y.1
Shah, K.2
Yang, F.3
Witucki, L.4
Shokat, K.M.5
-
77
-
-
0033613938
-
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
-
Luttrell L.M., Ferguson S.S., Daaka Y., Miller W.E., Maudsley S., Della Rocca G.J., Lin F., Kawakatsu H., Owada K., Luttrell D.K., et al. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 1999, 283:655-661.
-
(1999)
Science
, vol.283
, pp. 655-661
-
-
Luttrell, L.M.1
Ferguson, S.S.2
Daaka, Y.3
Miller, W.E.4
Maudsley, S.5
Della Rocca, G.J.6
Lin, F.7
Kawakatsu, H.8
Owada, K.9
Luttrell, D.K.10
-
78
-
-
80052436339
-
Chemical and genetic engineering of selective ion channel-ligand interactions
-
Magnus C.J., Lee P.H., Atasoy D., Su H.H., Looger L.L., Sternson S.M. Chemical and genetic engineering of selective ion channel-ligand interactions. Science 2011, 333:1292-1296.
-
(2011)
Science
, vol.333
, pp. 1292-1296
-
-
Magnus, C.J.1
Lee, P.H.2
Atasoy, D.3
Su, H.H.4
Looger, L.L.5
Sternson, S.M.6
-
79
-
-
84897454748
-
Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking
-
Mahler S.V., Vazey E.M., Beckley J.T., Keistler C.R., McGlinchey E.M., Kaufling J., Wilson S.P., Deisseroth K., Woodward J.J., Aston-Jones G. Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking. Nat. Neurosci. 2014, 17:577-585.
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 577-585
-
-
Mahler, S.V.1
Vazey, E.M.2
Beckley, J.T.3
Keistler, C.R.4
McGlinchey, E.M.5
Kaufling, J.6
Wilson, S.P.7
Deisseroth, K.8
Woodward, J.J.9
Aston-Jones, G.10
-
80
-
-
84930226866
-
Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling
-
Manglik A., Kim T.H., Masureel M., Altenbach C., Yang Z., Hilger D., Lerch M.T., Kobilka T.S., Thian F.S., Hubbell W.L., et al. Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling. Cell 2015, 161:1101-1111.
-
(2015)
Cell
, vol.161
, pp. 1101-1111
-
-
Manglik, A.1
Kim, T.H.2
Masureel, M.3
Altenbach, C.4
Yang, Z.5
Hilger, D.6
Lerch, M.T.7
Kobilka, T.S.8
Thian, F.S.9
Hubbell, W.L.10
-
81
-
-
84949623559
-
Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats
-
Marchant N.J., Whitaker L.R., Bossert J.M., Harvey B.K., Hope B.T., Kaganovsky K., Adhikary S., Prisinzano T.E., Vardy E., Roth B.L., Shaham Y. Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats. Neuropsychopharmacology 2016, 41:402-409.
-
(2016)
Neuropsychopharmacology
, vol.41
, pp. 402-409
-
-
Marchant, N.J.1
Whitaker, L.R.2
Bossert, J.M.3
Harvey, B.K.4
Hope, B.T.5
Kaganovsky, K.6
Adhikary, S.7
Prisinzano, T.E.8
Vardy, E.9
Roth, B.L.10
Shaham, Y.11
-
82
-
-
1642453638
-
RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms
-
Marion S., Weiner D.M., Caron M.G. RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms. J. Biol. Chem. 2004, 279:2945-2954.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 2945-2954
-
-
Marion, S.1
Weiner, D.M.2
Caron, M.G.3
-
83
-
-
84946129407
-
Hippocampal Remapping after Partial Inactivation of the Medial Entorhinal Cortex
-
Miao C., Cao Q., Ito H.T., Yamahachi H., Witter M.P., Moser M.B., Moser E.I. Hippocampal Remapping after Partial Inactivation of the Medial Entorhinal Cortex. Neuron 2015, 88:590-603.
