Tailoring the active site of chemzymes by using a chemogenetic-optimization procedure: Towards substrate-specific artificial hydrogenases based on the biotin-avidin technology

Angewandte Chemie - International Edition

Volumn 44, Issue 47, 2005, Pages 7764-7767

  Klein, Gérard ^a   Humbert, Nicolas ^a   Gradinaru, Julieta ^a   Ivanova, Anita ^a   Gilardoni, François ^a   Rusbandi, Untung E ^a   Ward, Thomas R ^a  

^a UNIVERSITY OF NEUCHÂTEL   (Switzerland)

Author keywords

Asymmetric catalysis; Combinatorial chemistry; Hydrogenation; Metalloenzymes; Mutagenesis

Indexed keywords

CATALYSIS; GENETIC ENGINEERING; HYDROGENATION; MUTAGENESIS; PROTEINS;

ASYMMETRIC CATALYSIS; BIOTIN-AVIDIN TECHNOLOGY; COMBINATORIAL CHEMISTRY; METALLOENZYMES;

ENZYMES;

BIOTIN; HYDROGENASE; STREPTAVIDIN;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; ENZYME SPECIFICITY; METHODOLOGY; OXIDATION REDUCTION REACTION; SYNTHESIS;

BINDING SITES; BIOTIN; COMBINATORIAL CHEMISTRY TECHNIQUES; HYDROGENASE; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; STREPTAVIDIN; SUBSTRATE SPECIFICITY;

EID: 28744432508     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200502000     Document Type: Article

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