Delayed administration of erythropoietin reducing hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome following traumatic brain injury in rats: Comparison of treatment with single and triple dose: Laboratory investigation

Journal of Neurosurgery

Volumn 113, Issue 3, 2010, Pages 598-608

  Xiong, Ye ^a   Mahmood, Asim ^a   Meng, Yuling ^a   Zhang, Yanlu ^a   Qu, Changsheng ^a   Schallert, Timothy ^d   Chopp, Michael ^b,c  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c OAKLAND UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Angiogenesis; Cell proliferation; Erythropoietin; Neurogenesis; Rat; Sensorimotor function; Spatial learning; Traumatic brain injury

Indexed keywords

BROXURIDINE; ERYTHROPOIETIN; SODIUM CHLORIDE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; BRAIN CELL; BRAIN FUNCTION; CELL COUNT; CELL LOSS; CELL PROLIFERATION; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; DENTATE GYRUS; DRUG DOSE COMPARISON; DRUG EFFICACY; HEMATOCRIT; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INJURY SCALE; MALE; MAZE TEST; MORRIS WATER MAZE TEST; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SHAM PROCEDURE; SINGLE DRUG DOSE; THERAPY DELAY; THERAPY EFFECT; TRAUMATIC BRAIN INJURY; TREATMENT RESPONSE; WISTAR RAT; ANGIOGENESIS; ANIMAL; BRAIN INJURIES; CELL DEATH; CONVALESCENCE; DISEASE MODEL; DRUG EFFECTS; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; TIME; TREATMENT OUTCOME; VASCULARIZATION;

ANIMALS; BRAIN INJURIES; CELL DEATH; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; HIPPOCAMPUS; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; NEUROGENESIS; NEURONS; NEUROPROTECTIVE AGENTS; PARIETAL LOBE; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; TIME FACTORS; TREATMENT OUTCOME;

EID: 77956905136     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2009.9.JNS09844     Document Type: Article

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