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Volumn 100, Issue 6, 2015, Pages F541-F551

New horizons for newborn brain protection: Enhancing endogenous neuroprotection

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID; ERYTHROPOIETIN; MELATONIN; NEUROPROTECTIVE AGENT;

EID: 84958182271     PISSN: 13592998     EISSN: 14682052     Source Type: Journal    
DOI: 10.1136/archdischild-2014-306284     Document Type: Review
Times cited : (171)

References (199)
  • 1
    • 84941178180 scopus 로고    scopus 로고
    • Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: An updated systematic analysis
    • Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet 2015;385:430-40.
    • (2015) Lancet , vol.385 , pp. 430-440
    • Liu, L.1    Oza, S.2    Hogan, D.3
  • 2
    • 84890939446 scopus 로고    scopus 로고
    • Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990
    • Lee AC, Kozuki N, Blencowe H, et al. Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990. Pediatr Res 2013;74(Suppl 1):50-72.
    • (2013) Pediatr Res , vol.74 , pp. 50-72
    • Lee, A.C.1    Kozuki, N.2    Blencowe, H.3
  • 3
    • 84904185064 scopus 로고    scopus 로고
    • Every Newborn: Progress, priorities, and potential beyond survival
    • Lawn JE, Blencowe H, Oza S, et al. Every Newborn: progress, priorities, and potential beyond survival. Lancet 2014;384:189-205.
    • (2014) Lancet , vol.384 , pp. 189-205
    • Lawn, J.E.1    Blencowe, H.2    Oza, S.3
  • 4
    • 77149149663 scopus 로고    scopus 로고
    • Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: Synthesis and meta-analysis of trial data
    • Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ 2010;340:c363.
    • (2010) BMJ , vol.340 , pp. c363
    • Edwards, A.D.1    Brocklehurst, P.2    Gunn, A.J.3
  • 5
    • 77954311734 scopus 로고    scopus 로고
    • Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy
    • Roka A, Azzopardi D. Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy. Early Hum Dev 2010;86:361-7.
    • (2010) Early Hum Dev , vol.86 , pp. 361-367
    • Roka, A.1    Azzopardi, D.2
  • 6
    • 0025838764 scopus 로고
    • How much of neonatal encephalopathy is due to birth asphyxia?
    • Nelson KB, Leviton A. How much of neonatal encephalopathy is due to birth asphyxia? Am J Dis Child 1991;145:1325-31.
    • (1991) Am J Dis Child , vol.145 , pp. 1325-1331
    • Nelson, K.B.1    Leviton, A.2
  • 7
    • 0035064940 scopus 로고    scopus 로고
    • Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury
    • Eklind S, Mallard C, Leverin AL, et al. Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury. Eur J Neurosci 2001;13:1101-16.
    • (2001) Eur J Neurosci , vol.13 , pp. 1101-1116
    • Eklind, S.1    Mallard, C.2    Leverin, A.L.3
  • 8
    • 73349083077 scopus 로고    scopus 로고
    • Lipopolysaccharide sensitizes neonatal hypoxic-ischemic brain injury in a MyD88-dependent manner
    • Wang X, Stridh L, Li W, et al. Lipopolysaccharide sensitizes neonatal hypoxic-ischemic brain injury in a MyD88-dependent manner. J Immunol 2009;183:7471-7.
    • (2009) J Immunol , vol.183 , pp. 7471-7477
    • Wang, X.1    Stridh, L.2    Li, W.3
  • 9
    • 0034166576 scopus 로고    scopus 로고
    • Infection, inflammation and the risk of cerebral palsy
    • Nelson KB, Willoughby RE. Infection, inflammation and the risk of cerebral palsy. Curr Opin Neurol 2000;13:133-9.
    • (2000) Curr Opin Neurol , vol.13 , pp. 133-139
    • Nelson, K.B.1    Willoughby, R.E.2
  • 10
    • 77549083577 scopus 로고    scopus 로고
    • Calcium, ischemia and excitotoxicity
    • Szydlowska K, Tymianski M. Calcium, ischemia and excitotoxicity. Cell Calcium 2010;47:122-9.
    • (2010) Cell Calcium , vol.47 , pp. 122-129
    • Szydlowska, K.1    Tymianski, M.2
  • 11
    • 33645297101 scopus 로고    scopus 로고
    • Post-hypoxic hypoperfusion is associated with suppression of cerebral metabolism and increased tissue oxygenation in near-term fetal sheep
    • Jensen EC, Bennet L, Hunter CJ, et al. Post-hypoxic hypoperfusion is associated with suppression of cerebral metabolism and increased tissue oxygenation in near-term fetal sheep. J Physiol 2006;572(Pt 1):131-9.
    • (2006) J Physiol , vol.572 , pp. 131-139
    • Jensen, E.C.1    Bennet, L.2    Hunter, C.J.3
  • 12
    • 34249859347 scopus 로고    scopus 로고
    • "Therapeutic time window" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets
    • Iwata O, Iwata S, Thornton JS, et al. "Therapeutic time window" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets. Brain Res 2007;1154:173-80.
    • (2007) Brain Res , vol.1154 , pp. 173-180
    • Iwata, O.1    Iwata, S.2    Thornton, J.S.3
  • 13
    • 49449093285 scopus 로고    scopus 로고
    • Supra- and sub-baseline phosphocreatine recovery in developing brain after transient hypoxia-ischaemia: Relation to baseline energetics, insult severity and outcome
    • Iwata O, Iwata S, Bainbridge A, et al. Supra- and sub-baseline phosphocreatine recovery in developing brain after transient hypoxia-ischaemia: relation to baseline energetics, insult severity and outcome. Brain 2008;131(Pt 8):2220-6.
    • (2008) Brain , vol.131 , pp. 2220-2226
    • Iwata, O.1    Iwata, S.2    Bainbridge, A.3
  • 14
    • 54349111940 scopus 로고    scopus 로고
    • Phosphorus magnetic resonance spectroscopy 2 h after perinatal cerebral hypoxia-ischemia prognosticates outcome in the newborn piglet
    • Cady EB, Iwata O, Bainbridge A, et al. Phosphorus magnetic resonance spectroscopy 2 h after perinatal cerebral hypoxia-ischemia prognosticates outcome in the newborn piglet. J Neurochem 2008;107:1027-35.
    • (2008) J Neurochem , vol.107 , pp. 1027-1035
    • Cady, E.B.1    Iwata, O.2    Bainbridge, A.3
  • 15
    • 0028079731 scopus 로고
    • Delayed ("secondary) " cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: Continuous 48-hour studies by phosphorus magnetic resonance spectroscopy
    • Lorek A, Takei Y, Cady EB, et al. Delayed ("secondary) " cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res 1994;36:699-706.
    • (1994) Pediatr Res , vol.36 , pp. 699-706
    • Lorek, A.1    Takei, Y.2    Cady, E.B.3
  • 16
    • 0024521338 scopus 로고
    • Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy
    • Azzopardi D, Wyatt JS, Cady EB, et al. Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res 1989;25:445-51.
    • (1989) Pediatr Res , vol.25 , pp. 445-451
    • Azzopardi, D.1    Wyatt, J.S.2    Cady, E.B.3
  • 17
    • 0029907291 scopus 로고    scopus 로고
    • Diagnostic and prognostic value of cerebral 31P magnetic resonance spectroscopy in neonates with perinatal asphyxia
    • Martin E, Buchli R, Ritter S, et al. Diagnostic and prognostic value of cerebral 31P magnetic resonance spectroscopy in neonates with perinatal asphyxia. Pediatr Res 1996;40:749-58.
    • (1996) Pediatr Res , vol.40 , pp. 749-758
    • Martin, E.1    Buchli, R.2    Ritter, S.3
  • 18
    • 0032797461 scopus 로고    scopus 로고
    • Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy
    • Robertson NJ, Cox IJ, Cowan FM, et al. Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy. Pediatr Res 1999;46:287-96.
    • (1999) Pediatr Res , vol.46 , pp. 287-296
    • Robertson, N.J.1    Cox, I.J.2    Cowan, F.M.3
  • 19
    • 0036895240 scopus 로고    scopus 로고
    • Brain alkaline intracellular pH after neonatal encephalopathy
    • Robertson NJ, Cowan FM, Cox IJ, et al. Brain alkaline intracellular pH after neonatal encephalopathy. Ann Neurol 2002;52:732-42.
    • (2002) Ann Neurol , vol.52 , pp. 732-742
    • Robertson, N.J.1    Cowan, F.M.2    Cox, I.J.3
  • 20
    • 84892517669 scopus 로고    scopus 로고
    • Mitochondria: Hub of injury responses in the developing brain
    • Hagberg H, Mallard C, Rousset CI, et al. Mitochondria: hub of injury responses in the developing brain. Lancet Neurol 2014;13:217-32.
    • (2014) Lancet Neurol , vol.13 , pp. 217-232
    • Hagberg, H.1    Mallard, C.2    Rousset, C.I.3
  • 22
    • 84861158230 scopus 로고    scopus 로고
    • Tertiary mechanisms of brain damage: A new hope for treatment of cerebral palsy?
    • Fleiss B, Gressens P. Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy? Lancet Neurol 2012;11:556-66.
    • (2012) Lancet Neurol , vol.11 , pp. 556-566
    • Fleiss, B.1    Gressens, P.2
  • 23
    • 51649094198 scopus 로고    scopus 로고
    • Therapeutics for neonatal brain injury
    • Gonzalez FF, Ferriero DM. Therapeutics for neonatal brain injury. Pharmacol Ther 2008;120:43-53.
    • (2008) Pharmacol Ther , vol.120 , pp. 43-53
    • Gonzalez, F.F.1    Ferriero, D.M.2
  • 24
  • 25
    • 0002449047 scopus 로고
    • Rectal temperature in the newborn after birth asphyxia
    • Burnard ED, Cross KW. Rectal temperature in the newborn after birth asphyxia. BMJ 1958;2:1197-9.
    • (1958) BMJ , vol.2 , pp. 1197-1199
    • Burnard, E.D.1    Cross, K.W.2
  • 27
    • 84873380508 scopus 로고    scopus 로고
    • Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model
    • Robertson NJ, Faulkner S, Fleiss B, et al. Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. Brain 2013;136(Pt 1):90-105.
