Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Sasaki, Koh ^a   Suzuki, Mika ^a   Mieda, Michihiro ^a   Tsujino, Natsuko ^a   Roth, Bryan ^b   Sakurai, Takeshi ^a,b  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OREXIN; PROTEIN FOS; CALCIUM; CHANNELRHODOPSIN 2, MOUSE; CLOZAPINE; CLOZAPINE N OXIDE; CLOZAPINE N-OXIDE; CRE RECOMBINASE; DRUG DERIVATIVE; INTEGRASE; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; NEUROPEPTIDE; OREXINS; RHODOPSIN; SIGNAL PEPTIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL ACTIVATION; CONTROLLED STUDY; DESIGNER RECEPTORS EXCLUSIVELY ACTIVATED BY DESIGNER DRUGS APPROACH; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; IN VIVO STUDY; MALE; MOUSE; NERVE CELL; NERVE CELL STIMULATION; NERVE FUNCTION; NEUROMODULATION; NONHUMAN; NONREM SLEEP; OREXIN NEURON; PHARMACOGENETICS; REM SLEEP; SLEEP; SLEEP TIME; WAKEFULNESS; ADENO ASSOCIATED VIRUS; ANIMAL; BLOOD BRAIN BARRIER; DRUG EFFECT; GENETICS; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; LIGHT RELATED PHENOMENA; METABOLISM; METHODOLOGY; MOLECULAR IMAGING; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ANIMALS; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; CALCIUM; CLOZAPINE; DEPENDOVIRUS; HUMANS; INJECTIONS, INTRAPERITONEAL; INTEGRASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, TRANSGENIC; MOLECULAR IMAGING; NEURONS; NEUROPEPTIDES; OPTICAL PROCESSES; PHARMACOGENETICS; RECEPTOR, MUSCARINIC M3; RECEPTOR, MUSCARINIC M4; RHODOPSIN; SLEEP; WAKEFULNESS;

EID: 79957609043     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020360     Document Type: Article

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