-
2
-
-
25444482429
-
Mammalian G proteins and their cell type specific functions
-
Wettschureck, N. & Offermanns, S. Mammalian G proteins and their cell type specific functions. Physiol. Rev. 85, 1159-1204 (2005).
-
(2005)
Physiol. Rev
, vol.85
, pp. 1159-1204
-
-
Wettschureck, N.1
Offermanns, S.2
-
3
-
-
1542358991
-
Inherited diseases involving G proteins and G protein-coupled receptors
-
Spiegel, A.M. & Weinstein, L.S. Inherited diseases involving G proteins and G protein-coupled receptors. Annu. Rev. Med. 55, 27-39 (2004).
-
(2004)
Annu. Rev. Med
, vol.55
, pp. 27-39
-
-
Spiegel, A.M.1
Weinstein, L.S.2
-
5
-
-
0031940393
-
Controlling signaling with a specifically designed Gi-coupled receptor
-
Coward, P. et al. Controlling signaling with a specifically designed Gi-coupled receptor. Proc. Natl. Acad. Sci. USA 95, 352-357 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 352-357
-
-
Coward, P.1
-
6
-
-
0035943605
-
Modification of the beta 2-adrenergic receptor to engineer a receptor-effector complex for gene therapy
-
Small, K.M., Brown, K.M., Forbes, S.L. & Liggett, S.B. Modification of the beta 2-adrenergic receptor to engineer a receptor-effector complex for gene therapy. J. Biol. Chem. 276, 31596-31601 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 31596-31601
-
-
Small, K.M.1
Brown, K.M.2
Forbes, S.L.3
Liggett, S.B.4
-
7
-
-
33847108842
-
Neoceptors: Reengineering GPCRs to recognize tailored ligands
-
Jacobson, K.A., Gao, Z.G. & Liang, B.T. Neoceptors: Reengineering GPCRs to recognize tailored ligands. Trends Pharmacol. Sci. 28, 111-116 (2007).
-
(2007)
Trends Pharmacol. Sci
, vol.28
, pp. 111-116
-
-
Jacobson, K.A.1
Gao, Z.G.2
Liang, B.T.3
-
8
-
-
34247640671
-
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
-
Armbruster, B.N., Li, X., Pausch, M.H., Herlitze, S. & Roth, B.L. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc. Natl. Acad. Sci. USA 104, 5163-5168 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 5163-5168
-
-
Armbruster, B.N.1
Li, X.2
Pausch, M.H.3
Herlitze, S.4
Roth, B.L.5
-
9
-
-
0026057332
-
Allele-specific activation of genetically engineered receptors
-
Strader, C.D. et al. Allele-specific activation of genetically engineered receptors. J. Biol. Chem. 266, 5-8 (1991).
-
(1991)
J. Biol. Chem
, vol.266
, pp. 5-8
-
-
Strader, C.D.1
-
10
-
-
77957055780
-
Integrated methods for modeling G-protein coupled receptors
-
Ballesteros, J.A. & Weinstein, H. Integrated methods for modeling G-protein coupled receptors. Meth. Neurosci. 25, 366-428 (1995).
-
(1995)
Meth. Neurosci
, vol.25
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.2
-
11
-
-
0032966673
-
Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice
-
Redfern, C.H. et al. Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat. Biotechnol. 17, 165-169 (1999).
-
(1999)
Nat. Biotechnol
, vol.17
, pp. 165-169
-
-
Redfern, C.H.1
-
12
-
-
15044353688
-
The receptors and coding logic for bitter taste
-
Mueller, K.L. et al. The receptors and coding logic for bitter taste. Nature 434, 225-229 (2005).
-
(2005)
Nature
, vol.434
, pp. 225-229
-
-
Mueller, K.L.1
-
13
-
-
0344823647
-
The receptors for mammalian sweet and umami taste
-
Zhao, G.Q. et al. The receptors for mammalian sweet and umami taste. Cell 115, 255-266 (2003).
-
(2003)
Cell
, vol.115
, pp. 255-266
-
-
Zhao, G.Q.1
-
14
-
-
0034712586
-
Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy
-
Redfern, C.H. et al. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc. Natl. Acad. Sci. USA 97, 4826-4831 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 4826-4831
-
-
Redfern, C.H.1
-
15
-
-
33847421779
-
-
Sweger, E.J., Casper, K.B., Scearce-Levie, K., Conklin, B.R. & McCarthy, K.D. Development of hydrocephalus in mice expressing the G(i -coupted GPCR Ro1 RASSL receptor in astrocytes. J. Neurosci. 27, 2309-2317 (2007).
