Designer receptor manipulations reveal a role of the locus coeruleus noradrenergic system in isoflurane general anesthesia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 10, 2014, Pages 3859-3864

  Vazey, Elena M ^a   Aston Jones, Gary ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Dreadd; Rassl

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; ANESTHETIC AGENT; DESIGNER DRUG; ISOFLURANE; NORADRENALIN;

ANESTHESIA INDUCTION; AROUSAL; ARTICLE; BRAIN CORTEX; BRAIN NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG SAFETY; ELECTROCORTICOGRAPHY; ELECTROENCEPHALOGRAM; ELECTROENCEPHALOGRAPHY; GENERAL ANESTHESIA; HUMAN; LOCUS CERULEUS; NERVE CELL; NEUROTRANSMISSION; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; TRANSGENE; TREATMENT DURATION;

DREADD; RASSL;

ADRENERGIC NEURONS; ANESTHESIA RECOVERY PERIOD; ANESTHESIA, GENERAL; ANIMALS; CLOZAPINE; ELECTROENCEPHALOGRAPHY; ISOFLURANE; LOCOMOTION; LOCUS COERULEUS; LUMINESCENT PROTEINS; NOREPINEPHRINE; RATS; RATS, LONG-EVANS;

EID: 84896268722     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1310025111     Document Type: Article

References (41)

