메뉴 건너뛰기




Volumn 4, Issue 5, 2013, Pages 1049-1059

DREADDs in drosophila: A pharmacogenetic approach for controlling behavior, neuronal signaling, and physiology in the fly

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; DESIGNER RECEPTORS EXCLUSIVELY ACTIVATED BY DESIGNER DRUG; G PROTEIN COUPLED RECEPTOR; MUSCARINIC RECEPTOR; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

EID: 84884145407     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.08.003     Document Type: Article
Times cited : (41)

References (48)
  • 2
    • 34247640671 scopus 로고    scopus 로고
    • Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
    • Armbruster B.N., Li X., Pausch M.H., Herlitze S., Roth B.L. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc. Natl. Acad. Sci. USA 2007, 104:5163-5168.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 5163-5168
    • Armbruster, B.N.1    Li, X.2    Pausch, M.H.3    Herlitze, S.4    Roth, B.L.5
  • 4
    • 79957954310 scopus 로고    scopus 로고
    • The serotonin 5-HT7Dro receptor is expressed in the brain of Drosophila, and is essential for normal courtship and mating
    • Becnel J., Johnson O., Luo J., Nässel D.R., Nichols C.D. The serotonin 5-HT7Dro receptor is expressed in the brain of Drosophila, and is essential for normal courtship and mating. PLoS ONE 2011, 6:e20800.
    • (2011) PLoS ONE , vol.6
    • Becnel, J.1    Johnson, O.2    Luo, J.3    Nässel, D.R.4    Nichols, C.D.5
  • 5
    • 26444621497 scopus 로고    scopus 로고
    • Millisecond-timescale, genetically targeted optical control of neural activity
    • Boyden E.S., Zhang F., Bamberg E., Nagel G., Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat. Neurosci. 2005, 8:1263-1268.
    • (2005) Nat. Neurosci. , vol.8 , pp. 1263-1268
    • Boyden, E.S.1    Zhang, F.2    Bamberg, E.3    Nagel, G.4    Deisseroth, K.5
  • 6
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand A.H., Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993, 118:401-415.
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 7
    • 78650744252 scopus 로고    scopus 로고
    • Monitoring heart function in larval Drosophila melanogaster for physiological studies
    • Cooper A.S., Rymond K.E., Ward M.A., Bocook E.L., Cooper R.L. Monitoring heart function in larval Drosophila melanogaster for physiological studies. J.Vis. Exp. 2009, 33:e1596.
    • (2009) J.Vis. Exp. , vol.33
    • Cooper, A.S.1    Rymond, K.E.2    Ward, M.A.3    Bocook, E.L.4    Cooper, R.L.5
  • 10
    • 0017655857 scopus 로고
    • Measurements on the depth of penetration of light (0.35--1.0 microgram) in tissue
    • Eichler J., Knof J., Lenz H. Measurements on the depth of penetration of light (0.35--1.0 microgram) in tissue. Radiat. Environ. Biophys. 1977, 14:239-242.
    • (1977) Radiat. Environ. Biophys. , vol.14 , pp. 239-242
    • Eichler, J.1    Knof, J.2    Lenz, H.3
  • 12
    • 0030175756 scopus 로고    scopus 로고
    • DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodies
    • Han K.A., Millar N.S., Grotewiel M.S., Davis R.L. DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodies. Neuron 1996, 16:1127-1135.
    • (1996) Neuron , vol.16 , pp. 1127-1135
    • Han, K.A.1    Millar, N.S.2    Grotewiel, M.S.3    Davis, R.L.4
  • 13
    • 77952168831 scopus 로고    scopus 로고
    • PDF receptor expression reveals direct interactions between circadian oscillators in Drosophila
    • Im S.H., Taghert P.H. PDF receptor expression reveals direct interactions between circadian oscillators in Drosophila. J.Comp. Neurol. 2010, 518:1925-1945.