    • (2013) Brain , vol.136 , pp. 90-105
    • Robertson, N.J.1    Faulkner, S.2    Fleiss, B.3
  • 28
    • 50649090061 scopus 로고    scopus 로고
    • Therapeutic hypothermia for birth asphyxia in low-resource settings: A pilot randomised controlled trial
    • Robertson NJ, Nakakeeto M, Hagmann C, et al. Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial. Lancet 2008;372:801-3.
    • (2008) Lancet , vol.372 , pp. 801-803
    • Robertson, N.J.1    Nakakeeto, M.2    Hagmann, C.3
  • 29
    • 0031801912 scopus 로고    scopus 로고
    • Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: Short- and long-term outcome
    • Bona E, Hagberg H, Loberg EM, et al. Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: short- and long-term outcome. Pediatr Res 1998;43:738-45.
    • (1998) Pediatr Res , vol.43 , pp. 738-745
    • Bona, E.1    Hagberg, H.2    Loberg, E.M.3
  • 30
    • 0028910724 scopus 로고
    • Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet
    • Thoresen M, Penrice J, Lorek A, et al. Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res 1995;37:667-70.
    • (1995) Pediatr Res , vol.37 , pp. 667-670
    • Thoresen, M.1    Penrice, J.2    Lorek, A.3
  • 31
    • 84874816264 scopus 로고    scopus 로고
    • Cooling for newborns with hypoxic ischaemic encephalopathy
    • Jacobs SE, Berg M, Hunt R, et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2013;1:CD003311.
    • (2013) Cochrane Database Syst Rev , vol.1 , pp. CD003311
    • Jacobs, S.E.1    Berg, M.2    Hunt, R.3
  • 32
    • 84898029778 scopus 로고    scopus 로고
    • The mechanisms and treatment of asphyxial encephalopathy
    • Wassink G, Gunn ER, Drury PP, et al. The mechanisms and treatment of asphyxial encephalopathy. Front Neurosci 2014;8:40.
    • (2014) Front Neurosci , vol.8 , pp. 40
    • Wassink, G.1    Gunn, E.R.2    Drury, P.P.3
  • 34
    • 0013694986 scopus 로고
    • Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain
    • Busto R, Globus MY, Dietrich WD, et al. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 1989;20:904-10.
    • (1989) Stroke , vol.20 , pp. 904-910
    • Busto, R.1    Globus, M.Y.2    Dietrich, W.D.3
  • 36
    • 84858706456 scopus 로고    scopus 로고
    • Neuroprotective mechanisms of hypothermia in brain ischaemia
    • Yenari MA, Han HS. Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci 2012;13:267-78.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 267-278
    • Yenari, M.A.1    Han, H.S.2
  • 37
    • 70349611684 scopus 로고    scopus 로고
    • Moderate hypothermia to treat perinatal asphyxial encephalopathy
    • Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009;361:1349-58.
    • (2009) N Engl J Med , vol.361 , pp. 1349-1358
    • Azzopardi, D.V.1    Strohm, B.2    Edwards, A.D.3
  • 38
    • 13844321255 scopus 로고    scopus 로고
    • Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: Multicentre randomised trial
    • Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005;365:663-70.
    • (2005) Lancet , vol.365 , pp. 663-670
    • Gluckman, P.D.1    Wyatt, J.S.2    Azzopardi, D.3
  • 39
    • 84865815652 scopus 로고    scopus 로고
    • Distribution and severity of hypoxic-ischaemic lesions on brain MRI following therapeutic cooling: Selective head versus whole body cooling. Archives of disease in childhood
    • Sarkar S, Donn SM, Bapuraj JR, et al. Distribution and severity of hypoxic-ischaemic lesions on brain MRI following therapeutic cooling: selective head versus whole body cooling. Archives of disease in childhood. Fetal Neonatal Ed 2012;97:F335-9.
    • (2012) Fetal Neonatal Ed , vol.97 , pp. F335-F339
    • Sarkar, S.1    Donn, S.M.2    Bapuraj, J.R.3
  • 40
    • 84861521265 scopus 로고    scopus 로고
    • Hypothermia for neonatal hypoxic ischemic encephalopathy: An updated systematic review and meta-analysis
    • Tagin MA, Woolcott CG, Vincer MJ, et al. Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis. Arch Pediatr Adolesc Med 2012;166:558-66.
    • (2012) Arch Pediatr Adolesc Med , vol.166 , pp. 558-566
    • Tagin, M.A.1    Woolcott, C.G.2    Vincer, M.J.3
  • 41
    • 84870820418 scopus 로고    scopus 로고
    • Therapeutic hypothermia for neonatal encephalopathy
    • Shankaran S. Therapeutic hypothermia for neonatal encephalopathy. Curr Treat Options Neurol 2012;14:608-19.
    • (2012) Curr Treat Options Neurol , vol.14 , pp. 608-619
    • Shankaran, S.1
  • 42
    • 84862162313 scopus 로고    scopus 로고
    • Implementation and conduct of therapeutic hypothermia for perinatal asphyxial encephalopathy in the UK-analysis of national data
    • Azzopardi D, Strohm B, Linsell L, et al. Implementation and conduct of therapeutic hypothermia for perinatal asphyxial encephalopathy in the UK-analysis of national data. PloS ONE 2012;7:e38504.
    • (2012) PloS ONE , vol.7 , pp. e38504
    • Azzopardi, D.1    Strohm, B.2    Linsell, L.3
  • 43
    • 84888588214 scopus 로고    scopus 로고
    • Induced hypothermia in severe bacterial meningitis: A randomized clinical trial
    • Mourvillier B, Tubach F, van de Beek D, et al. Induced hypothermia in severe bacterial meningitis: a randomized clinical trial. JAMA 2013;310:2174-83.
    • (2013) JAMA , vol.310 , pp. 2174-2183
    • Mourvillier, B.1    Tubach, F.2    Van De Beek, D.3
  • 44
    • 84895930412 scopus 로고    scopus 로고
    • Hypothermia is not neuroprotective after infection-sensitized neonatal hypoxic-ischemic brain injury
    • Osredkar D, Thoresen M, Maes E, et al. Hypothermia is not neuroprotective after infection-sensitized neonatal hypoxic-ischemic brain injury. Resuscitation 2014;85:567-72.
    • (2014) Resuscitation , vol.85 , pp. 567-572
    • Osredkar, D.1    Thoresen, M.2    Maes, E.3
  • 45
    • 79952117844 scopus 로고    scopus 로고
    • Placental pathology in asphyxiated newborns meeting the criteria for therapeutic hypothermia
    • e1-9
    • Wintermark P, Boyd T, Gregas MC, et al. Placental pathology in asphyxiated newborns meeting the criteria for therapeutic hypothermia. Am J Obstet Gynecol 2010;203:579 e1-9.
    • (2010) Am J Obstet Gynecol , vol.203 , pp. 579
    • Wintermark, P.1    Boyd, T.2    Gregas, M.C.3
  • 46
    • 84891472170 scopus 로고    scopus 로고
    • Molecular dialogs between the ischemic brain and the peripheral immune system: Dualistic roles in injury and repair
    • An C, Shi Y, Li P, et al. Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair. Prog Neurobiol 2014;115:6-24.
    • (2014) Prog Neurobiol , vol.115 , pp. 6-24
    • An, C.1    Shi, Y.2    Li, P.3
  • 47
    • 39349097270 scopus 로고    scopus 로고
    • Early neutrophilia is associated with volume of ischemic tissue in acute stroke
    • Buck BH, Liebeskind DS, Saver JL, et al. Early neutrophilia is associated with volume of ischemic tissue in acute stroke. Stroke 2008;39:355-60.
    • (2008) Stroke , vol.39 , pp. 355-360
    • Buck, B.H.1    Liebeskind, D.S.2    Saver, J.L.3
  • 48
    • 59649123881 scopus 로고    scopus 로고
    • Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
    • Liesz A, Suri-Payer E, Veltkamp C, et al. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med 2009;15:192-9.
    • (2009) Nat Med , vol.15 , pp. 192-199
    • Liesz, A.1    Suri-Payer, E.2    Veltkamp, C.3
  • 49
    • 0037165892 scopus 로고    scopus 로고
    • Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats
    • Kline AE, Bolinger BD, Kochanek PM, et al. Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats. Brain Res 2002;937:22-31.
    • (2002) Brain Res , vol.937 , pp. 22-31
    • Kline, A.E.1    Bolinger, B.D.2    Kochanek, P.M.3
  • 50
    • 59349092158 scopus 로고    scopus 로고
    • Stroke-induced immunodepression and post-stroke infections: Lessons from the preventive antibacterial therapy in stroke trial
    • Klehmet J, Harms H, Richter M, et al. Stroke-induced immunodepression and post-stroke infections: lessons from the preventive antibacterial therapy in stroke trial. Neuroscience 2009;158:1184-93.
    • (2009) Neuroscience , vol.158 , pp. 1184-1193
    • Klehmet, J.1    Harms, H.2    Richter, M.3
  • 51
    • 0036317335 scopus 로고    scopus 로고
    • Moderate hypothermia delays proinflammatory cytokine production of human peripheral blood mononuclear cells
    • Kimura A, Sakurada S, Ohkuni H, et al. Moderate hypothermia delays proinflammatory cytokine production of human peripheral blood mononuclear cells. Crit Care Med 2002;30:1499-502.
    • (2002) Crit Care Med , vol.30 , pp. 1499-1502
    • Kimura, A.1    Sakurada, S.2    Ohkuni, H.3
  • 52
    • 84856206648 scopus 로고    scopus 로고
    • Hypothermia, immune suppression and SDD: Can we have our cake and eat it?
    • Polderman KH. Hypothermia, immune suppression and SDD: can we have our cake and eat it? Crit Care 2011;15:144.
    • (2011) Crit Care , vol.15 , pp. 144
    • Polderman, K.H.1
  • 54
    • 84893226138 scopus 로고    scopus 로고
    • Therapeutic hypothermia and the risk of infection: A systematic review and meta-analysis
    • Geurts M, Macleod MR, Kollmar R, et al. Therapeutic hypothermia and the risk of infection: a systematic review and meta-analysis. Crit Care Med 2014;42:231-42.