-
Sweger, E.J., Casper, K.B., Scearce-Levie, K., Conklin, B.R. & McCarthy, K.D. Development of hydrocephalus in mice expressing the G(i -coupted GPCR Ro1 RASSL receptor in astrocytes. J. Neurosci. 27, 2309-2317 (2007).
-
-
-
-
16
-
-
40849114831
-
Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia
-
Peng, J. et al. Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinol. 149 1329-1337 (2007).
-
(2007)
Endocrinol
, vol.149
, pp. 1329-1337
-
-
Peng, J.1
-
17
-
-
0037428475
-
-
Claeysen, S., Joubert, L., Sebben, M., Bockaert, J. & Dumuis, A. A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL). J. Biol. Chem. 278, 699-702 (2003).
-
Claeysen, S., Joubert, L., Sebben, M., Bockaert, J. & Dumuis, A. A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL). J. Biol. Chem. 278, 699-702 (2003).
-
-
-
-
18
-
-
27144529199
-
(q/11)-coupled mutant histamine H(1) receptor F435A activated solely by synthetic ligands (RASSL)
-
Bruysters, M., Jongejan, A., Akdemir, A., Bakker, R.A. & Leurs, R.A.G. (q/11)-coupled mutant histamine H(1) receptor F435A activated solely by synthetic ligands (RASSL). J. Biol. Chem. 280, 34741-34746 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 34741-34746
-
-
Bruysters, M.1
Jongejan, A.2
Akdemir, A.3
Bakker, R.A.4
Leurs, R.A.G.5
-
19
-
-
0034119969
-
A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "satt-bridge disruption" mechanism
-
Kristiansen, K. et al. A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "satt-bridge disruption" mechanism. J. Pharmacol. Exp. Ther. 293, 735-746 (2000).
-
(2000)
J. Pharmacol. Exp. Ther
, vol.293
, pp. 735-746
-
-
Kristiansen, K.1
-
20
-
-
39849109213
-
Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo
-
Srinivasan, S., Santiago, P., Lubrano, C., Vaisse, C. & Conklin, B.R. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PLoS ONE 2, e668 (2007).
-
(2007)
PLoS ONE
, vol.2
-
-
Srinivasan, S.1
Santiago, P.2
Lubrano, C.3
Vaisse, C.4
Conklin, B.R.5
-
21
-
-
44449176620
-
Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor
-
Chang, W.C. et al. Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor. PLoS ONE 2, e1317 (2007).
-
(2007)
PLoS ONE
, vol.2
-
-
Chang, W.C.1
-
22
-
-
39549099297
-
Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass
-
Hsiao, E.C. et al. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc. Natl. Acad. Sci. USA 105, 1209-1214 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 1209-1214
-
-
Hsiao, E.C.1
-
23
-
-
0141953281
-
Unravelling multiple ligand-activation binding sites using RASSL receptors
-
Pauwels, P.J. Unravelling multiple ligand-activation binding sites using RASSL receptors. Trends Pharmacol. Sci. 24, 504-507 (2003).
-
(2003)
Trends Pharmacol. Sci
, vol.24
, pp. 504-507
-
-
Pauwels, P.J.1
-
24
-
-
0028126689
-
-
Bender, D., Holschbach, M. & Stocklin, G. Synthesis of n.c.a. carbon-11 labelled clozapine and its major metabolite clozapine-N-oxide and comparison of their biodistribution in mice. Nucl. Med. Biol. 21, 921-925 (1994).
-
Bender, D., Holschbach, M. & Stocklin, G. Synthesis of n.c.a. carbon-11 labelled clozapine and its major metabolite clozapine-N-oxide and comparison of their biodistribution in mice. Nucl. Med. Biol. 21, 921-925 (1994).
-
-
-
-
25
-
-
0031543433
-
G-protein-coupled receptors in Saccharomyces cerevisiae high-throughput screening assays for drug discovery
-
Pausch, M.H. G-protein-coupled receptors in Saccharomyces cerevisiae high-throughput screening assays for drug discovery. Trends Biotechnol. 15, 487-494 (1997).