-
(2015)
Neuron
, vol.88
, pp. 590-603
-
-
Miao, C.1
Cao, Q.2
Ito, H.T.3
Yamahachi, H.4
Witter, M.P.5
Moser, M.B.6
Moser, E.I.7
-
84
-
-
84866868206
-
Design and Functional Characterization of a Novel, Arrestin-Biased Designer G Protein-Coupled Receptor
-
Nakajima K.I., Wess J. Design and Functional Characterization of a Novel, Arrestin-Biased Designer G Protein-Coupled Receptor. Mol. Pharmacol. 2012, 82:575-582.
-
(2012)
Mol. Pharmacol.
, vol.82
, pp. 575-582
-
-
Nakajima, K.I.1
Wess, J.2
-
85
-
-
84873298278
-
The dynamic process of β(2)-adrenergic receptor activation
-
Nygaard R., Zou Y., Dror R.O., Mildorf T.J., Arlow D.H., Manglik A., Pan A.C., Liu C.W., Fung J.J., Bokoch M.P., et al. The dynamic process of β(2)-adrenergic receptor activation. Cell 2013, 152:532-542.
-
(2013)
Cell
, vol.152
, pp. 532-542
-
-
Nygaard, R.1
Zou, Y.2
Dror, R.O.3
Mildorf, T.J.4
Arlow, D.H.5
Manglik, A.6
Pan, A.C.7
Liu, C.W.8
Fung, J.J.9
Bokoch, M.P.10
-
86
-
-
84929939897
-
Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice
-
Ohmura Y., Tanaka K.F., Tsunematsu T., Yamanaka A., Yoshioka M. Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice. Int. J. Neuropsychopharmacol. 2014, 17:1777-1783.
-
(2014)
Int. J. Neuropsychopharmacol.
, vol.17
, pp. 1777-1783
-
-
Ohmura, Y.1
Tanaka, K.F.2
Tsunematsu, T.3
Yamanaka, A.4
Yoshioka, M.5
-
87
-
-
84899084091
-
Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal
-
Park J.S., Rhau B., Hermann A., McNally K.A., Zhou C., Gong D., Weiner O.D., Conklin B.R., Onuffer J., Lim W.A. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc. Natl. Acad. Sci. USA 2014, 111:5896-5901.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 5896-5901
-
-
Park, J.S.1
Rhau, B.2
Hermann, A.3
McNally, K.A.4
Zhou, C.5
Gong, D.6
Weiner, O.D.7
Conklin, B.R.8
Onuffer, J.9
Lim, W.A.10
-
88
-
-
84921792372
-
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism
-
271ra8
-
Peñagarikano O., Lázaro M.T., Lu X.H., Gordon A., Dong H., Lam H.A., Peles E., Maidment N.T., Murphy N.P., Yang X.W., et al. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Sci. Transl. Med. 2015, 7:271ra8.
-
(2015)
Sci. Transl. Med.
, vol.7
-
-
Peñagarikano, O.1
Lázaro, M.T.2
Lu, X.H.3
Gordon, A.4
Dong, H.5
Lam, H.A.6
Peles, E.7
Maidment, N.T.8
Murphy, N.P.9
Yang, X.W.10
-
89
-
-
84925773518
-
NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking
-
Pleil K.E., Rinker J.A., Lowery-Gionta E.G., Mazzone C.M., McCall N.M., Kendra A.M., Olson D.P., Lowell B.B., Grant K.A., Thiele T.E., Kash T.L. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat. Neurosci. 2015, 18:545-552.
-
(2015)
Nat. Neurosci.
, vol.18
, pp. 545-552
-
-
Pleil, K.E.1
Rinker, J.A.2
Lowery-Gionta, E.G.3
Mazzone, C.M.4
McCall, N.M.5
Kendra, A.M.6
Olson, D.P.7
Lowell, B.B.8
Grant, K.A.9
Thiele, T.E.10
Kash, T.L.11
-
90
-
-
80051658642
-
Crystal structure of the β2 adrenergic receptor-Gs protein complex
-
Rasmussen S.G., DeVree B.T., Zou Y., Kruse A.C., Chung K.Y., Kobilka T.S., Thian F.S., Chae P.S., Pardon E., Calinski D., et al. Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature 2011, 477:549-555.
