Chemical and genetic engineering of selective ion channel-ligand interactions

Science

Volumn 333, Issue 6047, 2011, Pages 1292-1296

  Magnus, Christopher J ^a   Lee, Peter H ^a   Atasoy, Deniz ^a   Su, Helen H ^a   Looger, Loren L ^a   Sternson, Scott M ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND GATED ION CHANNEL;

BRAIN; CYTOLOGY; GENETIC ENGINEERING; ION EXCHANGE; MAMMAL; PHYSIOLOGICAL RESPONSE; PROBE; PROTEIN;

ANIMAL BEHAVIOR; ARTICLE; BRAIN; CELL SPECIFICITY; CELL TYPE; CHEMICAL ENGINEERING; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IN VIVO STUDY; ION CONDUCTANCE; LIGAND BINDING; MAMMAL; MOLECULAR INTERACTION; MOLECULAR LIBRARY; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING;

ANIMALS; BENZAMIDES; BICYCLO COMPOUNDS; BRAIN; FEEDING BEHAVIOR; FEMALE; HEK293 CELLS; HUMANS; ION CHANNEL GATING; LIGAND-GATED ION CHANNELS; LIGANDS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MUTAGENESIS; NEURONS; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; QUINUCLIDINES; RECEPTORS, GLYCINE; RECEPTORS, NICOTINIC; RECEPTORS, SEROTONIN, 5-HT3; RECOMBINANT FUSION PROTEINS; SMALL MOLECULE LIBRARIES; STEREOISOMERISM;

ANIMALIA; MAMMALIA;

EID: 80052436339     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1206606     Document Type: Article

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