    • (2010) J.Comp. Neurol. , vol.518 , pp. 1925-1945
    • Im, S.H.1    Taghert, P.H.2
  • 14
    • 79955708471 scopus 로고    scopus 로고
    • PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila
    • Im S.H., Li W., Taghert P.H. PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila. PLoS ONE 2011, 6:e18974.
    • (2011) PLoS ONE , vol.6
    • Im, S.H.1    Li, W.2    Taghert, P.H.3
  • 15
    • 80052261680 scopus 로고    scopus 로고
    • Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster
    • Johnson O., Becnel J., Nichols C.D. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience 2011, 192:372-381.
    • (2011) Neuroscience , vol.192 , pp. 372-381
    • Johnson, O.1    Becnel, J.2    Nichols, C.D.3
  • 16
    • 68649116520 scopus 로고    scopus 로고
    • Drosophila mutants in phospholipid signaling have reduced olfactory responses as adults and larvae
    • Kain P., Chandrashekaran S., Rodrigues V., Hasan G. Drosophila mutants in phospholipid signaling have reduced olfactory responses as adults and larvae. J.Neurogenet. 2009, 23:303-312.
    • (2009) J.Neurogenet. , vol.23 , pp. 303-312
    • Kain, P.1    Chandrashekaran, S.2    Rodrigues, V.3    Hasan, G.4
  • 18
    • 0037083067 scopus 로고    scopus 로고
    • Targeted expression of tetanus neurotoxin interferes with behavioral responses to sensory input in Drosophila
    • Keller A., Sweeney S.T., Zars T., O'Kane C.J., Heisenberg M. Targeted expression of tetanus neurotoxin interferes with behavioral responses to sensory input in Drosophila. J.Neurobiol. 2002, 50:221-233.
    • (2002) J.Neurobiol. , vol.50 , pp. 221-233
    • Keller, A.1    Sweeney, S.T.2    Zars, T.3    O'Kane, C.J.4    Heisenberg, M.5
  • 19
    • 20544431534 scopus 로고    scopus 로고
    • The 5-hydroxytryptamine4 receptor exhibits frequency-dependent properties in synaptic plasticity and behavioural metaplasticity in the hippocampal CA1 region invivo
    • Kemp A., Manahan-Vaughan D. The 5-hydroxytryptamine4 receptor exhibits frequency-dependent properties in synaptic plasticity and behavioural metaplasticity in the hippocampal CA1 region invivo. Cereb. Cortex 2005, 15:1037-1043.
    • (2005) Cereb. Cortex , vol.15 , pp. 1037-1043
    • Kemp, A.1    Manahan-Vaughan, D.2
  • 20
    • 0035072239 scopus 로고    scopus 로고
    • Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons
    • Kitamoto T. Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons. J.Neurobiol. 2001, 47:81-92.
    • (2001) J.Neurobiol. , vol.47 , pp. 81-92
    • Kitamoto, T.1
  • 21
    • 0042697145 scopus 로고    scopus 로고
    • A functional assay for G-protein-coupled receptors using stably transformed insect tissue culture cell lines
    • Knight P.J., Pfeifer T.A., Grigliatti T.A. A functional assay for G-protein-coupled receptors using stably transformed insect tissue culture cell lines. Anal. Biochem. 2003, 320:88-103.
    • (2003) Anal. Biochem. , vol.320 , pp. 88-103
    • Knight, P.J.1    Pfeifer, T.A.2    Grigliatti, T.A.3
  • 22
    • 41149137076 scopus 로고    scopus 로고
    • Rapid consolidation to a radish and protein synthesis-dependent long-term memory after single-session appetitive olfactory conditioning in Drosophila
    • Krashes M.J., Waddell S. Rapid consolidation to a radish and protein synthesis-dependent long-term memory after single-session appetitive olfactory conditioning in Drosophila. J.Neurosci. 2008, 28:3103-3113.