-
(1997)
Trends Biotechnol
, vol.15
, pp. 487-494
-
-
Pausch, M.H.1
-
26
-
-
0025812324
-
Model systems for the study of seven-transmembrane-segment receptors
-
Dohlman, H.G., Thorner, J., Caron, M.G. & Lefkowitz, R.J. Model systems for the study of seven-transmembrane-segment receptors. Annu. Rev. Biochem. 60, 653-688 (1991).
-
(1991)
Annu. Rev. Biochem
, vol.60
, pp. 653-688
-
-
Dohlman, H.G.1
Thorner, J.2
Caron, M.G.3
Lefkowitz, R.J.4
-
27
-
-
33947399187
-
Rapid identification of functionally critical amino acids in a G protein-coupled receptor
-
Li, B. et al. Rapid identification of functionally critical amino acids in a G protein-coupled receptor. Nat. Methods 4, 169-174 (2007).
-
(2007)
Nat. Methods
, vol.4
, pp. 169-174
-
-
Li, B.1
-
28
-
-
15944366921
-
Yeast system as a screening tool for pharmacological assessment of g protein coupled receptors
-
Minic, J., Sautel, M., Salesse, R. & Pajot-Augy, E. Yeast system as a screening tool for pharmacological assessment of g protein coupled receptors. Curr. Med. Chem. 12, 961-969 (2005).
-
(2005)
Curr. Med. Chem
, vol.12
, pp. 961-969
-
-
Minic, J.1
Sautel, M.2
Salesse, R.3
Pajot-Augy, E.4
-
29
-
-
0037192858
-
Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6
-
Shapiro, D.A., Kristiansen, K., Weiner, O.M., Kroeze, W.K. & Roth, B.L. Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6. J. Biol. Chem. 277, 11441-11449 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 11441-11449
-
-
Shapiro, D.A.1
Kristiansen, K.2
Weiner, O.M.3
Kroeze, W.K.4
Roth, B.L.5
-
30
-
-
34447649922
-
Beta-arrestin-biased ligands at seven-transmembrane receptors
-
Violin, J.D. & Lefkowitz, R.J. Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol. Sci. 28, 416-422 (2007).
-
(2007)
Trends Pharmacol. Sci
, vol.28
, pp. 416-422
-
-
Violin, J.D.1
Lefkowitz, R.J.2
-
31
-
-
36448995359
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
-
Cherezov, V. et al. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318, 1258-1265 (2007).
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
-
32
-
-
33846017361
-
Drugs and valvular heart disease
-
Roth, B.L. Drugs and valvular heart disease. N. Engl. J. Med. 356, 6-9 (2007).
-
(2007)
N. Engl. J. Med
, vol.356
, pp. 6-9
-
-
Roth, B.L.1
-
33
-
-
0036033424
-
Constitutive activity of G-protein-coupled receptors: Cause of disease and common property of wild-type receptors
-
Seifert, R. & Wenzel-Seifert, K. Constitutive activity of G-protein-coupled receptors: Cause of disease and common property of wild-type receptors. Naunyn Schmiedebergs Arch. Pharmacol. 366 381-416 (2002).
-
(2002)
Naunyn Schmiedebergs Arch. Pharmacol
, vol.366
, pp. 381-416
-
-
Seifert, R.1
Wenzel-Seifert, K.2
-
34
-
-
0036463901
-
Efficacy at G-protein-coupled receptors
-
Kenakin, T. Efficacy at G-protein-coupled receptors. Nat. Rev. Drug Discov. 1, 103-110 (2002).
-
(2002)
Nat. Rev. Drug Discov
, vol.1
, pp. 103-110
-
-
Kenakin, T.1
-
35
-
-
9644279627
-
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
-
Srinivasan, S. et al. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J. Clin. Invest. 114, 1158-1164 (2004).
-
(2004)
J. Clin. Invest
, vol.114
, pp. 1158-1164
-
-
Srinivasan, S.1
-
36
-
-
36148996843
-
G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes
-
Winzell, M.S. & Ahren, B. G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes. Pharmacol. Ther. 116, 437-448 (2007).
-
(2007)
Pharmacol. Ther
, vol.116
, pp. 437-448
-
-
Winzell, M.S.1
Ahren, B.2
-
37
-
-
27544460207
-
Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling
-
Scearce-Levie, K., Lieberman, M.D., Elliott, H.H. & Conklin, B.R. Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling. BMC Biol. 3, 3 (2005).
-
(2005)
BMC Biol
, vol.3
, pp. 3
-
-
Scearce-Levie, K.1
Lieberman, M.D.2
Elliott, H.H.3
Conklin, B.R.4
|