Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 12, 2007, Pages 5163-5168

  Armbruster, Blaine N ^a   Li, Xiang ^a   Pausch, Mark H ^b   Herlitze, Stefan ^a   Roth, Bryan L ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Cell engineering; Molecular evolution; Receptorome

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CLOZAPINE N OXIDE; G PROTEIN COUPLED RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; TELOMERASE; CLOZAPINE; CLOZAPINE N-OXIDE; DESIGNER DRUG; DRUG DERIVATIVE; EPITOPE; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; LIGAND; MUSCARINIC M4 RECEPTOR; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL; UNCLASSIFIED DRUG;

ARTERY MUSCLE; ARTICLE; CELL IMMORTALIZATION; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CYTOLOGY; DRUG EFFECT; HYDROLYSIS; METABOLISM; NERVE CELL; PULMONARY ARTERY; RAT; SACCHAROMYCES CEREVISIAE; SMOOTH MUSCLE FIBER;

ANIMALS; CELL LINE, TRANSFORMED; CLOZAPINE; DESIGNER DRUGS; EPITOPES; EVOLUTION, MOLECULAR; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HIPPOCAMPUS; HUMANS; HYDROLYSIS; LIGANDS; MODELS, MOLECULAR; MUTANT PROTEINS; MYOCYTES, SMOOTH MUSCLE; NEURONS; PHOSPHATIDYLINOSITOLS; PROTEIN ENGINEERING; PULMONARY ARTERY; RATS; RECEPTOR, MUSCARINIC M3; RECEPTOR, MUSCARINIC M4; RECEPTORS, G-PROTEIN-COUPLED; SACCHAROMYCES CEREVISIAE;

EID: 34247640671     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700293104     Document Type: Article

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