    • (2008) J.Neurosci. , vol.28 , pp. 3103-3113
    • Krashes, M.J.1    Waddell, S.2
  • 26
    • 29044433616 scopus 로고    scopus 로고
    • Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses
    • Nagel G., Brauner M., Liewald J.F., Adeishvili N., Bamberg E., Gottschalk A. Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. Curr. Biol. 2005, 15:2279-2284.
    • (2005) Curr. Biol. , vol.15 , pp. 2279-2284
    • Nagel, G.1    Brauner, M.2    Liewald, J.F.3    Adeishvili, N.4    Bamberg, E.5    Gottschalk, A.6
  • 27
    • 77954589642 scopus 로고    scopus 로고
    • Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors
    • Nichols C.D., Roth B.L. Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors. Front. Mol. Neurosci. 2009, 2:16.
    • (2009) Front. Mol. Neurosci. , vol.2 , pp. 16
    • Nichols, C.D.1    Roth, B.L.2
  • 28
    • 0037049244 scopus 로고    scopus 로고
    • Hallucinogens and Drosophila: linking serotonin receptor activation to behavior
    • Nichols C.D., Ronesi J., Pratt W., Sanders-Bush E. Hallucinogens and Drosophila: linking serotonin receptor activation to behavior. Neuroscience 2002, 115:979-984.
    • (2002) Neuroscience , vol.115 , pp. 979-984
    • Nichols, C.D.1    Ronesi, J.2    Pratt, W.3    Sanders-Bush, E.4
  • 30
    • 0037123779 scopus 로고    scopus 로고
    • Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock
    • Nitabach M.N., Blau J., Holmes T.C. Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock. Cell 2002, 109:485-495.
    • (2002) Cell , vol.109 , pp. 485-495
    • Nitabach, M.N.1    Blau, J.2    Holmes, T.C.3
  • 31
    • 32544439026 scopus 로고    scopus 로고
    • Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods
    • Nitabach M.N., Wu Y., Sheeba V., Lemon W.C., Strumbos J., Zelensky P.K., White B.H., Holmes T.C. Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods. J.Neurosci. 2006, 26:479-489.
    • (2006) J.Neurosci. , vol.26 , pp. 479-489
    • Nitabach, M.N.1    Wu, Y.2    Sheeba, V.3    Lemon, W.C.4    Strumbos, J.5    Zelensky, P.K.6    White, B.H.7    Holmes, T.C.8
  • 32
    • 0035940416 scopus 로고    scopus 로고
    • A conditional tissue-specific transgene expression system using inducible GAL4
    • Osterwalder T., Yoon K.S., White B.H., Keshishian H. A conditional tissue-specific transgene expression system using inducible GAL4. Proc. Natl. Acad. Sci. USA 2001, 98:12596-12601.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12596-12601
    • Osterwalder, T.1    Yoon, K.S.2    White, B.H.3    Keshishian, H.4
  • 34
    • 0141762594 scopus 로고    scopus 로고
    • Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors
    • Perret B.G., Wagner R., Lecat S., Brillet K., Rabut G., Bucher B., Pattus F. Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors. Protein Expr. Purif. 2003, 31:123-132.
    • (2003) Protein Expr. Purif. , vol.31 , pp. 123-132
    • Perret, B.G.1    Wagner, R.2    Lecat, S.3    Brillet, K.4    Rabut, G.5    Bucher, B.6    Pattus, F.7
  • 35
  • 36
    • 0035940413 scopus 로고    scopus 로고
    • P[Switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster
    • Roman G., Endo K., Zong L., Davis R.L. P[Switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 2001, 98:12602-12607.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12602-12607
    • Roman, G.1    Endo, K.2    Zong, L.3    Davis, R.L.4
  • 38
    • 79957609043 scopus 로고    scopus 로고
    • Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice
    • Sasaki K., Suzuki M., Mieda M., Tsujino N., Roth B., Sakurai T. Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice. PLoS ONE 2011, 6:e20360.
