A chemical-genetic approach to study G protein regulation of β cell function in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 45, 2009, Pages 19197-19202

  Guettier, Jean Marc ^a   Gautam, Dinesh ^a   Scarselli, Marco ^a,d   De Azua, Inigo Ruiz ^a   Li, Jian Hua ^a   Rosemond, Erica ^a   Ma, Xiaochao ^b,e   Gonzalez, Frank J ^b   Armbruster, Blaine N ^c,f   Lu, Huiyan ^a   Roth, Bryan L ^c   Wess, Jürgen ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d EPFL   (Switzerland)

^e UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^f Millipore Corporation   (United States)

Author keywords

Beta cells; G protein coupled receptors; Transgenic mice; Type 2 diabetes

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN RELEASE; INSULIN RESISTANCE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CERCOPITHECUS AETHIOPS; CLOZAPINE; COS CELLS; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE TOLERANCE TEST; GTP-BINDING PROTEINS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 72649084796     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0906593106     Document Type: Article

References (24)

1. Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782-787.
2. Kahn CR (1994) Insulin action, diabetogenes, and the cause of type II diabetes (Banting Lecture). Diabetes 43:1066-1084.
3. Regard JB, et al. (2007) Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest 117:4034-4043.
4. Regard JB, Sato IT, Coughlin SR (2008) Anatomical profiling of G protein-coupled receptor expression. Cell 135:561-571.
5. Ahrén B (2009) Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov 8:369-385.
6. Doyle ME, Egan JM (2007) Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther 113:546-593.
7. Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131-2157.
8. Gilon P, Henquin JC (2001) Mechanisms and physiological significance of the cholinergic control of pancreatic β-cell function. Endocr Rev 22:565-604.
9. Gautam D, et al. (2006) A critical role for β cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab 3:449-461.
10. Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H (2005) The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab 1:245-258.
11. Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL (2007) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci USA 104:5163-5168.
12. Alexander GM, et al. (2009) Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63:27-39.
13. Del Prato S, Marchetti P, Bonadonna RC (2002) Phasic insulin release and metabolic regulation in type 2 diabetes. Diabetes 51(Suppl 1):S109-S116.
14. Nesher R, Cerasi E (2002) Modeling phasic insulin release: Immediate and time-dependent effects of glucose. Diabetes 51(Suppl 1):S53-S59.
15. Ohsugi M, et al. (2004) Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes. Diabetes 53:1496-1508.
16. Lingohr MK, et al. (2006) Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet β-cells. J Biol Chem 281:15884-15892.
17. Niessen M (2006) On the role of IRS2 in the regulation of functional β-cell mass. Arch Physiol Biochem 112:65-73.
18. White MF (2006) Regulating insulin signalingand β-cell function through IRS proteins.Can J Physiol Pharmacol 84:725-737.
19. αs in β-cells of transgenic mice causes counterregulation of the increased adenosine 3′,5′-monophosphate and insulin secretion. Endocrinology 134:42-47.
20. Conklin BR, et al. (2008) Engineering GPCR signaling pathways with RASSLs. Nat Methods 5:673-678.
21. Yamada M, et al. (2001) Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature 410:207-212.
22. Schöneberg T,Yun J, Wenkert D, Wess J (1996) Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co-expressed receptor polypeptide. EMBO J 15:1283-1291.
23. Wong SK, Parker EM, Ross EM (1990) Chimeric muscarinic cholinergic:β-adrenergic receptors that activate Gs in response to muscarinic agonists. J Biol Chem 265:6219-6224.
24. 3 muscarinic acetylcholine receptor. J Biol Chem 280:24870-24879.