1. Brown EN, Lydic R, Schiff ND (2010) General anesthesia, sleep, and coma. N EnglJ Med 363(27):2638-2650.
2. Kelz MB, et al. (2008) An essential role for orexins in emergence from general an esthesia. Proc Natl Acad Sci USA 105(4):1309-1314.
3. Luo T, Leung LS (2009) Basal forebrain histaminergic transmission modulates elec-troencephalographic activity and emergence from isoflurane anesthesia. Anesthesi-ology 111(4):725-733.
4. Solt K, et al. (2011) Methylphenidate actively induces emergence from general an esthesia. Anesthesiology 115(4):791-803.
5. Aston-Jones G, Chen S, Zhu Y, Oshinsky ML (2001) A neural circuit for circadian reg ulation of arousal. Nat Neurosci 4(7):732-738.
6. Hu FY, et al. (2012) Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine β-hydroxylase knockout mice. Anesthesiology 117(5): 1006-1017.
7. Pillay S, Vizuete JA, McCallum JB, Hudetz AG (2011) Norepinephrine infusion into nucleus basalis elicits microarousal in desflurane-anesthetized rats. Anesthesiology 115(4):733-742.
8. Berridge CW, Foote SL (1991) Effects of locus coeruleus activation on electroen-cephalographic activity in neocortex and hippocampus. J Neurosci 11(10):3135-3145.
9. Aston-Jones G, Shipley MT, Grazanna R (1995) The locus coeruleus, A5 and A7 nor-adrenergic cell groups. The Rat Nervous System, ed Paxinos G (Academic Press, New York), 2nd Ed, pp 183-214.
10. Steininger TL, Gong H, McGinty D, Szymusiak R (2001) Subregional organization of preoptic area/anterior hypothalamic projections to arousal-related monoaminergic cell groups. J Comp Neurol 429(4):638-653.
11. Samuels ER, Szabadi E (2008) Functional neuroanatomy of the noradrenergic locus coeruleus: Its roles in the regulation of arousal and autonomic function, part I: Principles of functional organisation. Curr Neuropharmacol 6(3):235-253.
12. Foote SL, Bloom FE, Aston-Jones G (1983) Nucleus locus ceruleus: New evidence of anatomical and physiological specificity. Physiol Rev63(3):844-914.
13. Carter ME, et al. (2010) Tuning arousal with optogenetic modulation of locus co eruleus neurons. Nat Neurosci 13(12):1526-1533.
14. Carter ME, et al. (2012) Mechanism for Hypocretin-mediated sleep-to-wake tran sitions. Proc Natl Acad Sci USA 109(39):E2635-E2644.
15. Gompf H, et al. (2009) Halothane-induced hypnosis is not accompanied by in-activation of orexinergic output in rodents. Anesthesiology 111 (5):1001-1009.
16. Hwang DY, Carlezon WA, Jr., Isacson O, Kim KS (2001) A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons. Hum Gene Ther 12(14):1731-1740.
17. Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL (2007) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci USA 104(12):5163-5168.
18. Alexander GM, et al. (2009) Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63(1):27-39.
19. Abbott SB, et al. (2009) Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats. J Neurosci 29(18): 5806-5819.
20. Vijn PC, Sneyd JR (1998) I.v. anaesthesia and EEG burst suppression in rats: Bolus in jections and closed-loop infusions. Br J Anaesth 81 (3):415-421.
21. Foëx P, Francis CM, Cutfield GR (1982) The interactions between beta-blockers and anaesthetics: Experimental observations. Acta Anaesthesiol Scand Suppl 76:38-46.
22. Friedman EB, et al. (2010) A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: Evidence for neural inertia. PLoS ONE 5(7):e11903.
23. Steyn-Ross ML, Steyn-Ross DA, Sleigh JW (2004) Modelling general anaesthesia as a first-order phase transition in the cortex. Prog Biophys Mol Biol 85(2-3):369-385.
24. Krashes MJ, et al. (2011) Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest 121(4):1424-1428.
25. Ferguson SM, et al. (2011) Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. Nat Neurosci 14(1):22-24.
26. van den Broek PL, van Rijn CM, van Egmond J, Coenen AM, Booij LH (2006) An ef fective correlation dimension and burst suppression ratio of the EEG in rat: Correla tion with sevoflurane-induced anaesthetic depth. Eur J Anaesthesiol 23(5):391-402.
27. Aston-Jones G, Bloom FE (1981) Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci 1 (8):876-886.
28. Franks NP (2008) General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 9(5):370-386.
29. Brown EN, Purdon PL, Van Dort CJ (2011) General anesthesia and altered states of arousal: A systems neuroscience analysis. Annu Rev Neurosci 34:601-628.
30. Yasui Y, Masaki E, Kato F (2007) Sevoflurane directly excites locus coeruleus neurons of rats. Anesthesiology 107(6):992-1002.
31. Saunier CF, et al. (1993) Activation of brain noradrenergic neurons during recovery from halothane anesthesia: Persistence of phasic activation after clonidine. Anes thesiology 79(5):1072-1082.
32. Chave S, et al. (1996) Effects of two volatile anesthetics (sevoflurane and halothane) on the hypothalamic noradrenaline release in rat brain. Brain Res 706(2):293-296.
33. Berridge CW, Page ME, Valentino RJ, Foote SL (1993) Effects of locus coeruleus in-activation on electroencephalographic activity in neocortex and hippocampus. Neu roscience 55(2):381-393.
34. Chemali JJ, Van Dort CJ, Brown EN, Solt K (2012) Active emergence from propofol general anesthesia is induced by methylphenidate. Anesthesiology 116(5):998-1005.
35. Thomas SA, Matsumoto AM, Palmiter RD (1995) Noradrenaline is essential for mouse fetal development. Nature 374(6523):643-646.
36. Samuels ER, Szabadi E (2008) Functional neuroanatomy of the noradrenergic locus coeruleus: Its roles in the regulation of arousal and autonomic function, part II: Physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans. Curr Neuropharmacol 6(3):254-285.
37. Nicholas AP, Hökfelt T, Pieribone VA (1996) The distribution and significance of CNS adrenoceptors examined with in situ hybridization. Trends Pharmacol Sci 17(7): 245-255.
38. Moore JT, et al. (2012) Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis. Curr Biol 22(21):2008-2016.
39. Segal DS, Mandell AJ (1970) Behavioral activation of rats during intraventricular in fusion of norepinephrine. Proc Natl Acad Sci USA 66(2):289-293.
40. Jodo E, Aston-Jones G (1997) Activation of locus coeruleus by prefrontal cortex is mediated by excitatory amino acid inputs. Brain Res 768(1-2):327-332.
41. Shiekhattar R, Aston-Jones G (1992) Local application of bicuculline potentiates NMDA receptor-mediated sensory responses of brain noradrenergic neurons. Synapse 10(1): 54-61.