    • (2014) Crit Care Med , vol.42 , pp. 231-242
    • Geurts, M.1    Macleod, M.R.2    Kollmar, R.3
  • 55
    • 70350450344 scopus 로고    scopus 로고
    • Lipopolysaccharide preconditioning reduces neuroinflammation against hypoxic ischemia and provides long-term outcome of neuroprotection in neonatal rat
    • Lin HY, Huang CC, Chang KF. Lipopolysaccharide preconditioning reduces neuroinflammation against hypoxic ischemia and provides long-term outcome of neuroprotection in neonatal rat. Pediatr Res 2009;66:254-9.
    • (2009) Pediatr Res , vol.66 , pp. 254-259
    • Lin, H.Y.1    Huang, C.C.2    Chang, K.F.3
  • 56
    • 69549120140 scopus 로고    scopus 로고
    • Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm
    • McAuliffe JJ, Loepke AW, Miles L, et al. Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm. Anesthesiology 2009;111:533-46.
    • (2009) Anesthesiology , vol.111 , pp. 533-546
    • McAuliffe, J.J.1    Loepke, A.W.2    Miles, L.3
  • 57
    • 10744222364 scopus 로고    scopus 로고
    • Transient ischemic attacks before ischemic stroke: Preconditioning the human brain? A multicenter magnetic resonance imaging study
    • Wegener S, Gottschalk B, Jovanovic V, et al. Transient ischemic attacks before ischemic stroke: preconditioning the human brain? A multicenter magnetic resonance imaging study. Stroke 2004;35:616-21.
    • (2004) Stroke , vol.35 , pp. 616-621
    • Wegener, S.1    Gottschalk, B.2    Jovanovic, V.3
  • 58
    • 0032881979 scopus 로고    scopus 로고
    • Attenuated stroke severity after prodromal TIA: A role for ischemic tolerance in the brain?
    • Weih M, Kallenberg K, Bergk A, et al. Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain? Stroke 1999;30:1851-4.
    • (1999) Stroke , vol.30 , pp. 1851-1854
    • Weih, M.1    Kallenberg, K.2    Bergk, A.3
  • 59
    • 20444473105 scopus 로고    scopus 로고
    • Ischemic preconditioning and preinfarction angina in the clinical arena
    • Rezkalla SH, Kloner RA. Ischemic preconditioning and preinfarction angina in the clinical arena. Nat Clin Pract Cardiovasc Med 2004;1:96-102.
    • (2004) Nat Clin Pract Cardiovasc Med , vol.1 , pp. 96-102
    • Rezkalla, S.H.1    Kloner, R.A.2
  • 61
    • 0037623908 scopus 로고    scopus 로고
    • Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning
    • Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 2003;285:H579-88.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285 , pp. H579-H588
    • Zhao, Z.Q.1    Corvera, J.S.2    Halkos, M.E.3
  • 62
    • 33646072198 scopus 로고    scopus 로고
    • Postconditioning: Reduction of reperfusion-induced injury
    • Zhao ZQ, Vinten-Johansen J. Postconditioning: reduction of reperfusion-induced injury. Cardiovasc Res 2006;70:200-11.
    • (2006) Cardiovasc Res , vol.70 , pp. 200-211
    • Zhao, Z.Q.1    Vinten-Johansen, J.2
  • 63
    • 57549115569 scopus 로고    scopus 로고
    • Delayed postconditioning protects against focal ischemic brain injury in rats
    • Ren C, Gao X, Niu G, et al. Delayed postconditioning protects against focal ischemic brain injury in rats. PloS ONE 2008;3:e3851.
    • (2008) PloS ONE , vol.3 , pp. e3851
    • Ren, C.1    Gao, X.2    Niu, G.3
  • 64
    • 84861533144 scopus 로고    scopus 로고
    • Remote ischemic conditioning: From bench to bedside
    • Lim SY, Hausenloy DJ. Remote ischemic conditioning: from bench to bedside. Front Physiol 2012;3:27.
    • (2012) Front Physiol , vol.3 , pp. 27
    • Lim, S.Y.1    Hausenloy, D.J.2
  • 65
    • 79953860165 scopus 로고    scopus 로고
    • Neurogenic pathway mediated remote preconditioning protects the brain from transient focal ischemic injury
    • Malhotra S, Naggar I, Stewart M, et al. Neurogenic pathway mediated remote preconditioning protects the brain from transient focal ischemic injury. Brain Res 2011;1386:184-90.
    • (2011) Brain Res , vol.1386 , pp. 184-190
    • Malhotra, S.1    Naggar, I.2    Stewart, M.3
  • 66
    • 84875586477 scopus 로고    scopus 로고
    • nNOS and p-ERK involvement in the neuroprotection exerted by remote postconditioning in rats subjected to transient middle cerebral artery occlusion
    • Pignataro G, Esposito E, Sirabella R, et al. nNOS and p-ERK involvement in the neuroprotection exerted by remote postconditioning in rats subjected to transient middle cerebral artery occlusion. Neurobiol Dis 2013;54:105-14.
    • (2013) Neurobiol Dis , vol.54 , pp. 105-114
    • Pignataro, G.1    Esposito, E.2    Sirabella, R.3
  • 67
    • 37449018893 scopus 로고    scopus 로고
    • Proenkephalin expression and enkephalin release are widely observed in non-neuronal tissues
    • Denning GM, Ackermann LW, Barna TJ, et al. Proenkephalin expression and enkephalin release are widely observed in non-neuronal tissues. Peptides 2008;29:83-92.
    • (2008) Peptides , vol.29 , pp. 83-92
    • Denning, G.M.1    Ackermann, L.W.2    Barna, T.J.3
  • 68
    • 34548147767 scopus 로고    scopus 로고
    • Protocols and mechanisms for remote ischemic preconditioning: A novel method for reducing ischemia reperfusion injury
    • Kanoria S, Jalan R, Seifalian AM, et al. Protocols and mechanisms for remote ischemic preconditioning: a novel method for reducing ischemia reperfusion injury. Transplantation 2007;84:445-58.
    • (2007) Transplantation , vol.84 , pp. 445-458
    • Kanoria, S.1    Jalan, R.2    Seifalian, A.M.3
  • 69
    • 71649083376 scopus 로고    scopus 로고
    • Remote ischemic preconditioning decreases adhesion and selectively modifies functional responses of human neutrophils
    • Shimizu M, Saxena P, Konstantinov IE, et al. Remote ischemic preconditioning decreases adhesion and selectively modifies functional responses of human neutrophils. J Surg Res 2010;158:155-61.
    • (2010) J Surg Res , vol.158 , pp. 155-161
    • Shimizu, M.1    Saxena, P.2    Konstantinov, I.E.3
  • 70
    • 80052213071 scopus 로고    scopus 로고
    • Protective conditioning of the brain: Expressway or roadblock?
    • Mergenthaler P, Dirnagl U. Protective conditioning of the brain: expressway or roadblock? J Physiol 2011;589(Pt 17):4147-55.
    • (2011) J Physiol , vol.589 , pp. 4147-4155
    • Mergenthaler, P.1    Dirnagl, U.2
  • 71
    • 73649124987 scopus 로고    scopus 로고
    • Remote ischemic conditioning: Evolution of the concept, mechanisms, and clinical application
    • Saxena P, Newman MA, Shehatha JS, et al. Remote ischemic conditioning: evolution of the concept, mechanisms, and clinical application. J Card Surg 2010;25:127-34.
    • (2010) J Card Surg , vol.25 , pp. 127-134
    • Saxena, P.1    Newman, M.A.2    Shehatha, J.S.3
  • 72
    • 56449100005 scopus 로고    scopus 로고
    • Remote ischemic preconditioning: A novel protective method from ischemia reperfusion injury-a review
    • Tapuria N, Kumar Y, Habib MM, et al. Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury-a review. J Surg Res 2008;150:304-30.
    • (2008) J Surg Res , vol.150 , pp. 304-330
    • Tapuria, N.1    Kumar, Y.2    Habib, M.M.3
  • 73
    • 79251638090 scopus 로고    scopus 로고
    • Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway
    • Zhou Y, Fathali N, Lekic T, et al. Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway. Stroke 2011;42:439-44.
    • (2011) Stroke , vol.42 , pp. 439-444
    • Zhou, Y.1    Fathali, N.2    Lekic, T.3
  • 74
    • 84936078040 scopus 로고    scopus 로고
    • Remote ischemic postconditioning alleviates cerebral ischemic injury by attenuating endoplasmic reticulum stress-mediated apoptosis
    • Liu X, Zhao S, Liu F, et al. Remote ischemic postconditioning alleviates cerebral ischemic injury by attenuating endoplasmic reticulum stress-mediated apoptosis. Transl Stroke Res 2014;5:692-700.
    • (2014) Transl Stroke Res , vol.5 , pp. 692-700
    • Liu, X.1    Zhao, S.2    Liu, F.3
  • 75
    • 84896517851 scopus 로고    scopus 로고
    • Delayed remote ischemic postconditioning improves long term sensory motor deficits in a neonatal hypoxic ischemic rat model
    • Drunalini Perera PN, Hu Q, Tang J, et al. Delayed remote ischemic postconditioning improves long term sensory motor deficits in a neonatal hypoxic ischemic rat model. PloS ONE 2014;9:e90258.
    • (2014) PloS ONE , vol.9 , pp. e90258
    • Drunalini Perera, P.N.1    Hu, Q.2    Tang, J.3
  • 76
    • 84977739086 scopus 로고    scopus 로고
    • Limb remote ischemic post-conditioning protects cerebral white matter in a piglet model of perinatal asphyxia
    • Ezzati M, Bainbridge A, Broad KD, et al. Limb remote ischemic post-conditioning protects cerebral white matter in a piglet model of perinatal asphyxia. PAS 2014;4118-305.
