Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors

Neuropharmacology

Volumn 71, Issue , 2013, Pages 282-291

  Pazos, M Ruth ^a   Mohammed, Nagat ^a   Lafuente, Hector ^b   Santos, Martin ^a   Martínez Pinilla, Eva ^c   Moreno, Estefania ^d   Valdizan, Elsa ^e,f   Romero, Julián ^g,h   Pazos, Angel ^e,f   Franco, Rafael ^c,d   Hillard, Cecilia J ^g   Alvarez, Francisco J ^b   Martínez Orgado, Jose ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b Gurutzetako Ospitalea   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

^e UNIVERSITY OF CANTABRIA   (Spain)

^f CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^g MEDICAL COLLEGE OF WISCONSIN   (United States)

^h HOSPITAL UNIVERSITARIO FUNDACIÓN ALCORCÓN   (Spain)

Author keywords

Brain; Cannabidiol; Cannabinoids; Hypoxia ischemia; Neuroprotection; Newborn; Pigs; Serotonin

Indexed keywords

6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; CANNABIDIOL; CANNABINOID 2 RECEPTOR; CHOLINE; CREATINE; GLUTAMIC ACID; GLUTATHIONE; INTERLEUKIN 1; LACTIC ACID; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N ACETYLASPARTIC ACID; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; BRAIN NERVE CELL; CELL VIABILITY; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; EMBRYO; EXCITOTOXICITY; HUMAN; HUMAN CELL; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IN VIVO STUDY; INFLAMMATION; MALE; NEUROPROTECTION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PIGLET; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN FUNCTION; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANIMALS, NEWBORN; BRAIN; BRAIN INJURIES; CANNABIDIOL; CANNABINOID RECEPTOR ANTAGONISTS; CANNABINOIDS; DISEASE MODELS, ANIMAL; HEK293 CELLS; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; MALE; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN MULTIMERIZATION; RANDOM ALLOCATION; RECEPTOR, CANNABINOID, CB2; RECEPTOR, SEROTONIN, 5-HT1A; RECOMBINANT FUSION PROTEINS; REPERFUSION INJURY; SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS; SUS SCROFA;

EID: 84878128163     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.03.027     Document Type: Article

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