Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking

Biological Psychiatry

Volumn 78, Issue 7, 2015, Pages 441-451

  Scofield, Michael D ^a   Boger, Heather A ^a   Smith, Rachel J ^a   Li, Hao ^a   Haydon, Philip G ^b   Kalivas, Peter W ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Astrocytes; Biosensor; Cocaine; DREADD; Glutamate; Reinstatement

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; CALCIUM CHANNEL N TYPE; CLOZAPINE N OXIDE; COCAINE; DESIGNER DRUG; DESIGNER RECEPTOR EXCLUSIVELY ACTIVATED BY A DESIGNER DRUG; GLUTAMIC ACID; PARVOVIRUS VECTOR; SOLUBLE N ETHYLMALEIMIDE SENSITIVE FACTOR ATTACHMENT PROTEIN; UNCLASSIFIED DRUG; CENTRAL NERVOUS SYSTEM AGENTS; CLOZAPINE; CLOZAPINE N-OXIDE; DOPAMINE UPTAKE INHIBITOR; G PROTEIN COUPLED RECEPTOR; METABOTROPIC RECEPTOR; SNARE PROTEIN; SUGAR INTAKE;

ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG SEEKING BEHAVIOR; ENZYMIC BIOSENSOR; EXTRACELLULAR SPACE; GLIA CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MACROGLIA; MALE; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; NUCLEUS ACCUMBENS CORE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SECRETION; RAT; ADMINISTRATION AND DOSAGE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; ASSOCIATION; COCAINE-RELATED DISORDERS; DISEASE MODEL; DRUG EFFECTS; DRUG SELF ADMINISTRATION; GENE THERAPY; GENETICS; METABOLISM; NUCLEUS ACCUMBENS; PATHOPHYSIOLOGY; PHYSIOLOGY; REINFORCEMENT; SPRAGUE DAWLEY RAT; SUGAR INTAKE; TRANSGENIC MOUSE;

ANIMALS; ASTROCYTES; CALCIUM CHANNELS, N-TYPE; CENTRAL NERVOUS SYSTEM AGENTS; CLOZAPINE; COCAINE; COCAINE-RELATED DISORDERS; CUES; DIETARY SUCROSE; DISEASE MODELS, ANIMAL; DOPAMINE UPTAKE INHIBITORS; DRUG-SEEKING BEHAVIOR; EXTINCTION, PSYCHOLOGICAL; GENETIC THERAPY; GLUTAMIC ACID; MALE; MICE, TRANSGENIC; NUCLEUS ACCUMBENS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, METABOTROPIC GLUTAMATE; SELF ADMINISTRATION; SNARE PROTEINS;

EID: 84941181664     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.02.016     Document Type: Article

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