    • (2014) PAS , pp. 4118-4305
    • Ezzati, M.1    Bainbridge, A.2    Broad, K.D.3
  • 77
    • 76049118074 scopus 로고    scopus 로고
    • Cerebral magnetic resonance biomarkers in neonatal encephalopathy: A meta-analysis
    • Thayyil S, Chandrasekaran M, Taylor A, et al. Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis. Pediatrics 2010;125:e382-95.
    • (2010) Pediatrics , vol.125 , pp. e382-e395
    • Thayyil, S.1    Chandrasekaran, M.2    Taylor, A.3
  • 78
    • 84864433615 scopus 로고    scopus 로고
    • Remote ischemic conditioning to protect against ischemia-reperfusion injury: A systematic review and meta-analysis
    • Brevoord D, Kranke P, Kuijpers M, et al. Remote ischemic conditioning to protect against ischemia-reperfusion injury: a systematic review and meta-analysis. PloS ONE 2012;7:e42179.
    • (2012) PloS ONE , vol.7 , pp. e42179
    • Brevoord, D.1    Kranke, P.2    Kuijpers, M.3
  • 79
    • 84879889610 scopus 로고    scopus 로고
    • Cardioprotective effect of remote ischemic postconditioning on children undergoing cardiac surgery: A randomized controlled trial
    • Zhong H, Gao Z, Chen M, et al. Cardioprotective effect of remote ischemic postconditioning on children undergoing cardiac surgery: a randomized controlled trial. Paediatr Anaesth 2013;23:726-33.
    • (2013) Paediatr Anaesth , vol.23 , pp. 726-733
    • Zhong, H.1    Gao, Z.2    Chen, M.3
  • 80
    • 84893657726 scopus 로고    scopus 로고
    • Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: A randomized trial
    • Hougaard KD, Hjort N, Zeidler D, et al. Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial. Stroke 2014;45:159-67.
    • (2014) Stroke , vol.45 , pp. 159-167
    • Hougaard, K.D.1    Hjort, N.2    Zeidler, D.3
  • 81
    • 84868294719 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of the cardioprotective effects of remote ischaemic preconditioning in open cardiac surgery
    • Pilcher JM, Young P, Weatherall M, et al. A systematic review and meta-analysis of the cardioprotective effects of remote ischaemic preconditioning in open cardiac surgery. J R Soc Med 2012;105:436-45.
    • (2012) J R Soc Med , vol.105 , pp. 436-445
    • Pilcher, J.M.1    Young, P.2    Weatherall, M.3
  • 82
    • 84872668883 scopus 로고    scopus 로고
    • Hurdles to clear before clinical translation of ischemic postconditioning against stroke
    • Zhao H. Hurdles to clear before clinical translation of ischemic postconditioning against stroke. Transl Stroke Res 2013;4:63-70.
    • (2013) Transl Stroke Res , vol.4 , pp. 63-70
    • Zhao, H.1
  • 83
    • 39749108884 scopus 로고    scopus 로고
    • Medical implications of melatonin: Receptormediated and receptor-independent actions
    • Reiter RJ, Tan DX, Manchester LC, et al. Medical implications of melatonin: receptormediated and receptor-independent actions. Adv Med Sci 2007;52:11-28.
    • (2007) Adv Med Sci , vol.52 , pp. 11-28
    • Reiter, R.J.1    Tan, D.X.2    Manchester, L.C.3
  • 84
    • 84857138170 scopus 로고    scopus 로고
    • Melatonin membrane receptors in peripheral tissues: Distribution and functions
    • Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, et al. Melatonin membrane receptors in peripheral tissues: distribution and functions. Mol Cell Endocrinol 2012;351:152-66.
    • (2012) Mol Cell Endocrinol , vol.351 , pp. 152-166
    • Slominski, R.M.1    Reiter, R.J.2    Schlabritz-Loutsevitch, N.3
  • 85
    • 0035110424 scopus 로고    scopus 로고
    • Melatonin, mitochondria, and cellular bioenergetics
    • Acuna-Castroviejo D, Martin M, Macias M, et al. Melatonin, mitochondria, and cellular bioenergetics. J Pineal Res 2001;30:65-74.
    • (2001) J Pineal Res , vol.30 , pp. 65-74
    • Acuna-Castroviejo, D.1    Martin, M.2    Macias, M.3
  • 86
    • 84872843163 scopus 로고    scopus 로고
    • Melatonin and mitochondrial dysfunction in the central nervous system
    • Cardinali DP, Pagano ES, Scacchi Bernasconi PA, et al. Melatonin and mitochondrial dysfunction in the central nervous system. Horm Behav 2013;63:322-30.
    • (2013) Horm Behav , vol.63 , pp. 322-330
    • Cardinali, D.P.1    Pagano, E.S.2    Scacchi Bernasconi, P.A.3
  • 87
    • 34848919892 scopus 로고    scopus 로고
    • Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis
    • Jou MJ, Peng TI, Yu PZ, et al. Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis. J Pineal Res 2007;43:389-403.
    • (2007) J Pineal Res , vol.43 , pp. 389-403
    • Jou, M.J.1    Peng, T.I.2    Yu, P.Z.3
  • 88
    • 84876283695 scopus 로고    scopus 로고
    • Melatonin antioxidative defense: Therapeutical implications for aging and neurodegenerative processes
    • Pandi-Perumal SR, BaHammam AS, Brown GM, et al. Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes. Neurotox Res 2013;23:267-300.
    • (2013) Neurotox Res , vol.23 , pp. 267-300
    • Pandi-Perumal, S.R.1    BaHammam, A.S.2    Brown, G.M.3
  • 89
    • 51649128880 scopus 로고    scopus 로고
    • Epigenetic targets for melatonin: Induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells
    • Sharma R, Ottenhof T, Rzeczkowska PA, et al. Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells. J Pineal Res 2008;45:277-84.
    • (2008) J Pineal Res , vol.45 , pp. 277-284
    • Sharma, R.1    Ottenhof, T.2    Rzeczkowska, P.A.3
  • 90
    • 0036828693 scopus 로고    scopus 로고
    • Melatonin receptors in human fetal brain: 2-[(125) I]iodomelatonin binding and MT1 gene expression
    • Thomas L, Purvis CC, Drew JE, et al. Melatonin receptors in human fetal brain: 2-[(125) I]iodomelatonin binding and MT1 gene expression. J Pineal Res 2002;33:218-24.
    • (2002) J Pineal Res , vol.33 , pp. 218-224
    • Thomas, L.1    Purvis, C.C.2    Drew, J.E.3
  • 91
    • 67649084063 scopus 로고    scopus 로고
    • Melatonin and the ovary: Physiological and pathophysiological implications
    • Tamura H, Nakamura Y, Korkmaz A, et al. Melatonin and the ovary: physiological and pathophysiological implications. Fertil Steril 2009;92:328-43.
    • (2009) Fertil Steril , vol.92 , pp. 328-343
    • Tamura, H.1    Nakamura, Y.2    Korkmaz, A.3
  • 93
    • 0031680529 scopus 로고    scopus 로고
    • Maternal-fetal transfer of melatonin in pregnant women near term
    • Okatani Y, Okamoto K, Hayashi K, et al. Maternal-fetal transfer of melatonin in pregnant women near term. J Pineal Res 1998;25:129-34.
    • (1998) J Pineal Res , vol.25 , pp. 129-134
    • Okatani, Y.1    Okamoto, K.2    Hayashi, K.3
  • 94
    • 0033998384 scopus 로고    scopus 로고
    • Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain
    • Okatani Y, Wakatsuki A, Kaneda C. Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain. J Pineal Res 2000;28:89-96.
    • (2000) J Pineal Res , vol.28 , pp. 89-96
    • Okatani, Y.1    Wakatsuki, A.2    Kaneda, C.3
  • 95
    • 0037276546 scopus 로고    scopus 로고
    • Emergence and evolution of the circadian rhythm of melatonin in children
    • Ardura J, Gutierrez R, Andres J, et al. Emergence and evolution of the circadian rhythm of melatonin in children. Horm Res 2003;59:66-72.
    • (2003) Horm Res , vol.59 , pp. 66-72
    • Ardura, J.1    Gutierrez, R.2    Andres, J.3
  • 96
    • 0026783289 scopus 로고
    • Development of melatonin production in infants and the impact of prematurity
    • Kennaway DJ, Stamp GE, Goble FC. Development of melatonin production in infants and the impact of prematurity. J Clin Endocrinol Metab 1992;75:367-9.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 367-369
    • Kennaway, D.J.1    Stamp, G.E.2    Goble, F.C.3
  • 97
    • 84872321727 scopus 로고    scopus 로고
    • High endogenous melatonin levels in critically Ill children: A Pilot study
    • Marseglia L, Aversa S, Barberi I, et al. High endogenous melatonin levels in critically Ill children: a Pilot study. J Pediatr 2013;162:357-60.
    • (2013) J Pediatr , vol.162 , pp. 357-360
    • Marseglia, L.1    Aversa, S.2    Barberi, I.3
  • 98
    • 41149168714 scopus 로고    scopus 로고
    • Endogenous melatonin increases in cerebrospinal fluid of patients after severe traumatic brain injury and correlates with oxidative stress and metabolic disarray
    • Seifman MA, Adamides AA, Nguyen PN, et al. Endogenous melatonin increases in cerebrospinal fluid of patients after severe traumatic brain injury and correlates with oxidative stress and metabolic disarray. Cereb Blood Flow Metab 2008;28:684-96.
    • (2008) Cereb Blood Flow Metab , vol.28 , pp. 684-696
    • Seifman, M.A.1    Adamides, A.A.2    Nguyen, P.N.3
  • 99
    • 79960343104 scopus 로고    scopus 로고
    • Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro
    • Fu J, Zhao SD, Liu HJ, et al. Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro. J Pineal Res 2011;51:104-12.
    • (2011) J Pineal Res , vol.51 , pp. 104-112
    • Fu, J.1    Zhao, S.D.2    Liu, H.J.3
  • 100
    • 0036135872 scopus 로고    scopus 로고
    • Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge
    • Husson I, Mesples B, Bac P, et al. Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge. Ann Neurol 2002;51:82-92.