-
(2011)
Nature
, vol.477
, pp. 549-555
-
-
Rasmussen, S.G.1
DeVree, B.T.2
Zou, Y.3
Kruse, A.C.4
Chung, K.Y.5
Kobilka, T.S.6
Thian, F.S.7
Chae, P.S.8
Pardon, E.9
Calinski, D.10
-
91
-
-
79960937702
-
Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition
-
Ray R.S., Corcoran A.E., Brust R.D., Kim J.C., Richerson G.B., Nattie E., Dymecki S.M. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science 2011, 333:637-642.
-
(2011)
Science
, vol.333
, pp. 637-642
-
-
Ray, R.S.1
Corcoran, A.E.2
Brust, R.D.3
Kim, J.C.4
Richerson, G.B.5
Nattie, E.6
Dymecki, S.M.7
-
92
-
-
0032966673
-
Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice
-
Redfern C.H., Coward P., Degtyarev M.Y., Lee E.K., Kwa A.T., Hennighausen L., Bujard H., Fishman G.I., Conklin B.R. Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat. Biotechnol. 1999, 17:165-169.
-
(1999)
Nat. Biotechnol.
, vol.17
, pp. 165-169
-
-
Redfern, C.H.1
Coward, P.2
Degtyarev, M.Y.3
Lee, E.K.4
Kwa, A.T.5
Hennighausen, L.6
Bujard, H.7
Fishman, G.I.8
Conklin, B.R.9
-
93
-
-
0034712586
-
Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy
-
Redfern C.H., Degtyarev M.Y., Kwa A.T., Salomonis N., Cotte N., Nanevicz T., Fidelman N., Desai K., Vranizan K., Lee E.K., et al. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc. Natl. Acad. Sci. USA 2000, 97:4826-4831.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 4826-4831
-
-
Redfern, C.H.1
Degtyarev, M.Y.2
Kwa, A.T.3
Salomonis, N.4
Cotte, N.5
Nanevicz, T.6
Fidelman, N.7
Desai, K.8
Vranizan, K.9
Lee, E.K.10
-
94
-
-
84870493042
-
NOBEL 2012 Chemistry: Studies of a ubiquitous receptor family
-
Roth B.L., Marshall F.H. NOBEL 2012 Chemistry: Studies of a ubiquitous receptor family. Nature 2012, 492:57.
-
(2012)
Nature
, vol.492
, pp. 57
-
-
Roth, B.L.1
Marshall, F.H.2
-
95
-
-
0026638381
-
Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors
-
Roth B.L., Ciaranello R.D., Meltzer H.Y. Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors. J. Pharmacol. Exp. Ther. 1992, 260:1361-1365.
-
(1992)
J. Pharmacol. Exp. Ther.
, vol.260
, pp. 1361-1365
-
-
Roth, B.L.1
Ciaranello, R.D.2
Meltzer, H.Y.3
-
96
-
-
0028261434
-
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-and 5-hydroxytryptamine-receptors
-
Roth B.L., Craigo S.C., Choudhary M.S., Uluer A., Monsma F.J., Shen Y., Meltzer H.Y., Sibley D.R. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-and 5-hydroxytryptamine-receptors. J. Pharmacol. Exp. Ther. 1994, 268:1403-1410.
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.268
, pp. 1403-1410
-
-
Roth, B.L.1
Craigo, S.C.2
Choudhary, M.S.3
Uluer, A.4
Monsma, F.J.5
Shen, Y.6
Meltzer, H.Y.7
Sibley, D.R.8
-
97
-
-
0028990758
-
D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs
-
Roth B.L., Tandra S., Burgess L.H., Sibley D.R., Meltzer H.Y. D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs. Psychopharmacology (Berl.) 1995, 120:365-368.
-
(1995)
Psychopharmacology (Berl.)