    • (2011) PLoS ONE , vol.6
    • Sasaki, K.1    Suzuki, M.2    Mieda, M.3    Tsujino, N.4    Roth, B.5    Sakurai, T.6
  • 39
    • 0026542571 scopus 로고
    • A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns
    • Saudou F., Boschert U., Amlaiky N., Plassat J.L., Hen R. A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns. EMBO J. 1992, 11:7-17.
    • (1992) EMBO J. , vol.11 , pp. 7-17
    • Saudou, F.1    Boschert, U.2    Amlaiky, N.3    Plassat, J.L.4    Hen, R.5
  • 41
    • 0030273379 scopus 로고    scopus 로고
    • Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth
    • Schuster C.M., Davis G.W., Fetter R.D., Goodman C.S. Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron 1996, 17:641-654.
    • (1996) Neuron , vol.17 , pp. 641-654
    • Schuster, C.M.1    Davis, G.W.2    Fetter, R.D.3    Goodman, C.S.4
  • 42
    • 56349125022 scopus 로고    scopus 로고
    • Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain
    • Shang Y., Griffith L.C., Rosbash M. Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain. Proc. Natl. Acad. Sci. USA 2008, 105:19587-19594.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 19587-19594
    • Shang, Y.1    Griffith, L.C.2    Rosbash, M.3
  • 43
    • 0028483237 scopus 로고
    • Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions
    • Stewart B.A., Atwood H.L., Renger J.J., Wang J., Wu C.F. Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions. J.Comp. Physiol. A. 1994, 175:179-191.
    • (1994) J.Comp. Physiol. A. , vol.175 , pp. 179-191
    • Stewart, B.A.1    Atwood, H.L.2    Renger, J.J.3    Wang, J.4    Wu, C.F.5
  • 44
    • 0027479044 scopus 로고
    • Organizing activity of wingless protein in Drosophila
    • Struhl G., Basler K. Organizing activity of wingless protein in Drosophila. Cell 1993, 72:527-540.
    • (1993) Cell , vol.72 , pp. 527-540
    • Struhl, G.1    Basler, K.2
  • 46
    • 0034198716 scopus 로고    scopus 로고
    • Human mu-opioid receptor overexpressed in Sf9 insect cells functionally coupled to endogenous Gi/o proteins
    • Wei Q., Zhou D.H., Shen Q.X., Chen J., Chen L.W., Wang T.L., Pei G., Chi Z.Q. Human mu-opioid receptor overexpressed in Sf9 insect cells functionally coupled to endogenous Gi/o proteins. Cell Res. 2000, 10:93-102.
    • (2000) Cell Res. , vol.10 , pp. 93-102
    • Wei, Q.1    Zhou, D.H.2    Shen, Q.X.3    Chen, J.4    Chen, L.W.5    Wang, T.L.6    Pei, G.7    Chi, Z.Q.8
  • 47
    • 0034724897 scopus 로고    scopus 로고
    • Localization of a short-term memory in Drosophila
    • Zars T., Fischer M., Schulz R., Heisenberg M. Localization of a short-term memory in Drosophila. Science 2000, 288:672-675.
    • (2000) Science , vol.288 , pp. 672-675
    • Zars, T.1    Fischer, M.2    Schulz, R.3    Heisenberg, M.4
  • 48
    • 35748963218 scopus 로고    scopus 로고
    • A toolbox for light control of Drosophila behaviors through Channelrhodopsin 2-mediated photoactivation of targeted neurons
    • Zhang W., Ge W., Wang Z. A toolbox for light control of Drosophila behaviors through Channelrhodopsin 2-mediated photoactivation of targeted neurons. Eur. J. Neurosci. 2007, 26:2405-2416.
    • (2007) Eur. J. Neurosci. , vol.26 , pp. 2405-2416
    • Zhang, W.1    Ge, W.2    Wang, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.