    • (2002) Ann Neurol , vol.51 , pp. 82-92
    • Husson, I.1    Mesples, B.2    Bac, P.3
  • 101
    • 78650832429 scopus 로고    scopus 로고
    • Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke
    • Villapol S, Fau S, Renolleau S, et al. Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke. Pediatr Res 2011;69:51-5.
    • (2011) Pediatr Res , vol.69 , pp. 51-55
    • Villapol, S.1    Fau, S.2    Renolleau, S.3
  • 102
    • 33646338244 scopus 로고    scopus 로고
    • Hypoxic regulation of the fetal cerebral circulation
    • Pearce W. Hypoxic regulation of the fetal cerebral circulation. J Appl Physiol 2006;100:731-8.
    • (2006) J Appl Physiol , vol.100 , pp. 731-738
    • Pearce, W.1
  • 103
    • 84857088282 scopus 로고    scopus 로고
    • The use and misuse of oxygen during the neonatal period
    • Vento M, Escobar J, Cernada M, et al. The use and misuse of oxygen during the neonatal period. Clin Perinatol 2012;39:165-76.
    • (2012) Clin Perinatol , vol.39 , pp. 165-176
    • Vento, M.1    Escobar, J.2    Cernada, M.3
  • 104
    • 0032931407 scopus 로고    scopus 로고
    • Melatonin protects against ischemia and reperfusion-induced oxidative lipid and DNA damage in fetal rat brain
    • Wakatsuki A, Okatani Y, Izumiya C, et al. Melatonin protects against ischemia and reperfusion-induced oxidative lipid and DNA damage in fetal rat brain. J Pineal Res 1999;26:147-52.
    • (1999) J Pineal Res , vol.26 , pp. 147-152
    • Wakatsuki, A.1    Okatani, Y.2    Izumiya, C.3
  • 105
    • 84874949228 scopus 로고    scopus 로고
    • On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK
    • Galano A, Tan DX, Reiter RJ. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res 2013;54:245-57.
    • (2013) J Pineal Res , vol.54 , pp. 245-257
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 106
    • 0342894684 scopus 로고    scopus 로고
    • Melatonin is a scavenger of peroxynitrite
    • Gilad E, Cuzzocrea S, Zingarelli B, et al. Melatonin is a scavenger of peroxynitrite. Life Sci 1997;60:PL169-74.
    • (1997) Life Sci , vol.60 , pp. PL169-PL174
    • Gilad, E.1    Cuzzocrea, S.2    Zingarelli, B.3
  • 107
    • 68249129060 scopus 로고    scopus 로고
    • Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines
    • Hardeland R, Tan DX, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009;47:109-26.
    • (2009) J Pineal Res , vol.47 , pp. 109-126
    • Hardeland, R.1    Tan, D.X.2    Reiter, R.J.3
  • 108
    • 10744224028 scopus 로고    scopus 로고
    • Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): Scavenging of free radicals and prevention of protein destruction
    • Ressmeyer AR, Mayo JC, Zelosko V, et al. Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction. Redox Rep 2003;8:205-13.
    • (2003) Redox Rep , vol.8 , pp. 205-213
    • Ressmeyer, A.R.1    Mayo, J.C.2    Zelosko, V.3
  • 109
    • 33845536018 scopus 로고    scopus 로고
    • One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    • Tan DX, Manchester LC, Terron MP, et al. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007;42:28-42.
    • (2007) J Pineal Res , vol.42 , pp. 28-42
    • Tan, D.X.1    Manchester, L.C.2    Terron, M.P.3
  • 110
    • 23244440004 scopus 로고    scopus 로고
    • Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion
    • Miller SL, Yan EB, Castillo-Melendez M, et al. Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion. Dev Neurosci 2005;27:200-10.
    • (2005) Dev Neurosci , vol.27 , pp. 200-210
    • Miller, S.L.1    Yan, E.B.2    Castillo-Melendez, M.3
  • 111
    • 0032810962 scopus 로고    scopus 로고
    • Oxidative damage in fetal rat brain induced by ischemia and subsequent reperfusion. Relation to arachidonic acid peroxidation
    • Wakatsuki A, Izumiya C, Okatani Y, et al. Oxidative damage in fetal rat brain induced by ischemia and subsequent reperfusion. Relation to arachidonic acid peroxidation. Biol Neonate 1999;76:84-91.
    • (1999) Biol Neonate , vol.76 , pp. 84-91
    • Wakatsuki, A.1    Izumiya, C.2    Okatani, Y.3
  • 112
    • 0034889907 scopus 로고    scopus 로고
    • Melatonin protects against ischemia/reperfusion-induced oxidative damage to mitochondria in fetal rat brain
    • Wakatsuki A, Okatani Y, Shinohara K, et al. Melatonin protects against ischemia/reperfusion-induced oxidative damage to mitochondria in fetal rat brain. J Pineal Res 2001;31:167-72.
    • (2001) J Pineal Res , vol.31 , pp. 167-172
    • Wakatsuki, A.1    Okatani, Y.2    Shinohara, K.3
  • 113
    • 0035188910 scopus 로고    scopus 로고
    • Melatonin protects fetal rat brain against oxidative mitochondrial damage
    • Wakatsuki A, Okatani Y, Shinohara K, et al. Melatonin protects fetal rat brain against oxidative mitochondrial damage. J Pineal Res 2001;30:22-8.
    • (2001) J Pineal Res , vol.30 , pp. 22-28
    • Wakatsuki, A.1    Okatani, Y.2    Shinohara, K.3
  • 114
    • 84863872445 scopus 로고    scopus 로고
    • Prophylactic administration of melatonin to the mother throughout pregnancy can protect against oxidative cerebral damage in neonatal rats
    • Watanabe K, Hamada F, Wakatsuki A, et al. Prophylactic administration of melatonin to the mother throughout pregnancy can protect against oxidative cerebral damage in neonatal rats. J Matern Fetal Neonatal Med 2012;25:1254-9.
    • (2012) J Matern Fetal Neonatal Med , vol.25 , pp. 1254-1259
    • Watanabe, K.1    Hamada, F.2    Wakatsuki, A.3
  • 115
    • 7644221985 scopus 로고    scopus 로고
    • Maternally administered melatonin protects against ischemia and reperfusion-induced oxidative mitochondrial damage in premature fetal rat brain
    • Watanabe K, Wakatsuki A, Shinohara K, et al. Maternally administered melatonin protects against ischemia and reperfusion-induced oxidative mitochondrial damage in premature fetal rat brain. J Pineal Res 2004;37:276-80.
    • (2004) J Pineal Res , vol.37 , pp. 276-280
    • Watanabe, K.1    Wakatsuki, A.2    Shinohara, K.3
  • 116
    • 84874006827 scopus 로고    scopus 로고
    • Mechanisms of melatonin-induced protection in the brain of late gestation fetal sheep in response to hypoxia
    • Yawno T, Castillo-Melendez M, Jenkin G, et al. Mechanisms of melatonin-induced protection in the brain of late gestation fetal sheep in response to hypoxia. Dev Neurosci 2012;34:543-51.
    • (2012) Dev Neurosci , vol.34 , pp. 543-551
    • Yawno, T.1    Castillo-Melendez, M.2    Jenkin, G.3
  • 117
    • 78649713485 scopus 로고    scopus 로고
    • Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model
    • Cetinkaya M, Alkan T, Ozyener F, et al. Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model. Neonatology 2011;99:302-10.
    • (2011) Neonatology , vol.99 , pp. 302-310
    • Cetinkaya, M.1    Alkan, T.2    Ozyener, F.3
  • 118
    • 68549121055 scopus 로고    scopus 로고
    • Neuroprotective properties of melatonin in a model of birth asphyxia in the spiny mouse (Acomys cahirinus)
    • Hutton LC, Abbass M, Dickinson H, et al. Neuroprotective properties of melatonin in a model of birth asphyxia in the spiny mouse (Acomys cahirinus). Dev Neurosci 2009;31:437-51.
    • (2009) Dev Neurosci , vol.31 , pp. 437-451
    • Hutton, L.C.1    Abbass, M.2    Dickinson, H.3
  • 119
    • 77749336553 scopus 로고    scopus 로고
    • Melatonin protects periventricular white matter from damage due to hypoxia
    • Kaur C, Sivakumar V, Ling EA. Melatonin protects periventricular white matter from damage due to hypoxia. J Pineal Res 2010;48:185-93.
    • (2010) J Pineal Res , vol.48 , pp. 185-193
    • Kaur, C.1    Sivakumar, V.2    Ling, E.A.3
  • 120
    • 84866878763 scopus 로고    scopus 로고
    • Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model
    • Ozyener F, Cetinkaya M, Alkan T, et al. Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model. Restor Neurol Neurosci 2012;30:435-44.
    • (2012) Restor Neurol Neurosci , vol.30 , pp. 435-444
    • Ozyener, F.1    Cetinkaya, M.2    Alkan, T.3
  • 121
    • 33846463411 scopus 로고    scopus 로고
    • Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion
    • Welin AK, Svedin P, Lapatto R, et al. Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion. Pediatr Res 2007;61:153-8.
    • (2007) Pediatr Res , vol.61 , pp. 153-158
    • Welin, A.K.1    Svedin, P.2    Lapatto, R.3
  • 122
    • 14044261745 scopus 로고    scopus 로고
    • Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2/interleukin-2 receptor system
    • Carrillo-Vico A, Lardone PJ, Fernandez-Santos JM, et al. Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2/interleukin-2 receptor system. J Clin Endocrinol Metab 2005;90:992-1000.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 992-1000
    • Carrillo-Vico, A.1    Lardone, P.J.2    Fernandez-Santos, J.M.3
  • 124
    • 84859399596 scopus 로고    scopus 로고
    • The use of melatonin in hypoxic-ischemic brain damage: An experimental study
    • Balduini W, Carloni S, Perrone S, et al. The use of melatonin in hypoxic-ischemic brain damage: an experimental study. J Matern Fetal Neonatal Med 2012;25(Suppl 1):119-24.