, vol.120
, pp. 365-368
-
-
Roth, B.L.1
Tandra, S.2
Burgess, L.H.3
Sibley, D.R.4
Meltzer, H.Y.5
-
98
-
-
0020391631
-
Review important concepts of receptor theory
-
Ruffolo R.R. Review important concepts of receptor theory. J. Auton. Pharmacol. 1982, 2:277-295.
-
(1982)
J. Auton. Pharmacol.
, vol.2
, pp. 277-295
-
-
Ruffolo, R.R.1
-
99
-
-
84936855430
-
Inhibiting the Activity of CA1 Hippocampal Neurons Prevents the Recall of Contextual Fear Memory in Inducible ArchT Transgenic Mice
-
Sakaguchi M., Kim K., Yu L.M., Hashikawa Y., Sekine Y., Okumura Y., Kawano M., Hayashi M., Kumar D., Boyden E.S., et al. Inhibiting the Activity of CA1 Hippocampal Neurons Prevents the Recall of Contextual Fear Memory in Inducible ArchT Transgenic Mice. PLoS ONE 2015, 10:e0130163.
-
(2015)
PLoS ONE
, vol.10
-
-
Sakaguchi, M.1
Kim, K.2
Yu, L.M.3
Hashikawa, Y.4
Sekine, Y.5
Okumura, Y.6
Kawano, M.7
Hayashi, M.8
Kumar, D.9
Boyden, E.S.10
-
100
-
-
0027513982
-
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model
-
Samama P., Cotecchia S., Costa T., Lefkowitz R.J. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J. Biol. Chem. 1993, 268:4625-4636.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 4625-4636
-
-
Samama, P.1
Cotecchia, S.2
Costa, T.3
Lefkowitz, R.J.4
-
101
-
-
0028209348
-
Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor
-
Samama P., Pei G., Costa T., Cotecchia S., Lefkowitz R.J. Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor. Mol. Pharmacol. 1994, 45:390-394.
-
(1994)
Mol. Pharmacol.
, vol.45
, pp. 390-394
-
-
Samama, P.1
Pei, G.2
Costa, T.3
Cotecchia, S.4
Lefkowitz, R.J.5
-
102
-
-
79957609043
-
Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice
-
Sasaki K., Suzuki M., Mieda M., Tsujino N., Roth B., Sakurai T. Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice. PLoS ONE 2011, 6:e20360.
-
(2011)
PLoS ONE
, vol.6
-
-
Sasaki, K.1
Suzuki, M.2
Mieda, M.3
Tsujino, N.4
Roth, B.5
Sakurai, T.6
-
103
-
-
0037657915
-
A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse
-
Schnütgen F., Doerflinger N., Calléja C., Wendling O., Chambon P., Ghyselinck N.B. A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse. Nat. Biotechnol. 2003, 21:562-565.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 562-565
-
-
Schnütgen, F.1
Doerflinger, N.2
Calléja, C.3
Wendling, O.4
Chambon, P.5
Ghyselinck, N.B.6
-
104
-
-
84941181664
-
Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking
-
Scofield M.D., Boger H.A., Smith R.J., Li H., Haydon P.G., Kalivas P.W. Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking. Biol. Psychiatry 2015, 78:441-451.
-
(2015)
Biol. Psychiatry
, vol.78
, pp. 441-451
-
-
Scofield, M.D.1
Boger, H.A.2
Smith, R.J.3
Li, H.4
Haydon, P.G.5
Kalivas, P.W.6
-
105
-
-
84860513814
-
Structure-based drug screening for G-protein-coupled receptors
-
Shoichet B.K., Kobilka B.K. Structure-based drug screening for G-protein-coupled receptors. Trends Pharmacol. Sci. 2012, 33:268-272.
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 268-272
-
-
Shoichet, B.K.1
Kobilka, B.K.2
-
106
-
-
84906232914
-
Visualization of arrestin recruitment by a G-protein-coupled receptor
-
Shukla A.K., Westfield G.H., Xiao K., Reis R.I., Huang L.Y., Tripathi-Shukla P., Qian J., Li S., Blanc A., Oleskie A.N., et al. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature 2014, 512:218-222.