    • (2012) J Matern Fetal Neonatal Med , vol.25 , pp. 119-124
    • Balduini, W.1    Carloni, S.2    Perrone, S.3
  • 125
    • 34147182756 scopus 로고    scopus 로고
    • N-acetylcysteine reduces lipopolysaccharidesensitized hypoxic-ischemic brain injury
    • Wang X, Svedin P, Nie C, et al. N-acetylcysteine reduces lipopolysaccharidesensitized hypoxic-ischemic brain injury. Ann Neurol 2007;61:263-71.
    • (2007) Ann Neurol , vol.61 , pp. 263-271
    • Wang, X.1    Svedin, P.2    Nie, C.3
  • 126
    • 0344069780 scopus 로고    scopus 로고
    • Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats
    • Jahnke G, Marr M, Myers C, et al. Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats. Toxicol Sci 1999;50:271-9.
    • (1999) Toxicol Sci , vol.50 , pp. 271-279
    • Jahnke, G.1    Marr, M.2    Myers, C.3
  • 127
    • 33644869714 scopus 로고    scopus 로고
    • Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: Meta-analysis
    • Buscemi N, Vandermeer B, Hooton N, et al. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. BMJ 2006;332:385-93.
    • (2006) BMJ , vol.332 , pp. 385-393
    • Buscemi, N.1    Vandermeer, B.2    Hooton, N.3
  • 128
    • 0035204767 scopus 로고    scopus 로고
    • Effects of melatonin treatment in septic newborns
    • Gitto E, Karbownik M, Reiter RJ, et al. Effects of melatonin treatment in septic newborns. Pediatr Res 2001;50:756-60.
    • (2001) Pediatr Res , vol.50 , pp. 756-760
    • Gitto, E.1    Karbownik, M.2    Reiter, R.J.3
  • 129
    • 2342476969 scopus 로고    scopus 로고
    • Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: Beneficial effects of melatonin
    • Gitto E, Reiter RJ, Cordaro SP, et al. Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin. Am J Perinatol 2004;21:209-16.
    • (2004) Am J Perinatol , vol.21 , pp. 209-216
    • Gitto, E.1    Reiter, R.J.2    Cordaro, S.P.3
  • 130
    • 0034755034 scopus 로고    scopus 로고
    • Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: Reduction by melatonin
    • Fulia F, Gitto E, Cuzzocrea S, et al. Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin. J Pineal Res 2001;31:343-9.
    • (2001) J Pineal Res , vol.31 , pp. 343-349
    • Fulia, F.1    Gitto, E.2    Cuzzocrea, S.3
  • 131
    • 84911888674 scopus 로고    scopus 로고
    • Melatonin use for neuroprotection in perinatal asphyxia: A randomized controlled pilot study
    • Epub ahead of print
    • Aly H, Elmahdy H, El-Dib M, et al. Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study. J Perinatol 2014 doi: 10.1038/jp. 2014.186. [Epub ahead of print].
    • (2014) J Perinatol
    • Aly, H.1    Elmahdy, H.2    El-Dib, M.3
  • 132
    • 84858337595 scopus 로고    scopus 로고
    • Which neuroprotective agents are ready for bench to bedside translation in the newborn infant?
    • e4
    • Robertson NJ, Tan S, Groenendaal F, et al. Which neuroprotective agents are ready for bench to bedside translation in the newborn infant? J Pediatr 2012;160:544-52 e4.
    • (2012) J Pediatr , vol.160 , pp. 544-552
    • Robertson, N.J.1    Tan, S.2    Groenendaal, F.3
  • 133
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • Pacher P, Batkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006;58:389-462.
    • (2006) Pharmacol Rev , vol.58 , pp. 389-462
    • Pacher, P.1    Batkai, S.2    Kunos, G.3
  • 134
    • 44849141696 scopus 로고    scopus 로고
    • Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
    • Ahn K, McKinney MK, Cravatt BF. Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem Rev 2008;108:1687-707.
    • (2008) Chem Rev , vol.108 , pp. 1687-1707
    • Ahn, K.1    McKinney, M.K.2    Cravatt, B.F.3
  • 135
    • 34447575641 scopus 로고    scopus 로고
    • Endocannabinoids and related compounds: Walking back and forth between plant natural products and animal physiology
    • Di Marzo V, Bisogno T, De Petrocellis L. Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiology. Chem Biol 2007;14:741-56.
    • (2007) Chem Biol , vol.14 , pp. 741-756
    • Di Marzo, V.1    Bisogno, T.2    De Petrocellis, L.3
  • 136
    • 1442348425 scopus 로고    scopus 로고
    • Massive accumulation of N-acylethanolamines after stroke. Cell signalling in acute cerebral ischemia?
    • Berger C, Schmid PC, Schabitz WR, et al. Massive accumulation of N-acylethanolamines after stroke. Cell signalling in acute cerebral ischemia? J Neurochem 2004;88:1159-67.
    • (2004) J Neurochem , vol.88 , pp. 1159-1167
    • Berger, C.1    Schmid, P.C.2    Schabitz, W.R.3
  • 138
    • 84863511021 scopus 로고    scopus 로고
    • Type-1 cannabinoid receptor signaling in neuronal development
    • Gaffuri AL, Ladarre D, Lenkei Z. Type-1 cannabinoid receptor signaling in neuronal development. Pharmacology 2012;90:19-39.
    • (2012) Pharmacology , vol.90 , pp. 19-39
    • Gaffuri, A.L.1    Ladarre, D.2    Lenkei, Z.3
  • 139
    • 42249098694 scopus 로고    scopus 로고
    • Endocannabinoid functions controlling neuronal specification during brain development
    • Harkany T, Keimpema E, Barabas K, et al. Endocannabinoid functions controlling neuronal specification during brain development. Mol Cell Endocrinol 2008;286(1-2 Suppl 1):S84-90.
    • (2008) Mol Cell Endocrinol , vol.286 , Issue.1-2 , pp. S84-S90
    • Harkany, T.1    Keimpema, E.2    Barabas, K.3
  • 140
    • 0038730716 scopus 로고    scopus 로고
    • Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain
    • Mato S, Del Olmo E, Pazos A. Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain. Eur J Neurosci 2003;17:1747-54.
    • (2003) Eur J Neurosci , vol.17 , pp. 1747-1754
    • Mato, S.1    Del Olmo, E.2    Pazos, A.3
  • 141
    • 0033671023 scopus 로고    scopus 로고
    • Ligand-receptor signaling with endocannabinoids in preimplantation embryo development and implantation
    • Paria BC, Dey SK. Ligand-receptor signaling with endocannabinoids in preimplantation embryo development and implantation. Chem Phys Lipids 2000;108:211-20.
    • (2000) Chem Phys Lipids , vol.108 , pp. 211-220
    • Paria, B.C.1    Dey, S.K.2
  • 142
    • 0035158856 scopus 로고    scopus 로고
    • Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death
    • Hansen HH, Ikonomidou C, Bittigau P, et al. Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death. J Neurochem 2001;76:39-46.
    • (2001) J Neurochem , vol.76 , pp. 39-46
    • Hansen, H.H.1    Ikonomidou, C.2    Bittigau, P.3
  • 143
    • 0035807380 scopus 로고    scopus 로고
    • An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
    • Panikashvili D, Simeonidou C, Ben-Shabat S, et al. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature 2001;413:527-31.
    • (2001) Nature , vol.413 , pp. 527-531
    • Panikashvili, D.1    Simeonidou, C.2    Ben-Shabat, S.3
  • 144
    • 0034685625 scopus 로고    scopus 로고
    • Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain
    • Sugiura T, Yoshinaga N, Kondo S, et al. Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain. Biochem Biophys Res Commun 2000;271:654-8.
    • (2000) Biochem Biophys Res Commun , vol.271 , pp. 654-658
    • Sugiura, T.1    Yoshinaga, N.2    Kondo, S.3
  • 145
    • 24644450190 scopus 로고    scopus 로고
    • Cannabinoid receptors and their role in neuroprotection
    • van der Stelt M, Di Marzo V. Cannabinoid receptors and their role in neuroprotection. Neuromolecular Med 2005;7:37-50.
    • (2005) Neuromolecular Med , vol.7 , pp. 37-50
    • Van Der Stelt, M.1    Di Marzo, V.2
  • 146
    • 0037661996 scopus 로고    scopus 로고
    • Role of endogenous cannabinoids in synaptic signaling
    • Freund TF, Katona I, Piomelli D. Role of endogenous cannabinoids in synaptic signaling. Physiol Rev 2003;83:1017-66.
    • (2003) Physiol Rev , vol.83 , pp. 1017-1066
    • Freund, T.F.1    Katona, I.2    Piomelli, D.3
  • 147
    • 33644837127 scopus 로고    scopus 로고
    • Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity
    • Kim SH, Won SJ, Mao XO, et al. Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity. Mol Pharmacol 2006;69:691-6.
    • (2006) Mol Pharmacol , vol.69 , pp. 691-696
    • Kim, S.H.1    Won, S.J.2    Mao, X.O.3
  • 148
    • 0141865717 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    • Marsicano G, Goodenough S, Monory K, et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 2003;302:84-8.
    • (2003) Science , vol.302 , pp. 84-88
    • Marsicano, G.1    Goodenough, S.2    Monory, K.3
  • 149
    • 0036773310 scopus 로고    scopus 로고
    • Acute neuronal injury, excitotoxicity, and the endocannabinoid system
    • van der Stelt M, Veldhuis WB, Maccarrone M, et al. Acute neuronal injury, excitotoxicity, and the endocannabinoid system. Mol Neurobiol 2002;26:317-46.
    • (2002) Mol Neurobiol , vol.26 , pp. 317-346
    • Van Der Stelt, M.1    Veldhuis, W.B.2    Maccarrone, M.3
  • 150
    • 0032982520 scopus 로고    scopus 로고
    • The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells
    • Waksman Y, Olson JM, Carlisle SJ, et al. The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells. J Pharmacol Exp Ther 1999;288:1357-66.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 1357-1366
    • Waksman, Y.1    Olson, J.M.2    Carlisle, S.J.3
  • 151
    • 18844400058 scopus 로고    scopus 로고
    • Cannabinoid-based drugs as anti-inflammatory therapeutics
    • Klein TW. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nature Rev Immunol 2005;5:400-11.
    • (2005) Nature Rev Immunol , vol.5 , pp. 400-411
    • Klein, T.W.1
  • 152
    • 77952302634 scopus 로고    scopus 로고
    • Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment
    • Murikinati S, Juttler E, Keinert T, et al. Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment. FASEB J 2010;24:788-98.
    • (2010) FASEB J , vol.24 , pp. 788-798
    • Murikinati, S.1    Juttler, E.2    Keinert, T.3
  • 153
    • 58049170379 scopus 로고    scopus 로고
    • Endocannabinoid signaling in microglial cells
    • Stella N. Endocannabinoid signaling in microglial cells. Neuropharmacology 2009;56(Suppl 1):244-53.
    • (2009) Neuropharmacology , vol.56 , pp. 244-253
    • Stella, N.1
  • 154
    • 77954177664 scopus 로고    scopus 로고
    • Cannabinoids and the immune system: An overview
    • Tanasescu R, Constantinescu CS. Cannabinoids and the immune system: an overview. Immunobiology 2010;215:588-97.
    • (2010) Immunobiology , vol.215 , pp. 588-597
    • Tanasescu, R.1    Constantinescu, C.S.2
  • 155
    • 1842611884 scopus 로고    scopus 로고
    • Cannabinoids and neuroinflammation
    • Walter L, Stella N. Cannabinoids and neuroinflammation. Br J Pharmacol 2004;141:775-85.
    • (2004) Br J Pharmacol , vol.141 , pp. 775-785
    • Walter, L.1    Stella, N.2
  • 156
    • 0034467577 scopus 로고    scopus 로고
    • Control of the cell survival/death decision by cannabinoids
    • Guzman M, Sanchez C, Galve-Roperh I. Control of the cell survival/death decision by cannabinoids. J Mol Med 2001;78:613-25.
    • (2001) J Mol Med , vol.78 , pp. 613-625
    • Guzman, M.1    Sanchez, C.2    Galve-Roperh, I.3
  • 158
    • 0037111841 scopus 로고    scopus 로고
    • Cannabinoids promote oligodendrocyte progenitor survival: Involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    • Molina-Holgado E, Vela JM, Arevalo-Martin A, et al. Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling. JNeurosci 2002;22:9742-53.
    • (2002) JNeurosci , vol.22 , pp. 9742-9753
    • Molina-Holgado, E.1    Vela, J.M.2    Arevalo-Martin, A.3
  • 159
    • 34547484379 scopus 로고    scopus 로고
    • Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain
    • Ozaita A, Puighermanal E, Maldonado R. Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. J Neurochem 2007;102:1105-14.
    • (2007) J Neurochem , vol.102 , pp. 1105-1114
    • Ozaita, A.1    Puighermanal, E.2    Maldonado, R.3
  • 160
    • 84863380403 scopus 로고    scopus 로고
    • Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions
    • Ramirez SH, Hasko J, Skuba A, et al. Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions. J Neurosci 2012;32:4004-16.
    • (2012) J Neurosci , vol.32 , pp. 4004-4016
    • Ramirez, S.H.1    Hasko, J.2    Skuba, A.3
  • 161
    • 65549125084 scopus 로고    scopus 로고
    • Selective CB2 receptor agonism protects central neurons from remote axotomy-induced apoptosis through the PI3K/Akt pathway
    • Viscomi MT, Oddi S, Latini L, et al. Selective CB2 receptor agonism protects central neurons from remote axotomy-induced apoptosis through the PI3K/Akt pathway. J Neurosci 2009;29:4564-70.
    • (2009) J Neurosci , vol.29 , pp. 4564-4570
    • Viscomi, M.T.1    Oddi, S.2    Latini, L.3
  • 162
    • 84856290630 scopus 로고    scopus 로고
    • The cannabinoid WIN 55212-2 mitigates apoptosis and mitochondrial dysfunction after hypoxia ischemia
    • Alonso-Alconada D, Alvarez A, Alvarez FJ, et al. The cannabinoid WIN 55212-2 mitigates apoptosis and mitochondrial dysfunction after hypoxia ischemia. Neurochem Res 2012;37:161-70.
    • (2012) Neurochem Res , vol.37 , pp. 161-170
    • Alonso-Alconada, D.1    Alvarez, A.2    Alvarez, F.J.3
  • 163
    • 78149360225 scopus 로고    scopus 로고
    • The cannabinoid receptor agonist WIN 55, 212-2 reduces the initial cerebral damage after hypoxic-ischemic injury in fetal lambs
    • Alonso-Alconada D, Alvarez FJ, Alvarez A, et al. The cannabinoid receptor agonist WIN 55, 212-2 reduces the initial cerebral damage after hypoxic-ischemic injury in fetal lambs. Brain Res 2010;1362:150-9.
    • (2010) Brain Res , vol.1362 , pp. 150-159
    • Alonso-Alconada, D.1    Alvarez, F.J.2    Alvarez, A.3
  • 164
    • 34250783075 scopus 로고    scopus 로고
    • The cannabinoid agonist WIN55212 reduces brain damage in an in vivo model of hypoxic-ischemic encephalopathy in newborn rats
    • Fernandez-Lopez D, Pazos MR, Tolon RM, et al. The cannabinoid agonist WIN55212 reduces brain damage in an in vivo model of hypoxic-ischemic encephalopathy in newborn rats. Pediatr Res 2007;62:255-60.
    • (2007) Pediatr Res , vol.62 , pp. 255-260
    • Fernandez-Lopez, D.1    Pazos, M.R.2    Tolon, R.M.3
  • 165
    • 78650419708 scopus 로고    scopus 로고
    • The cannabinoid WIN55212-2 promotes neural repair after neonatal hypoxia-ischemia
    • Fernandez-Lopez D, Pradillo JM, Garcia-Yebenes I, et al. The cannabinoid WIN55212-2 promotes neural repair after neonatal hypoxia-ischemia. Stroke 2010;41:2956-64.
    • (2010) Stroke , vol.41 , pp. 2956-2964
    • Fernandez-Lopez, D.1    Pradillo, J.M.2    Garcia-Yebenes, I.3
  • 166
    • 80051774451 scopus 로고    scopus 로고
    • Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs
    • Lafuente H, Alvarez FJ, Pazos MR, et al. Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs. Pediatr Res 2011;70:272-7.
    • (2011) Pediatr Res , vol.70 , pp. 272-277
    • Lafuente, H.1    Alvarez, F.J.2    Pazos, M.R.3
  • 167
    • 84878128163 scopus 로고    scopus 로고
    • Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT (1A) and CB2 receptors
    • Pazos MR, Mohammed N, Lafuente H, et al. Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT (1A) and CB2 receptors. Neuropharmacology 2013;71:282-91.
    • (2013) Neuropharmacology , vol.71 , pp. 282-291
    • Pazos, M.R.1    Mohammed, N.2    Lafuente, H.3
  • 168
    • 0041621495 scopus 로고    scopus 로고
    • Drug-induced hypothermia reduces ischemic damage: Effects of the cannabinoid HU-210
    • Leker RR, Gai N, Mechoulam R, et al. Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210. Stroke 2003;34:2000-6.
    • (2003) Stroke , vol.34 , pp. 2000-2006
    • Leker, R.R.1    Gai, N.2    Mechoulam, R.3
  • 169
    • 84875408832 scopus 로고    scopus 로고
    • The pharmacologic and clinical effects of medical cannabis
    • Borgelt LM, Franson KL, Nussbaum AM, et al. The pharmacologic and clinical effects of medical cannabis. Pharmacotherapy 2013;33:195-209.
    • (2013) Pharmacotherapy , vol.33 , pp. 195-209
    • Borgelt, L.M.1    Franson, K.L.2    Nussbaum, A.M.3
  • 170
    • 0037218316 scopus 로고    scopus 로고
    • Therapeutic potential of cannabinoids in CNS disease
    • Croxford JL. Therapeutic potential of cannabinoids in CNS disease. CNS Drugs 2003;17:179-202.
    • (2003) CNS Drugs , vol.17 , pp. 179-202
    • Croxford, J.L.1
  • 171
    • 29044436727 scopus 로고    scopus 로고
    • Efficacy and safety of dexanabinol in severe traumatic brain injury: Results of a phase III randomised, placebo-controlled, clinical trial
    • Maas AI, Murray G, Henney H III, et al. Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial. Lancet Neurol 2006;5:38-45.
    • (2006) Lancet Neurol , vol.5 , pp. 38-45
    • Maas, A.I.1    Murray, G.2    Henney, H.3
  • 172
    • 84908142375 scopus 로고    scopus 로고
    • Erythropoietin: Emerging role of erythropoietin in neonatal neuroprotection
    • Rangarajan V, Juul SE. Erythropoietin: emerging role of erythropoietin in neonatal neuroprotection. Pediatr Neurol 2014;51:481-8.
    • (2014) Pediatr Neurol , vol.51 , pp. 481-488
    • Rangarajan, V.1    Juul, S.E.2
  • 173
    • 0030636320 scopus 로고    scopus 로고
    • Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
    • Morishita E, Masuda S, Nagao M, et al. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 1997;76:105-16.
    • (1997) Neuroscience , vol.76 , pp. 105-116
    • Morishita, E.1    Masuda, S.2    Nagao, M.3
  • 174
    • 0035064310 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture
    • Nagai A, Nakagawa E, Choi HB, et al. Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J Neuropathol Exp Neurol 2001;60:386-92.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 386-392
    • Nagai, A.1    Nakagawa, E.2    Choi, H.B.3
  • 175
    • 0030017580 scopus 로고    scopus 로고
    • Brain capillary endothelial cells express two forms of erythropoietin receptor mRNA
    • Yamaji R, Okada T, Moriya M, et al. Brain capillary endothelial cells express two forms of erythropoietin receptor mRNA. Eur J Biochem 1996;239:494-500.
    • (1996) Eur J Biochem , vol.239 , pp. 494-500
    • Yamaji, R.1    Okada, T.2    Moriya, M.3
  • 176
    • 0034368238 scopus 로고    scopus 로고
    • Neuroprotection and angiogenesis: Dual role of erythropoietin in brain ischemia
    • Marti HH, Bernaudin M, Petit E, et al. Neuroprotection and angiogenesis: dual role of erythropoietin in brain ischemia. News Physiol Sci 2000;15:225-9.