-
(2014)
Nature
, vol.512
, pp. 218-222
-
-
Shukla, A.K.1
Westfield, G.H.2
Xiao, K.3
Reis, R.I.4
Huang, L.Y.5
Tripathi-Shukla, P.6
Qian, J.7
Li, S.8
Blanc, A.9
Oleskie, A.N.10
-
107
-
-
84870518549
-
A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development
-
Soskis M.J., Ho H.Y., Bloodgood B.L., Robichaux M.A., Malik A.N., Ataman B., Rubin A.A., Zieg J., Zhang C., Shokat K.M., et al. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat. Neurosci. 2012, 15:1645-1654.
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 1645-1654
-
-
Soskis, M.J.1
Ho, H.Y.2
Bloodgood, B.L.3
Robichaux, M.A.4
Malik, A.N.5
Ataman, B.6
Rubin, A.A.7
Zieg, J.8
Zhang, C.9
Shokat, K.M.10
-
108
-
-
84939832832
-
Propagation of conformational changes during μ-opioid receptor activation
-
Sounier R., Mas C., Steyaert J., Laeremans T., Manglik A., Huang W., Kobilka B.K., Déméné H., Granier S. Propagation of conformational changes during μ-opioid receptor activation. Nature 2015, 524:375-378.
-
(2015)
Nature
, vol.524
, pp. 375-378
-
-
Sounier, R.1
Mas, C.2
Steyaert, J.3
Laeremans, T.4
Manglik, A.5
Huang, W.6
Kobilka, B.K.7
Déméné, H.8
Granier, S.9
-
109
-
-
84901009992
-
Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior
-
Stachniak T.J., Ghosh A., Sternson S.M. Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior. Neuron 2014, 82:797-808.
-
(2014)
Neuron
, vol.82
, pp. 797-808
-
-
Stachniak, T.J.1
Ghosh, A.2
Sternson, S.M.3
-
110
-
-
84904676650
-
Chemogenetic tools to interrogate brain functions
-
Sternson S.M., Roth B.L. Chemogenetic tools to interrogate brain functions. Annu. Rev. Neurosci. 2014, 37:387-407.
-
(2014)
Annu. Rev. Neurosci.
, vol.37
, pp. 387-407
-
-
Sternson, S.M.1
Roth, B.L.2
-
111
-
-
84900516697
-
Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)
-
Strachan R.T., Sun J.P., Rominger D.H., Violin J.D., Ahn S., Rojas Bie Thomsen A., Zhu X., Kleist A., Costa T., Lefkowitz R.J. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J. Biol. Chem. 2014, 289:14211-14224.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 14211-14224
-
-
Strachan, R.T.1
Sun, J.P.2
Rominger, D.H.3
Violin, J.D.4
Ahn, S.5
Rojas Bie Thomsen, A.6
Zhu, X.7
Kleist, A.8
Costa, T.9
Lefkowitz, R.J.10
-
112
-
-
0026057332
-
Allele-specific activation of genetically engineered receptors
-
Strader C.D., Gaffney T., Sugg E.E., Candelore M.R., Keys R., Patchett A.A., Dixon R.A. Allele-specific activation of genetically engineered receptors. J. Biol. Chem. 1991, 266:5-8.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 5-8
-
-
Strader, C.D.1
Gaffney, T.2
Sugg, E.E.3
Candelore, M.R.4
Keys, R.5
Patchett, A.A.6
Dixon, R.A.7
-
113
-
-
0031773724
-
Ribozyme chemogenetics
-
Strobel S.A. Ribozyme chemogenetics. Biopolymers 1998, 48:65-81.
-
(1998)
Biopolymers
, vol.48
, pp. 65-81
-
-
Strobel, S.A.1
-
114
-
-
33847421779
-
Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes
-
Sweger E.J., Casper K.B., Scearce-Levie K., Conklin B.R., McCarthy K.D. Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes. J. Neurosci. 2007, 27:2309-2317.
-
(2007)
J. Neurosci.
, vol.27
, pp. 2309-2317
-
-
Sweger, E.J.1
Casper, K.B.2
Scearce-Levie, K.3
Conklin, B.R.4
McCarthy, K.D.5
-
115
-
-
84947733057
-
Activity of raphe serotonergic neurons controls emotional behaviors
-
Teissier A., Chemiakine A., Inbar B., Bagchi S., Ray R.S., Palmiter R.D., Dymecki S.M., Moore H., Ansorge M.S. Activity of raphe serotonergic neurons controls emotional behaviors. Cell Rep. 2015, 13:1965-1976.
-
(2015)
Cell Rep.
, vol.13
, pp. 1965-1976
-
-
Teissier, A.1
Chemiakine, A.2
Inbar, B.3
Bagchi, S.4
Ray, R.S.5
Palmiter, R.D.6
Dymecki, S.M.7
Moore, H.8
Ansorge, M.S.9
-
116
-
-
79960663747
-
Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice
-
Tsunematsu T., Kilduff T.S., Boyden E.S., Takahashi S., Tominaga M., Yamanaka A. Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice. J. Neurosci. 2011, 31:10529-10539.
-
(2011)
J. Neurosci.
, vol.31
, pp. 10529-10539
-
-
Tsunematsu, T.1
Kilduff, T.S.2
Boyden, E.S.3
Takahashi, S.4
Tominaga, M.5
Yamanaka, A.6
-
117
-
-
84920828713
-
DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility
-
Urban D.J., Roth B.L. DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annu. Rev. Pharmacol. Toxicol. 2015, 55:399-417.
-
(2015)
Annu. Rev. Pharmacol. Toxicol.
, vol.55
, pp. 399-417
-
-
Urban, D.J.1
Roth, B.L.2
-
118
-
-
84960863666
-
Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons
-
Urban D.J., Zhu H., Marcinkiewcz C.A., Michaelides M., Oshibuchi H., Rhea D., Aryal D.K., Farrell M.S., Lowery-Gionta E., Olsen R.H., et al. Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons. Neuropsychopharmacology 2015, 10.1038/npp.2015.293.
-
(2015)
Neuropsychopharmacology
-
-
Urban, D.J.1
Zhu, H.2
Marcinkiewcz, C.A.3
Michaelides, M.4
Oshibuchi, H.5
Rhea, D.6
Aryal, D.K.7
Farrell, M.S.8
Lowery-Gionta, E.9
Olsen, R.H.10
-
119
-
-
84873306058
-
Conformational ensembles in GPCR activation
-
Vardy E., Roth B.L. Conformational ensembles in GPCR activation. Cell 2013, 152:385-386.
-
(2013)
Cell
, vol.152
, pp. 385-386
-
-
Vardy, E.1
Roth, B.L.2
-
120
-
-
84930244375
-
A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior
-
Vardy E., Robinson J.E., Li C., Olsen R.H., DiBerto J.F., Giguere P.M., Sassano F.M., Huang X.P., Zhu H., Urban D.J., et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron 2015, 86:936-946.
-
(2015)
Neuron
, vol.86
, pp. 936-946
-
-
Vardy, E.1
Robinson, J.E.2
Li, C.3
Olsen, R.H.4
DiBerto, J.F.5
Giguere, P.M.6
Sassano, F.M.7
Huang, X.P.8
Zhu, H.9
Urban, D.J.10
-
121
-
-
84896268722
-
Designer receptor manipulations reveal a role of the locus coeruleus noradrenergic system in isoflurane general anesthesia
-
Vazey E.M., Aston-Jones G. Designer receptor manipulations reveal a role of the locus coeruleus noradrenergic system in isoflurane general anesthesia. Proc. Natl. Acad. Sci. USA 2014, 111:3859-3864.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 3859-3864
-
-
Vazey, E.M.1
Aston-Jones, G.2
-
122
-
-
84877631485
-
Structural features for functional selectivity at serotonin receptors
-
Wacker D., Wang C., Katritch V., Han G.W., Huang X.P., Vardy E., McCorvy J.D., Jiang Y., Chu M., Siu F.Y., et al. Structural features for functional selectivity at serotonin receptors. Science 2013, 340:615-619.