    • (2000) News Physiol Sci , vol.15 , pp. 225-229
    • Marti, H.H.1    Bernaudin, M.2    Petit, E.3
  • 177
    • 0033509001 scopus 로고    scopus 로고
    • Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia
    • Kilic E, Ozdemir YG, Bolay H, et al. Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. J Cereb Blood Flow Metab 1999;19:511-6.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 511-516
    • Kilic, E.1    Ozdemir, Y.G.2    Bolay, H.3
  • 178
    • 34548501737 scopus 로고    scopus 로고
    • Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation
    • Chen ZY, Asavaritikrai P, Prchal JT, et al. Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation. J Biol Chem 2007;282:25875-83.
    • (2007) J Biol Chem , vol.282 , pp. 25875-25883
    • Chen, Z.Y.1    Asavaritikrai, P.2    Prchal, J.T.3
  • 179
    • 0042122371 scopus 로고    scopus 로고
    • Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin
    • Prass K, Scharff A, Ruscher K, et al. Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke 2003;34:1981-6.
    • (2003) Stroke , vol.34 , pp. 1981-1986
    • Prass, K.1    Scharff, A.2    Ruscher, K.3
  • 180
    • 27244450463 scopus 로고    scopus 로고
    • Protecting neurons
    • Ferriero DM. Protecting neurons. Epilepsia 2005;46(Suppl 7):45-51.
    • (2005) Epilepsia , vol.46 , pp. 45-51
    • Ferriero, D.M.1
  • 181
    • 69049113908 scopus 로고    scopus 로고
    • Microarray analysis of high-dose recombinant erythropoietin treatment of unilateral brain injury in neonatal mouse hippocampus
    • Juul SE, Beyer RP, Bammler TK, et al. Microarray analysis of high-dose recombinant erythropoietin treatment of unilateral brain injury in neonatal mouse hippocampus. Pediatr Res 2009;65:485-92.
    • (2009) Pediatr Res , vol.65 , pp. 485-492
    • Juul, S.E.1    Beyer, R.P.2    Bammler, T.K.3
  • 182
  • 183
    • 33847203208 scopus 로고    scopus 로고
    • Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives
    • Villa P, van Beek J, Larsen AK, et al. Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives. Cereb Blood Flow Metab 2007;27:552-63.
    • (2007) Cereb Blood Flow Metab , vol.27 , pp. 552-563
    • Villa, P.1    Van Beek, J.2    Larsen, A.K.3
  • 184
    • 84876229852 scopus 로고    scopus 로고
    • Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke
    • Gonzalez FF, Larpthaveesarp A, McQuillen P, et al. Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. Stroke 2013;44:753-8.
    • (2013) Stroke , vol.44 , pp. 753-758
    • Gonzalez, F.F.1    Larpthaveesarp, A.2    McQuillen, P.3
  • 185
    • 77956905136 scopus 로고    scopus 로고
    • Delayed administration of erythropoietin reducing hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome following traumatic brain injury in rats: Comparison of treatment with single and triple dose
    • Xiong Y, Mahmood A, Meng Y, et al. Delayed administration of erythropoietin reducing hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome following traumatic brain injury in rats: comparison of treatment with single and triple dose. J Neurosurg 2010;113:598-608.
    • (2010) J Neurosurg , vol.113 , pp. 598-608
    • Xiong, Y.1    Mahmood, A.2    Meng, Y.3
  • 186
    • 84888424178 scopus 로고    scopus 로고
    • Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives
    • Kaneko N, Kako E, Sawamoto K. Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives. Front Cell Neurosci 2013;7:235.
    • (2013) Front Cell Neurosci , vol.7 , pp. 235
    • Kaneko, N.1    Kako, E.2    Sawamoto, K.3
  • 187
    • 33745271531 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration
    • Wang L, Zhang ZG, Zhang RL, et al. Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration. J Neurosci 2006;26:5996-6003.
    • (2006) J Neurosci , vol.26 , pp. 5996-6003
    • Wang, L.1    Zhang, Z.G.2    Zhang, R.L.3
  • 188
    • 78650808369 scopus 로고    scopus 로고
    • Beneficial effect of erythropoietin on sensorimotor function and white matter after hypoxia-ischemia in neonatal mice
    • Fan X, Heijnen CJ, van der KM, et al. Beneficial effect of erythropoietin on sensorimotor function and white matter after hypoxia-ischemia in neonatal mice. Pediatr Res 2011;69:56-61.
    • (2011) Pediatr Res , vol.69 , pp. 56-61
    • Fan, X.1    Heijnen, C.J.2    Der Van, K.M.3
  • 189
    • 68349103103 scopus 로고    scopus 로고
    • Erythropoietin sustains cognitive function and brain volume after neonatal stroke
    • Gonzalez FF, Abel R, Almli CR, et al. Erythropoietin sustains cognitive function and brain volume after neonatal stroke. Dev Neurosci 2009;31:403-11.
    • (2009) Dev Neurosci , vol.31 , pp. 403-411
    • Gonzalez, F.F.1    Abel, R.2    Almli, C.R.3
  • 190
    • 84899749426 scopus 로고    scopus 로고
    • Multi-modal assessment of long-term erythropoietin treatment after neonatal hypoxic-ischemic injury in rat brain
    • van de Looij Y, Chatagner A, Quairiaux C, et al. Multi-modal assessment of long-term erythropoietin treatment after neonatal hypoxic-ischemic injury in rat brain. PloS ONE 2014;9:e95643.
    • (2014) PloS ONE , vol.9 , pp. e95643
    • Van De Looij, Y.1    Chatagner, A.2    Quairiaux, C.3
  • 191
    • 84890561886 scopus 로고    scopus 로고
    • Concurrent erythropoietin and hypothermia treatment improve outcomes in a term nonhuman primate model of perinatal asphyxia
    • Traudt CM, McPherson RJ, Bauer LA, et al. Concurrent erythropoietin and hypothermia treatment improve outcomes in a term nonhuman primate model of perinatal asphyxia. Dev Neurosci 2013;35:491-503.
    • (2013) Dev Neurosci , vol.35 , pp. 491-503
    • Traudt, C.M.1    McPherson, R.J.2    Bauer, L.A.3
  • 192
    • 33846428477 scopus 로고    scopus 로고
    • Safety of high-dose recombinant erythropoietin in a neonatal rat model
    • McPherson RJ, Demers EJ, Juul SE. Safety of high-dose recombinant erythropoietin in a neonatal rat model. Neonatology 2007;91:36-43.
    • (2007) Neonatology , vol.91 , pp. 36-43
    • McPherson, R.J.1    Demers, E.J.2    Juul, S.E.3
  • 193
    • 49849104424 scopus 로고    scopus 로고
    • A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: Pharmacokinetics and safety
    • Juul SE, McPherson RJ, Bauer LA, et al. A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safety. Pediatrics 2008;122:383-91.
    • (2008) Pediatrics , vol.122 , pp. 383-391
    • Juul, S.E.1    McPherson, R.J.2    Bauer, L.A.3
  • 194
    • 84894293541 scopus 로고    scopus 로고
    • Feasibility and safety of erythropoietin for neuroprotection after perinatal arterial ischemic stroke
    • e1-2
    • Benders MJ, van der Aa NE, Roks M, et al. Feasibility and safety of erythropoietin for neuroprotection after perinatal arterial ischemic stroke. J Pediatr 2014;164:481-6 e1-2.
    • (2014) J Pediatr , vol.164 , pp. 481-486
    • Benders, M.J.1    Van Der Aa, N.E.2    Roks, M.3
  • 195
    • 84867170513 scopus 로고    scopus 로고
    • Erythropoietin for neuroprotection in neonatal encephalopathy: Safety and pharmacokinetics
    • Wu YW, Bauer LA, Ballard RA, et al. Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics. Pediatrics 2012;130:683-91.
    • (2012) Pediatrics , vol.130 , pp. 683-691
    • Wu, Y.W.1    Bauer, L.A.2    Ballard, R.A.3
  • 196
    • 84877096674 scopus 로고    scopus 로고
    • Erythropoietin receptor (EpoR) agonism is used to treat a wide range of disease
    • Sanchis-Gomar F, Perez-Quilis C, Lippi G. Erythropoietin receptor (EpoR) agonism is used to treat a wide range of disease. Mol Med 2013;19:62-4.
    • (2013) Mol Med , vol.19 , pp. 62-64
    • Sanchis-Gomar, F.1    Perez-Quilis, C.2    Lippi, G.3
  • 197
    • 84908267635 scopus 로고    scopus 로고
    • Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy
    • Rogers EE, Bonifacio SL, Glass HC, et al. Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy. Pediatr Neurol 2014;51:657-62.
    • (2014) Pediatr Neurol , vol.51 , pp. 657-662
    • Rogers, E.E.1    Bonifacio, S.L.2    Glass, H.C.3
  • 198
    • 34147098024 scopus 로고    scopus 로고
    • A comparison of high-dose recombinant erythropoietin treatment regimens in brain-injured neonatal rats
    • Kellert BA, McPherson RJ, Juul SE. A comparison of high-dose recombinant erythropoietin treatment regimens in brain-injured neonatal rats. Pediatr Res 2007;61:451-5.
    • (2007) Pediatr Res , vol.61 , pp. 451-455
    • Kellert, B.A.1    McPherson, R.J.2    Juul, S.E.3
  • 199
    • 84905446814 scopus 로고    scopus 로고
    • Single dose recombinant erythropoietin versus moderate hypothermia for neonatal hypoxic ischemic encephalopathy in low resource settings
    • Hassell
    • El Shimi MS, Awad HA, Hassanein SM, et al. Single dose recombinant erythropoietin versus moderate hypothermia for neonatal hypoxic ischemic encephalopathy in low resource settings. J Matern Fetal Neonatal Med 2014;27:1295-300. Hassell
    • (2014) J Matern Fetal Neonatal Med , vol.27 , pp. 1295-1300
    • El Shimi, M.S.1    Awad, H.A.2    Hassanein, S.M.3


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