-
(2013)
Science
, vol.340
, pp. 615-619
-
-
Wacker, D.1
Wang, C.2
Katritch, V.3
Han, G.W.4
Huang, X.P.5
Vardy, E.6
McCorvy, J.D.7
Jiang, Y.8
Chu, M.9
Siu, F.Y.10
-
123
-
-
84877607189
-
Structural basis for molecular recognition at serotonin receptors
-
Wang C., Jiang Y., Ma J., Wu H., Wacker D., Katritch V., Han G.W., Liu W., Huang X.P., Vardy E., et al. Structural basis for molecular recognition at serotonin receptors. Science 2013, 340:610-614.
-
(2013)
Science
, vol.340
, pp. 610-614
-
-
Wang, C.1
Jiang, Y.2
Ma, J.3
Wu, H.4
Wacker, D.5
Katritch, V.6
Han, G.W.7
Liu, W.8
Huang, X.P.9
Vardy, E.10
-
124
-
-
84875807317
-
Conformation guides molecular efficacy in docking screens of activated β-adrenergic G protein coupled receptor
-
Weiss D.R., Ahn S., Sassano M.F., Kleist A., Zhu X., Strachan R., Roth B.L., Lefkowitz R.J., Shoichet B.K. Conformation guides molecular efficacy in docking screens of activated β-adrenergic G protein coupled receptor. ACS Chem. Biol. 2013, 8:1018-1026.
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 1018-1026
-
-
Weiss, D.R.1
Ahn, S.2
Sassano, M.F.3
Kleist, A.4
Zhu, X.5
Strachan, R.6
Roth, B.L.7
Lefkowitz, R.J.8
Shoichet, B.K.9
-
125
-
-
0032705446
-
Engineering in a region of bulk tolerance into the 5-HT2A receptor
-
Westkaemper R., Glennon R., Hyde E., Choudhary M., Khan N., Roth B. Engineering in a region of bulk tolerance into the 5-HT2A receptor. Eur. J. Med. Chem. 1999, 34:441-447.
-
(1999)
Eur. J. Med. Chem.
, vol.34
, pp. 441-447
-
-
Westkaemper, R.1
Glennon, R.2
Hyde, E.3
Choudhary, M.4
Khan, N.5
Roth, B.6
-
126
-
-
0037417982
-
Photochemical gating of heterologous ion channels: remote control over genetically designated populations of neurons
-
Zemelman B.V., Nesnas N., Lee G.A., Miesenbock G. Photochemical gating of heterologous ion channels: remote control over genetically designated populations of neurons. Proc. Natl. Acad. Sci. USA 2003, 100:1352-1357.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 1352-1357
-
-
Zemelman, B.V.1
Nesnas, N.2
Lee, G.A.3
Miesenbock, G.4
-
127
-
-
84902551486
-
Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory
-
Zhu H., Pleil K.E., Urban D.J., Moy S.S., Kash T.L., Roth B.L. Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory. Neuropsychopharmacology 2014, 39:1880-1892.
-
(2014)
Neuropsychopharmacology
, vol.39
, pp. 1880-1892
-
-
Zhu, H.1
Pleil, K.E.2
Urban, D.J.3
Moy, S.S.4
Kash, T.L.5
Roth, B.L.6
-
128
-
-
0034664128
-
G(olf)alpha mediates dopamine D1 receptor signaling
-
Zhuang X., Belluscio L., Hen R. G(olf)alpha mediates dopamine D1 receptor signaling. J. Neurosci. 2000, 20:RC91.
-
(2000)
J. Neurosci.
, vol.20
, pp. RC91
-
-
Zhuang, X.1
Belluscio, L.2
Hen, R.3
|